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Protein

Endothelin B receptor

Gene

EDNRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.1 Publication

GO - Molecular functioni

  • endothelin receptor activity Source: BHF-UCL
  • peptide hormone binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136160-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SignaLinkiP24530.
SIGNORiP24530.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin B receptor
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:EDNRB
Synonyms:ETRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:3180. EDNRB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 101ExtracellularSequence analysisAdd BLAST75
Transmembranei102 – 126Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini127 – 137CytoplasmicSequence analysisAdd BLAST11
Transmembranei138 – 163Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini164 – 175ExtracellularSequence analysisAdd BLAST12
Transmembranei176 – 197Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini198 – 218CytoplasmicSequence analysisAdd BLAST21
Transmembranei219 – 243Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini244 – 271ExtracellularSequence analysisAdd BLAST28
Transmembranei272 – 296Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini297 – 324CytoplasmicSequence analysisAdd BLAST28
Transmembranei325 – 350Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini351 – 362ExtracellularSequence analysisAdd BLAST12
Transmembranei363 – 389Helical; Name=7Sequence analysisAdd BLAST27
Topological domaini390 – 442CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane raft Source: Ensembl
  • nuclear membrane Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Waardenburg syndrome 4A (WS4A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the association of Waardenburg features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
See also OMIM:277580
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003470183A → G in WS4A. 1 PublicationCorresponds to variant rs104894388dbSNPEnsembl.1
Natural variantiVAR_015294292F → L in WS4A. 1 Publication1
Hirschsprung disease 2 (HSCR2)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child.
See also OMIM:600155
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003471276W → C in HSCR2. 1 PublicationCorresponds to variant rs104894387dbSNPEnsembl.1
Natural variantiVAR_003473319R → W in HSCR2; sporadic. 2 PublicationsCorresponds to variant rs200363611dbSNPEnsembl.1
Natural variantiVAR_003474374M → I in HSCR2. 1 Publication1
Natural variantiVAR_003475383P → L in HSCR2; familial. 2 Publications1
ABCD syndrome (ABCDS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by albinism, black lock at temporal occipital region, bilateral deafness, aganglionosis of the large intestine and total absence of neurocytes and nerve fibers in the small intestine.
See also OMIM:600501

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi402C → S: Abolishes palmitoylation; when associated with S-403 and S-405. 1 Publication1
Mutagenesisi403C → S: Abolishes palmitoylation; when associated with S-402 and S-405. 1 Publication1
Mutagenesisi405C → S: Abolishes palmitoylation; when associated with S-402 and S-403. 1 Publication1

Keywords - Diseasei

Albinism, Deafness, Disease mutation, Hirschsprung disease, Waardenburg syndrome

Organism-specific databases

DisGeNETi1910.
MalaCardsiEDNRB.
MIMi142623. phenotype.
277580. phenotype.
600155. phenotype.
600501. phenotype.
OpenTargetsiENSG00000136160.
Orphaneti388. Hirschsprung disease.
897. Waardenburg-Shah syndrome.
PharmGKBiPA27618.

Chemistry databases

ChEMBLiCHEMBL1785.
DrugBankiDB06403. Ambrisentan.
DB00559. Bosentan.
DB08932. MACITENTAN.
DB06268. Sitaxentan.
GuidetoPHARMACOLOGYi220.

Polymorphism and mutation databases

BioMutaiEDNRB.
DMDMi119622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001272927 – 442Endothelin B receptorAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi174 ↔ 255PROSITE-ProRule annotation
Modified residuei305PhosphoserineBy similarity1
Lipidationi402S-palmitoyl cysteine1 Publication1
Lipidationi403S-palmitoyl cysteineSequence analysis1
Lipidationi405S-palmitoyl cysteineSequence analysis1
Modified residuei419PhosphoserineBy similarity1
Modified residuei439PhosphotyrosineBy similarity1
Modified residuei440PhosphoserineBy similarity1
Modified residuei441PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP24530.
MaxQBiP24530.
PaxDbiP24530.
PeptideAtlasiP24530.
PRIDEiP24530.

