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P24556

- LYTA_STAAU

UniProt

P24556 - LYTA_STAAU

Protein

Autolysin

Gene

lytA

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Autolysin strictly depends on the presence of choline-containing cell walls for activity.

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. establishment of competence for transformation Source: UniProtKB-KW
    2. peptidoglycan catabolic process Source: InterPro
    3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation, Competence, Sporulation

    Protein family/group databases

    MEROPSiC51.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autolysin (EC:3.5.1.28)
    Alternative name(s):
    N-acetylmuramoyl-L-alanine amidase
    Gene namesi
    Name:lytA
    OrganismiStaphylococcus aureus
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481AutolysinPRO_0000070441Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP24556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 142136Peptidase C51PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 peptidase C51 domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.40.80.10. 1 hit.
    InterProiIPR002502. Amidase_domain.
    IPR007921. CHAP_dom.
    IPR003646. SH3-like_bac-type.
    [Graphical view]
    PfamiPF01510. Amidase_2. 1 hit.
    PF05257. CHAP. 1 hit.
    PF08460. SH3_5. 1 hit.
    [Graphical view]
    SMARTiSM00644. Ami_2. 1 hit.
    SM00287. SH3b. 1 hit.
    [Graphical view]
    SUPFAMiSSF55846. SSF55846. 1 hit.
    PROSITEiPS50911. CHAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24556-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAKLTKNEF IERLKTSEGK QFNVDLWYGF QCFDYANAGW KVLFGLLLKG    50
    LGAKDIPFAN NFDGLATVYQ NTPDFLAQPG DMVVFGSNYG AGYGHVAWVI 100
    EATLDYIIVY EQNWLGGGWT DGIEQPAGVG KKLQDDNMLM ISLCGLSVRI 150
    LKVRQRHDQF NLLHKHPKKE TAKPQPKAVE LKIIKDVVKG YDLPKRGSNP 200
    KGIVIHNDAG SKGATAEAYR NGLVNAPLSR LEAGIAHSYV SGNTVWQALD 250
    ESQVGWHTAN QIGNKYYYGI EVCQSMGADN ATFLKNEQAT FQECARLLKK 300
    WGLPANRNTI RLHNEFTSTS CPHRSSVLHT GFDPVTRGLL PEDKRLQLKD 350
    YFIKQIRAYM DGKIPVATVS NESSASSNTV KPVASAWKRN KYGTYYMEES 400
    ARFTNGNQPI TVRKVGPFLS CPVGYQFQPG GYCDYTEVML QDGHVWVGYT 450
    WEGQRYYLPI RTWNGSAPPN QILGDLWGEI S 481
    Length:481
    Mass (Da):53,819
    Last modified:March 1, 1992 - v1
    Checksum:i6D5A1620D97359EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76714 Genomic DNA. No translation available.
    PIRiJQ1147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76714 Genomic DNA. No translation available.
    PIRi JQ1147.

    3D structure databases

    ProteinModelPortali P24556.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C51.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.80.10. 1 hit.
    InterProi IPR002502. Amidase_domain.
    IPR007921. CHAP_dom.
    IPR003646. SH3-like_bac-type.
    [Graphical view ]
    Pfami PF01510. Amidase_2. 1 hit.
    PF05257. CHAP. 1 hit.
    PF08460. SH3_5. 1 hit.
    [Graphical view ]
    SMARTi SM00644. Ami_2. 1 hit.
    SM00287. SH3b. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55846. SSF55846. 1 hit.
    PROSITEi PS50911. CHAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity."
      Wang X., Wilkinson B.J., Jayaswal R.K.
      Gene 102:105-109(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiLYTA_STAAU
    AccessioniPrimary (citable) accession number: P24556
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3