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Protein

Paired box protein Pax-3

Gene

Pax3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi219 – 278HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: MGI
  • sequence-specific DNA binding Source: MGI
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: MGI

GO - Biological processi

  • cardiac muscle cell differentiation Source: UniProtKB
  • cell migration Source: MGI
  • cell proliferation Source: MGI
  • developmental pigmentation Source: MGI
  • heart development Source: MGI
  • mammary gland specification Source: MGI
  • muscle organ development Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neural crest cell migration Source: MGI
  • neural crest formation Source: InterPro
  • neural tube closure Source: MGI
  • neural tube development Source: MGI
  • neuron fate commitment Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of somitogenesis Source: MGI
  • skeletal muscle cell differentiation Source: UniProtKB
  • skeletal muscle organ development Source: MGI
  • spinal cord association neuron differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Myogenesis, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-3
Gene namesi
Name:Pax3
Synonyms:Pax-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97487. Pax3.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

The Splotch (Sp) mouse mutant displays defects in neural tube closure in the form of exencephaly and spina bifida. The splotch-delayed (Spd) phenotype is less severe than the other Sp alleles.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501791 – 479Paired box protein Pax-3Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei201PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei209PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24610.
PaxDbiP24610.
PeptideAtlasiP24610.
PRIDEiP24610.

PTM databases

iPTMnetiP24610.
PhosphoSitePlusiP24610.

Expressioni

Developmental stagei

Expressed during early neurogenesis.

Gene expression databases

BgeeiENSMUSG00000004872.
CleanExiMM_PAX3.
ExpressionAtlasiP24610. baseline and differential.
GenevisibleiP24610. MM.

Interactioni

Subunit structurei

Can bind to DNA as homodimer or a heterodimer with PAX7. Interacts with DAXX. Interacts with PAXBP1; the interaction links PAX3 to a WDR5-containing histone methyltransferase complex. Interacts with TBX18.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMD4P550363EBI-1208116,EBI-359318From a different organism.
RAD23BP547274EBI-1208116,EBI-954531From a different organism.
Rb1P134053EBI-1208116,EBI-971782
RBL1P287493EBI-1208116,EBI-971402From a different organism.
RBL2Q089993EBI-1208116,EBI-971439From a different organism.
UBBP0CG472EBI-1208116,EBI-413034From a different organism.

Protein-protein interaction databases

BioGridi202030. 21 interactors.
IntActiP24610. 7 interactors.
MINTiMINT-4653013.
STRINGi10090.ENSMUSP00000004994.

Structurei

3D structure databases

ProteinModelPortaliP24610.
SMRiP24610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 161PairedPROSITE-ProRule annotationAdd BLAST128

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.
HOVERGENiHBG009115.
InParanoidiP24610.
KOiK09381.
PhylomeDBiP24610.

Family and domain databases

CDDicd00131. PAX. 1 hit.
Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR033038. Pax3.
IPR022106. Pax7_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR24329:SF307. PTHR24329:SF307. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PF12360. Pax7. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP
60 70 80 90 100
LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA
110 120 130 140 150
IGGSKPKQVT TPDVEKKIEE YKRENPGMFS WEIRDKLLKD AVCDRNTVPS
160 170 180 190 200
VSSISRILRS KFGKGEEEEA DLERKEAEES EKKAKHSIDG ILSERASAPQ
210 220 230 240 250
SDEGSDIDSE PDLPLKRKQR RSRTTFTAEQ LEELERAFER THYPDIYTRE
260 270 280 290 300
ELAQRAKLTE ARVQVWFSNR RARWRKQAGA NQLMAFNHLI PGGFPPTAMP
310 320 330 340 350
TLPTYQLSET SYQPTSIPQA VSDPSSTVHR PQPLPPSTVH QSTIPSNADS
360 370 380 390 400
SSAYCLPSTR HGFSSYTDSF VPPSGPSNPM NPTIGNGLSP QVMGLLTNHG
410 420 430 440 450
GVPHQPQTDY ALSPLTGGLE PTTTVSASCS QRLEHMKNVD SLPTSQPYCP
460 470
PTYSTAGYSM DPVTGYQYGQ YGQSKPWTF
Length:479
Mass (Da):52,949
Last modified:March 1, 2005 - v2
Checksum:i8806E551FFB755A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140D → G in BAC32185 (PubMed:16141072).Curated1
Sequence conflicti310T → H in CAA42008 (PubMed:2022185).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti42G → R in Spd. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59358 mRNA. Translation: CAA42008.1.
AK014337 mRNA. Translation: BAB29280.1.
AK045018 mRNA. Translation: BAC32185.1.
AK148354 mRNA. Translation: BAE28501.1.
S66429 mRNA. Translation: AAB20359.1.
S66433 mRNA. Translation: AAB20360.1.
CCDSiCCDS15082.1.
PIRiS15031.
RefSeqiNP_001152992.1. NM_001159520.1.
NP_032807.3. NM_008781.4.
UniGeneiMm.1371.

Genome annotation databases

EnsembliENSMUST00000087086; ENSMUSP00000084320; ENSMUSG00000004872.
GeneIDi18505.
KEGGimmu:18505.
UCSCiuc007bqb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59358 mRNA. Translation: CAA42008.1.
AK014337 mRNA. Translation: BAB29280.1.
AK045018 mRNA. Translation: BAC32185.1.
AK148354 mRNA. Translation: BAE28501.1.
S66429 mRNA. Translation: AAB20359.1.
S66433 mRNA. Translation: AAB20360.1.
CCDSiCCDS15082.1.
PIRiS15031.
RefSeqiNP_001152992.1. NM_001159520.1.
NP_032807.3. NM_008781.4.
UniGeneiMm.1371.

3D structure databases

ProteinModelPortaliP24610.
SMRiP24610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202030. 21 interactors.
IntActiP24610. 7 interactors.
MINTiMINT-4653013.
STRINGi10090.ENSMUSP00000004994.

PTM databases

iPTMnetiP24610.
PhosphoSitePlusiP24610.

Proteomic databases

MaxQBiP24610.
PaxDbiP24610.
PeptideAtlasiP24610.
PRIDEiP24610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087086; ENSMUSP00000084320; ENSMUSG00000004872.
GeneIDi18505.
KEGGimmu:18505.
UCSCiuc007bqb.2. mouse.

Organism-specific databases

CTDi5077.
MGIiMGI:97487. Pax3.

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.
HOVERGENiHBG009115.
InParanoidiP24610.
KOiK09381.
PhylomeDBiP24610.

Enzyme and pathway databases

ReactomeiR-MMU-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiPax3. mouse.
PROiP24610.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004872.
CleanExiMM_PAX3.
ExpressionAtlasiP24610. baseline and differential.
GenevisibleiP24610. MM.

Family and domain databases

CDDicd00131. PAX. 1 hit.
Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR033038. Pax3.
IPR022106. Pax7_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR24329:SF307. PTHR24329:SF307. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PF12360. Pax7. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAX3_MOUSE
AccessioniPrimary (citable) accession number: P24610
Secondary accession number(s): Q3UFQ9, Q8BRE7, Q9CXI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 2005
Last modified: November 30, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.