PTM databases

iPTMnetiP24530.
PhosphoSitePlusiP24530.
SwissPalmiP24530.

Expressioni

Tissue specificityi

Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.1 Publication

Gene expression databases

BgeeiENSG00000136160.
ExpressionAtlasiP24530. baseline and differential.
GenevisibleiP24530. HS.

Organism-specific databases

HPAiCAB017842.
HPA027546.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EDN1P053052EBI-6624656,EBI-715181

Protein-protein interaction databases

BioGridi108232. 27 interactors.
IntActiP24530. 1 interactor.
MINTiMINT-107127.
STRINGi9606.ENSP00000366416.

Chemistry databases

BindingDBiP24530.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GLHX-ray2.80A66-303[»]
A313-395[»]
5GLIX-ray2.50A66-303[»]
A313-395[»]
ProteinModelPortaliP24530.
SMRiP24530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOVERGENiHBG051443.
InParanoidiP24530.
KOiK04198.
OMAiTAEIMTP.
PhylomeDBiP24530.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P24530-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPPPSLCGR ALVALVLACG LSRIWGEERG FPPDRATPLL QTAEIMTPPT
60 70 80 90 100
KTLWPKGSNA SLARSLAPAE VPKGDRTAGS PPRTISPPPC QGPIEIKETF
110 120 130 140 150
KYINTVVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH
160 170 180 190 200
IVIDIPINVY KLLAEDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY
210 220 230 240 250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DIITMDYKGS
260 270 280 290 300
YLRICLLHPV QKTAFMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM
310 320 330 340 350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY
360 370 380 390 400
NQNDPNRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC
410 420 430 440
LCCWCQSFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS
Length:442
Mass (Da):49,644
Last modified:March 1, 1992 - v1
Checksum:iCD4F96CF92C7C51E
GO
Isoform B (identifier: P24530-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     399-442: SCLCCWCQSF...FRSSNKYSSS → AGPHVGNKLV...MWPERKSNNN

Show »
Length:436
Mass (Da):48,710
Checksum:iA10BD0DD646F981E
GO
Isoform C (identifier: P24530-3) [UniParc]FASTAAdd to basket
Also known as: Delta-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNKSTCLMAA...RTPSGAGSSM

Show »
Length:532
Mass (Da):59,480
Checksum:i9734B81C0064F533
GO

Sequence cautioni

The sequence BAD92435 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → P in AAB19411 (PubMed:1713452).Curated1
Sequence conflicti16V → L (PubMed:7536888).Curated1
Sequence conflicti22 – 24SRI → LGV (PubMed:7536888).Curated3
Sequence conflicti35R → K (PubMed:7536888).Curated1
Sequence conflicti45I → M in BAD92435 (Ref. 12) Curated1
Sequence conflicti58S → P in BAF83388 (PubMed:14702039).Curated1
Sequence conflicti140I → V (PubMed:7536888).Curated1
Sequence conflicti385A → V in BAF83388 (PubMed:14702039).Curated1
Isoform C (identifier: P24530-3)
Sequence conflicti79 – 84SGHRTP → RPPDA in AAD24541 (PubMed:10072757).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0192855P → T.1 PublicationCorresponds to variant rs12720160dbSNPEnsembl.1
Natural variantiVAR_0146757L → Q.Corresponds to variant rs5345dbSNPEnsembl.1
Natural variantiVAR_01467617L → F.Corresponds to variant rs5346dbSNPEnsembl.1
Natural variantiVAR_00346957G → S Associated with increased susceptibility for Hirschsprung disease; sex-dependent gene dosage effect. 4 PublicationsCorresponds to variant rs1801710dbSNPEnsembl.1
Natural variantiVAR_02425576R → M.Corresponds to variant rs2228271dbSNPEnsembl.1
Natural variantiVAR_014677112F → V.Corresponds to variant rs5347dbSNPEnsembl.1
Natural variantiVAR_003470183A → G in WS4A. 1 PublicationCorresponds to variant rs104894388dbSNPEnsembl.1
Natural variantiVAR_014678244T → M.Corresponds to variant rs5350dbSNPEnsembl.1
Natural variantiVAR_003471276W → C in HSCR2. 1 PublicationCorresponds to variant rs104894387dbSNPEnsembl.1
Natural variantiVAR_015294292F → L in WS4A. 1 Publication1
Natural variantiVAR_003472305S → N.2 PublicationsCorresponds to variant rs5352dbSNPEnsembl.1
Natural variantiVAR_003473319R → W in HSCR2; sporadic. 2 PublicationsCorresponds to variant rs200363611dbSNPEnsembl.1
Natural variantiVAR_003474374M → I in HSCR2. 1 Publication1
Natural variantiVAR_003475383P → L in HSCR2; familial. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0018781M → MNKSTCLMAAETPSKRWRLH CLAFSQRFVRAGPACSSREA CSSPRAGWNPAGFRLPGRWS PFVALHLVCQIREALKLRSG HRTPSGAGSSM in isoform C. 1 Publication1
Alternative sequenceiVSP_001879399 – 442SCLCC…KYSSS → AGPHVGNKLVMLFSVNIECD GTVNQNPTMWPERKSNNN in isoform B. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74921 mRNA. Translation: AAA58465.1.
D90402 mRNA. Translation: BAA14398.1.
S44866 mRNA. Translation: AAB19411.1.
S57283 mRNA. Translation: AAB25531.1.
D13168 Genomic DNA. Translation: BAA02445.1.
L06623 mRNA. Translation: AAA52342.1.
X99250 mRNA. Translation: CAA67623.1.
AF114165 mRNA. Translation: AAD24541.1.
AY275463 mRNA. Translation: AAP32295.1.
AB209198 mRNA. Translation: BAD92435.1. Different initiation.
AK290699 mRNA. Translation: BAF83388.1.
AY547312 Genomic DNA. Translation: AAS38516.1.
AL139002 Genomic DNA. Translation: CAM16893.1.
AL139002 Genomic DNA. Translation: CAH72430.1.
CH471093 Genomic DNA. Translation: EAW80573.1.
CH471093 Genomic DNA. Translation: EAW80575.1.
BC014472 mRNA. Translation: AAH14472.1.
AJ458188 Genomic DNA. Translation: CAD30645.1.
AJ458189 Genomic DNA. Translation: CAD30646.1.
AJ458190 Genomic DNA. Translation: CAD30647.1.
AJ458191 Genomic DNA. Translation: CAD30648.1.
CCDSiCCDS45059.1. [P24530-2]
CCDS55902.1. [P24530-3]
CCDS9461.1. [P24530-1]
PIRiA46609. JQ1042.
RefSeqiNP_000106.1. NM_000115.4. [P24530-1]
NP_001116131.1. NM_001122659.2. [P24530-1]
NP_001188326.1. NM_001201397.1. [P24530-3]
NP_003982.1. NM_003991.3. [P24530-2]
UniGeneiHs.732046.
Hs.743195.
Hs.82002.

Genome annotation databases

EnsembliENST00000334286; ENSP00000335311; ENSG00000136160. [P24530-1]
ENST00000377211; ENSP00000366416; ENSG00000136160. [P24530-3]
ENST00000626030; ENSP00000486202; ENSG00000136160. [P24530-2]
GeneIDi1910.
KEGGihsa:1910.
UCSCiuc001vko.3. human. [P24530-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74921 mRNA. Translation: AAA58465.1.
D90402 mRNA. Translation: BAA14398.1.
S44866 mRNA. Translation: AAB19411.1.
S57283 mRNA. Translation: AAB25531.1.
D13168 Genomic DNA. Translation: BAA02445.1.
L06623 mRNA. Translation: AAA52342.1.
X99250 mRNA. Translation: CAA67623.1.
AF114165 mRNA. Translation: AAD24541.1.
AY275463 mRNA. Translation: AAP32295.1.
AB209198 mRNA. Translation: BAD92435.1. Different initiation.
AK290699 mRNA. Translation: BAF83388.1.
AY547312 Genomic DNA. Translation: AAS38516.1.
AL139002 Genomic DNA. Translation: CAM16893.1.
AL139002 Genomic DNA. Translation: CAH72430.1.
CH471093 Genomic DNA. Translation: EAW80573.1.
CH471093 Genomic DNA. Translation: EAW80575.1.
BC014472 mRNA. Translation: AAH14472.1.
AJ458188 Genomic DNA. Translation: CAD30645.1.
AJ458189 Genomic DNA. Translation: CAD30646.1.
AJ458190 Genomic DNA. Translation: CAD30647.1.
AJ458191 Genomic DNA. Translation: CAD30648.1.
CCDSiCCDS45059.1. [P24530-2]
CCDS55902.1. [P24530-3]
CCDS9461.1. [P24530-1]
PIRiA46609. JQ1042.
RefSeqiNP_000106.1. NM_000115.4. [P24530-1]
NP_001116131.1. NM_001122659.2. [P24530-1]
NP_001188326.1. NM_001201397.1. [P24530-3]
NP_003982.1. NM_003991.3. [P24530-2]
UniGeneiHs.732046.
Hs.743195.
Hs.82002.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GLHX-ray2.80A66-303[»]
A313-395[»]
5GLIX-ray2.50A66-303[»]
A313-395[»]
ProteinModelPortaliP24530.
SMRiP24530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108232. 27 interactors.
IntActiP24530. 1 interactor.
MINTiMINT-107127.
STRINGi9606.ENSP00000366416.

Chemistry databases

BindingDBiP24530.
ChEMBLiCHEMBL1785.
DrugBankiDB06403. Ambrisentan.
DB00559. Bosentan.
DB08932. MACITENTAN.
DB06268. Sitaxentan.
GuidetoPHARMACOLOGYi220.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP24530.
PhosphoSitePlusiP24530.
SwissPalmiP24530.

Polymorphism and mutation databases

BioMutaiEDNRB.
DMDMi119622.

Proteomic databases

EPDiP24530.
MaxQBiP24530.
PaxDbiP24530.
PeptideAtlasiP24530.
PRIDEiP24530.

Protocols and materials databases

DNASUi1910.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334286; ENSP00000335311; ENSG00000136160. [P24530-1]
ENST00000377211; ENSP00000366416; ENSG00000136160. [P24530-3]
ENST00000626030; ENSP00000486202; ENSG00000136160. [P24530-2]
GeneIDi1910.
KEGGihsa:1910.
UCSCiuc001vko.3. human. [P24530-1]

Organism-specific databases

CTDi1910.
DisGeNETi1910.
GeneCardsiEDNRB.
GeneReviewsiEDNRB.
HGNCiHGNC:3180. EDNRB.
HPAiCAB017842.
HPA027546.
MalaCardsiEDNRB.
MIMi131244. gene.
142623. phenotype.
277580. phenotype.
600155. phenotype.
600501. phenotype.
neXtProtiNX_P24530.
OpenTargetsiENSG00000136160.
Orphaneti388. Hirschsprung disease.
897. Waardenburg-Shah syndrome.
PharmGKBiPA27618.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOVERGENiHBG051443.
InParanoidiP24530.
KOiK04198.
OMAiTAEIMTP.
PhylomeDBiP24530.
TreeFamiTF331292.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136160-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SignaLinkiP24530.
SIGNORiP24530.

Miscellaneous databases

GeneWikiiEndothelin_receptor_type_B.
GenomeRNAii1910.
PROiP24530.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136160.
ExpressionAtlasiP24530. baseline and differential.
GenevisibleiP24530. HS.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDNRB_HUMAN
AccessioniPrimary (citable) accession number: P24530
Secondary accession number(s): A2A2Z8
, A8K3T4, O15343, Q59GB1, Q5W0G9, Q8NHM6, Q8NHM7, Q8NHM8, Q8NHM9, Q9UD23, Q9UQK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 195 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.