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Protein

Tyrosine-protein kinase Tec

Gene

Tec

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-82'. May also be involved in the regulation of osteoclast differentiation.6 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Enzyme regulationi

Activated by tyrosine phosphorylation by a wide range of cytokine stimulations. When T-cells or B-cells receptors are activated, a series of phosphorylation leads to the recruitment of TEC to the cell membrane, where it is phosphorylated at Tyr-518. Also activated in response to SCF. Integrin engagement induces tyrosine phosphorylation of TEC in platelets. STAP1 participates in a positive feedback loop by increasing the activity of TEC. SOCS1 is an inhibitor of TEC kinase activity.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi121ZincBy similarity1
Metal bindingi132ZincBy similarity1
Metal bindingi133ZincBy similarity1
Metal bindingi143ZincBy similarity1
Binding sitei397ATPPROSITE-ProRule annotation1
Active sitei488Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri113 – 149Btk-typePROSITE-ProRule annotationAdd BLAST37
Nucleotide bindingi375 – 383ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Adaptive immunity, Immunity

Keywords - Ligandi

ATP-binding, Lipid-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiR-MMU-2871809. FCERI mediated Ca+2 mobilization.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Tec (EC:2.7.10.2)
Gene namesi
Name:Tec
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98662. Tec.

Subcellular locationi

  • Cytoplasm
  • Cell membrane; Peripheral membrane protein
  • Cytoplasmcytoskeleton

  • Note: Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi397K → M: Impairs kinase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881711 – 630Tyrosine-protein kinase TecAdd BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei227PhosphotyrosineBy similarity1
Modified residuei518Phosphotyrosine; by autocatalysis, LYN and JAK2Combined sources1 Publication1

Post-translational modificationi

Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-518. Undergoes also tyrosine phosphorylation during platelet activation.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP24604.
PeptideAtlasiP24604.
PRIDEiP24604.

PTM databases

iPTMnetiP24604.
PhosphoSitePlusiP24604.

Expressioni

Tissue specificityi

Preferentially expressed in liver. Expression is also seen in the hematopoietic cells such as bone marrow, thymus and spleen. Lower expression is seen in the heart, kidney and ovary.

Gene expression databases

BgeeiENSMUSG00000029217.

Interactioni

Subunit structurei

Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with CD28, FASLG, FGF2, GRB10 and KIT (By similarity). Interacts with VAV1 and JAK2. Interacts with LYN.By similarity2 Publications

Protein-protein interaction databases

BioGridi204103. 2 interactors.
IntActiP24604. 1 interactor.
MINTiMINT-5167157.
STRINGi10090.ENSMUSP00000071836.

Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi183 – 185Combined sources3
Beta strandi192 – 196Combined sources5
Beta strandi204 – 209Combined sources6
Beta strandi211 – 219Combined sources9
Beta strandi221 – 223Combined sources3
Beta strandi225 – 229Combined sources5
Beta strandi232 – 236Combined sources5
Turni237 – 241Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL5NMR-A181-244[»]
ProteinModelPortaliP24604.
SMRiP24604.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24604.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 111PHPROSITE-ProRule annotationAdd BLAST108
Domaini178 – 238SH3PROSITE-ProRule annotationAdd BLAST61
Domaini246 – 344SH2PROSITE-ProRule annotationAdd BLAST99
Domaini369 – 622Protein kinasePROSITE-ProRule annotationAdd BLAST254

Domaini

The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its targeting to the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain.1 Publication
The SH3 domain is essential for its targeting to activated CD28 costimulatory molecule.By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.PROSITE-ProRule annotation
Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri113 – 149Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233859.
HOVERGENiHBG008761.
InParanoidiP24604.
KOiK07364.
PhylomeDBiP24604.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00402. TECBTKDOMAIN.
PR00109. TYRKINASE.
SMARTiSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P24604-1) [UniParc]FASTAAdd to basket
Also known as: TecIV

