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Protein

Retinal dehydrogenase 1

Gene

Aldh1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity).By similarity

Catalytic activityi

Retinal + NAD+ + H2O = retinoate + NADH.By similarity

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei170Transition state stabilizerBy similarity1
Active sitei269Proton acceptorPROSITE-ProRule annotation1
Active sitei303NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 170NADBy similarity4
Nucleotide bindingi193 – 196NADBy similarity4
Nucleotide bindingi226 – 227NADBy similarity2
Nucleotide bindingi246 – 247NADBy similarity2
Nucleotide bindingi269 – 271NADBy similarity3
Nucleotide bindingi349 – 353NADBy similarity5
Nucleotide bindingi400 – 402NADBy similarity3

GO - Molecular functioni

GO - Biological processi

  • 9-cis-retinoic acid biosynthetic process Source: MGI
  • 9-cis-retinoic acid metabolic process Source: MGI
  • embryonic eye morphogenesis Source: MGI
  • optic cup morphogenesis involved in camera-type eye development Source: MGI
  • oxidation-reduction process Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • protein homotetramerization Source: MGI
  • response to drug Source: MGI
  • response to ethanol Source: MGI
  • response to oxidative stress Source: MGI
  • retinoic acid biosynthetic process Source: MGI
  • retinoic acid metabolic process Source: MGI
  • retinoid metabolic process Source: MGI
  • retinol metabolic process Source: MGI

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDAi1.2.1.36 3474
ReactomeiR-MMU-5365859 RA biosynthesis pathway
R-MMU-70350 Fructose catabolism
R-MMU-71384 Ethanol oxidation
SABIO-RKiP24549
UniPathwayiUPA00912

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal dehydrogenase 1Curated (EC:1.2.1.-By similarity, EC:1.2.1.36By similarity)
Short name:
RALDH 1Curated
Short name:
RalDH1Curated
Alternative name(s):
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A1Imported
Aldehyde dehydrogenase, cytosolic1 Publication
Gene namesi
Name:Aldh1a1Imported
Synonyms:Ahd-2, Ahd2, Aldh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1353450 Aldh1a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000564172 – 501Retinal dehydrogenase 1Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1
Modified residuei252N6-acetyllysineBy similarity1
Modified residuei337PhosphothreonineBy similarity1
Modified residuei353N6-acetyllysineBy similarity1
Modified residuei367N6-acetyllysineBy similarity1
Modified residuei410N6-acetyllysineBy similarity1
Modified residuei413PhosphoserineBy similarity1
Modified residuei419N6-acetyllysineBy similarity1
Modified residuei435N6-acetyllysineBy similarity1
Modified residuei495N6-acetyllysineBy similarity1

Post-translational modificationi

The N-terminus is blocked most probably by acetylation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP24549
PaxDbiP24549
PeptideAtlasiP24549
PRIDEiP24549

2D gel databases

REPRODUCTION-2DPAGEiIPI00626662
P24549
SWISS-2DPAGEiP24549

PTM databases

iPTMnetiP24549
PhosphoSitePlusiP24549
SwissPalmiP24549

Expressioni

Tissue specificityi

Expressed in the liver, lung, and testis. Apparently not expressed at detectable levels in kidney, stomach, ovary, heart, and brain.

Gene expression databases

BgeeiENSMUSG00000053279
CleanExiMM_ALDH1A1
GenevisibleiP24549 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198063, 2 interactors
IntActiP24549, 4 interactors
MINTiP24549
STRINGi10090.ENSMUSP00000084918

Structurei

3D structure databases

ProteinModelPortaliP24549
SMRiP24549
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00760000118999
HOGENOMiHOG000271505
HOVERGENiHBG000097
InParanoidiP24549
KOiK07249
OMAiGEWVKPV
OrthoDBiEOG091G05E8
PhylomeDBiP24549
TreeFamiTF300455

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPAQPAVP APLADLKIQH TKIFINNEWH NSVSGKKFPV LNPATEEVIC
60 70 80 90 100
HVEEGDKADV DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR
110 120 130 140 150
LLLATMEALN GGKVFANAYL SDLGGCIKAL KYCAGWADKI HGQTIPSDGD
160 170 180 190 200
IFTYTRREPI GVCGQIIPWN FPMLMFIWKI GPALSCGNTV VVKPAEQTPL
210 220 230 240 250
TALHLASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDVD KVAFTGSTQV
260 270 280 290 300
GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDIAVEF AHHGVFYHQG
310 320 330 340 350
QCCVAASRIF VEESVYDEFV KRSVERAKKY VLGNPLTPGI NQGPQIDKEQ
360 370 380 390 400
HDKILDLIES GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE
410 420 430 440 450
IFGPVQQIMK FKSVDDVIKR ANNTTYGLAA GLFTKDLDKA ITVSSALQAG
460 470 480 490 500
VVWVNCYMML SAQCPFGGFK MSGNGRELGE HGLYEYTELK TVAMKISQKN

S
Length:501
Mass (Da):54,468
Last modified:January 23, 2007 - v5
Checksum:i0E428151B799BD1D
GO

Sequence cautioni

The sequence AAH44729 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8A → R in AAA37202 (PubMed:2055490).Curated1
Sequence conflicti8A → R in AAA37203 (PubMed:2055490).Curated1
Sequence conflicti45T → S in AAB32754 (PubMed:7993664).Curated1
Sequence conflicti51H → Q in AAB32754 (PubMed:7993664).Curated1
Sequence conflicti87R → C in AAA37202 (PubMed:2055490).Curated1
Sequence conflicti140I → Y AA sequence (PubMed:1935685).Curated1
Sequence conflicti458M → I in AAA37202 (PubMed:2055490).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74570 mRNA Translation: AAA37202.1
M74571 Genomic DNA Translation: AAA37203.1
S75713 mRNA Translation: AAB32754.2
S77047 Genomic DNA No translation available.
BC044729 mRNA Translation: AAH44729.1 Different initiation.
BC054386 mRNA Translation: AAH54386.1
CCDSiCCDS29695.1
PIRiJQ1004
RefSeqiNP_038495.2, NM_013467.3
UniGeneiMm.250866

Genome annotation databases

EnsembliENSMUST00000087638; ENSMUSP00000084918; ENSMUSG00000053279
GeneIDi11668
KEGGimmu:11668
UCSCiuc008gym.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAL1A1_MOUSE
AccessioniPrimary (citable) accession number: P24549
Secondary accession number(s): Q7TQJ0, Q811J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 173 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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