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Protein

Phosphoglycerate kinase

Gene

pgk1

Organism
Hypocrea rufa (Trichoderma viride)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk1)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40SubstrateBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei171SubstrateBy similarity1
Binding sitei220ATPBy similarity1
Binding sitei313ATP; via carbonyl oxygenBy similarity1
Binding sitei344ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi373 – 376ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk1
Synonyms:pgk
OrganismiHypocrea rufa (Trichoderma viride)
Taxonomic identifieri5547 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458911 – 417Phosphoglycerate kinaseAdd BLAST417

Proteomic databases

PRIDEiP24590

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP24590
SMRiP24590
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni64 – 67Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 4 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P24590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSNKLSIT DVDVKGKRVL IRVDFNVPLD ENKNITNPQR IAGAIPTIKH
60 70 80 90 100
ALDNGAKAVI LMSHLGRPNG AVNAKYSLKP VVPKLEELLG KPVTFAPDCV
110 120 130 140 150
GPEVEAIVNK ADNGAVILLE NLRFHIEEEG SSKDKEGNKT KADKAKVEEF
160 170 180 190 200
RKGLTALGDV YVNDAFGTAH RAHSSMVGVD LPQKAAGFLM KKELDYFAKA
210 220 230 240 250
LESPQRPFLA ILGGAKVSDK IQLIDNLLDK VNTLIICGGM AFTFKKVLDN
260 270 280 290 300
LAIGDSLFDK AGAETVPKLV EKAKAKNVKI VLPTDFITAD KFDKDANTGL
310 320 330 340 350
ATDKDGIPDG WMGLDCGDES IKLYKEAIDE AKTILWNGPA GVFEFEKFAG
360 370 380 390 400
GTKATLDAVV EGCKNGKIVI IGGGDTATVA AKYGVEDKLS HVSTGGGASL
410
ELLEGKELPG VTALSSK
Length:417
Mass (Da):44,381
Last modified:July 1, 1993 - v2
Checksum:i99B7B75838C1805D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24 – 29Missing (PubMed:1588821).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54284 Genomic DNA Translation: CAA38181.1
PIRiS13596
S25381

Similar proteinsi

Entry informationi

Entry nameiPGK_HYPRU
AccessioniPrimary (citable) accession number: P24590
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

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