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFNTILEEI LIKRSQQKKK TSLLNYKERL CVLPKSVLSY YEGRAEKKYR
60 70 80 90 100
KGVIDISKIK CVEIVKNDDG VIPCQNKFPF QVVHDANTLY IFAPSPQSRD
110 120 130 140 150
RWVKKLKEEI KNNNNIMIKY HPKFWADGSY QCCRQTEKLA PGCEKYNLFE
160 170 180 190 200
SSIRKTLPPA PEIKKRRPPP PIPPEEENTE EIVVAMYDFQ ATEAHDLRLE
210 220 230 240 250
RGQEYIILEK NDLHWWRARD KYGSEGYIPS NYVTGKKSNN LDQYEWYCRN
260 270 280 290 300
TNRSKAEQLL RTEDKEGGFM VRDSSQPGLY TVSLYTKFGG EGSSGFRHYH
310 320 330 340 350
IKETATSPKK YYLAEKHAFG SIPEIIEYHK HNAAGLVTRL RYPVSTKGKN
360 370 380 390 400
APTTAGFSYD KWEINPSELT FMRELGSGLF GVVRLGKWRA QYKVAIKAIR
410 420 430 440 450
EGAMCEEDFI EEAKVMMKLT HPKLVQLYGV CTQQKPIYIV TEFMERGCLL
460 470 480 490 500
NFLRQRQGHF SRDMLLSMCQ DVCEGMEYLE RNSFIHRDLA ARNCLVNEAG
510 520 530 540 550
VVKVSDFGMA RYVLDDQYTS SSGAKFPVKW CPPEVFNYSR FSSKSDVWSF
560 570 580 590 600
GVLMWEIFTE GRMPFEKNTN YEVVTMVTRG HRLHRPKLAT KYLYEVMLRC
610 620 630
WQERPEGRPS LEDLLRTIDE LVECEETFGR
Length:630
Mass (Da):73,426
Last modified:November 1, 1995 - v2
Checksum:i262640EE90D4A6D2
GO
Isoform 2 (identifier: P24604-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: MNFNTILEEI...DANTLYIFAP → MMVSFPVKINFHS
     224-245: Missing.

Show »
Length:527
Mass (Da):61,523
Checksum:i72819611523F0872
GO
Isoform 3 (identifier: P24604-3) [UniParc]FASTAAdd to basket
Also known as: TecIIb

The sequence of this isoform differs from the canonical sequence as follows:
     604-630: RPEGRPSLEDLLRTIDELVECEETFGR → ESCLCRVAQDLSSKNLIGSRF

Show »
Length:624
Mass (Da):72,592
Checksum:i196018BC9EC862A5
GO
Isoform 4 (identifier: P24604-4) [UniParc]FASTAAdd to basket
Also known as: TecIIa

The sequence of this isoform differs from the canonical sequence as follows:
     224-245: Missing.
     604-630: RPEGRPSLEDLLRTIDELVECEETFGR → ESCLCRVAQDLSSKNLIGSRF

Show »
Length:602
Mass (Da):70,104
Checksum:iB213B18A8519E4F5
GO
Isoform 5 (identifier: P24604-5) [UniParc]FASTAAdd to basket
Also known as: TecIII

The sequence of this isoform differs from the canonical sequence as follows:
     224-245: Missing.

Show »
Length:608
Mass (Da):70,938
Checksum:iC43EF410FD030DA1
GO
Isoform 6 (identifier: P24604-6) [UniParc]FASTAAdd to basket
Also known as: TecI

The sequence of this isoform differs from the canonical sequence as follows:
     82-100: VVHDANTLYIFAPSPQSRD → STKQGPMGEEVKRRNKEQQ
     101-630: Missing.

