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P24594

- IBP5_RAT

UniProt

P24594 - IBP5_RAT

Protein

Insulin-like growth factor-binding protein 5

Gene

Igfbp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

    GO - Molecular functioni

    1. insulin-like growth factor binding Source: RGD

    GO - Biological processi

    1. cellular response to cAMP Source: Ensembl
    2. glucose homeostasis Source: Ensembl
    3. glucose metabolic process Source: Ensembl
    4. hair follicle morphogenesis Source: Ensembl
    5. intracellular signal transduction Source: RGD
    6. mammary gland involution Source: Ensembl
    7. negative regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
    8. negative regulation of osteoblast differentiation Source: Ensembl
    9. negative regulation of smooth muscle cell migration Source: Ensembl
    10. negative regulation of smooth muscle cell proliferation Source: Ensembl
    11. negative regulation of translation Source: Ensembl
    12. osteoblast differentiation Source: Ensembl
    13. positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
    14. positive regulation of protein kinase B signaling Source: Ensembl
    15. regulation of cell growth Source: Ensembl
    16. regulation of glucose metabolic process Source: Ensembl
    17. skeletal muscle tissue growth Source: RGD
    18. striated muscle cell differentiation Source: Ensembl
    19. type B pancreatic cell proliferation Source: Ensembl

    Keywords - Ligandi

    Growth factor binding

    Protein family/group databases

    MEROPSiI31.952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 5
    Short name:
    IBP-5
    Short name:
    IGF-binding protein 5
    Short name:
    IGFBP-5
    Gene namesi
    Name:Igfbp5
    Synonyms:Igfbp-5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi2876. Igfbp5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 271252Insulin-like growth factor-binding protein 5PRO_0000014388Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
    Disulfide bondi66 ↔ 79PROSITE-ProRule annotation
    Disulfide bondi191 ↔ 218PROSITE-ProRule annotation
    Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
    Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP24594.

    Expressioni

    Tissue specificityi

    Mostly in kidney.

    Gene expression databases

    GenevestigatoriP24594.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-204226.
    STRINGi10116.ENSRNOP00000023530.

    Structurei

    3D structure databases

    ProteinModelPortaliP24594.
    SMRiP24594. Positions 24-104.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 10281IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini188 – 26275Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42882.
    GeneTreeiENSGT00550000074457.
    HOGENOMiHOG000253012.
    HOVERGENiHBG002631.
    InParanoidiP24594.
    OMAiYREQAKI.
    OrthoDBiEOG74N5HG.
    PhylomeDBiP24594.
    TreeFamiTF331211.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR012213. IGFBP-5.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF4. PTHR11551:SF4. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01981. IGFBPFAMILY5.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24594-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVISVVLLLL AACAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP    50
    GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL 100
    NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA 150
    VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESDQGP CRRHMEASLQ 200
    EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL 250
    PGMEYVDGDF QCHAFDSSNV E 271
    Length:271
    Mass (Da):30,298
    Last modified:March 1, 1992 - v1
    Checksum:i545B4C48F9BB5493
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62781 mRNA. Translation: AAA53533.1.
    L08275 Genomic DNA. No translation available.
    PIRiJC1463.
    RefSeqiNP_036949.1. NM_012817.1.
    UniGeneiRn.1593.

    Genome annotation databases

    EnsembliENSRNOT00000023530; ENSRNOP00000023530; ENSRNOG00000017206.
    GeneIDi25285.
    KEGGirno:25285.
    UCSCiRGD:2876. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62781 mRNA. Translation: AAA53533.1 .
    L08275 Genomic DNA. No translation available.
    PIRi JC1463.
    RefSeqi NP_036949.1. NM_012817.1.
    UniGenei Rn.1593.

    3D structure databases

    ProteinModelPortali P24594.
    SMRi P24594. Positions 24-104.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-204226.
    STRINGi 10116.ENSRNOP00000023530.

    Protein family/group databases

    MEROPSi I31.952.

    Proteomic databases

    PRIDEi P24594.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000023530 ; ENSRNOP00000023530 ; ENSRNOG00000017206 .
    GeneIDi 25285.
    KEGGi rno:25285.
    UCSCi RGD:2876. rat.

    Organism-specific databases

    CTDi 3488.
    RGDi 2876. Igfbp5.

    Phylogenomic databases

    eggNOGi NOG42882.
    GeneTreei ENSGT00550000074457.
    HOGENOMi HOG000253012.
    HOVERGENi HBG002631.
    InParanoidi P24594.
    OMAi YREQAKI.
    OrthoDBi EOG74N5HG.
    PhylomeDBi P24594.
    TreeFami TF331211.

    Miscellaneous databases

    NextBioi 606017.
    PROi P24594.

    Gene expression databases

    Genevestigatori P24594.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR012213. IGFBP-5.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF4. PTHR11551:SF4. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01981. IGFBPFAMILY5.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human."
      Shimasaki S., Shimonaka M., Zhang H.-P., Ling N.
      J. Biol. Chem. 266:10646-10653(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-53.
      Tissue: Ovary.
    2. "Cloning of the rat insulin-like growth factor binding protein-5 gene and DNA sequence analysis of its promoter region."
      Zhu X., Ling N., Shimasaki S.
      Biochem. Biophys. Res. Commun. 190:1045-1052(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiIBP5_RAT
    AccessioniPrimary (citable) accession number: P24594
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3