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P24556

- LYTA_STAAU

UniProt

P24556 - LYTA_STAAU

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Protein

Autolysin

Gene
lytA
Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Autolysin strictly depends on the presence of choline-containing cell walls for activity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. establishment of competence for transformation Source: UniProtKB-KW
  2. peptidoglycan catabolic process Source: InterPro
  3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation, Competence, Sporulation

Protein family/group databases

MEROPSiC51.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Autolysin (EC:3.5.1.28)
Alternative name(s):
N-acetylmuramoyl-L-alanine amidase
Gene namesi
Name:lytA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481AutolysinPRO_0000070441Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP24556.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 142136Peptidase C51Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR007921. CHAP_dom.
IPR003646. SH3-like_bac-type.
[Graphical view]
PfamiPF01510. Amidase_2. 1 hit.
PF05257. CHAP. 1 hit.
PF08460. SH3_5. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
SM00287. SH3b. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
PROSITEiPS50911. CHAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24556-1 [UniParc]FASTAAdd to Basket

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MQAKLTKNEF IERLKTSEGK QFNVDLWYGF QCFDYANAGW KVLFGLLLKG    50
LGAKDIPFAN NFDGLATVYQ NTPDFLAQPG DMVVFGSNYG AGYGHVAWVI 100
EATLDYIIVY EQNWLGGGWT DGIEQPAGVG KKLQDDNMLM ISLCGLSVRI 150
LKVRQRHDQF NLLHKHPKKE TAKPQPKAVE LKIIKDVVKG YDLPKRGSNP 200
KGIVIHNDAG SKGATAEAYR NGLVNAPLSR LEAGIAHSYV SGNTVWQALD 250
ESQVGWHTAN QIGNKYYYGI EVCQSMGADN ATFLKNEQAT FQECARLLKK 300
WGLPANRNTI RLHNEFTSTS CPHRSSVLHT GFDPVTRGLL PEDKRLQLKD 350
YFIKQIRAYM DGKIPVATVS NESSASSNTV KPVASAWKRN KYGTYYMEES 400
ARFTNGNQPI TVRKVGPFLS CPVGYQFQPG GYCDYTEVML QDGHVWVGYT 450
WEGQRYYLPI RTWNGSAPPN QILGDLWGEI S 481
Length:481
Mass (Da):53,819
Last modified:March 1, 1992 - v1
Checksum:i6D5A1620D97359EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76714 Genomic DNA. No translation available.
PIRiJQ1147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76714 Genomic DNA. No translation available.
PIRi JQ1147.

3D structure databases

ProteinModelPortali P24556.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C51.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR007921. CHAP_dom.
IPR003646. SH3-like_bac-type.
[Graphical view ]
Pfami PF01510. Amidase_2. 1 hit.
PF05257. CHAP. 1 hit.
PF08460. SH3_5. 1 hit.
[Graphical view ]
SMARTi SM00644. Ami_2. 1 hit.
SM00287. SH3b. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
PROSITEi PS50911. CHAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity."
    Wang X., Wilkinson B.J., Jayaswal R.K.
    Gene 102:105-109(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLYTA_STAAU
AccessioniPrimary (citable) accession number: P24556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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