Show »
Length:100
Mass (Da):11,723
Checksum:i32AB0BC0567F2CEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23L → P in AAD43404 (PubMed:10343129).Curated1
Sequence conflicti23L → P in AAD43402 (PubMed:10343129).Curated1
Sequence conflicti23L → P in AAD43405 (PubMed:10343129).Curated1
Sequence conflicti23L → P in AAD43406 (PubMed:10343129).Curated1
Sequence conflicti23L → P in AAD43407 (PubMed:10343129).Curated1
Sequence conflicti31C → F in AAD43404 (PubMed:10343129).Curated1
Sequence conflicti31C → F in AAD43402 (PubMed:10343129).Curated1
Sequence conflicti31C → F in AAD43405 (PubMed:10343129).Curated1
Sequence conflicti31C → F in AAD43406 (PubMed:10343129).Curated1
Sequence conflicti31C → F in AAD43407 (PubMed:10343129).Curated1
Sequence conflicti34P → T in AAD43404 (PubMed:10343129).Curated1
Sequence conflicti34P → T in AAD43402 (PubMed:10343129).Curated1
Sequence conflicti34P → T in AAD43405 (PubMed:10343129).Curated1
Sequence conflicti34P → T in AAD43406 (PubMed:10343129).Curated1
Sequence conflicti34P → T in AAD43407 (PubMed:10343129).Curated1
Sequence conflicti535V → E in AAA40018 (PubMed:2482828).Curated1
Sequence conflicti550 – 553FGVL → YGIP in AAA40018 (PubMed:2482828).Curated4
Sequence conflicti590T → S in AAD43402 (PubMed:10343129).Curated1
Sequence conflicti590T → S in AAD43405 (PubMed:10343129).Curated1
Sequence conflicti590T → S in AAD43406 (PubMed:10343129).Curated1
Sequence conflicti590T → S in AAD43407 (PubMed:10343129).Curated1
Sequence conflicti611L → F in AAD43404 (PubMed:10343129).Curated1
Sequence conflicti611L → F in AAD43402 (PubMed:10343129).Curated1
Sequence conflicti611L → F in AAD43405 (PubMed:10343129).Curated1
Sequence conflicti611L → F in AAD43406 (PubMed:10343129).Curated1
Sequence conflicti611L → F in AAD43407 (PubMed:10343129).Curated1
Sequence conflicti611L → F in CAA39196 (PubMed:2284097).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0050121 – 94MNFNT…YIFAP → MMVSFPVKINFHS in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_00501382 – 100VVHDA…PQSRD → STKQGPMGEEVKRRNKEQQ in isoform 6. CuratedAdd BLAST19
Alternative sequenceiVSP_005014101 – 630Missing in isoform 6. CuratedAdd BLAST530
Alternative sequenceiVSP_005015224 – 245Missing in isoform 2, isoform 4 and isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_005016604 – 630RPEGR…ETFGR → ESCLCRVAQDLSSKNLIGSR F in isoform 3 and isoform 4. CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S53716 mRNA. Translation: AAA13515.2.
AF071938, AF071936, AF071937 Genomic DNA. Translation: AAD43404.1.
AF071946
, AF071936, AF071937, AF071938, AF071939, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43402.1.
AF071946
, AF071936, AF071937, AF071938, AF071939, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43405.1.
AF071946
, AF071936, AF071937, AF071938, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43406.1.
AF071946
, AF071936, AF071937, AF071938, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43407.1.
X55663 mRNA. Translation: CAA39196.1.
M33427 mRNA. Translation: AAA40018.1.
CCDSiCCDS51515.1. [P24604-5]
CCDS51516.1. [P24604-1]
PIRiJU0215.
S13763.
T01380.
RefSeqiNP_001106931.1. NM_001113460.2.
NP_001106932.1. NM_001113461.2.
NP_001106935.1. NM_001113464.2.
XP_006503908.1. XM_006503845.3.
XP_006503909.1. XM_006503846.3.
XP_011239020.1. XM_011240718.2.
XP_011239021.1. XM_011240719.2.
UniGeneiMm.319581.

Genome annotation databases

GeneIDi21682.
KEGGimmu:21682.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S53716 mRNA. Translation: AAA13515.2.
AF071938, AF071936, AF071937 Genomic DNA. Translation: AAD43404.1.
AF071946
, AF071936, AF071937, AF071938, AF071939, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43402.1.
AF071946
, AF071936, AF071937, AF071938, AF071939, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43405.1.
AF071946
, AF071936, AF071937, AF071938, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43406.1.
AF071946
, AF071936, AF071937, AF071938, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43407.1.
X55663 mRNA. Translation: CAA39196.1.
M33427 mRNA. Translation: AAA40018.1.
CCDSiCCDS51515.1. [P24604-5]
CCDS51516.1. [P24604-1]
PIRiJU0215.
S13763.
T01380.
RefSeqiNP_001106931.1. NM_001113460.2.
NP_001106932.1. NM_001113461.2.
NP_001106935.1. NM_001113464.2.
XP_006503908.1. XM_006503845.3.
XP_006503909.1. XM_006503846.3.
XP_011239020.1. XM_011240718.2.
XP_011239021.1. XM_011240719.2.
UniGeneiMm.319581.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL5NMR-A181-244[»]
ProteinModelPortaliP24604.
SMRiP24604.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204103. 2 interactors.
IntActiP24604. 1 interactor.
MINTiMINT-5167157.
STRINGi10090.ENSMUSP00000071836.

PTM databases

iPTMnetiP24604.
PhosphoSitePlusiP24604.

Proteomic databases

PaxDbiP24604.
PeptideAtlasiP24604.
PRIDEiP24604.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi21682.
KEGGimmu:21682.

Organism-specific databases

CTDi7006.
MGIiMGI:98662. Tec.

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233859.
HOVERGENiHBG008761.
InParanoidiP24604.
KOiK07364.
PhylomeDBiP24604.

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiR-MMU-2871809. FCERI mediated Ca+2 mobilization.

Miscellaneous databases

EvolutionaryTraceiP24604.
PROiP24604.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029217.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00402. TECBTKDOMAIN.
PR00109. TYRKINASE.
SMARTiSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEC_MOUSE
AccessioniPrimary (citable) accession number: P24604
Secondary accession number(s): Q9R1M9
, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.