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Protein

Protein kinase C-like 1

Gene

PKC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cell growth and for the G2->M transition of the cell division cycle. Mediates a protein kinase cascade; it activates BCK1 which itself activates MKK1/MKK2.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei853ATPPROSITE-ProRule annotation1
Active sitei949Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri414 – 461Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri481 – 531Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51
Nucleotide bindingi830 – 838ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein kinase C activity Source: SGD

GO - Biological processi

  • actin filament organization Source: SGD
  • autophagy of peroxisome Source: SGD
  • cellular bud neck septin ring organization Source: SGD
  • fungal-type cell wall biogenesis Source: InterPro
  • intracellular signal transduction Source: SGD
  • peptidyl-serine phosphorylation Source: GO_Central
  • positive regulation of cytoplasmic mRNA processing body assembly Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of fungal-type cell wall organization Source: SGD
  • regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: SGD
  • signal transduction Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-28989-MONOMER
BRENDAi2.7.11.13 984
ReactomeiR-SCE-111933 Calmodulin induced events
R-SCE-114508 Effects of PIP2 hydrolysis
R-SCE-114516 Disinhibition of SNARE formation
R-SCE-1169091 Activation of NF-kappaB in B cells
R-SCE-1489509 DAG and IP3 signaling
R-SCE-202424 Downstream TCR signaling
R-SCE-2029485 Role of phospholipids in phagocytosis
R-SCE-2179392 EGFR Transactivation by Gastrin
R-SCE-2871837 FCERI mediated NF-kB activation
R-SCE-399997 Acetylcholine regulates insulin secretion
R-SCE-4419969 Depolymerisation of the Nuclear Lamina
R-SCE-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-SCE-5218921 VEGFR2 mediated cell proliferation
R-SCE-5607764 CLEC7A (Dectin-1) signaling
R-SCE-5625740 RHO GTPases activate PKNs
R-SCE-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-SCE-6798695 Neutrophil degranulation
R-SCE-76005 Response to elevated platelet cytosolic Ca2+

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-like 1 (EC:2.7.11.13)
Short name:
PKC 1
Gene namesi
Name:PKC1
Synonyms:HPO2, STT1
Ordered Locus Names:YBL105C
ORF Names:YBL0807
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL105C
SGDiS000000201 PKC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557381 – 1151Protein kinase C-like 1Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24583
PaxDbiP24583
PRIDEiP24583

PTM databases

CarbonylDBiP24583
iPTMnetiP24583

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TOP2P067862EBI-9860,EBI-19352

Protein-protein interaction databases

BioGridi32598, 1047 interactors
DIPiDIP-1516N
IntActiP24583, 18 interactors
MINTiP24583
STRINGi4932.YBL105C

Structurei

3D structure databases

ProteinModelPortaliP24583
SMRiP24583
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 67REM-1 1PROSITE-ProRule annotationAdd BLAST67
Domaini106 – 183REM-1 2PROSITE-ProRule annotationAdd BLAST78
Domaini196 – 288C2Add BLAST93
Domaini824 – 1083Protein kinasePROSITE-ProRule annotationAdd BLAST260
Domaini1084 – 1151AGC-kinase C-terminalAdd BLAST68

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri414 – 461Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri481 – 531Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00820000126964
HOGENOMiHOG000176156
InParanoidiP24583
KOiK02677
OMAiLCKEDMW
OrthoDBiEOG092C0HH3

Family and domain databases

CDDicd00029 C1, 2 hits
cd08689 C2_fungal_Pkc1p, 1 hit
cd11620 HR1_PKC-like_2_fungi, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037778 C2_fungal_PKC
IPR011072 HR1_rho-bd
IPR036274 HR1_rpt_sf
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR037312 PKC-like_HR1
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00168 C2, 1 hit
PF02185 HR1, 2 hits
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00742 Hr1, 2 hits
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF46585 SSF46585, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS51860 REM_1, 2 hits
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

