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Protein

Lysosomal acid phosphatase

Gene

Acp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42NucleophileBy similarity1
Active sitei287Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • autophagic cell death Source: MGI
  • lysosome organization Source: MGI
  • response to organic substance Source: MGI
  • skeletal system development Source: MGI

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal acid phosphatase (EC:3.1.3.2)
Short name:
LAP
Gene namesi
Name:Acp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:87882 Acp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 381LumenalSequence analysisAdd BLAST351
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 423CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Add BLAST30
ChainiPRO_000002396131 – 423Lysosomal acid phosphataseAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi159 ↔ 370By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi212 ↔ 310By similarity
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi345 ↔ 349By similarity
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP24638
PaxDbiP24638
PeptideAtlasiP24638
PRIDEiP24638

PTM databases

iPTMnetiP24638
PhosphoSitePlusiP24638
SwissPalmiP24638

Expressioni

Gene expression databases

BgeeiENSMUSG00000002103
CleanExiMM_ACP2
ExpressionAtlasiP24638 baseline and differential
GenevisibleiP24638 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002172

Structurei

3D structure databases

ProteinModelPortaliP24638
SMRiP24638
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3720 Eukaryota
ENOG410ZVBQ LUCA
GeneTreeiENSGT00530000062956
HOGENOMiHOG000231439
HOVERGENiHBG002203
InParanoidiP24638
KOiK14410
OMAiFLHLTEP
OrthoDBiEOG091G09FA
PhylomeDBiP24638
TreeFamiTF312893

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit
PS00778 HIS_ACID_PHOSPHAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRQTGWSQ AALLQFLLGM CLTVMPPIQA RSLRFVTLLY RHGDRSPVKT
60 70 80 90 100
YPKDPYQEEK WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV
110 120 130 140 150
YVRSTDFDRT LMSAEANLAG LFPPNEVQHF NPNISWQPIP VHTVPITEDR
160 170 180 190 200
LLKFPLGPCP RYEQLQNETR QTPEYQNRSI QNAQFLNMVA NETGLTNVTL
210 220 230 240 250
ETIWNVYDTL FCEQTHGLLL PPWASPQTVQ RLSQLKDFSF LFLFGIHEQV
260 270 280 290 300
QKARLQGGVL LAQILKNLTL MATTSQFPKL LVYSAHDTTL VALQMALNVY
310 320 330 340 350
NGKQAPYASC HIFELYQEDN GNFSVEMYFR NDSKKAPWPL ILPGCPHRCP
360 370 380 390 400
LQDFLRLTEP VIPKDWQKEC QLANDTADTE VIVALAVCGS ILFLLIVLLL
410 420
TILFRMQAQP PGYHHVADRE DHA
Length:423
Mass (Da):48,509
Last modified:July 11, 2003 - v2
Checksum:iAFD7A5C90A4F2AF4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131N → S in CAA40485 (PubMed:2059337).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023343 mRNA Translation: AAH23343.1
X57199 mRNA Translation: CAA40485.1
CCDSiCCDS16427.1
PIRiS14742
RefSeqiNP_031413.1, NM_007387.2
UniGeneiMm.45570

Genome annotation databases

EnsembliENSMUST00000002172; ENSMUSP00000002172; ENSMUSG00000002103
GeneIDi11432
KEGGimmu:11432
UCSCiuc008kvf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPPAL_MOUSE
AccessioniPrimary (citable) accession number: P24638
Secondary accession number(s): Q8QZT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 11, 2003
Last modified: June 20, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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