Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P24604

- TEC_MOUSE

UniProt

P24604 - TEC_MOUSE

Protein

Tyrosine-protein kinase Tec

Gene

Tec

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-82'. May also be involved in the regulation of osteoclast differentiation.6 Publications

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Enzyme regulationi

    Activated by tyrosine phosphorylation by a wide range of cytokine stimulations. When T-cells or B-cells receptors are activated, a series of phosphorylation leads to the recruitment of TEC to the cell membrane, where it is phosphorylated at Tyr-518. Also activated in response to SCF. Integrin engagement induces tyrosine phosphorylation of TEC in platelets. STAP1 participates in a positive feedback loop by increasing the activity of TEC. SOCS1 is an inhibitor of TEC kinase activity.4 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi121 – 1211ZincBy similarity
    Metal bindingi132 – 1321ZincBy similarity
    Metal bindingi133 – 1331ZincBy similarity
    Metal bindingi143 – 1431ZincBy similarity
    Binding sitei397 – 3971ATPPROSITE-ProRule annotation
    Active sitei488 – 4881Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri113 – 14937Btk-typePROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi375 – 3839ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. lipid binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    5. protein binding Source: MGI

    GO - Biological processi

    1. immune system process Source: UniProtKB-KW
    2. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Keywords - Ligandi

    ATP-binding, Lipid-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3474.
    ReactomeiREACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_188578. Signaling by SCF-KIT.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase Tec (EC:2.7.10.2)
    Gene namesi
    Name:Tec
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:98662. Tec.

    Subcellular locationi

    Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasmcytoskeleton
    Note: Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP By similarity.By similarity

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. cytoskeleton Source: UniProtKB-SubCell
    3. cytosol Source: Reactome
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi397 – 3971K → M: Impairs kinase activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 630630Tyrosine-protein kinase TecPRO_0000088171Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei205 – 2051Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei227 – 2271PhosphotyrosineBy similarity
    Modified residuei518 – 5181Phosphotyrosine; by autocatalysis, LYN and JAK23 Publications

    Post-translational modificationi

    Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-518. Undergoes also tyrosine phosphorylation during platelet activation.5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP24604.

    PTM databases

    PhosphoSiteiP24604.

    Expressioni

    Tissue specificityi

    Preferentially expressed in liver. Expression is also seen in the hematopoietic cells such as bone marrow, thymus and spleen. Lower expression is seen in the heart, kidney and ovary.

    Gene expression databases

    ArrayExpressiP24604.
    BgeeiP24604.
    GenevestigatoriP24604.

    Interactioni

    Subunit structurei

    Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with CD28, FASLG, FGF2, GRB10 and KIT By similarity. Interacts with VAV1 and JAK2. Interacts with LYN.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi204103. 2 interactions.
    IntActiP24604. 1 interaction.
    MINTiMINT-5167157.

    Structurei

    Secondary structure

    1
    630
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi183 – 1853
    Beta strandi192 – 1965
    Beta strandi204 – 2096
    Beta strandi211 – 2199
    Beta strandi221 – 2233
    Beta strandi225 – 2295
    Beta strandi232 – 2365
    Turni237 – 2415

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1GL5NMR-A181-244[»]
    ProteinModelPortaliP24604.
    SMRiP24604. Positions 1-623.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP24604.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 111108PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 23861SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini246 – 34499SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini369 – 622254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its targeting to the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain.1 Publication
    The SH3 domain is essential for its targeting to activated CD28 costimulatory molecule.By similarity

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.PROSITE-ProRule annotation
    Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri113 – 14937Btk-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    SH2 domain, SH3 domain, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00640000091251.
    HOGENOMiHOG000233859.
    HOVERGENiHBG008761.
    InParanoidiP24604.
    KOiK07364.
    OrthoDBiEOG7KM5SC.
    PhylomeDBiP24604.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR001562. Znf_Btk_motif.
    [Graphical view]
    PfamiPF00779. BTK. 1 hit.
    PF00169. PH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00402. TECBTKDOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00107. BTK. 1 hit.
    SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P24604-1) [UniParc]FASTAAdd to Basket

