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P24581

- MTNX_NEILA

UniProt

P24581 - MTNX_NEILA

Protein

Cytosine-specific methyltransferase NlaX

Gene

nlaXM

Organism
Neisseria lactamica
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    • Comment

    Functioni

    This methylase recognizes the double-stranded sequence CCNGG, causes specific methylation on C-2 on both strands.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei74 – 741PROSITE-ProRule annotation

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi2158. M.NlaX.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytosine-specific methyltransferase NlaX (EC:2.1.1.37)
    Short name:
    M.NlaX
    Gene namesi
    Name:nlaXM
    OrganismiNeisseria lactamica
    Taxonomic identifieri486 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Cytosine-specific methyltransferase NlaXPRO_0000087911Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP24581.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 308307SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00145. DNA_methylase. 1 hit.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    PROSITEiPS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24581-1 [UniParc]FASTAAdd to Basket

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    MFKIIDLFAG IGGIRLGFEQ AFDDVRCVFS SEIDKYAVQT YQANHGGETV    50
    CGDITQTDVA DIPDHDILSA GFPCQPFSQA GLKKGFADTR GTLFFDIERI 100
    LLAKKPQAFL LENVKQLKGH DKGRTLQVIL AHLQQAGYKV YTEVLKARDF 150
    GIPQNRERIY LVGFLNHDVD FRFPQPIGQA TAVGDILEAY PDEKYTISDK 200
    LWQGYQRRKA ENRAAGKGFG YGLFNAESAY TNTISARYYK DGSEILIEQP 250
    GKNPRKITPP EAARLQGFPD SFQIPVSDAQ AYRQFGNSVC VPVIRAIAEQ 300
    MKAALSAVSD RKV 313
    Length:313
    Mass (Da):34,843
    Last modified:March 1, 1992 - v1
    Checksum:iE75150C89ABEA611
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54485 Genomic DNA. Translation: CAA38357.1.
    PIRiS12037. XYNHCL.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54485 Genomic DNA. Translation: CAA38357.1 .
    PIRi S12037. XYNHCL.

    3D structure databases

    ProteinModelPortali P24581.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 2158. M.NlaX.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00145. DNA_methylase. 1 hit.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    PROSITEi PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of two tandemly arranged DNA methyltransferase genes of Neisseria lactamica: an adenine-specific M.NlaIII and a cytosine-type methylase."
      Labbe D., Hoeltke H.J., Lau P.C.K.
      Mol. Gen. Genet. 224:101-110(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 23970 / CCUG 5853 / DSM 4691 / NCDC A7515 / NCTC 10617.

    Entry informationi

    Entry nameiMTNX_NEILA
    AccessioniPrimary (citable) accession number: P24581
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3