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Protein

Insulin-like growth factor-binding protein 5

Gene

IGFBP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000115461-MONOMER.
ZFISH:ENSG00000115461-MONOMER.
ReactomeiR-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
SIGNORiP24593.

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Gene namesi
Name:IGFBP5
Synonyms:IBP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5474. IGFBP5.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • insulin-like growth factor binding protein complex Source: BHF-UCL
  • insulin-like growth factor ternary complex Source: BHF-UCL
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3488.
OpenTargetsiENSG00000115461.
PharmGKBiPA29707.

Chemistry databases

ChEMBLiCHEMBL2665.

Polymorphism and mutation databases

BioMutaiIGFBP5.
DMDMi124069.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001438521 – 272Insulin-like growth factor-binding protein 5Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 59PROSITE-ProRule annotation1 Publication
Disulfide bondi67 ↔ 80PROSITE-ProRule annotation1 Publication
Modified residuei116Phosphoserine; by FAM20C1 Publication1
Glycosylationi172O-linked (HexNAc...)1 Publication1
Disulfide bondi192 ↔ 219PROSITE-ProRule annotation1 Publication
Disulfide bondi230 ↔ 241PROSITE-ProRule annotation1 Publication
Disulfide bondi243 ↔ 263PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP24593.
PaxDbiP24593.
PeptideAtlasiP24593.
PRIDEiP24593.

PTM databases

iPTMnetiP24593.
PhosphoSitePlusiP24593.

Miscellaneous databases

PMAP-CutDBP24593.

Expressioni

Tissue specificityi

Osteosarcoma, and at lower levels in liver, kidney and brain.

Gene expression databases

BgeeiENSG00000115461.
CleanExiHS_IGFBP5.
ExpressionAtlasiP24593. baseline and differential.
GenevisibleiP24593. HS.

Organism-specific databases

HPAiCAB009216.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109709. 11 interactors.
DIPiDIP-48433N.
IntActiP24593. 8 interactors.
MINTiMINT-1378863.
STRINGi9606.ENSP00000233813.

Chemistry databases

BindingDBiP24593.

Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi79 – 81Combined sources3
Turni84 – 86Combined sources3
Helixi89 – 94Combined sources6
Beta strandi98 – 101Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BOENMR-A60-106[»]
1H59X-ray2.10B60-112[»]
ProteinModelPortaliP24593.
SMRiP24593.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24593.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 103IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini189 – 263Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJJ2. Eukaryota.
ENOG4111GGG. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP24593.
OMAiYREQAKI.
OrthoDBiEOG091G0EIN.
PhylomeDBiP24593.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE
60 70 80 90 100
PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC
110 120 130 140 150
LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE
160 170 180 190 200
AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL
210 220 230 240 250
QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK
260 270
LPGMEYVDGD FQCHTFDSSN VE
Length:272
Mass (Da):30,570
Last modified:March 1, 1992 - v1
Checksum:i0A7AD37C6EEA3A81
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019284138R → W.1 PublicationCorresponds to variant rs11575194dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65062 mRNA. Translation: AAD04730.1.
M62782 mRNA. Translation: AAA53505.1.
L27559
, L27556, L27557, L27558 Genomic DNA. Translation: AAA72051.1.
AF055033 mRNA. Translation: AAC09368.1.
BT019706 mRNA. Translation: AAV38512.1.
BT019707 mRNA. Translation: AAV38513.1.
AY534685 Genomic DNA. Translation: AAS16353.1.
BC011453 mRNA. Translation: AAH11453.1.
CCDSiCCDS2405.1.
PIRiA53748.
RefSeqiNP_000590.1. NM_000599.3.
UniGeneiHs.607212.

Genome annotation databases

EnsembliENST00000233813; ENSP00000233813; ENSG00000115461.
GeneIDi3488.
KEGGihsa:3488.
UCSCiuc002vgj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65062 mRNA. Translation: AAD04730.1.
M62782 mRNA. Translation: AAA53505.1.
L27559
, L27556, L27557, L27558 Genomic DNA. Translation: AAA72051.1.
AF055033 mRNA. Translation: AAC09368.1.
BT019706 mRNA. Translation: AAV38512.1.
BT019707 mRNA. Translation: AAV38513.1.
AY534685 Genomic DNA. Translation: AAS16353.1.
BC011453 mRNA. Translation: AAH11453.1.
CCDSiCCDS2405.1.
PIRiA53748.
RefSeqiNP_000590.1. NM_000599.3.
UniGeneiHs.607212.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BOENMR-A60-106[»]
1H59X-ray2.10B60-112[»]
ProteinModelPortaliP24593.
SMRiP24593.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109709. 11 interactors.
DIPiDIP-48433N.
IntActiP24593. 8 interactors.
MINTiMINT-1378863.
STRINGi9606.ENSP00000233813.

Chemistry databases

BindingDBiP24593.
ChEMBLiCHEMBL2665.

Protein family/group databases

MEROPSiI31.952.

PTM databases

iPTMnetiP24593.
PhosphoSitePlusiP24593.

Polymorphism and mutation databases

BioMutaiIGFBP5.
DMDMi124069.

Proteomic databases

EPDiP24593.
PaxDbiP24593.
PeptideAtlasiP24593.
PRIDEiP24593.

Protocols and materials databases

DNASUi3488.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233813; ENSP00000233813; ENSG00000115461.
GeneIDi3488.
KEGGihsa:3488.
UCSCiuc002vgj.5. human.

Organism-specific databases

CTDi3488.
DisGeNETi3488.
GeneCardsiIGFBP5.
HGNCiHGNC:5474. IGFBP5.
HPAiCAB009216.
MIMi146734. gene.
neXtProtiNX_P24593.
OpenTargetsiENSG00000115461.
PharmGKBiPA29707.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJJ2. Eukaryota.
ENOG4111GGG. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP24593.
OMAiYREQAKI.
OrthoDBiEOG091G0EIN.
PhylomeDBiP24593.
TreeFamiTF331211.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000115461-MONOMER.
ZFISH:ENSG00000115461-MONOMER.
ReactomeiR-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
SIGNORiP24593.

Miscellaneous databases

ChiTaRSiIGFBP5. human.
EvolutionaryTraceiP24593.
GeneWikiiIGFBP5.
GenomeRNAii3488.
PMAP-CutDBP24593.
PROiP24593.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115461.
CleanExiHS_IGFBP5.
ExpressionAtlasiP24593. baseline and differential.
GenevisibleiP24593. HS.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBP5_HUMAN
AccessioniPrimary (citable) accession number: P24593
Secondary accession number(s): Q5U0A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 180 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.