Reviewed, UniProtKB/Swiss-Prot P24540 (ACYP1_PIG)

Names and origin

Protein names

Recommended name:
    Acylphosphatase-1
    EC=3.6.1.7
Alternative name(s):
    Acylphosphate phosphohydrolase 1
    Acylphosphatase, organ-common type isozyme

Gene names

Name:	ACYP1
Synonyms:	ACYPE

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate.
Tissue specificity	Organ-common type isozyme is found in many different tissues.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Coding sequence diversity	Alternative initiation
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	acylphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Note: It is uncertain whether isoform ACYA is produced by alternative initiation or another biological event.

Isoform ACYB (identifier: P24540-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform ACYA (identifier: P24540-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Note: Initiator methionine is removed. Contains an N-acetylalanine at position 2.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed; in isoform ACYB Ref.1
	Chain	2 – 101	100	Acylphosphatase-1		PRO_0000158537
Regions
	Domain	11 – 101	91	Acylphosphatase-like
Sites
	Active site	26	1	Potential
	Active site	44	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylserine; in isoform ACYB
Natural variations
	Alternative sequence	1 – 2	2	Missing in isoform ACYA.		VSP_026024

Sequences

	Sequence		Length	Mass (Da)
	Isoform ACYB [UniParc]. Last modified January 23, 2007. Version 2. Checksum: F707C03DEE1BF18A	FASTA	101	11,427
	10 20 30 40 50 60 MSMAEGDTLI SVDYEVFGKV QGVFFRKYTQ AEGKKLGLVG WVQNTDQGTV QGQLQGPTSK 70 80 90 100 VRHMQEWLET RGSPKSHIDR ASFNNEKVIS KLDYSDFQIV K
	Isoform ACYA. Checksum: 16007AE67640EB3B	FASTA	99	11,209
	10 20 30 40 50 60 MAEGDTLISV DYEVFGKVQG VFFRKYTQAE GKKLGLVGWV QNTDQGTVQG QLQGPTSKVR 70 80 90 HMQEWLETRG SPKSHIDRAS FNNEKVISKL DYSDFQIVK

References

[1]

"The primary structure of two molecular species of porcine organ-common type acylphosphatase." Mizuno Y., Kanesaka Y., Fujita H., Minowa O., Shiokawa H. J. Biochem. 110:790-794(1991) [PubMed: 1664426] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-101 (ISOFORM ACYA), PROTEIN SEQUENCE OF 4-101 (ISOFORM ACYB), ACETYLATION OF N-TERMINUS. Tissue: Brain and Testis.

Cross-references

3D structure databases
HSSP	HSSP built from PDB template 2ACY based on UniProtKB P41500.
SMR	P24540. Positions 4-101.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P24540.
Enzyme and pathway databases
BRENDA	3.6.1.7. 249.
Family and domain databases
InterPro	IPR001792. Acylphosphatase. IPR017968. Acylphosphatase_CS. [Graphical view]
PANTHER	PTHR10029. Acylphosphatase. 1 hit.
Pfam	PF00708. Acylphosphatase. 1 hit. [Graphical view]
ProDom	PD001884. Acylphosphatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00150. ACYLPHOSPHATASE_1. 1 hit. PS00151. ACYLPHOSPHATASE_2. 1 hit. PS51160. ACYLPHOSPHATASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACYP1_PIG

Accession

Primary (citable) accession number: P24540

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)