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Protein

Autolysin

Gene

lytA

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Autolysin strictly depends on the presence of choline-containing cell walls for activity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCell wall biogenesis/degradation, Competence, Sporulation

Protein family/group databases

MEROPSiC51.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Autolysin (EC:3.5.1.28)
Alternative name(s):
N-acetylmuramoyl-L-alanine amidase
Gene namesi
Name:lytA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704411 – 481AutolysinAdd BLAST481

Proteomic databases

PRIDEiP24556.

Structurei

3D structure databases

ProteinModelPortaliP24556.
SMRiP24556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 142Peptidase C51PROSITE-ProRule annotationAdd BLAST136
Domaini398 – 466SH3bPROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiView protein in InterPro
IPR002502. Amidase_domain.
IPR007921. CHAP_dom.
IPR003646. SH3-like_bac-type.
PfamiView protein in Pfam
PF01510. Amidase_2. 1 hit.
PF05257. CHAP. 1 hit.
PF08460. SH3_5. 1 hit.
SMARTiView protein in SMART
SM00644. Ami_2. 1 hit.
SM00287. SH3b. 1 hit.
SUPFAMiSSF55846. SSF55846. 1 hit.
PROSITEiView protein in PROSITE
PS50911. CHAP. 1 hit.
PS51781. SH3B. 1 hit.

Sequencei

Sequence statusi: Complete.

P24556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAKLTKNEF IERLKTSEGK QFNVDLWYGF QCFDYANAGW KVLFGLLLKG
60 70 80 90 100
LGAKDIPFAN NFDGLATVYQ NTPDFLAQPG DMVVFGSNYG AGYGHVAWVI
110 120 130 140 150
EATLDYIIVY EQNWLGGGWT DGIEQPAGVG KKLQDDNMLM ISLCGLSVRI
160 170 180 190 200
LKVRQRHDQF NLLHKHPKKE TAKPQPKAVE LKIIKDVVKG YDLPKRGSNP
210 220 230 240 250
KGIVIHNDAG SKGATAEAYR NGLVNAPLSR LEAGIAHSYV SGNTVWQALD
260 270 280 290 300
ESQVGWHTAN QIGNKYYYGI EVCQSMGADN ATFLKNEQAT FQECARLLKK
310 320 330 340 350
WGLPANRNTI RLHNEFTSTS CPHRSSVLHT GFDPVTRGLL PEDKRLQLKD
360 370 380 390 400
YFIKQIRAYM DGKIPVATVS NESSASSNTV KPVASAWKRN KYGTYYMEES
410 420 430 440 450
ARFTNGNQPI TVRKVGPFLS CPVGYQFQPG GYCDYTEVML QDGHVWVGYT
460 470 480
WEGQRYYLPI RTWNGSAPPN QILGDLWGEI S
Length:481
Mass (Da):53,819
Last modified:March 1, 1992 - v1
Checksum:i6D5A1620D97359EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76714 Genomic DNA. No translation available.
PIRiJQ1147.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLYTA_STAAU
AccessioniPrimary (citable) accession number: P24556
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: March 15, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families