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P24549

- AL1A1_MOUSE

UniProt

P24549 - AL1A1_MOUSE

Protein

Retinal dehydrogenase 1

Gene

Aldh1a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 5 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    In addition to the activity on acetaldehyde and related substrates, is also involved in the oxidation of aldehydes derived from biogenic amines such as epinephrine and norepinephrine, as well as the aldehydes generated via lipid peroxidation. Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid By similarity.By similarity

    Catalytic activityi

    Retinal + NAD+ + H2O = retinoate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei170 – 1701Transition state stabilizerBy similarity
    Active sitei269 – 2691Proton acceptorPROSITE-ProRule annotation
    Active sitei303 – 3031NucleophilePROSITE-ProRule annotation
    Binding sitei456 – 4561NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi246 – 2516NADBy similarity

    GO - Molecular functioni

    1. 3-chloroallyl aldehyde dehydrogenase activity Source: MGI
    2. benzaldehyde dehydrogenase (NAD+) activity Source: Ensembl
    3. retinal dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 9-cis-retinoic acid biosynthetic process Source: MGI
    2. embryonic eye morphogenesis Source: MGI
    3. estrous cycle phase Source: Ensembl
    4. kidney development Source: Ensembl
    5. liver development Source: Ensembl
    6. midgut development Source: Ensembl
    7. optic cup morphogenesis involved in camera-type eye development Source: MGI
    8. positive regulation of apoptotic process Source: MGI
    9. protein homotetramerization Source: Ensembl
    10. response to drug Source: MGI
    11. response to estradiol Source: Ensembl
    12. response to ethanol Source: Ensembl
    13. response to oxidative stress Source: Ensembl
    14. response to retinoic acid Source: Ensembl
    15. retinoic acid metabolic process Source: MGI
    16. retinol metabolic process Source: MGI

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BRENDAi1.2.1.36. 3474.
    SABIO-RKP24549.
    UniPathwayiUPA00912.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal dehydrogenase 1 (EC:1.2.1.36)
    Short name:
    RALDH 1
    Short name:
    RalDH1
    Alternative name(s):
    ALDH-E1
    ALHDII
    Aldehyde dehydrogenase family 1 member A1
    Aldehyde dehydrogenase, cytosolic
    Gene namesi
    Name:Aldh1a1
    Synonyms:Ahd-2, Ahd2, Aldh1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1353450. Aldh1a1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 501500Retinal dehydrogenase 1PRO_0000056417Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei91 – 911N6-acetyllysineBy similarity
    Modified residuei128 – 1281N6-acetyllysineBy similarity
    Modified residuei252 – 2521N6-acetyllysineBy similarity
    Modified residuei353 – 3531N6-acetyllysineBy similarity
    Modified residuei367 – 3671N6-acetyllysineBy similarity
    Modified residuei410 – 4101N6-acetyllysineBy similarity
    Modified residuei419 – 4191N6-acetyllysineBy similarity
    Modified residuei435 – 4351N6-acetyllysineBy similarity
    Modified residuei495 – 4951N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP24549.
    PaxDbiP24549.
    PRIDEiP24549.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00626662.
    P24549.
    SWISS-2DPAGEP24549.

    PTM databases

    PhosphoSiteiP24549.

    Expressioni

    Tissue specificityi

    Expressed in the liver, lung, and testis. Apparently not expressed at detectable levels in kidney, stomach, ovary, heart, and brain.

    Gene expression databases

    BgeeiP24549.
    CleanExiMM_ALDH1A1.
    GenevestigatoriP24549.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    IntActiP24549. 4 interactions.
    MINTiMINT-1859401.

    Structurei

    3D structure databases

    ProteinModelPortaliP24549.
    SMRiP24549. Positions 9-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni300 – 3056Antabuse binding

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00550000074289.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiP24549.
    KOiK07249.
    OMAiEWHDSAS.
    OrthoDBiEOG7PS1F7.
    PhylomeDBiP24549.
    TreeFamiTF300455.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24549-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPAQPAVP APLADLKIQH TKIFINNEWH NSVSGKKFPV LNPATEEVIC    50
    HVEEGDKADV DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR 100
    LLLATMEALN GGKVFANAYL SDLGGCIKAL KYCAGWADKI HGQTIPSDGD 150
    IFTYTRREPI GVCGQIIPWN FPMLMFIWKI GPALSCGNTV VVKPAEQTPL 200
    TALHLASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDVD KVAFTGSTQV 250
    GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDIAVEF AHHGVFYHQG 300
    QCCVAASRIF VEESVYDEFV KRSVERAKKY VLGNPLTPGI NQGPQIDKEQ 350
    HDKILDLIES GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE 400
    IFGPVQQIMK FKSVDDVIKR ANNTTYGLAA GLFTKDLDKA ITVSSALQAG 450
    VVWVNCYMML SAQCPFGGFK MSGNGRELGE HGLYEYTELK TVAMKISQKN 500
    S 501
    Length:501
    Mass (Da):54,468
    Last modified:January 23, 2007 - v5
    Checksum:i0E428151B799BD1D
    GO

