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P24610

- PAX3_MOUSE

UniProt

P24610 - PAX3_MOUSE

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Protein

Paired box protein Pax-3

Gene

Pax3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi219 – 27860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cardiac muscle cell differentiation Source: UniProtKB
  2. cell migration Source: MGI
  3. cell proliferation Source: MGI
  4. developmental pigmentation Source: MGI
  5. heart development Source: MGI
  6. mammary gland specification Source: MGI
  7. muscle organ development Source: MGI
  8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  9. neural crest cell migration Source: MGI
  10. neural tube closure Source: MGI
  11. neural tube development Source: MGI
  12. neuron fate commitment Source: MGI
  13. positive regulation of cell proliferation Source: MGI
  14. positive regulation of transcription, DNA-templated Source: MGI
  15. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  16. regulation of somitogenesis Source: MGI
  17. skeletal muscle cell differentiation Source: UniProtKB
  18. spinal cord association neuron differentiation Source: MGI
  19. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Myogenesis, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-3
Gene namesi
Name:Pax3
Synonyms:Pax-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:97487. Pax3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

The Splotch (Sp) mouse mutant displays defects in neural tube closure in the form of exencephaly and spina bifida. The splotch-delayed (Spd) phenotype is less severe than the other Sp alleles.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Paired box protein Pax-3PRO_0000050179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011PhosphoserineBy similarity
Modified residuei205 – 2051PhosphoserineBy similarity
Modified residuei209 – 2091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24610.
PRIDEiP24610.

PTM databases

PhosphoSiteiP24610.

Expressioni

Developmental stagei

Expressed during early neurogenesis.

Gene expression databases

BgeeiP24610.
CleanExiMM_PAX3.
ExpressionAtlasiP24610. baseline and differential.
GenevestigatoriP24610.

Interactioni

Subunit structurei

Can bind to DNA as homodimer or a heterodimer with PAX7. Interacts with DAXX. Interacts with PAXBP1; the interaction links PAX3 to a WDR5-containing histone methyltransferase complex. Interacts with TBX18.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMD4P550363EBI-1208116,EBI-359318From a different organism.
RAD23BP547274EBI-1208116,EBI-954531From a different organism.
Rb1P134053EBI-1208116,EBI-971782
RBL1P287493EBI-1208116,EBI-971402From a different organism.
RBL2Q089993EBI-1208116,EBI-971439From a different organism.
UBBP0CG472EBI-1208116,EBI-413034From a different organism.

Protein-protein interaction databases

BioGridi202030. 21 interactions.
IntActiP24610. 7 interactions.
MINTiMINT-4653013.

Structurei

3D structure databases

ProteinModelPortaliP24610.
SMRiP24610. Positions 35-158, 219-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 161128PairedPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiNOG326044.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.
HOVERGENiHBG009115.
InParanoidiP24610.
KOiK09381.
PhylomeDBiP24610.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022106. Pax7.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PF12360. Pax7. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24610-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP
60 70 80 90 100
LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA
110 120 130 140 150
IGGSKPKQVT TPDVEKKIEE YKRENPGMFS WEIRDKLLKD AVCDRNTVPS
160 170 180 190 200
VSSISRILRS KFGKGEEEEA DLERKEAEES EKKAKHSIDG ILSERASAPQ
210 220 230 240 250
SDEGSDIDSE PDLPLKRKQR RSRTTFTAEQ LEELERAFER THYPDIYTRE
260 270 280 290 300
ELAQRAKLTE ARVQVWFSNR RARWRKQAGA NQLMAFNHLI PGGFPPTAMP
310 320 330 340 350
TLPTYQLSET SYQPTSIPQA VSDPSSTVHR PQPLPPSTVH QSTIPSNADS
360 370 380 390 400
SSAYCLPSTR HGFSSYTDSF VPPSGPSNPM NPTIGNGLSP QVMGLLTNHG
410 420 430 440 450
GVPHQPQTDY ALSPLTGGLE PTTTVSASCS QRLEHMKNVD SLPTSQPYCP
460 470
PTYSTAGYSM DPVTGYQYGQ YGQSKPWTF
Length:479
Mass (Da):52,949
Last modified:March 1, 2005 - v2
Checksum:i8806E551FFB755A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1401D → G in BAC32185. (PubMed:16141072)Curated
Sequence conflicti310 – 3101T → H in CAA42008. (PubMed:2022185)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421G → R in Spd. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59358 mRNA. Translation: CAA42008.1.
AK014337 mRNA. Translation: BAB29280.1.
AK045018 mRNA. Translation: BAC32185.1.
AK148354 mRNA. Translation: BAE28501.1.
S66429 mRNA. Translation: AAB20359.1.
S66433 mRNA. Translation: AAB20360.1.
CCDSiCCDS15082.1.
PIRiS15031.
RefSeqiNP_001152992.1. NM_001159520.1.
NP_032807.3. NM_008781.4.
UniGeneiMm.1371.

