Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Paired box protein Pax-3

Gene

Pax3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi219 – 278HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • sequence-specific DNA binding Source: MGI
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGI

GO - Biological processi

  • cardiac muscle cell differentiation Source: UniProtKB
  • cell migration Source: MGI
  • cell proliferation Source: MGI
  • developmental pigmentation Source: MGI
  • heart development Source: MGI
  • mammary gland specification Source: MGI
  • muscle organ development Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • neural crest cell migration Source: MGI
  • neural tube closure Source: MGI
  • neural tube development Source: MGI
  • neuron fate commitment Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of somitogenesis Source: MGI
  • skeletal muscle cell differentiation Source: UniProtKB
  • skeletal muscle organ development Source: MGI
  • spinal cord association neuron differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processMyogenesis, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-3
Gene namesi
Name:Pax3
Synonyms:Pax-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97487 Pax3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

The Splotch (Sp) mouse mutant displays defects in neural tube closure in the form of exencephaly and spina bifida. The splotch-delayed (Spd) phenotype is less severe than the other Sp alleles.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501791 – 479Paired box protein Pax-3Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei201PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei209PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24610
PaxDbiP24610
PeptideAtlasiP24610
PRIDEiP24610

PTM databases

iPTMnetiP24610
PhosphoSitePlusiP24610

Expressioni

Developmental stagei

Expressed during early neurogenesis.

Gene expression databases

BgeeiENSMUSG00000004872
CleanExiMM_PAX3
ExpressionAtlasiP24610 baseline and differential
GenevisibleiP24610 MM

Interactioni

Subunit structurei

Can bind to DNA as homodimer or a heterodimer with PAX7. Interacts with DAXX. Interacts with PAXBP1; the interaction links PAX3 to a WDR5-containing histone methyltransferase complex. Interacts with TBX18. Interacts with SOX10 (By similarity).By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi202030, 21 interactors
CORUMiP24610
IntActiP24610, 7 interactors
MINTiP24610
STRINGi10090.ENSMUSP00000004994

Structurei

3D structure databases

ProteinModelPortaliP24610
SMRiP24610
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 161PairedPROSITE-ProRule annotationAdd BLAST128

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiKOG0849 Eukaryota
ENOG410XS01 LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230939
HOVERGENiHBG009115
InParanoidiP24610
KOiK09381
PhylomeDBiP24610

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001523 Paired_dom
IPR022106 Pax7_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00292 PAX, 1 hit
PF12360 Pax7, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

P24610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP
60 70 80 90 100
LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA
110 120 130 140 150
IGGSKPKQVT TPDVEKKIEE YKRENPGMFS WEIRDKLLKD AVCDRNTVPS
160 170 180 190 200
VSSISRILRS KFGKGEEEEA DLERKEAEES EKKAKHSIDG ILSERASAPQ
210 220 230 240 250
SDEGSDIDSE PDLPLKRKQR RSRTTFTAEQ LEELERAFER THYPDIYTRE
260 270 280 290 300
ELAQRAKLTE ARVQVWFSNR RARWRKQAGA NQLMAFNHLI PGGFPPTAMP
310 320 330 340 350
TLPTYQLSET SYQPTSIPQA VSDPSSTVHR PQPLPPSTVH QSTIPSNADS
360 370 380 390 400
SSAYCLPSTR HGFSSYTDSF VPPSGPSNPM NPTIGNGLSP QVMGLLTNHG
410 420 430 440 450
GVPHQPQTDY ALSPLTGGLE PTTTVSASCS QRLEHMKNVD SLPTSQPYCP
460 470
PTYSTAGYSM DPVTGYQYGQ YGQSKPWTF
Length:479
Mass (Da):52,949
Last modified:March 1, 2005 - v2
Checksum:i8806E551FFB755A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140D → G in BAC32185 (PubMed:16141072).Curated1
Sequence conflicti310T → H in CAA42008 (PubMed:2022185).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti42G → R in Spd. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59358 mRNA Translation: CAA42008.1
AK014337 mRNA Translation: BAB29280.1
AK045018 mRNA Translation: BAC32185.1
AK148354 mRNA Translation: BAE28501.1
S66429 mRNA Translation: AAB20359.1
S66433 mRNA Translation: AAB20360.1
CCDSiCCDS15082.1
PIRiS15031
RefSeqiNP_001152992.1, NM_001159520.1
NP_032807.3, NM_008781.4
UniGeneiMm.1371

Genome annotation databases

EnsembliENSMUST00000087086; ENSMUSP00000084320; ENSMUSG00000004872
GeneIDi18505
KEGGimmu:18505
UCSCiuc007bqb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPAX3_MOUSE
AccessioniPrimary (citable) accession number: P24610
Secondary accession number(s): Q3UFQ9, Q8BRE7, Q9CXI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health