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Protein

Bacterioferritin

Gene

bfr

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bCuratedNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.Curated
  • Fe cationBy similarityNote: Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18Iron 1PROSITE-ProRule annotation1
Metal bindingi48Iron (heme axial ligand); shared with dimeric partnerPROSITE-ProRule annotation1
Metal bindingi51Iron 1PROSITE-ProRule annotation1
Metal bindingi51Iron 2PROSITE-ProRule annotation1
Metal bindingi54Iron 1PROSITE-ProRule annotation1
Metal bindingi94Iron 2PROSITE-ProRule annotation1
Metal bindingi128Iron 1PROSITE-ProRule annotation1
Metal bindingi128Iron 2PROSITE-ProRule annotation1
Metal bindingi131Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin (EC:1.16.3.1)
Short name:
BFR
Gene namesi
Name:bfr
Ordered Locus Names:sll1341
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001926131 – 156BacterioferritinAdd BLAST156

Proteomic databases

PRIDEiP24602.

Interactioni

Subunit structurei

Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.By similarity

Structurei

3D structure databases

ProteinModelPortaliP24602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 146Ferritin-like diironPROSITE-ProRule annotationAdd BLAST146

Sequence similaritiesi

Belongs to the bacterioferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000262383.
InParanoidiP24602.
KOiK03594.
OMAiHEMQDET.
PhylomeDBiP24602.

Family and domain databases

CDDicd00907. Bacterioferritin. 1 hit.
Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR00754. bfr. 1 hit.
PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGKPAVLAQ LHKLLRGELA ARDQYFIHSR MYQDWGLEKL YSRIDHEMQD
60 70 80 90 100
ETAHASLLIE RILFLEETPD LSQQDPIRVG KTVPEMLQYD LDYEYEVIAN
110 120 130 140 150
LKEAMAVCEQ EQDYQSRDLL LKILADTEED HAYWLEKQLG LIEKIGLQNY

LQSQMS
Length:156
Mass (Da):18,331
Last modified:November 1, 1997 - v2
Checksum:i7C1A13B31157AF86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53 – 54AH → HA AA sequence (PubMed:1536655).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18637.1.
PIRiS76725.

Genome annotation databases

EnsemblBacteriaiBAA18637; BAA18637; BAA18637.
KEGGisyn:sll1341.
PATRICi23843424. VBISynSp132158_3248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18637.1.
PIRiS76725.

3D structure databases

ProteinModelPortaliP24602.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP24602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18637; BAA18637; BAA18637.
KEGGisyn:sll1341.
PATRICi23843424. VBISynSp132158_3248.

Phylogenomic databases

HOGENOMiHOG000262383.
InParanoidiP24602.
KOiK03594.
OMAiHEMQDET.
PhylomeDBiP24602.

Family and domain databases

CDDicd00907. Bacterioferritin. 1 hit.
Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR00754. bfr. 1 hit.
PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBFR_SYNY3
AccessioniPrimary (citable) accession number: P24602
Secondary accession number(s): P74531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.