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Protein

Cytosine-specific methyltransferase NlaX

Gene

nlaXM

Organism
Neisseria lactamica
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CCNGG, causes specific methylation on C-2 on both strands.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi2158. M.NlaX.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosine-specific methyltransferase NlaX (EC:2.1.1.37)
Short name:
M.NlaX
Gene namesi
Name:nlaXM
OrganismiNeisseria lactamica
Taxonomic identifieri486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000879111 – 313Cytosine-specific methyltransferase NlaXAdd BLAST313

Structurei

3D structure databases

ProteinModelPortaliP24581.
SMRiP24581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 308SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST307

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DVF. Bacteria.
COG0270. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR029063. SAM-dependent_MTases.
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiView protein in PROSITE
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.

Sequencei

Sequence statusi: Complete.

P24581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKIIDLFAG IGGIRLGFEQ AFDDVRCVFS SEIDKYAVQT YQANHGGETV
60 70 80 90 100
CGDITQTDVA DIPDHDILSA GFPCQPFSQA GLKKGFADTR GTLFFDIERI
110 120 130 140 150
LLAKKPQAFL LENVKQLKGH DKGRTLQVIL AHLQQAGYKV YTEVLKARDF
160 170 180 190 200
GIPQNRERIY LVGFLNHDVD FRFPQPIGQA TAVGDILEAY PDEKYTISDK
210 220 230 240 250
LWQGYQRRKA ENRAAGKGFG YGLFNAESAY TNTISARYYK DGSEILIEQP
260 270 280 290 300
GKNPRKITPP EAARLQGFPD SFQIPVSDAQ AYRQFGNSVC VPVIRAIAEQ
310
MKAALSAVSD RKV
Length:313
Mass (Da):34,843
Last modified:March 1, 1992 - v1
Checksum:iE75150C89ABEA611
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54485 Genomic DNA. Translation: CAA38357.1.
PIRiS12037. XYNHCL.

Similar proteinsi

Entry informationi

Entry nameiMTNX_NEILA
AccessioniPrimary (citable) accession number: P24581
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families