    Also known as: TecIV

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNFNTILEEI LIKRSQQKKK TSLLNYKERL CVLPKSVLSY YEGRAEKKYR    50
    KGVIDISKIK CVEIVKNDDG VIPCQNKFPF QVVHDANTLY IFAPSPQSRD 100
    RWVKKLKEEI KNNNNIMIKY HPKFWADGSY QCCRQTEKLA PGCEKYNLFE 150
    SSIRKTLPPA PEIKKRRPPP PIPPEEENTE EIVVAMYDFQ ATEAHDLRLE 200
    RGQEYIILEK NDLHWWRARD KYGSEGYIPS NYVTGKKSNN LDQYEWYCRN 250
    TNRSKAEQLL RTEDKEGGFM VRDSSQPGLY TVSLYTKFGG EGSSGFRHYH 300
    IKETATSPKK YYLAEKHAFG SIPEIIEYHK HNAAGLVTRL RYPVSTKGKN 350
    APTTAGFSYD KWEINPSELT FMRELGSGLF GVVRLGKWRA QYKVAIKAIR 400
    EGAMCEEDFI EEAKVMMKLT HPKLVQLYGV CTQQKPIYIV TEFMERGCLL 450
    NFLRQRQGHF SRDMLLSMCQ DVCEGMEYLE RNSFIHRDLA ARNCLVNEAG 500
    VVKVSDFGMA RYVLDDQYTS SSGAKFPVKW CPPEVFNYSR FSSKSDVWSF 550
    GVLMWEIFTE GRMPFEKNTN YEVVTMVTRG HRLHRPKLAT KYLYEVMLRC 600
    WQERPEGRPS LEDLLRTIDE LVECEETFGR 630
    Length:630
    Mass (Da):73,426
    Last modified:November 1, 1995 - v2
    Checksum:i262640EE90D4A6D2
    GO
    Isoform 2 (identifier: P24604-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-94: MNFNTILEEI...DANTLYIFAP → MMVSFPVKINFHS
         224-245: Missing.

    Show »
    Length:527
    Mass (Da):61,523
    Checksum:i72819611523F0872
    GO
    Isoform 3 (identifier: P24604-3) [UniParc]FASTAAdd to Basket

    Also known as: TecIIb

    The sequence of this isoform differs from the canonical sequence as follows:
         604-630: RPEGRPSLEDLLRTIDELVECEETFGR → ESCLCRVAQDLSSKNLIGSRF

    Show »
    Length:624
    Mass (Da):72,592
    Checksum:i196018BC9EC862A5
    GO
    Isoform 4 (identifier: P24604-4) [UniParc]FASTAAdd to Basket

    Also known as: TecIIa

    The sequence of this isoform differs from the canonical sequence as follows:
         224-245: Missing.
         604-630: RPEGRPSLEDLLRTIDELVECEETFGR → ESCLCRVAQDLSSKNLIGSRF

    Show »
    Length:602
    Mass (Da):70,104
    Checksum:iB213B18A8519E4F5
    GO
    Isoform 5 (identifier: P24604-5) [UniParc]FASTAAdd to Basket

    Also known as: TecIII

    The sequence of this isoform differs from the canonical sequence as follows:
         224-245: Missing.

    Show »
    Length:608
    Mass (Da):70,938
    Checksum:iC43EF410FD030DA1
    GO
    Isoform 6 (identifier: P24604-6) [UniParc]FASTAAdd to Basket

    Also known as: TecI

    The sequence of this isoform differs from the canonical sequence as follows:
         82-100: VVHDANTLYIFAPSPQSRD → STKQGPMGEEVKRRNKEQQ
         101-630: Missing.

