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P24636

- TBB4_ARATH

UniProt

P24636 - TBB4_ARATH

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Protein

Tubulin beta-4 chain

Gene

TUBB4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi140 – 1467GTPSequence Analysis

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. structural constituent of cytoskeleton Source: TAIR

GO - Biological processi

  1. microtubule-based process Source: InterPro
  2. protein polymerization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_187849. Kinesins.
REACT_216620. Post-chaperonin tubulin folding pathway.
REACT_236222. Prefoldin mediated transfer of substrate to CCT/TriC.
REACT_247277. Formation of tubulin folding intermediates by CCT/TriC.
REACT_269139. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta-4 chain
Alternative name(s):
Beta-4-tubulin
Gene namesi
Name:TUBB4
Synonyms:TUB4
Ordered Locus Names:At5g44340
ORF Names:K9L2.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G44340.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: TAIR
  2. cell wall Source: TAIR
  3. chloroplast stroma Source: TAIR
  4. cytosol Source: TAIR
  5. Golgi apparatus Source: TAIR
  6. microtubule Source: UniProtKB-KW
  7. plasma membrane Source: TAIR
  8. plasmodesma Source: TAIR
  9. tubulin complex Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Tubulin beta-4 chainPRO_0000048323Add
BLAST

Proteomic databases

PaxDbiP24636.
PRIDEiP24636.

Expressioni

Gene expression databases

GenevestigatoriP24636.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Protein-protein interaction databases

BioGridi19709. 3 interactions.
IntActiP24636. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP24636.
SMRiP24636. Positions 2-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiCOG5023.
HOGENOMiHOG000165710.
InParanoidiP24636.
KOiK07375.
OMAiTPPPHIF.
PhylomeDBiP24636.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR013838. Beta-tubulin_BS.
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
PS00228. TUBULIN_B_AUTOREG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24636-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MREILHIQGG QCGNQIGAKF WEVICDEHGI DHTGQYVGDS PLQLERIDVY
60 70 80 90 100
FNEASGGKYV PRAVLMDLEP GTMDSLRSGP FGQIFRPDNF VFGQSGAGNN
110 120 130 140 150
WAKGHYTEGA ELIDSVLDVV RKEAENSDCL QGFQVCHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRMMMTFSVF PSPKVSDTVV EPYNATLSVH QLVENADECM
210 220 230 240 250
VLDNEALYDI CFRTLKLANP TFGDLNHLIS ATMSGVTCCL RFPGQLNSDL
260 270 280 290 300
RKLAVNLIPF PRLHFFMVGF APLTSRGSQQ YSALSVPELT QQMWDAKNMM
310 320 330 340 350
CAADPRHGRY LTASAVFRGK LSTKEVDEQM MNIQNKNSSY FVEWIPNNVK
360 370 380 390 400
SSVCDIAPKG LKMASTFIGN STSIQEMFRR VSEQFTAMFR RKAFLHWYTG
410 420 430 440
EGMDEMEFTE AESNMNDLVA EYQQYQDATA GEEEYEEEEE EYET
Length:444
Mass (Da):49,823
Last modified:January 10, 2003 - v2
Checksum:iEEDC37FE26D1E80D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti313 – 3131A → R in AAA32757. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21415 Genomic DNA. Translation: AAA32757.1.
AB011475 Genomic DNA. Translation: BAB10119.1.
CP002688 Genomic DNA. Translation: AED95098.1.
AY059075 mRNA. Translation: AAL15181.1.
AY035141 mRNA. Translation: AAK59645.1.
PIRiS68122.
RefSeqiNP_199247.1. NM_123801.1.
UniGeneiAt.47572.
At.66973.
At.70628.
At.74833.

Genome annotation databases

EnsemblPlantsiAT5G44340.1; AT5G44340.1; AT5G44340.
GeneIDi834459.
KEGGiath:AT5G44340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21415 Genomic DNA. Translation: AAA32757.1 .
AB011475 Genomic DNA. Translation: BAB10119.1 .
CP002688 Genomic DNA. Translation: AED95098.1 .
AY059075 mRNA. Translation: AAL15181.1 .
AY035141 mRNA. Translation: AAK59645.1 .
PIRi S68122.
RefSeqi NP_199247.1. NM_123801.1.
UniGenei At.47572.
At.66973.
At.70628.
At.74833.

3D structure databases

ProteinModelPortali P24636.
SMRi P24636. Positions 2-427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 19709. 3 interactions.
IntActi P24636. 3 interactions.

Proteomic databases

PaxDbi P24636.
PRIDEi P24636.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G44340.1 ; AT5G44340.1 ; AT5G44340 .
GeneIDi 834459.
KEGGi ath:AT5G44340.

Organism-specific databases

TAIRi AT5G44340.

Phylogenomic databases

eggNOGi COG5023.
HOGENOMi HOG000165710.
InParanoidi P24636.
KOi K07375.
OMAi TPPPHIF.
PhylomeDBi P24636.

Enzyme and pathway databases

Reactomei REACT_187849. Kinesins.
REACT_216620. Post-chaperonin tubulin folding pathway.
REACT_236222. Prefoldin mediated transfer of substrate to CCT/TriC.
REACT_247277. Formation of tubulin folding intermediates by CCT/TriC.
REACT_269139. Orphan transporters.

Gene expression databases

Genevestigatori P24636.

Family and domain databases

Gene3Di 1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProi IPR013838. Beta-tubulin_BS.
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view ]
PANTHERi PTHR11588. PTHR11588. 1 hit.
Pfami PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view ]
PRINTSi PR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTi SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEi PS00227. TUBULIN. 1 hit.
PS00228. TUBULIN_B_AUTOREG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The relatively large beta-tubulin gene family of Arabidopsis contains a member with an unusual transcribed 5' noncoding sequence."
    Marks M.D., West J., Weeks D.P.
    Plant Mol. Biol. 10:91-104(1987)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
    Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiTBB4_ARATH
AccessioniPrimary (citable) accession number: P24636
Secondary accession number(s): Q9FKV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 10, 2003
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are nine genes coding for beta-tubulin.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3