P24583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSQLEQNI KKKIAVEENI IRGASALKKK TSNVMVIQKC NTNIREARQN
60 70 80 90 100
LEYLEDSLKK LRLKTAQQSQ GENGSEDNER CNSKEYGFLS TKSPNEHIFS
110 120 130 140 150
RLDLVKYDCP SLAQRIQYML QQLEFKLQVE KQYQEANTKL TKLYQIDGDQ
160 170 180 190 200
RSSSAAEGGA MESKYRIQML NKALKKYQAI NVDFDQFKHQ PNDIMDNQQP
210 220 230 240 250
KFRRKQLTGV LTIGITAARD VDHIQSPMFA RKPESYVTIK IDDTIKARTK
260 270 280 290 300
PSRNDRWSED FQIPVEKGNE IEITVYDKVN DSLIPVAIMW LLLSDIAEEI
310 320 330 340 350
RKKKAGQTNE QQGWVNASNI NGGSSLASEE GSTLTSTYSN SAIQSTSAKN
360 370 380 390 400
VQGENTSTSQ ISTNSWFVLE PSGQILLTLG FHKSSQIERK QLMGGLHRHG
410 420 430 440 450
AIINRKEEIF EQHGHHFVQK SFYNIMCCAY CGDFLRYTGF QCQDCKFLCH
460 470 480 490 500
KKCYTNVVTK CIAKTSTDTD PDEAKLNHRI PHRFLPTSNR GTKWCCHCGY
510 520 530 540 550
ILPWGRHKVR KCSECGIMCH AQCAHLVPDF CGMSMEMANK ILKTIQDTKR
560 570 580 590 600
NQEKKKRTVP SAQLGSSIGT ANGSDLSPSK LAERANAPLP PQPRKHDKTP
610 620 630 640 650
SPQKVGRDSP TKQHDPIIDK RISLQTHGRE KLNKFIDENE AYLNFTEGAQ
660 670 680 690 700
QTAEFSSPEK TLDPTSNRRS LGLTDLSIEH SQTWESKDDL MRDELELWKA
710 720 730 740 750
QREEMELEIK QDSGEIQEDL EVDHIDLETK QKLDWENKND FREADLTIDS
760 770 780 790 800
THTNPFRDMN SETFQIEQDH ASKEVLQETV SLAPTSTHAS RTTDQQSPQK
810 820 830 840 850
SQTSTSAKHK KRAAKRRKVS LDNFVLLKVL GKGNFGKVIL SKSKNTDRLC
860 870 880 890 900
AIKVLKKDNI IQNHDIESAR AEKKVFLLAT KTKHPFLTNL YCSFQTENRI
910 920 930 940 950
YFAMEFIGGG DLMWHVQNQR LSVRRAKFYA AEVLLALKYF HDNGVIYRDL
960 970 980 990 1000
KLENILLTPE GHIKIADYGL CKDEMWYGNR TSTFCGTPEF MAPEILKEQE
1010 1020 1030 1040 1050
YTKAVDWWAF GVLLYQMLLC QSPFSGDDED EVFNAILTDE PLYPIDMAGE
1060 1070 1080 1090 1100
IVQIFQGLLT KDPEKRLGAG PRDADEVMEE PFFRNINFDD ILNLRVKPPY
1110 1120 1130 1140 1150
IPEIKSPEDT SYFEQEFTSA PPTLTPLPSV LTTSQQEEFR GFSFMPDDLD

L
Length:1,151
Mass (Da):131,477
Last modified:July 27, 2011 - v3
Checksum:i8200EC2A2C6E649E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81C → F in CAA55990 (PubMed:7502586).Curated1
Sequence conflicti81C → F in CAA84932 (PubMed:7813418).Curated1
Sequence conflicti244T → S in AAA34878 (PubMed:2196995).Curated1
Sequence conflicti606G → E in AAA34878 (PubMed:2196995).Curated1
Sequence conflicti621R → K in AAA34878 (PubMed:2196995).Curated1
Sequence conflicti621R → K in CAA55990 (PubMed:7502586).Curated1
Sequence conflicti621R → K in CAA84932 (PubMed:7813418).Curated1
Sequence conflicti623S → P in AAA34878 (PubMed:2196995).Curated1
Sequence conflicti789A → P in CAA55990 (PubMed:7502586).Curated1
Sequence conflicti789A → P in CAA84932 (PubMed:7813418).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti958T → I in cly5; temperature-sensitive mutation that cause cell lysis at high temperature. 1
Natural varianti1023P → S in cly7; temperature-sensitive mutation that cause cell lysis at high temperature. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32491 mRNA Translation: AAA34878.1
X79489 Genomic DNA Translation: CAA55990.1
Z35866 Genomic DNA Translation: CAA84932.1
BK006936 Genomic DNA Translation: DAA07018.2
PIRiS45390
RefSeqiNP_009445.2, NM_001178345.2

Genome annotation databases

EnsemblFungiiYBL105C; YBL105C; YBL105C
GeneIDi852169
KEGGisce:YBL105C

Similar proteinsi

Entry informationi

Entry nameiKPC1_YEAST
AccessioniPrimary (citable) accession number: P24583
Secondary accession number(s): D6VPP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 189 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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