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Protein

Argininosuccinate synthase

Gene

argG

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43ATP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei99CitrullineBy similarity1
Binding sitei129ATP; via amide nitrogenBy similarity1
Binding sitei131AspartateBy similarity1
Binding sitei131ATPBy similarity1
Binding sitei135AspartateBy similarity1
Binding sitei135CitrullineBy similarity1
Binding sitei136AspartateBy similarity1
Binding sitei136ATPBy similarity1
Binding sitei139CitrullineBy similarity1
Binding sitei192CitrullineBy similarity1
Binding sitei194ATPBy similarity1
Binding sitei201CitrullineBy similarity1
Binding sitei203CitrullineBy similarity1
Binding sitei280CitrullineBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 25ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:SCO7036
ORF Names:SC4G1.02
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001487082 – 481Argininosuccinate synthaseAdd BLAST480

Proteomic databases

PRIDEiP24532

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi100226.SCO7036

Structurei

3D structure databases

ProteinModelPortaliP24532
SMRiP24532
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230094
InParanoidiP24532
KOiK01940
OMAiAFHIRSG
OrthoDBiPOG091H01U0
PhylomeDBiP24532

Family and domain databases

Gene3Di1.10.287.400, 1 hit
3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00581 Arg_succ_synth_type2, 1 hit
InterProiView protein in InterPro
IPR023437 Arg_succ_synth_type2_subfam
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR024074 AS_cat/multimer_dom_body
IPR024073 AS_multimer_C_tail
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24532-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVLTSLPT GERVGIAFSG GLDTSVAVAW MRDKGAVPCT YTADIGQYDE
60 70 80 90 100
PDIASVPDRA KTYGAEVARL VDCRAALVEE GLAALTCGAF HIRSGGRAYF
110 120 130 140 150
NTTPLGRAVT GTLLVRAMLE DDVQIWGDGS TFKGNDIERF YRYGLLANPQ
160 170 180 190 200
LRIYKPWLDA DFVTELGGRK EMSEWLVAHD LPYRDSTEKA YSTDANIWGA
210 220 230 240 250
THEAKTLEHL DTGVETVEPI MGVRFWDPSV EIAPEDVTIG FDQGRPVTIN
260 270 280 290 300
GKEFASAVDL VMEANAVGGR HGMGMSDQIE NRIIEAKSRG IYEAPGMALL
310 320 330 340 350
HAAYERLVNA IHNEDTLAQY HTEGRRLGRL MYEGRWLDPQ SLMIRESLQR
360 370 380 390 400
WVGSAVTGEV TLRLRRGEDY SILDTTGPAF SYHPDKLSME RTEDSAFGPV
410 420 430 440 450
DRIGQLTMRN LDIADSRAKL EQYAGLGLIG TANPAIGAAQ AAATGLIGAM
460 470 480
PEGGAQAIAS RGEVSADDEL LDRAAMESGT D
Length:481
Mass (Da):52,270
Last modified:January 23, 2007 - v4
Checksum:i18E7DE4BEABF98B3
GO

Sequence cautioni

The sequence BAA00691 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75 – 83AALVEEGLA → RRWSRRGWG in BAA00691 (Ref. 1) Curated9
Sequence conflicti181L → F in BAA00691 (Ref. 1) Curated1
Sequence conflicti265 – 272NAVGGRHG → TPSAAGTA in BAA00691 (Ref. 1) Curated8
Sequence conflicti326R → P in BAA00691 (Ref. 1) Curated1
Sequence conflicti426 – 428LGL → SRF in BAA00691 (Ref. 1) Curated3
Sequence conflicti435A → P in BAA00691 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00799 Genomic DNA Translation: BAA00691.1 Different initiation.
AL939130 Genomic DNA Translation: CAC01534.1
PIRiJQ1057 AJSMRC
RefSeqiNP_631098.1, NC_003888.3
WP_003972108.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAC01534; CAC01534; CAC01534
GeneIDi1102474
KEGGisco:SCO7036
PATRICifig|100226.15.peg.7140

Similar proteinsi

Entry informationi

Entry nameiASSY_STRCO
AccessioniPrimary (citable) accession number: P24532
Secondary accession number(s): Q9FC47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 135 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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