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Protein

Insulin-like growth factor-binding protein 5

Gene

Igfbp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  1. fibronectin binding Source: GO_Central
  2. insulin-like growth factor binding Source: RGD
  3. insulin-like growth factor I binding Source: GO_Central
  4. insulin-like growth factor II binding Source: GO_Central

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. glucose homeostasis Source: Ensembl
  3. glucose metabolic process Source: Ensembl
  4. hair follicle morphogenesis Source: Ensembl
  5. intracellular signal transduction Source: RGD
  6. mammary gland involution Source: Ensembl
  7. negative regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
  8. negative regulation of osteoblast differentiation Source: Ensembl
  9. negative regulation of smooth muscle cell migration Source: Ensembl
  10. negative regulation of smooth muscle cell proliferation Source: Ensembl
  11. negative regulation of translation Source: Ensembl
  12. osteoblast differentiation Source: Ensembl
  13. positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
  14. positive regulation of protein kinase B signaling Source: Ensembl
  15. regulation of cell growth Source: Ensembl
  16. regulation of glucose metabolic process Source: Ensembl
  17. regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
  18. skeletal muscle tissue growth Source: RGD
  19. striated muscle cell differentiation Source: Ensembl
  20. type B pancreatic cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiREACT_250882. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Gene namesi
Name:Igfbp5
Synonyms:Igfbp-5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi2876. Igfbp5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 271252Insulin-like growth factor-binding protein 5PRO_0000014388Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Disulfide bondi66 ↔ 79PROSITE-ProRule annotation
Disulfide bondi191 ↔ 218PROSITE-ProRule annotation
Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP24594.

Expressioni

Tissue specificityi

Mostly in kidney.

Gene expression databases

GenevestigatoriP24594.

Interactioni

Protein-protein interaction databases

MINTiMINT-204226.
STRINGi10116.ENSRNOP00000023530.

Structurei

3D structure databases

ProteinModelPortaliP24594.
SMRiP24594. Positions 24-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10281IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini188 – 26275Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42882.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP24594.
OMAiYREQAKI.
OrthoDBiEOG74N5HG.
PhylomeDBiP24594.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24594-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVISVVLLLL AACAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP
60 70 80 90 100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL
110 120 130 140 150
NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA
160 170 180 190 200
VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESDQGP CRRHMEASLQ
210 220 230 240 250
EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL
260 270
PGMEYVDGDF QCHAFDSSNV E
Length:271
Mass (Da):30,298
Last modified:March 1, 1992 - v1
Checksum:i545B4C48F9BB5493
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62781 mRNA. Translation: AAA53533.1.
L08275 Genomic DNA. No translation available.
PIRiJC1463.
RefSeqiNP_036949.1. NM_012817.1.
UniGeneiRn.1593.

Genome annotation databases

EnsembliENSRNOT00000023530; ENSRNOP00000023530; ENSRNOG00000017206.
GeneIDi25285.
KEGGirno:25285.
UCSCiRGD:2876. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62781 mRNA. Translation: AAA53533.1.
L08275 Genomic DNA. No translation available.
PIRiJC1463.
RefSeqiNP_036949.1. NM_012817.1.
UniGeneiRn.1593.

3D structure databases

ProteinModelPortaliP24594.
SMRiP24594. Positions 24-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-204226.
STRINGi10116.ENSRNOP00000023530.

Protein family/group databases

MEROPSiI31.952.

Proteomic databases

PRIDEiP24594.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023530; ENSRNOP00000023530; ENSRNOG00000017206.
GeneIDi25285.
KEGGirno:25285.
UCSCiRGD:2876. rat.

Organism-specific databases

CTDi3488.
RGDi2876. Igfbp5.

Phylogenomic databases

eggNOGiNOG42882.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP24594.
OMAiYREQAKI.
OrthoDBiEOG74N5HG.
PhylomeDBiP24594.
TreeFamiTF331211.

Enzyme and pathway databases

ReactomeiREACT_250882. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

NextBioi606017.
PROiP24594.

Gene expression databases

GenevestigatoriP24594.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human."
    Shimasaki S., Shimonaka M., Zhang H.-P., Ling N.
    J. Biol. Chem. 266:10646-10653(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-53.
    Tissue: Ovary.
  2. "Cloning of the rat insulin-like growth factor binding protein-5 gene and DNA sequence analysis of its promoter region."
    Zhu X., Ling N., Shimasaki S.
    Biochem. Biophys. Res. Commun. 190:1045-1052(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiIBP5_RAT
AccessioniPrimary (citable) accession number: P24594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: February 4, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.