    Sequence cautioni

    The sequence AAH44729.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81A → R in AAA37202. (PubMed:2055490)Curated
    Sequence conflicti8 – 81A → R in AAA37203. (PubMed:2055490)Curated
    Sequence conflicti45 – 451T → S in AAB32754. (PubMed:7993664)Curated
    Sequence conflicti51 – 511H → Q in AAB32754. (PubMed:7993664)Curated
    Sequence conflicti87 – 871R → C in AAA37202. (PubMed:2055490)Curated
    Sequence conflicti140 – 1401I → Y AA sequence (PubMed:1935685)Curated
    Sequence conflicti458 – 4581M → I in AAA37202. (PubMed:2055490)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74570 mRNA. Translation: AAA37202.1.
    M74571 Genomic DNA. Translation: AAA37203.1.
    S75713 mRNA. Translation: AAB32754.2.
    S77047 Genomic DNA. No translation available.
    BC044729 mRNA. Translation: AAH44729.1. Different initiation.
    BC054386 mRNA. Translation: AAH54386.1.
    CCDSiCCDS29695.1.
    PIRiJQ1004.
    RefSeqiNP_038495.2. NM_013467.3.
    UniGeneiMm.250866.

    Genome annotation databases

    EnsembliENSMUST00000087638; ENSMUSP00000084918; ENSMUSG00000053279.
    GeneIDi11668.
    KEGGimmu:11668.
    UCSCiuc008gym.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74570 mRNA. Translation: AAA37202.1 .
    M74571 Genomic DNA. Translation: AAA37203.1 .
    S75713 mRNA. Translation: AAB32754.2 .
    S77047 Genomic DNA. No translation available.
    BC044729 mRNA. Translation: AAH44729.1 . Different initiation.
    BC054386 mRNA. Translation: AAH54386.1 .
    CCDSi CCDS29695.1.
    PIRi JQ1004.
    RefSeqi NP_038495.2. NM_013467.3.
    UniGenei Mm.250866.

    3D structure databases

    ProteinModelPortali P24549.
    SMRi P24549. Positions 9-501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P24549. 4 interactions.
    MINTi MINT-1859401.

    PTM databases

    PhosphoSitei P24549.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00626662.
    P24549.
    SWISS-2DPAGE P24549.

    Proteomic databases

    MaxQBi P24549.
    PaxDbi P24549.
    PRIDEi P24549.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087638 ; ENSMUSP00000084918 ; ENSMUSG00000053279 .
    GeneIDi 11668.
    KEGGi mmu:11668.
    UCSCi uc008gym.1. mouse.

    Organism-specific databases

    CTDi 216.
    MGIi MGI:1353450. Aldh1a1.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00550000074289.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    InParanoidi P24549.
    KOi K07249.
    OMAi EWHDSAS.
    OrthoDBi EOG7PS1F7.
    PhylomeDBi P24549.
    TreeFami TF300455.

    Enzyme and pathway databases

    UniPathwayi UPA00912 .
    BRENDAi 1.2.1.36. 3474.
    SABIO-RK P24549.

    Miscellaneous databases

    NextBioi 279287.
    PROi P24549.
    SOURCEi Search...

    Gene expression databases

    Bgeei P24549.
    CleanExi MM_ALDH1A1.
    Genevestigatori P24549.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a cytosolic aldehyde dehydrogenase-encoding cDNA from mouse liver."
      Rongnoparut P., Weaver S.
      Gene 101:261-265(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: BALB/c and C57BL/6.
      Tissue: Liver.
    2. "DNA sequence analysis of the cytosolic acetaldehyde dehydrogenase gene (Ahd-2) in mouse strains with variable ethanol preferences."
      Bond S.L., Singh S.M.
      Biochem. Med. Metab. Biol. 52:155-159(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/ReJ, BALB/c and C57BL/6J.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon and Liver.
    4. "Aldehyde dehydrogenase is a positional marker in the retina."
      McCaffery P., Tempst P., Lara G., Drager U.C.
      Development 112:693-702(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-52; 140-156; 211-230; 309-320; 330-349; 400-410; 421-435 AND 477-490.
      Tissue: Embryonic retina.

    Entry informationi

    Entry nameiAL1A1_MOUSE
    AccessioniPrimary (citable) accession number: P24549
    Secondary accession number(s): Q7TQJ0, Q811J0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 142 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3