Genome annotation databases

EnsembliENSMUST00000087086; ENSMUSP00000084320; ENSMUSG00000004872.
GeneIDi18505.
KEGGimmu:18505.
UCSCiuc007bqb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59358 mRNA. Translation: CAA42008.1 .
AK014337 mRNA. Translation: BAB29280.1 .
AK045018 mRNA. Translation: BAC32185.1 .
AK148354 mRNA. Translation: BAE28501.1 .
S66429 mRNA. Translation: AAB20359.1 .
S66433 mRNA. Translation: AAB20360.1 .
CCDSi CCDS15082.1.
PIRi S15031.
RefSeqi NP_001152992.1. NM_001159520.1.
NP_032807.3. NM_008781.4.
UniGenei Mm.1371.

3D structure databases

ProteinModelPortali P24610.
SMRi P24610. Positions 35-158, 219-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202030. 21 interactions.
IntActi P24610. 7 interactions.
MINTi MINT-4653013.

PTM databases

PhosphoSitei P24610.

Proteomic databases

MaxQBi P24610.
PRIDEi P24610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087086 ; ENSMUSP00000084320 ; ENSMUSG00000004872 .
GeneIDi 18505.
KEGGi mmu:18505.
UCSCi uc007bqb.2. mouse.

Organism-specific databases

CTDi 5077.
MGIi MGI:97487. Pax3.

Phylogenomic databases

eggNOGi NOG326044.
GeneTreei ENSGT00680000099553.
HOGENOMi HOG000230939.
HOVERGENi HBG009115.
InParanoidi P24610.
KOi K09381.
PhylomeDBi P24610.

Miscellaneous databases

ChiTaRSi Pax3. mouse.
NextBioi 294224.
PROi P24610.
SOURCEi Search...

Gene expression databases

Bgeei P24610.
CleanExi MM_PAX3.
ExpressionAtlasi P24610. baseline and differential.
Genevestigatori P24610.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022106. Pax7.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PF12360. Pax7. 1 hit.
[Graphical view ]
PRINTSi PR00027. PAIREDBOX.
SMARTi SM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pax-3, a novel murine DNA binding protein expressed during early neurogenesis."
    Goulding M.D., Chalepakis G., Deutsch U., Erselius J.R., Gruss P.
    EMBO J. 10:1135-1147(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3."
    Epstein D.J., Vekemans M., Gros P.
    Cell 67:767-774(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 219-260, DISEASE, FUNCTION.
  4. "T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm."
    Farin H.F., Mansouri A., Petry M., Kispert A.
    J. Biol. Chem. 283:25372-25380(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TBX18.
  5. "Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism."
    Diao Y., Guo X., Li Y., Sun K., Lu L., Jiang L., Fu X., Zhu H., Sun H., Wang H., Wu Z.
    Cell Stem Cell 11:231-241(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PAXBP1.
  6. "The splotch-delayed (Spd) mouse mutant carries a point mutation within the paired box of the Pax-3 gene."
    Vogan K.J., Epstein D.J., Trasler D.G., Gros P.
    Genomics 17:364-369(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SPD ARG-42.

Entry informationi

Entry nameiPAX3_MOUSE
AccessioniPrimary (citable) accession number: P24610
Secondary accession number(s): Q3UFQ9, Q8BRE7, Q9CXI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 2005
Last modified: November 26, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3