Skip Header

Contribute Send feedback
Read comments (?) or add your own

P24545 (PMA1_ZYGRO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasma membrane ATPase
EC=3.6.3.6
Alternative name(s):
Proton pump
OrganismZygosaccharomyces rouxii (Candida mogii)
Taxonomic identifier4956 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Zygosaccharomyces

Protein attributes

Sequence length920 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 920920Plasma membrane ATPase
PRO_0000046273

Regions

Topological domain1 – 117117Cytoplasmic Potential
Transmembrane118 – 13821Helical; Name=1; Potential
Topological domain139 – 1424Extracellular Potential
Transmembrane143 – 16220Helical; Name=2; Potential
Topological domain163 – 293131Cytoplasmic Potential
Transmembrane294 – 31522Helical; Name=3; Potential
Topological domain316 – 32611Extracellular Potential
Transmembrane327 – 34923Helical; Name=4; Potential
Topological domain350 – 721372Cytoplasmic Potential
Transmembrane722 – 74019Helical; Name=5; Potential
Topological domain741 – 75616Extracellular Potential
Transmembrane757 – 77620Helical; Name=6; Potential
Topological domain777 – 82650Cytoplasmic Potential
Transmembrane827 – 84721Helical; Name=7; Potential
Topological domain848 – 85912Extracellular Potential
Transmembrane860 – 87617Helical; Name=8; Potential
Topological domain877 – 92044Cytoplasmic Potential

Sites

Active site38014-aspartylphosphate intermediate By similarity
Metal binding6361Magnesium By similarity
Metal binding6401Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P24545 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 2E2F93178C80F009

FASTA920100,062
        10         20         30         40         50         60 
MSDERITEKP PHQQPESEGE PVPEEEVEEE TEEEVPDEQS SEDDDIDGLI DELQSQEAHE 

        70         80         90        100        110        120 
EAEEDDGPAA AGEARKIPEE LLQTDPSVGL SSDEVVNRRK KYGLNQMREE SENLLVKFLM 

       130        140        150        160        170        180 
FFIGPIQFVM EAAAVLAAGL EDWVDFGVIC GLLFLNAGVG FIQEFQAGSI VEELKKTLAN 

       190        200        210        220        230        240 
TATVIRDGSV QEAPANEIVP GDILKLEDGT VIPADGRLVT EECFLQVDQS SITGESLAVD 

       250        260        270        280        290        300 
KHYGDEVFSS STVKRGEGFM IVTATGDNTF VGRAASLVNA AAGGQGHFTE VLNGIGVILL 

       310        320        330        340        350        360 
VLVVITLLLI WTACFYRTVR IVPILRYTLG ITIVGVPVGL PAVVTTTMAG GAAYLAKKQA 

       370        380        390        400        410        420 
IVQKLSAIES LAGVEILCSD KTGTLTKNKL SLHEPYTVEG VSSDDLMLTA CLAASRKKKG 

       430        440        450        460        470        480 
LDAIDKAFLK SLAQYPKAKG ALTKYKVLEF HPFDPVSKKV TAVVESPEGE RIICVKGAPL 

       490        500        510        520        530        540 
FVLKTVEEDH PIPEDVHENY ENKVAELASR GFRALGVARK RGEGHWEILG VMPCMDPPRD 

       550        560        570        580        590        600 
DTAATVNEAK RLGLSVKMLT GDAVGIAKET CRQLGLGTNI YDAERLGLGG GGSMPGSEMY 

       610        620        630        640        650        660 
DFVENADGFA EVFPQHKFAV VDILQQRGYL VAMTGDGVND APSLKKADTG IAVEGATDAA 

       670        680        690        700        710        720 
RSAADIVFLA PGLSAIIDAL KTSRQIFHRM YAYVVYRIAL SLHLEIFLGL WIAILNHSLD 

       730        740        750        760        770        780 
IDLIVFIAIF ADVATLAIAY DNAPFSPSPV KWNLPRLWGM SIMMGIILAA GTWITLTTMF 

       790        800        810        820        830        840 
LPKGGIIQNF GSIDGILFLE ISLTENWLIF ITRAVGPFWS SIPSWQLAGA VFVVDVVATM 

       850        860        870        880        890        900 
FTLFGWWSQN WTDIVTVVRI YIWSIGIFCC LGGAYYLMSE SETFDRLMNG KPLKENKSTR 

       910        920 
SVEDFLASMR RVSTQHEKGN

« Hide

References

[1]"Molecular cloning and sequencing of plasma membrane H(+)-ATPase gene from the salt-tolerant yeast Zygosaccharomyces rouxii."
Watanabe Y., Shiramizu M., Tamai Y.
J. Biochem. 110:237-240(1991) [PubMed: 1837019] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 42981 / IAM 12879 / JCM 22060 / S-96.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D10764 Genomic DNA. Translation: BAA01594.1.
PIRPXKZP. JX0181.

3D structure databases

ProteinModelPortalP24545.
SMRP24545. Positions 48-918.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR000695. ATPase_P-typ_H-transp.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006534. ATPase_P-typ_PM_proton-efflux.
IPR023298. ATPase_P-typ_TM_dom.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits.
G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
PANTHERPTHR24093:SF61. PTHR24093:SF61. 1 hit.
PfamPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePMA1_ZYGRO
AccessionPrimary (citable) accession number: P24545
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 19, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents