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Protein

Insulin-like growth factor-binding protein 6

Gene

IGFBP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  • insulin-like growth factor I binding Source: GO_Central
  • insulin-like growth factor II binding Source: GO_Central
  • receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • cellular protein metabolic process Source: Reactome
  • negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
  • negative regulation of cell proliferation Source: ProtInc
  • regulation of cell growth Source: InterPro
  • regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167779-MONOMER.
ReactomeiR-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 6
Short name:
IBP-6
Short name:
IGF-binding protein 6
Short name:
IGFBP-6
Gene namesi
Name:IGFBP6
Synonyms:IBP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:5475. IGFBP6.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: GO_Central
  • Golgi apparatus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3489.
OpenTargetsiENSG00000167779.
PharmGKBiPA29708.

Chemistry databases

ChEMBLiCHEMBL2139.

Polymorphism and mutation databases

BioMutaiIGFBP6.
DMDMi124068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 273 PublicationsAdd BLAST27
ChainiPRO_000001438928 – 240Insulin-like growth factor-binding protein 6Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 32PROSITE-ProRule annotation1 Publication
Disulfide bondi40 ↔ 44PROSITE-ProRule annotation1 Publication
Disulfide bondi57 ↔ 63PROSITE-ProRule annotation1 Publication
Disulfide bondi71 ↔ 84PROSITE-ProRule annotation1 Publication
Disulfide bondi78 ↔ 104PROSITE-ProRule annotation1 Publication
Glycosylationi126O-linked (HexNAc...)2 Publications1
Glycosylationi144O-linked (HexNAc...)By similarity1
Glycosylationi145O-linked (HexNAc...)By similarity1
Glycosylationi146O-linked (HexNAc...)By similarity1
Glycosylationi152O-linked (HexNAc...)By similarity1
Disulfide bondi163 ↔ 190PROSITE-ProRule annotation1 Publication
Disulfide bondi201 ↔ 212PROSITE-ProRule annotation1 Publication
Disulfide bondi214 ↔ 234PROSITE-ProRule annotation1 Publication

Post-translational modificationi

O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP24592.
PaxDbiP24592.
PeptideAtlasiP24592.
PRIDEiP24592.

PTM databases

iPTMnetiP24592.
PhosphoSitePlusiP24592.
UniCarbKBiP24592.

Expressioni

Gene expression databases

BgeeiENSG00000167779.
CleanExiHS_IGFBP6.
ExpressionAtlasiP24592. baseline and differential.
GenevisibleiP24592. HS.

Organism-specific databases

HPAiHPA008005.

Interactioni

GO - Molecular functioni

  • insulin-like growth factor I binding Source: GO_Central
  • insulin-like growth factor II binding Source: GO_Central
  • receptor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi109710. 7 interactors.
IntActiP24592. 6 interactors.
MINTiMINT-2859943.
STRINGi9606.ENSP00000301464.

Chemistry databases

BindingDBiP24592.

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi162 – 177Combined sources16
Turni179 – 181Combined sources3
Beta strandi182 – 188Combined sources7
Beta strandi198 – 208Combined sources11
Beta strandi212 – 215Combined sources4
Turni226 – 228Combined sources3
Turni231 – 233Combined sources3
Beta strandi234 – 236Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RMJNMR-A161-240[»]
DisProtiDP00211.
ProteinModelPortaliP24592.
SMRiP24592.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24592.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 107IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST80
Domaini160 – 234Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVZ3. Eukaryota.
ENOG410YQXU. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP24592.
OMAiRDQQRNP.
OrthoDBiEOG091G0L46.
PhylomeDBiP24592.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR022326. IGFBP-6.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01982. IGFBPFAMILY6.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPHRLLPPL LLLLALLLAA SPGGALARCP GCGQGVQAGC PGGCVEEEDG
60 70 80 90 100
GSPAEGCAEA EGCLRREGQE CGVYTPNCAP GLQCHPPKDD EAPLRALLLG
110 120 130 140 150
RGRCLPARAP AVAEENPKES KPQAGTARPQ DVNRRDQQRN PGTSTTPSQP
160 170 180 190 200
NSAGVQDTEM GPCRRHLDSV LQQLQTEVYR GAQTLYVPNC DHRGFYRKRQ
210 220 230 240
CRSSQGQRRG PCWCVDRMGK SLPGSPDGNG SSSCPTGSSG
Length:240
Mass (Da):25,322
Last modified:March 1, 1992 - v1
Checksum:i285308231C025009
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → C in AAA88070 (PubMed:1719383).Curated1
Sequence conflicti28 – 29RC → AA AA sequence (PubMed:1697583).Curated2
Sequence conflicti28 – 29RC → LA AA sequence (PubMed:2154495).Curated2
Sequence conflicti32C → H AA sequence (PubMed:1697583).Curated1
Sequence conflicti55 – 57EGC → QGG AA sequence (PubMed:1697583).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018932128R → G.1 PublicationCorresponds to variant rs9658616dbSNPEnsembl.1
Natural variantiVAR_049565134R → L.Corresponds to variant rs34995393dbSNPEnsembl.1
Natural variantiVAR_018933217R → Q.1 PublicationCorresponds to variant rs6413498dbSNPEnsembl.1
Natural variantiVAR_011907236T → P.Corresponds to variant rs1053134dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62402 mRNA. Translation: AAB06187.1.
AJ006952 Genomic DNA. Translation: CAA07346.1.
AY443494 Genomic DNA. Translation: AAR05445.1.
BC003507 mRNA. Translation: AAH03507.1.
BC005007 mRNA. Translation: AAH05007.1.
BC010162 mRNA. Translation: AAH10162.1.
BC011708 mRNA. Translation: AAH11708.1.
M69054 mRNA. Translation: AAA88070.1.
CCDSiCCDS8846.1.
PIRiA39842.
S05699.
RefSeqiNP_002169.1. NM_002178.2.
UniGeneiHs.274313.

Genome annotation databases

EnsembliENST00000301464; ENSP00000301464; ENSG00000167779.
GeneIDi3489.
KEGGihsa:3489.
UCSCiuc001sbu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62402 mRNA. Translation: AAB06187.1.
AJ006952 Genomic DNA. Translation: CAA07346.1.
AY443494 Genomic DNA. Translation: AAR05445.1.
BC003507 mRNA. Translation: AAH03507.1.
BC005007 mRNA. Translation: AAH05007.1.
BC010162 mRNA. Translation: AAH10162.1.
BC011708 mRNA. Translation: AAH11708.1.
M69054 mRNA. Translation: AAA88070.1.
CCDSiCCDS8846.1.
PIRiA39842.
S05699.
RefSeqiNP_002169.1. NM_002178.2.
UniGeneiHs.274313.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RMJNMR-A161-240[»]
DisProtiDP00211.
ProteinModelPortaliP24592.
SMRiP24592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109710. 7 interactors.
IntActiP24592. 6 interactors.
MINTiMINT-2859943.
STRINGi9606.ENSP00000301464.

Chemistry databases

BindingDBiP24592.
ChEMBLiCHEMBL2139.

Protein family/group databases

MEROPSiI31.952.

PTM databases

iPTMnetiP24592.
PhosphoSitePlusiP24592.
UniCarbKBiP24592.

Polymorphism and mutation databases

BioMutaiIGFBP6.
DMDMi124068.

Proteomic databases

MaxQBiP24592.
PaxDbiP24592.
PeptideAtlasiP24592.
PRIDEiP24592.

Protocols and materials databases

DNASUi3489.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301464; ENSP00000301464; ENSG00000167779.
GeneIDi3489.
KEGGihsa:3489.
UCSCiuc001sbu.2. human.

Organism-specific databases

CTDi3489.
DisGeNETi3489.
GeneCardsiIGFBP6.
HGNCiHGNC:5475. IGFBP6.
HPAiHPA008005.
MIMi146735. gene.
neXtProtiNX_P24592.
OpenTargetsiENSG00000167779.
PharmGKBiPA29708.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVZ3. Eukaryota.
ENOG410YQXU. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP24592.
OMAiRDQQRNP.
OrthoDBiEOG091G0L46.
PhylomeDBiP24592.
TreeFamiTF331211.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167779-MONOMER.
ReactomeiR-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

EvolutionaryTraceiP24592.
GeneWikiiIGFBP6.
GenomeRNAii3489.
PROiP24592.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167779.
CleanExiHS_IGFBP6.
ExpressionAtlasiP24592. baseline and differential.
GenevisibleiP24592. HS.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR022326. IGFBP-6.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01982. IGFBPFAMILY6.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBP6_HUMAN
AccessioniPrimary (citable) accession number: P24592
Secondary accession number(s): Q14492
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.