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Protein

Insulin-like growth factor-binding protein 5

Gene

Igfbp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-RNO-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-RNO-8957275. Post-translational protein phosphorylation.

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Gene namesi
Name:Igfbp5
Synonyms:Igfbp-5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2876. Igfbp5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001438820 – 271Insulin-like growth factor-binding protein 5Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Disulfide bondi66 ↔ 79PROSITE-ProRule annotation
Modified residuei115PhosphoserineBy similarity1
Disulfide bondi191 ↔ 218PROSITE-ProRule annotation
Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP24594.
PRIDEiP24594.

PTM databases

iPTMnetiP24594.
PhosphoSitePlusiP24594.

Expressioni

Tissue specificityi

Mostly in kidney.

Gene expression databases

BgeeiENSRNOG00000017206.
ExpressionAtlasiP24594. baseline and differential.
GenevisibleiP24594. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP24594. 1 interactor.
MINTiMINT-204226.
STRINGi10116.ENSRNOP00000023530.

Structurei

3D structure databases

ProteinModelPortaliP24594.
SMRiP24594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 102IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini188 – 262Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJJ2. Eukaryota.
ENOG4111GGG. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP24594.
OMAiLPIDKHE.
PhylomeDBiP24594.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF17. PTHR11551:SF17. 1 hit.
PfamiView protein in Pfam
PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiView protein in PROSITE
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24594-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVISVVLLLL AACAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP
60 70 80 90 100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL
110 120 130 140 150
NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA
160 170 180 190 200
VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESDQGP CRRHMEASLQ
210 220 230 240 250
EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL
260 270
PGMEYVDGDF QCHAFDSSNV E
Length:271
Mass (Da):30,298
Last modified:March 1, 1992 - v1
Checksum:i545B4C48F9BB5493
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62781 mRNA. Translation: AAA53533.1.
L08275 Genomic DNA. No translation available.
PIRiJC1463.
RefSeqiNP_036949.1. NM_012817.1.
UniGeneiRn.1593.

Genome annotation databases

EnsembliENSRNOT00000023530; ENSRNOP00000023530; ENSRNOG00000017206.
GeneIDi25285.
KEGGirno:25285.
UCSCiRGD:2876. rat.

Similar proteinsi

Entry informationi

Entry nameiIBP5_RAT
AccessioniPrimary (citable) accession number: P24594
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 27, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome