Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P24556 (LYTA_STAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Autolysin

EC=3.5.1.28
Alternative name(s):
N-acetylmuramoyl-L-alanine amidase
Gene names
Name:lytA
OrganismStaphylococcus aureus
Taxonomic identifier1280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Autolysin strictly depends on the presence of choline-containing cell walls for activity.

Catalytic activity

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Contains 1 peptidase C51 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Autolysin
PRO_0000070441

Regions

Domain7 – 142136Peptidase C51

Sequences

Sequence LengthMass (Da)Tools
P24556 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 6D5A1620D97359EA

FASTA48153,819
        10         20         30         40         50         60 
MQAKLTKNEF IERLKTSEGK QFNVDLWYGF QCFDYANAGW KVLFGLLLKG LGAKDIPFAN 

        70         80         90        100        110        120 
NFDGLATVYQ NTPDFLAQPG DMVVFGSNYG AGYGHVAWVI EATLDYIIVY EQNWLGGGWT 

       130        140        150        160        170        180 
DGIEQPAGVG KKLQDDNMLM ISLCGLSVRI LKVRQRHDQF NLLHKHPKKE TAKPQPKAVE 

       190        200        210        220        230        240 
LKIIKDVVKG YDLPKRGSNP KGIVIHNDAG SKGATAEAYR NGLVNAPLSR LEAGIAHSYV 

       250        260        270        280        290        300 
SGNTVWQALD ESQVGWHTAN QIGNKYYYGI EVCQSMGADN ATFLKNEQAT FQECARLLKK 

       310        320        330        340        350        360 
WGLPANRNTI RLHNEFTSTS CPHRSSVLHT GFDPVTRGLL PEDKRLQLKD YFIKQIRAYM 

       370        380        390        400        410        420 
DGKIPVATVS NESSASSNTV KPVASAWKRN KYGTYYMEES ARFTNGNQPI TVRKVGPFLS 

       430        440        450        460        470        480 
CPVGYQFQPG GYCDYTEVML QDGHVWVGYT WEGQRYYLPI RTWNGSAPPN QILGDLWGEI 


S 

« Hide

References

[1]"Sequence analysis of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity."
Wang X., Wilkinson B.J., Jayaswal R.K.
Gene 102:105-109(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M76714 Genomic DNA. No translation available.
PIRJQ1147.

3D structure databases

ProteinModelPortalP24556.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC51.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.80.10. 1 hit.
InterProIPR002502. Amidase_domain.
IPR007921. CHAP_dom.
IPR003646. SH3-like_bac-type.
[Graphical view]
PfamPF01510. Amidase_2. 1 hit.
PF05257. CHAP. 1 hit.
PF08460. SH3_5. 1 hit.
[Graphical view]
SMARTSM00644. Ami_2. 1 hit.
SM00287. SH3b. 1 hit.
[Graphical view]
SUPFAMSSF55846. SSF55846. 1 hit.
PROSITEPS50911. CHAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYTA_STAAU
AccessionPrimary (citable) accession number: P24556
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries