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P24593

- IBP5_HUMAN

UniProt

P24593 - IBP5_HUMAN

Protein

Insulin-like growth factor-binding protein 5

Gene

IGFBP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

    GO - Molecular functioni

    1. insulin-like growth factor I binding Source: BHF-UCL
    2. protein binding Source: BHF-UCL

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. cellular response to cAMP Source: UniProtKB
    3. cellular response to organic cyclic compound Source: UniProtKB
    4. glucose homeostasis Source: Ensembl
    5. glucose metabolic process Source: Ensembl
    6. hair follicle morphogenesis Source: Ensembl
    7. intracellular signal transduction Source: Ensembl
    8. mammary gland involution Source: Ensembl
    9. negative regulation of cell migration Source: BHF-UCL
    10. negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
    11. negative regulation of osteoblast differentiation Source: Ensembl
    12. negative regulation of smooth muscle cell migration Source: BHF-UCL
    13. negative regulation of smooth muscle cell proliferation Source: BHF-UCL
    14. negative regulation of translation Source: BHF-UCL
    15. osteoblast differentiation Source: Ensembl
    16. positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
    17. positive regulation of protein kinase B signaling Source: Ensembl
    18. regulation of cell growth Source: Ensembl
    19. regulation of glucose metabolic process Source: Ensembl
    20. signal transduction Source: ProtInc
    21. skeletal muscle tissue growth Source: Ensembl
    22. striated muscle cell differentiation Source: Ensembl
    23. type B pancreatic cell proliferation Source: Ensembl

    Keywords - Ligandi

    Growth factor binding

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000115461-MONOMER.
    ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Protein family/group databases

    MEROPSiI31.952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 5
    Short name:
    IBP-5
    Short name:
    IGF-binding protein 5
    Short name:
    IGFBP-5
    Gene namesi
    Name:IGFBP5
    Synonyms:IBP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5474. IGFBP5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. insulin-like growth factor binding protein complex Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29707.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 272252Insulin-like growth factor-binding protein 5PRO_0000014385Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi45 ↔ 591 PublicationPROSITE-ProRule annotation
    Disulfide bondi67 ↔ 801 PublicationPROSITE-ProRule annotation
    Glycosylationi172 – 1721O-linked (HexNAc...)1 Publication
    Disulfide bondi192 ↔ 2191 PublicationPROSITE-ProRule annotation
    Disulfide bondi230 ↔ 2411 PublicationPROSITE-ProRule annotation
    Disulfide bondi243 ↔ 2631 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP24593.
    PeptideAtlasiP24593.
    PRIDEiP24593.

    PTM databases

    PhosphoSiteiP24593.

    Miscellaneous databases

    PMAP-CutDBP24593.

    Expressioni

    Tissue specificityi

    Osteosarcoma, and at lower levels in liver, kidney and brain.

    Gene expression databases

    ArrayExpressiP24593.
    BgeeiP24593.
    CleanExiHS_IGFBP5.
    GenevestigatoriP24593.

    Organism-specific databases

    HPAiCAB009216.

    Interactioni

    Protein-protein interaction databases

    BioGridi109709. 10 interactions.
    DIPiDIP-48433N.
    IntActiP24593. 3 interactions.
    MINTiMINT-1378863.
    STRINGi9606.ENSP00000233813.

    Structurei

    Secondary structure

    1
    272
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi79 – 813
    Turni84 – 863
    Helixi89 – 946
    Beta strandi98 – 1014

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BOENMR-A60-106[»]
    1H59X-ray2.10B60-112[»]
    ProteinModelPortaliP24593.
    SMRiP24593. Positions 25-105, 190-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP24593.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 10381IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini189 – 26375Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42882.
    HOGENOMiHOG000253012.
    HOVERGENiHBG002631.
    InParanoidiP24593.
    OMAiYREQAKI.
    OrthoDBiEOG74N5HG.
    PhylomeDBiP24593.
    TreeFamiTF331211.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR012213. IGFBP-5.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF4. PTHR11551:SF4. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01981. IGFBPFAMILY5.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24593-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE    50
    PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC 100
    LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE 150
    AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL 200
    QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK 250
    LPGMEYVDGD FQCHTFDSSN VE 272
    Length:272
    Mass (Da):30,570
    Last modified:March 1, 1992 - v1
    Checksum:i0A7AD37C6EEA3A81
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti138 – 1381R → W.1 Publication
    Corresponds to variant rs11575194 [ dbSNP | Ensembl ].
    VAR_019284

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65062 mRNA. Translation: AAD04730.1.
    M62782 mRNA. Translation: AAA53505.1.
    L27559
    , L27556, L27557, L27558 Genomic DNA. Translation: AAA72051.1.
    AF055033 mRNA. Translation: AAC09368.1.
    BT019706 mRNA. Translation: AAV38512.1.
    BT019707 mRNA. Translation: AAV38513.1.
    AY534685 Genomic DNA. Translation: AAS16353.1.
    BC011453 mRNA. Translation: AAH11453.1.
    CCDSiCCDS2405.1.
    PIRiA53748.
    RefSeqiNP_000590.1. NM_000599.3.
    UniGeneiHs.607212.

