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P24551

- ANXA1_RODSP

UniProt

P24551 - ANXA1_RODSP

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Protein
Annexin A1
Gene
ANXA1, ANX1
Organism
Rodentia sp.
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. calcium-dependent phospholipid binding Source: UniProtKB-KW
  3. phospholipase A2 inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A1
Alternative name(s):
Annexin I
Annexin-1
Calpactin II
Calpactin-2
Lipocortin I
Gene namesi
Name:ANXA1
Synonyms:ANX1
OrganismiRodentia sp.
Taxonomic identifieri69158 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaunclassified Rodentia

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cell projectioncilium By similarity. Basolateral cell membrane By similarity
Note: Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium By similarity. Found in the cytoplasm of type II pneumocytes and alveolar macrophages By similarity.

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. cilium Source: UniProtKB-SubCell
  3. cytoplasm Source: UniProtKB-SubCell
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 346345Annexin A1
PRO_0000067465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei5 – 51Phosphoserine; by TRPM7 By similarity
Cross-linki19 – 19Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?) By similarity
Modified residuei21 – 211Phosphotyrosine; by EGFR By similarity
Modified residuei27 – 271Phosphoserine; by PKC By similarity
Modified residuei37 – 371Phosphoserine By similarity
Modified residuei312 – 3121N6-acetyllysine By similarity

Post-translational modificationi

Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity By similarity.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein

Interactioni

Subunit structurei

Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF By similarity.

Structurei

3D structure databases

ProteinModelPortaliP24551.
SMRiP24551. Positions 2-344.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 11161Annexin 1
Add
BLAST
Repeati123 – 18361Annexin 2
Add
BLAST
Repeati207 – 26761Annexin 3
Add
BLAST
Repeati282 – 34261Annexin 4
Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.
Contains 4 annexin repeats.

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

HOVERGENiHBG061815.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002388. AnnexinI.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24551-1 [UniParc]FASTAAdd to Basket

« Hide

MAMVSEFINQ ACYLEKQEQE YIEIVKSYKG GPAHAVSPYP SFDPSSDVAA    50
LHKGIMVNGV DEATILDLLT KRYNAQRHHL KAVYIQETGE PLDETLKKAL 100
TGHIQELLLA MIKTPAQFDG NELRAAMKAV GTDEETLIEI LWTRSNQQIR 150
EITSVYREEL KKDIAKYQTS DTSGEFRDAL LALAKGNRCE DMSVNQDIAD 200
TDARALYQAA ERRNGTDVNV FNTILTTKKY PHLRNKFQNY RKYTEEDMKK 250
ALDIELKGQI EKCLTTIAKC GTSTPAFFAE KLYEAMKGAG TRHKTLIRIM 300
VSRSEIDSDQ IKVFYQKKYG VPLCQAILDE TKGAYEKILV ALEGGN 346
Length:346
Mass (Da):39,053
Last modified:January 23, 2007 - v3
Checksum:i99930C41B682D12F
GO

Sequence databases

PIRiS13044. LUJP1.

Cross-referencesi

Sequence databases

PIRi S13044. LUJP1.

3D structure databases

ProteinModelPortali P24551.
SMRi P24551. Positions 2-344.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG061815.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002388. AnnexinI.
[Graphical view ]
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA structure and expression of calpactin, a peptide involved in Ca2(+)-dependent cell aggregation in sponges."
    Robitzki A., Schroeder H.C., Ugarkovic D., Gramzow M., Fritsche U., Batel R., Mueller W.E.G.
    Biochem. J. 271:415-420(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Duret L.
    Unpublished observations (FEB-1996)
    Cited for: DOUBTS ON BIOLOGICAL SOURCE OF PROTEIN.
  3. Mueller W.E.G.
    Unpublished observations (APR-1996)
    Cited for: AGREEMENT WITH RODENT CONTAMINATION.

Entry informationi

Entry nameiANXA1_RODSP
AccessioniPrimary (citable) accession number: P24551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally (1 Publication) thought to originate from the sponge Geodia cydonium, but, on the basis of phylogenetic studies (1 Publication) it seems very probable that the DNA sequence coding for this protein comes from a rodent as agreed by the original authors ().

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi