Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P24617 (T2P2_NEIGO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-2 restriction enzyme NgoPII

Short name=R.NgoPII
EC=3.1.21.4
Alternative name(s):
Endonuclease NgoPII
Type II restriction enzyme NgoPII
Gene names
Name:ngoPIIR
Synonyms:dcrB
OrganismNeisseria gonorrhoeae
Taxonomic identifier485 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Recognizes the double-stranded sequence GGCC and cleaves after G-2.

Catalytic activity

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

Ontologies

Keywords
   Biological processRestriction system
   Molecular functionEndonuclease
Hydrolase
Nuclease
Gene Ontology (GO)
   Biological_processDNA restriction-modification system

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

Type II site-specific deoxyribonuclease activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Type-2 restriction enzyme NgoPII
PRO_0000077348

Sequences

Sequence LengthMass (Da)Tools
P24617 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 1BF8B25BEEC96903

FASTA27831,501
        10         20         30         40         50         60 
MNIIDAIINL ANNPVVGVES HSQSNNRANQ AGDALEEYVK DLFSGSFNLN ETQRIARHAK 

        70         80         90        100        110        120 
VFSYLGNNSN PPDAMLRNGD AIEVKKIESK DSALALNSSH PKSKLSVDDS MLTKACKDAE 

       130        140        150        160        170        180 
KWEEKDIIYI VGVVDKKKNL KHLAMVYGID YCADAECYLK IKNQIKEGIG NIGGIQFAET 

       190        200        210        220        230        240 
KELGRVNRID PLNITYLRVR GMWGIENPWF VFNYIYQRNM EKSFNFMAII NEDKWNSFNN 

       250        260        270 
TDKLLAIQDS KLAISDIKIK NPNNPARLRN AKLITYHL 

« Hide

References

[1]"Nucleotide sequence and genetic organization of the NgoPII restriction-modification system of Neisseria gonorrhoeae."
Sullivan K.M., Saunders J.R.
Mol. Gen. Genet. 216:380-387(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: P9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52661 Genomic DNA. Translation: CAA36887.1.
PIRS04419.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

REBASE1331. NgoPII.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR019046. Restrct_endonuc_II_NgoPII.
[Graphical view]
PfamPF09521. RE_NgoPII. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameT2P2_NEIGO
AccessionPrimary (citable) accession number: P24617
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries