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P24532

- ASSY_STRCO

UniProt

P24532 - ASSY_STRCO

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Protein
Argininosuccinate synthase
Gene
argG, SCO7036, SC4G1.02
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei99 – 991Citrulline By similarity
Binding sitei129 – 1291ATP; via amide nitrogen By similarity
Binding sitei131 – 1311Aspartate By similarity
Binding sitei131 – 1311ATP By similarity
Binding sitei135 – 1351Aspartate By similarity
Binding sitei135 – 1351Citrulline By similarity
Binding sitei136 – 1361Aspartate By similarity
Binding sitei136 – 1361ATP By similarity
Binding sitei139 – 1391Citrulline By similarity
Binding sitei192 – 1921Citrulline By similarity
Binding sitei194 – 1941ATP By similarity
Binding sitei201 – 2011Citrulline By similarity
Binding sitei203 – 2031Citrulline By similarity
Binding sitei280 – 2801Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 259ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:SCO7036
ORF Names:SC4G1.02
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 481480Argininosuccinate synthaseUniRule annotation
PRO_0000148708Add
BLAST

Proteomic databases

PRIDEiP24532.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO7036.

Structurei

3D structure databases

ProteinModelPortaliP24532.
SMRiP24532. Positions 2-432.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230094.
KOiK01940.
OMAiRQEMSEF.
OrthoDBiEOG6K9QCV.
PhylomeDBiP24532.

Family and domain databases

Gene3Di1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00581. Arg_succ_synth_type2.
InterProiIPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24532-1 [UniParc]FASTAAdd to Basket

« Hide

MSKVLTSLPT GERVGIAFSG GLDTSVAVAW MRDKGAVPCT YTADIGQYDE    50
PDIASVPDRA KTYGAEVARL VDCRAALVEE GLAALTCGAF HIRSGGRAYF 100
NTTPLGRAVT GTLLVRAMLE DDVQIWGDGS TFKGNDIERF YRYGLLANPQ 150
LRIYKPWLDA DFVTELGGRK EMSEWLVAHD LPYRDSTEKA YSTDANIWGA 200
THEAKTLEHL DTGVETVEPI MGVRFWDPSV EIAPEDVTIG FDQGRPVTIN 250
GKEFASAVDL VMEANAVGGR HGMGMSDQIE NRIIEAKSRG IYEAPGMALL 300
HAAYERLVNA IHNEDTLAQY HTEGRRLGRL MYEGRWLDPQ SLMIRESLQR 350
WVGSAVTGEV TLRLRRGEDY SILDTTGPAF SYHPDKLSME RTEDSAFGPV 400
DRIGQLTMRN LDIADSRAKL EQYAGLGLIG TANPAIGAAQ AAATGLIGAM 450
PEGGAQAIAS RGEVSADDEL LDRAAMESGT D 481
Length:481
Mass (Da):52,270
Last modified:January 23, 2007 - v4
Checksum:i18E7DE4BEABF98B3
GO

Sequence cautioni

The sequence BAA00691.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 839AALVEEGLA → RRWSRRGWG in BAA00691. 1 Publication
Sequence conflicti181 – 1811L → F in BAA00691. 1 Publication
Sequence conflicti265 – 2728NAVGGRHG → TPSAAGTA in BAA00691. 1 Publication
Sequence conflicti326 – 3261R → P in BAA00691. 1 Publication
Sequence conflicti426 – 4283LGL → SRF in BAA00691. 1 Publication
Sequence conflicti435 – 4351A → P in BAA00691. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00799 Genomic DNA. Translation: BAA00691.1. Different initiation.
AL939130 Genomic DNA. Translation: CAC01534.1.
PIRiJQ1057. AJSMRC.
RefSeqiNP_631098.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC01534; CAC01534; CAC01534.
GeneIDi1102474.
KEGGisco:SCO7036.
PATRICi23743995. VBIStrCoe124346_7140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00799 Genomic DNA. Translation: BAA00691.1 . Different initiation.
AL939130 Genomic DNA. Translation: CAC01534.1 .
PIRi JQ1057. AJSMRC.
RefSeqi NP_631098.1. NC_003888.3.

3D structure databases

ProteinModelPortali P24532.
SMRi P24532. Positions 2-432.
ModBasei Search...

Protein-protein interaction databases

STRINGi 100226.SCO7036.

Proteomic databases

PRIDEi P24532.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC01534 ; CAC01534 ; CAC01534 .
GeneIDi 1102474.
KEGGi sco:SCO7036.
PATRICi 23743995. VBIStrCoe124346_7140.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230094.
KOi K01940.
OMAi RQEMSEF.
OrthoDBi EOG6K9QCV.
PhylomeDBi P24532.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00581. Arg_succ_synth_type2.
InterProi IPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the gene encoding argininosuccinate synthetase in Streptomyces coelicolor A3(2)."
    Ishihara H., Urabe H., Kasama H., Ogawara H.
    Nihon Hosenkin Gakkaishi 5:14-17(1991)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiASSY_STRCO
AccessioniPrimary (citable) accession number: P24532
Secondary accession number(s): Q9FC47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 117 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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