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P24610

- PAX3_MOUSE

UniProt

P24610 - PAX3_MOUSE

Protein

Paired box protein Pax-3

Gene

Pax3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi219 – 27860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. protein binding Source: IntAct
    3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    4. sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cardiac muscle cell differentiation Source: UniProtKB
    2. cell migration Source: MGI
    3. cell proliferation Source: MGI
    4. developmental pigmentation Source: MGI
    5. heart development Source: MGI
    6. mammary gland specification Source: MGI
    7. muscle organ development Source: MGI
    8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    9. neural crest cell migration Source: MGI
    10. neural tube closure Source: MGI
    11. neural tube development Source: MGI
    12. neuron fate commitment Source: MGI
    13. positive regulation of cell proliferation Source: MGI
    14. positive regulation of transcription, DNA-templated Source: MGI
    15. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    16. regulation of somitogenesis Source: MGI
    17. skeletal muscle cell differentiation Source: UniProtKB
    18. spinal cord association neuron differentiation Source: MGI
    19. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Myogenesis, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired box protein Pax-3
    Gene namesi
    Name:Pax3
    Synonyms:Pax-3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:97487. Pax3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    The Splotch (Sp) mouse mutant displays defects in neural tube closure in the form of exencephaly and spina bifida. The splotch-delayed (Spd) phenotype is less severe than the other Sp alleles.1 Publication

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Paired box protein Pax-3PRO_0000050179Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei201 – 2011PhosphoserineBy similarity
    Modified residuei205 – 2051PhosphoserineBy similarity
    Modified residuei209 – 2091PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP24610.

    PTM databases

    PhosphoSiteiP24610.

    Expressioni

    Developmental stagei

    Expressed during early neurogenesis.

    Gene expression databases

    BgeeiP24610.
    CleanExiMM_PAX3.
    GenevestigatoriP24610.

    Interactioni

    Subunit structurei

    Can bind to DNA as homodimer or a heterodimer with PAX7. Interacts with DAXX By similarity. Interacts with PAXBP1; the interaction links PAX3 to a WDR5-containing histone methyltransferase complex.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PSMD4P550363EBI-1208116,EBI-359318From a different organism.
    RAD23BP547274EBI-1208116,EBI-954531From a different organism.
    Rb1P134053EBI-1208116,EBI-971782
    RBL1P287493EBI-1208116,EBI-971402From a different organism.
    RBL2Q089993EBI-1208116,EBI-971439From a different organism.
    UBBP0CG472EBI-1208116,EBI-413034From a different organism.

    Protein-protein interaction databases

    BioGridi202030. 21 interactions.
    IntActiP24610. 7 interactions.
    MINTiMINT-4653013.

    Structurei

    3D structure databases

    ProteinModelPortaliP24610.
    SMRiP24610. Positions 35-158, 219-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 161128PairedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 paired domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, Paired box

    Phylogenomic databases

    eggNOGiNOG326044.
    GeneTreeiENSGT00680000099553.
    HOGENOMiHOG000230939.
    HOVERGENiHBG009115.
    KOiK09381.
    PhylomeDBiP24610.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR022106. Pax7.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00292. PAX. 1 hit.
    PF12360. Pax7. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SMARTiSM00389. HOX. 1 hit.
    SM00351. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24610-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP    50
    LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA 100
    IGGSKPKQVT TPDVEKKIEE YKRENPGMFS WEIRDKLLKD AVCDRNTVPS 150
    VSSISRILRS KFGKGEEEEA DLERKEAEES EKKAKHSIDG ILSERASAPQ 200
    SDEGSDIDSE PDLPLKRKQR RSRTTFTAEQ LEELERAFER THYPDIYTRE 250
    ELAQRAKLTE ARVQVWFSNR RARWRKQAGA NQLMAFNHLI PGGFPPTAMP 300
    TLPTYQLSET SYQPTSIPQA VSDPSSTVHR PQPLPPSTVH QSTIPSNADS 350
    SSAYCLPSTR HGFSSYTDSF VPPSGPSNPM NPTIGNGLSP QVMGLLTNHG 400
    GVPHQPQTDY ALSPLTGGLE PTTTVSASCS QRLEHMKNVD SLPTSQPYCP 450
    PTYSTAGYSM DPVTGYQYGQ YGQSKPWTF 479
    Length:479
    Mass (Da):52,949
    Last modified:March 1, 2005 - v2
    Checksum:i8806E551FFB755A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti140 – 1401D → G in BAC32185. (PubMed:16141072)Curated
    Sequence conflicti310 – 3101T → H in CAA42008. (PubMed:2022185)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421G → R in Spd. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59358 mRNA. Translation: CAA42008.1.
    AK014337 mRNA. Translation: BAB29280.1.
    AK045018 mRNA. Translation: BAC32185.1.
    AK148354 mRNA. Translation: BAE28501.1.
    S66429 mRNA. Translation: AAB20359.1.
    S66433 mRNA. Translation: AAB20360.1.
    CCDSiCCDS15082.1.
    PIRiS15031.
    RefSeqiNP_001152992.1. NM_001159520.1.
    NP_032807.3. NM_008781.4.
    UniGeneiMm.1371.

