##gff-version 3 P24604 UniProtKB Chain 1 630 . . . ID=PRO_0000088171;Note=Tyrosine-protein kinase Tec P24604 UniProtKB Domain 4 111 . . . Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 P24604 UniProtKB Domain 178 238 . . . Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 P24604 UniProtKB Domain 246 344 . . . Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191 P24604 UniProtKB Domain 369 622 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P24604 UniProtKB Zinc finger 113 149 . . . Note=Btk-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00432 P24604 UniProtKB Active site 488 488 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028 P24604 UniProtKB Binding site 121 121 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00432 P24604 UniProtKB Binding site 132 132 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00432 P24604 UniProtKB Binding site 133 133 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00432 P24604 UniProtKB Binding site 143 143 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00432 P24604 UniProtKB Binding site 375 383 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P24604 UniProtKB Binding site 397 397 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P24604 UniProtKB Modified residue 205 205 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42680 P24604 UniProtKB Modified residue 227 227 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P42680 P24604 UniProtKB Modified residue 518 518 . . . Note=Phosphotyrosine%3B by autocatalysis%2C LYN and JAK2;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:9473212,ECO:0007744|PubMed:17947660,ECO:0007744|PubMed:19144319;Dbxref=PMID:17947660,PMID:19144319,PMID:9473212 P24604 UniProtKB Alternative sequence 1 94 . . . ID=VSP_005012;Note=In isoform 2. MNFNTILEEILIKRSQQKKKTSLLNYKERLCVLPKSVLSYYEGRAEKKYRKGVIDISKIKCVEIVKNDDGVIPCQNKFPFQVVHDANTLYIFAP->MMVSFPVKINFHS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2284097;Dbxref=PMID:2284097 P24604 UniProtKB Alternative sequence 82 100 . . . ID=VSP_005013;Note=In isoform 6. VVHDANTLYIFAPSPQSRD->STKQGPMGEEVKRRNKEQQ;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24604 UniProtKB Alternative sequence 101 630 . . . ID=VSP_005014;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24604 UniProtKB Alternative sequence 224 245 . . . ID=VSP_005015;Note=In isoform 2%2C isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2284097;Dbxref=PMID:2284097 P24604 UniProtKB Alternative sequence 604 630 . . . ID=VSP_005016;Note=In isoform 3 and isoform 4. RPEGRPSLEDLLRTIDELVECEETFGR->ESCLCRVAQDLSSKNLIGSRF;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24604 UniProtKB Mutagenesis 397 397 . . . Note=Impairs kinase activity. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8621063;Dbxref=PMID:8621063 P24604 UniProtKB Sequence conflict 23 23 . . . Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24604 UniProtKB Sequence conflict 31 31 . . . Note=C->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24604 UniProtKB Sequence conflict 34 34 . . . Note=P->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24604 UniProtKB Sequence conflict 535 535 . . . Note=V->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24604 UniProtKB Sequence conflict 550 553 . . . Note=FGVL->YGIP;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24604 UniProtKB Sequence conflict 590 590 . . . Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24604 UniProtKB Sequence conflict 611 611 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24604 UniProtKB Beta strand 183 185 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GL5 P24604 UniProtKB Beta strand 192 196 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GL5 P24604 UniProtKB Beta strand 204 209 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GL5 P24604 UniProtKB Beta strand 211 219 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GL5 P24604 UniProtKB Beta strand 221 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GL5 P24604 UniProtKB Beta strand 225 229 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GL5 P24604 UniProtKB Beta strand 232 236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GL5 P24604 UniProtKB Turn 237 241 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GL5