    Show »
    Length:100
    Mass (Da):11,723
    Checksum:i32AB0BC0567F2CEC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231L → P in AAD43404. (PubMed:10343129)Curated
    Sequence conflicti23 – 231L → P in AAD43402. (PubMed:10343129)Curated
    Sequence conflicti23 – 231L → P in AAD43405. (PubMed:10343129)Curated
    Sequence conflicti23 – 231L → P in AAD43406. (PubMed:10343129)Curated
    Sequence conflicti23 – 231L → P in AAD43407. (PubMed:10343129)Curated
    Sequence conflicti31 – 311C → F in AAD43404. (PubMed:10343129)Curated
    Sequence conflicti31 – 311C → F in AAD43402. (PubMed:10343129)Curated
    Sequence conflicti31 – 311C → F in AAD43405. (PubMed:10343129)Curated
    Sequence conflicti31 – 311C → F in AAD43406. (PubMed:10343129)Curated
    Sequence conflicti31 – 311C → F in AAD43407. (PubMed:10343129)Curated
    Sequence conflicti34 – 341P → T in AAD43404. (PubMed:10343129)Curated
    Sequence conflicti34 – 341P → T in AAD43402. (PubMed:10343129)Curated
    Sequence conflicti34 – 341P → T in AAD43405. (PubMed:10343129)Curated
    Sequence conflicti34 – 341P → T in AAD43406. (PubMed:10343129)Curated
    Sequence conflicti34 – 341P → T in AAD43407. (PubMed:10343129)Curated
    Sequence conflicti535 – 5351V → E in AAA40018. (PubMed:2482828)Curated
    Sequence conflicti550 – 5534FGVL → YGIP in AAA40018. (PubMed:2482828)Curated
    Sequence conflicti590 – 5901T → S in AAD43402. (PubMed:10343129)Curated
    Sequence conflicti590 – 5901T → S in AAD43405. (PubMed:10343129)Curated
    Sequence conflicti590 – 5901T → S in AAD43406. (PubMed:10343129)Curated
    Sequence conflicti590 – 5901T → S in AAD43407. (PubMed:10343129)Curated
    Sequence conflicti611 – 6111L → F in AAD43404. (PubMed:10343129)Curated
    Sequence conflicti611 – 6111L → F in AAD43402. (PubMed:10343129)Curated
    Sequence conflicti611 – 6111L → F in AAD43405. (PubMed:10343129)Curated
    Sequence conflicti611 – 6111L → F in AAD43406. (PubMed:10343129)Curated
    Sequence conflicti611 – 6111L → F in AAD43407. (PubMed:10343129)Curated
    Sequence conflicti611 – 6111L → F in CAA39196. (PubMed:2284097)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9494MNFNT…YIFAP → MMVSFPVKINFHS in isoform 2. 1 PublicationVSP_005012Add
    BLAST
    Alternative sequencei82 – 10019VVHDA…PQSRD → STKQGPMGEEVKRRNKEQQ in isoform 6. CuratedVSP_005013Add
    BLAST
    Alternative sequencei101 – 630530Missing in isoform 6. CuratedVSP_005014Add
    BLAST
    Alternative sequencei224 – 24522Missing in isoform 2, isoform 4 and isoform 5. 1 PublicationVSP_005015Add
    BLAST
    Alternative sequencei604 – 63027RPEGR…ETFGR → ESCLCRVAQDLSSKNLIGSR F in isoform 3 and isoform 4. CuratedVSP_005016Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S53716 mRNA. Translation: AAA13515.2.
    AF071938, AF071936, AF071937 Genomic DNA. Translation: AAD43404.1.
    AF071946
    , AF071936, AF071937, AF071938, AF071939, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43402.1.
    AF071946
    , AF071936, AF071937, AF071938, AF071939, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43405.1.
    AF071946
    , AF071936, AF071937, AF071938, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43406.1.
    AF071946
    , AF071936, AF071937, AF071938, AF071940, AF071941, AF071942, AF071943, AF071944, AF071945 Genomic DNA. Translation: AAD43407.1.
    X55663 mRNA. Translation: CAA39196.1.
    M33427 mRNA. Translation: AAA40018.1.
    CCDSiCCDS51515.1. [P24604-5]
    CCDS51516.1. [P24604-1]
    PIRiJU0215.
    S13763.
    T01380.
    RefSeqiNP_001106931.1. NM_001113460.2.
    NP_001106932.1. NM_001113461.2.
    NP_001106935.1. NM_001113464.2.
    XP_006503908.1. XM_006503845.1.
    XP_006503909.1. XM_006503846.1.
    UniGeneiMm.319581.

    Genome annotation databases

    EnsembliENSMUST00000138842; ENSMUSP00000120155; ENSMUSG00000029217.
    ENSMUST00000149533; ENSMUSP00000123258; ENSMUSG00000029217.
    GeneIDi21682.
    KEGGimmu:21682.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S53716 mRNA. Translation: AAA13515.2 .
    AF071938 , AF071936 , AF071937 Genomic DNA. Translation: AAD43404.1 .
    AF071946
    , AF071936 , AF071937 , AF071938 , AF071939 , AF071940 , AF071941 , AF071942 , AF071943 , AF071944 , AF071945 Genomic DNA. Translation: AAD43402.1 .
    AF071946
    , AF071936 , AF071937 , AF071938 , AF071939 , AF071940 , AF071941 , AF071942 , AF071943 , AF071944 , AF071945 Genomic DNA. Translation: AAD43405.1 .
    AF071946
    , AF071936 , AF071937 , AF071938 , AF071940 , AF071941 , AF071942 , AF071943 , AF071944 , AF071945 Genomic DNA. Translation: AAD43406.1 .
    AF071946
    , AF071936 , AF071937 , AF071938 , AF071940 , AF071941 , AF071942 , AF071943 , AF071944 , AF071945 Genomic DNA. Translation: AAD43407.1 .
    X55663 mRNA. Translation: CAA39196.1 .
    M33427 mRNA. Translation: AAA40018.1 .
    CCDSi CCDS51515.1. [P24604-5 ]
    CCDS51516.1. [P24604-1 ]
    PIRi JU0215.
    S13763.
    T01380.
    RefSeqi NP_001106931.1. NM_001113460.2.
    NP_001106932.1. NM_001113461.2.
    NP_001106935.1. NM_001113464.2.
    XP_006503908.1. XM_006503845.1.
    XP_006503909.1. XM_006503846.1.
    UniGenei Mm.319581.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1GL5 NMR - A 181-244 [» ]
    ProteinModelPortali P24604.
    SMRi P24604. Positions 1-623.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204103. 2 interactions.
    IntActi P24604. 1 interaction.
    MINTi MINT-5167157.