    Genome annotation databases

    EnsembliENST00000233813; ENSP00000233813; ENSG00000115461.
    GeneIDi3488.
    KEGGihsa:3488.
    UCSCiuc002vgj.4. human.

    Polymorphism databases

    DMDMi124069.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65062 mRNA. Translation: AAD04730.1 .
    M62782 mRNA. Translation: AAA53505.1 .
    L27559
    , L27556 , L27557 , L27558 Genomic DNA. Translation: AAA72051.1 .
    AF055033 mRNA. Translation: AAC09368.1 .
    BT019706 mRNA. Translation: AAV38512.1 .
    BT019707 mRNA. Translation: AAV38513.1 .
    AY534685 Genomic DNA. Translation: AAS16353.1 .
    BC011453 mRNA. Translation: AAH11453.1 .
    CCDSi CCDS2405.1.
    PIRi A53748.
    RefSeqi NP_000590.1. NM_000599.3.
    UniGenei Hs.607212.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BOE NMR - A 60-106 [» ]
    1H59 X-ray 2.10 B 60-112 [» ]
    ProteinModelPortali P24593.
    SMRi P24593. Positions 25-105, 190-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109709. 10 interactions.
    DIPi DIP-48433N.
    IntActi P24593. 3 interactions.
    MINTi MINT-1378863.
    STRINGi 9606.ENSP00000233813.

    Chemistry

    BindingDBi P24593.
    ChEMBLi CHEMBL2665.

    Protein family/group databases

    MEROPSi I31.952.

    PTM databases

    PhosphoSitei P24593.

    Polymorphism databases

    DMDMi 124069.

    Proteomic databases

    PaxDbi P24593.
    PeptideAtlasi P24593.
    PRIDEi P24593.

    Protocols and materials databases

    DNASUi 3488.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233813 ; ENSP00000233813 ; ENSG00000115461 .
    GeneIDi 3488.
    KEGGi hsa:3488.
    UCSCi uc002vgj.4. human.

    Organism-specific databases

    CTDi 3488.
    GeneCardsi GC02M217504.
    HGNCi HGNC:5474. IGFBP5.
    HPAi CAB009216.
    MIMi 146734. gene.
    neXtProti NX_P24593.
    PharmGKBi PA29707.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42882.
    HOGENOMi HOG000253012.
    HOVERGENi HBG002631.
    InParanoidi P24593.
    OMAi YREQAKI.
    OrthoDBi EOG74N5HG.
    PhylomeDBi P24593.
    TreeFami TF331211.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000115461-MONOMER.
    Reactomei REACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Miscellaneous databases

    ChiTaRSi IGFBP5. human.
    EvolutionaryTracei P24593.
    GeneWikii IGFBP5.
    GenomeRNAii 3488.
    NextBioi 13718.
    PMAP-CutDB P24593.
    PROi P24593.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P24593.
    Bgeei P24593.
    CleanExi HS_IGFBP5.
    Genevestigatori P24593.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR012213. IGFBP-5.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF4. PTHR11551:SF4. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01981. IGFBPFAMILY5.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a new human insulin-like growth factor binding protein."
      Kiefer M.C., Ioh R.S., Bauer D.M., Zapf J.
      Biochem. Biophys. Res. Commun. 176:219-225(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Osteosarcoma.
    2. "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human."
      Shimasaki S., Shimonaka M., Zhang H.-P., Ling N.
      J. Biol. Chem. 266:10646-10653(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5."
      Allander S.V., Larsson C., Ehrenborg E., Suwanichkul A., Weber G., Morris S.L., Bajalica S., Kiefer M.C., Luthman H., Powell D.R.
      J. Biol. Chem. 269:10891-10898(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Yu W., Gibbs R.A.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. NIEHS SNPs program
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TRP-138.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    8. "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells."
      Andress D.L., Birnbaum R.S.
      Biochem. Biophys. Res. Commun. 176:213-218(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-43.
    9. "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5."
      Standker L., Wobst P., Mark S., Forssmann W.-G.
      FEBS Lett. 441:281-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 141-178 AND 209-223, GLYCOSYLATION AT THR-172.
      Tissue: Plasma.
    10. "Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation."
      Nili M., Mukherjee A., Shinde U., David L., Rotwein P.
      J. Biol. Chem. 287:1510-1519(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.
    11. "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions."
      Kalus W., Zweckstetter M., Renner C., Sanchez Y., Georgescu J., Grol M., Demuth D., Schumacher R., Dony C., Lang K., Holak T.A.
      EMBO J. 17:6558-6572(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 60-106.

    Entry informationi

    Entry nameiIBP5_HUMAN
    AccessioniPrimary (citable) accession number: P24593
    Secondary accession number(s): Q5U0A3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 159 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3