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P24532

- ASSY_STRCO

UniProt

P24532 - ASSY_STRCO

Protein

Argininosuccinate synthase

Gene

argG

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei99 – 991CitrullineBy similarity
    Binding sitei129 – 1291ATP; via amide nitrogenBy similarity
    Binding sitei131 – 1311AspartateBy similarity
    Binding sitei131 – 1311ATPBy similarity
    Binding sitei135 – 1351AspartateBy similarity
    Binding sitei135 – 1351CitrullineBy similarity
    Binding sitei136 – 1361AspartateBy similarity
    Binding sitei136 – 1361ATPBy similarity
    Binding sitei139 – 1391CitrullineBy similarity
    Binding sitei192 – 1921CitrullineBy similarity
    Binding sitei194 – 1941ATPBy similarity
    Binding sitei201 – 2011CitrullineBy similarity
    Binding sitei203 – 2031CitrullineBy similarity
    Binding sitei280 – 2801CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:argG
    Ordered Locus Names:SCO7036
    ORF Names:SC4G1.02
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 481480Argininosuccinate synthasePRO_0000148708Add
    BLAST

    Proteomic databases

    PRIDEiP24532.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi100226.SCO7036.

    Structurei

    3D structure databases

    ProteinModelPortaliP24532.
    SMRiP24532. Positions 2-432.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230094.
    KOiK01940.
    OMAiRQEMSEF.
    OrthoDBiEOG6K9QCV.
    PhylomeDBiP24532.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24532-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKVLTSLPT GERVGIAFSG GLDTSVAVAW MRDKGAVPCT YTADIGQYDE    50
    PDIASVPDRA KTYGAEVARL VDCRAALVEE GLAALTCGAF HIRSGGRAYF 100
    NTTPLGRAVT GTLLVRAMLE DDVQIWGDGS TFKGNDIERF YRYGLLANPQ 150
    LRIYKPWLDA DFVTELGGRK EMSEWLVAHD LPYRDSTEKA YSTDANIWGA 200
    THEAKTLEHL DTGVETVEPI MGVRFWDPSV EIAPEDVTIG FDQGRPVTIN 250
    GKEFASAVDL VMEANAVGGR HGMGMSDQIE NRIIEAKSRG IYEAPGMALL 300
    HAAYERLVNA IHNEDTLAQY HTEGRRLGRL MYEGRWLDPQ SLMIRESLQR 350
    WVGSAVTGEV TLRLRRGEDY SILDTTGPAF SYHPDKLSME RTEDSAFGPV 400
    DRIGQLTMRN LDIADSRAKL EQYAGLGLIG TANPAIGAAQ AAATGLIGAM 450
    PEGGAQAIAS RGEVSADDEL LDRAAMESGT D 481
    Length:481
    Mass (Da):52,270
    Last modified:January 23, 2007 - v4
    Checksum:i18E7DE4BEABF98B3
    GO

    Sequence cautioni

    The sequence BAA00691.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 839AALVEEGLA → RRWSRRGWG in BAA00691. 1 PublicationCurated
    Sequence conflicti181 – 1811L → F in BAA00691. 1 PublicationCurated
    Sequence conflicti265 – 2728NAVGGRHG → TPSAAGTA in BAA00691. 1 PublicationCurated
    Sequence conflicti326 – 3261R → P in BAA00691. 1 PublicationCurated
    Sequence conflicti426 – 4283LGL → SRF in BAA00691. 1 PublicationCurated
    Sequence conflicti435 – 4351A → P in BAA00691. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00799 Genomic DNA. Translation: BAA00691.1. Different initiation.
    AL939130 Genomic DNA. Translation: CAC01534.1.
    PIRiJQ1057. AJSMRC.
    RefSeqiNP_631098.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAC01534; CAC01534; CAC01534.
    GeneIDi1102474.
    KEGGisco:SCO7036.
    PATRICi23743995. VBIStrCoe124346_7140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00799 Genomic DNA. Translation: BAA00691.1 . Different initiation.
    AL939130 Genomic DNA. Translation: CAC01534.1 .
    PIRi JQ1057. AJSMRC.
    RefSeqi NP_631098.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali P24532.
    SMRi P24532. Positions 2-432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO7036.

    Proteomic databases

    PRIDEi P24532.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC01534 ; CAC01534 ; CAC01534 .
    GeneIDi 1102474.
    KEGGi sco:SCO7036.
    PATRICi 23743995. VBIStrCoe124346_7140.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230094.
    KOi K01940.
    OMAi RQEMSEF.
    OrthoDBi EOG6K9QCV.
    PhylomeDBi P24532.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the gene encoding argininosuccinate synthetase in Streptomyces coelicolor A3(2)."
      Ishihara H., Urabe H., Kasama H., Ogawara H.
      Nihon Hosenkin Gakkaishi 5:14-17(1991)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A3(2) / NRRL B-16638.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiASSY_STRCO
    AccessioniPrimary (citable) accession number: P24532
    Secondary accession number(s): Q9FC47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3