    PTM databases

    PhosphoSitei P24604.

    Proteomic databases

    PRIDEi P24604.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000138842 ; ENSMUSP00000120155 ; ENSMUSG00000029217 .
    ENSMUST00000149533 ; ENSMUSP00000123258 ; ENSMUSG00000029217 .
    GeneIDi 21682.
    KEGGi mmu:21682.

    Organism-specific databases

    CTDi 7006.
    MGIi MGI:98662. Tec.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00640000091251.
    HOGENOMi HOG000233859.
    HOVERGENi HBG008761.
    InParanoidi P24604.
    KOi K07364.
    OrthoDBi EOG7KM5SC.
    PhylomeDBi P24604.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3474.
    Reactomei REACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_188578. Signaling by SCF-KIT.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

    Miscellaneous databases

    EvolutionaryTracei P24604.
    NextBioi 300992.
    PROi P24604.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P24604.
    Bgeei P24604.
    Genevestigatori P24604.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR001562. Znf_Btk_motif.
    [Graphical view ]
    Pfami PF00779. BTK. 1 hit.
    PF00169. PH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00402. TECBTKDOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00107. BTK. 1 hit.
    SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit."
      Mano H., Mano K., Tang B., Koehler M., Yi T., Gilbert D.J., Jenkins N.A., Copeland N.G., Ihle J.N.
      Oncogene 8:417-424(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Splice variants of the mouse Tec gene are differentially expressed in vivo."
      Merkel A.L., Atmosukarto I.I.C., Stevens K., Rathjen P.D., Booker G.W.
      Cytogenet. Cell Genet. 84:132-139(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 3; 4; 5 AND 6).
      Strain: 129.
    3. "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver."
      Mano H., Ishikawa F., Nishida J., Hirai H., Takaku F.
      Oncogene 5:1781-1786(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-630 (ISOFORM 2).
      Strain: BALB/c.
      Tissue: Liver.
    4. "The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family."
      Wilks A.F., Kurban R.R., Hovens C.M., Ralph S.J.
      Gene 85:67-74(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 485-553.
    5. "Tec protein tyrosine kinase is involved in the signaling mechanism of granulocyte colony-stimulating factor receptor."
      Miyazato A., Yamashita Y., Hatake K., Miura Y., Ozawa K., Mano H.
      Cell Growth Differ. 7:1135-1139(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, ENZYME REGULATION, INTERACTION WITH VAV1.
    6. "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase."
      Mano H., Yamashita Y., Miyazato A., Miura Y., Ozawa K.
      FASEB J. 10:637-642(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY LYN, ENZYME REGULATION, MUTAGENESIS OF LYS-397.
    7. "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription."
      Yamashita Y., Watanabe S., Miyazato A., Ohya K., Ikeda U., Shimada K., Komatsu N., Hatake K., Miura Y., Ozawa K., Mano H.
      Blood 91:1496-1507(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION OF JAK2, PHOSPHORYLATION AT TYR-518.
    8. "Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway."
      Yang W.C., Olive D.
      Eur. J. Immunol. 29:1842-1849(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, FUNCTION IN THE CD28 SIGNALING PATHWAY.
    9. "The role of Tec protein-tyrosine kinase in T cell signaling."
      Yang W.C., Ghiotto M., Barbarat B., Olive D.
      J. Biol. Chem. 274:607-617(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD28, ENZYME REGULATION, FUNCTION IN PHOSPHORYLATION OF DOK1.
    10. "The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule."
      Garcon F., Ghiotto M., Gerard A., Yang W.C., Olive D., Nunes J.A.
      Eur. J. Immunol. 34:1972-1980(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DOMAIN.
    11. "Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy."
      Kane L.P., Watkins S.C.
      J. Biol. Chem. 280:21949-21954(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    12. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-518, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell.
    13. Cited for: FUNCTION.
    14. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-518, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: SUBCELLULAR LOCATION.
    16. "TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF."
      Li F., Jiang Y., Zheng Q., Yang X., Wang S.
      Biochem. Biophys. Res. Commun. 404:79-85(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN THE HGF-INDUCED ERK SIGNALING PATHWAY.
    17. "The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domain."
      Pursglove S.E., Mulhern T.D., Mackay J.P., Hinds M.G., Booker G.W.
      J. Biol. Chem. 277:755-762(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 179-245.

    Entry informationi

    Entry nameiTEC_MOUSE
    AccessioniPrimary (citable) accession number: P24604
    Secondary accession number(s): Q9R1M9
    , Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 155 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3