    Genome annotation databases

    EnsembliENSMUST00000087086; ENSMUSP00000084320; ENSMUSG00000004872.
    GeneIDi18505.
    KEGGimmu:18505.
    UCSCiuc007bqb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59358 mRNA. Translation: CAA42008.1 .
    AK014337 mRNA. Translation: BAB29280.1 .
    AK045018 mRNA. Translation: BAC32185.1 .
    AK148354 mRNA. Translation: BAE28501.1 .
    S66429 mRNA. Translation: AAB20359.1 .
    S66433 mRNA. Translation: AAB20360.1 .
    CCDSi CCDS15082.1.
    PIRi S15031.
    RefSeqi NP_001152992.1. NM_001159520.1.
    NP_032807.3. NM_008781.4.
    UniGenei Mm.1371.

    3D structure databases

    ProteinModelPortali P24610.
    SMRi P24610. Positions 35-158, 219-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202030. 21 interactions.
    IntActi P24610. 7 interactions.
    MINTi MINT-4653013.

    PTM databases

    PhosphoSitei P24610.

    Proteomic databases

    PRIDEi P24610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087086 ; ENSMUSP00000084320 ; ENSMUSG00000004872 .
    GeneIDi 18505.
    KEGGi mmu:18505.
    UCSCi uc007bqb.2. mouse.

    Organism-specific databases

    CTDi 5077.
    MGIi MGI:97487. Pax3.

    Phylogenomic databases

    eggNOGi NOG326044.
    GeneTreei ENSGT00680000099553.
    HOGENOMi HOG000230939.
    HOVERGENi HBG009115.
    KOi K09381.
    PhylomeDBi P24610.

    Miscellaneous databases

    ChiTaRSi PAX3. mouse.
    NextBioi 294224.
    PROi P24610.
    SOURCEi Search...

    Gene expression databases

    Bgeei P24610.
    CleanExi MM_PAX3.
    Genevestigatori P24610.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR022106. Pax7.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00292. PAX. 1 hit.
    PF12360. Pax7. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SMARTi SM00389. HOX. 1 hit.
    SM00351. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pax-3, a novel murine DNA binding protein expressed during early neurogenesis."
      Goulding M.D., Chalepakis G., Deutsch U., Erselius J.R., Gruss P.
      EMBO J. 10:1135-1147(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    3. "Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3."
      Epstein D.J., Vekemans M., Gros P.
      Cell 67:767-774(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 219-260, DISEASE, FUNCTION.
    4. "Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism."
      Diao Y., Guo X., Li Y., Sun K., Lu L., Jiang L., Fu X., Zhu H., Sun H., Wang H., Wu Z.
      Cell Stem Cell 11:231-241(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PAXBP1.
    5. "The splotch-delayed (Spd) mouse mutant carries a point mutation within the paired box of the Pax-3 gene."
      Vogan K.J., Epstein D.J., Trasler D.G., Gros P.
      Genomics 17:364-369(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SPD ARG-42.

    Entry informationi

    Entry nameiPAX3_MOUSE
    AccessioniPrimary (citable) accession number: P24610
    Secondary accession number(s): Q3UFQ9, Q8BRE7, Q9CXI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3