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P24590 (PGK_HYPRU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk1
Synonyms:pgk
OrganismHypocrea rufa (Trichoderma viride)
Taxonomic identifier5547 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145891

Regions

Nucleotide binding373 – 3764ATP By similarity
Region24 – 263Substrate binding By similarity
Region64 – 674Substrate binding By similarity

Sites

Binding site401Substrate By similarity
Binding site1231Substrate By similarity
Binding site1711Substrate By similarity
Binding site2201ATP By similarity
Binding site3131ATP; via carbonyl oxygen By similarity
Binding site3441ATP By similarity

Experimental info

Sequence conflict24 – 296Missing Ref.2

Sequences

Sequence LengthMass (Da)Tools
P24590 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: 99B7B75838C1805D

FASTA41744,381
        10         20         30         40         50         60 
MSLSNKLSIT DVDVKGKRVL IRVDFNVPLD ENKNITNPQR IAGAIPTIKH ALDNGAKAVI 

        70         80         90        100        110        120 
LMSHLGRPNG AVNAKYSLKP VVPKLEELLG KPVTFAPDCV GPEVEAIVNK ADNGAVILLE 

       130        140        150        160        170        180 
NLRFHIEEEG SSKDKEGNKT KADKAKVEEF RKGLTALGDV YVNDAFGTAH RAHSSMVGVD 

       190        200        210        220        230        240 
LPQKAAGFLM KKELDYFAKA LESPQRPFLA ILGGAKVSDK IQLIDNLLDK VNTLIICGGM 

       250        260        270        280        290        300 
AFTFKKVLDN LAIGDSLFDK AGAETVPKLV EKAKAKNVKI VLPTDFITAD KFDKDANTGL 

       310        320        330        340        350        360 
ATDKDGIPDG WMGLDCGDES IKLYKEAIDE AKTILWNGPA GVFEFEKFAG GTKATLDAVV 

       370        380        390        400        410 
EGCKNGKIVI IGGGDTATVA AKYGVEDKLS HVSTGGGASL ELLEGKELPG VTALSSK 

« Hide

References

[1]"Sequence of the Trichoderma viride phosphoglycerate kinase gene."
Goldman G.H., Villarroel R., van Montagu M., Herrera-Estrella A.
Nucleic Acids Res. 18:6717-6717(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: T9 BR47.
[2]"Molecular characterization and regulation of the phosphoglycerate kinase gene from Trichoderma viride."
Goldman G.H., Geremia R.A., Caplan A.B., Vila S.B., Villarroel R., van Montagu M., Herrera-Estrella A.
Mol. Microbiol. 6:1231-1242(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: T9 BR47.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54284 Genomic DNA. Translation: CAA38181.1.
PIRS13596.
S25381.

3D structure databases

ProteinModelPortalP24590.
SMRP24590. Positions 2-417.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_HYPRU
AccessionPrimary (citable) accession number: P24590
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 1, 1993
Last modified: February 19, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways