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P24529

- TY3H_MOUSE

UniProt

P24529 - TY3H_MOUSE

Protein

Tyrosine 3-monooxygenase

Gene

Th

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Plays an important role in the physiology of adrenergic neurons.

    Catalytic activityi

    L-tyrosine + tetrahydrobiopterin + O2 = L-dopa + 4a-hydroxytetrahydrobiopterin.

    Cofactori

    Fe2+ ion.

    Enzyme regulationi

    Phosphorylation leads to an increase in the catalytic activity.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi331 – 3311IronBy similarity
    Metal bindingi336 – 3361IronBy similarity
    Metal bindingi376 – 3761IronBy similarity

    GO - Molecular functioni

    1. amino acid binding Source: Ensembl
    2. dopamine binding Source: Ensembl
    3. ferric iron binding Source: Ensembl
    4. ferrous iron binding Source: Ensembl
    5. oxygen binding Source: Ensembl
    6. tetrahydrobiopterin binding Source: Ensembl
    7. tyrosine 3-monooxygenase activity Source: MGI

    GO - Biological processi

    1. cellular response to drug Source: Ensembl
    2. cellular response to glucose stimulus Source: Ensembl
    3. cellular response to growth factor stimulus Source: Ensembl
    4. cellular response to manganese ion Source: Ensembl
    5. cellular response to nicotine Source: Ensembl
    6. cerebral cortex development Source: Ensembl
    7. circadian sleep/wake cycle Source: Ensembl
    8. dopamine biosynthetic process from tyrosine Source: MGI
    9. eating behavior Source: MGI
    10. embryonic camera-type eye morphogenesis Source: BHF-UCL
    11. epinephrine biosynthetic process Source: Ensembl
    12. eye photoreceptor cell development Source: BHF-UCL
    13. fatty acid metabolic process Source: Ensembl
    14. glycoside metabolic process Source: Ensembl
    15. heart development Source: MGI
    16. isoquinoline alkaloid metabolic process Source: Ensembl
    17. learning Source: MGI
    18. locomotory behavior Source: MGI
    19. mating behavior Source: MGI
    20. memory Source: MGI
    21. multicellular organismal aging Source: Ensembl
    22. neurotransmitter biosynthetic process Source: UniProtKB-KW
    23. norepinephrine biosynthetic process Source: Ensembl
    24. organ morphogenesis Source: MGI
    25. phthalate metabolic process Source: Ensembl
    26. phytoalexin metabolic process Source: Ensembl
    27. regulation of heart contraction Source: MGI
    28. response to activity Source: Ensembl
    29. response to amphetamine Source: Ensembl
    30. response to corticosterone Source: Ensembl
    31. response to electrical stimulus Source: Ensembl
    32. response to estradiol Source: Ensembl
    33. response to ethanol Source: Ensembl
    34. response to ether Source: Ensembl
    35. response to herbicide Source: Ensembl
    36. response to hypoxia Source: Ensembl
    37. response to light stimulus Source: Ensembl
    38. response to lipopolysaccharide Source: Ensembl
    39. response to nutrient levels Source: Ensembl
    40. response to peptide hormone Source: Ensembl
    41. response to pyrethroid Source: Ensembl
    42. response to salt stress Source: Ensembl
    43. response to water deprivation Source: Ensembl
    44. response to zinc ion Source: Ensembl
    45. sensory perception of sound Source: Ensembl
    46. social behavior Source: Ensembl
    47. sphingolipid metabolic process Source: Ensembl
    48. synaptic transmission, dopaminergic Source: MGI
    49. synaptic vesicle amine transport Source: Ensembl
    50. terpene metabolic process Source: Ensembl
    51. visual perception Source: BHF-UCL

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Catecholamine biosynthesis, Neurotransmitter biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_217777. Catecholamine biosynthesis.
    UniPathwayiUPA00747; UER00733.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine 3-monooxygenase (EC:1.14.16.2)
    Alternative name(s):
    Tyrosine 3-hydroxylase
    Short name:
    TH
    Gene namesi
    Name:Th
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:98735. Th.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. cytoplasm Source: MGI
    3. cytoplasmic side of plasma membrane Source: Ensembl
    4. cytosol Source: Ensembl
    5. dendrite Source: Ensembl
    6. melanosome membrane Source: Ensembl
    7. mitochondrion Source: Ensembl
    8. neuron projection Source: MGI
    9. nucleus Source: MGI
    10. perikaryon Source: MGI
    11. smooth endoplasmic reticulum Source: Ensembl
    12. synaptic vesicle Source: Ensembl
    13. terminal bouton Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 498497Tyrosine 3-monooxygenasePRO_0000205562Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Phosphoserine; by CaMK2By similarity
    Modified residuei31 – 311PhosphoserineBy similarity
    Modified residuei40 – 401Phosphoserine; by CaMK2 and PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP24529.
    PaxDbiP24529.
    PRIDEiP24529.

    PTM databases

    PhosphoSiteiP24529.

    Expressioni

    Gene expression databases

    BgeeiP24529.
    CleanExiMM_TH.
    GenevestigatoriP24529.

    Interactioni

    Protein-protein interaction databases

    IntActiP24529. 1 interaction.
    MINTiMINT-4138908.
    STRINGi10090.ENSMUSP00000000219.

    Structurei

    3D structure databases

    ProteinModelPortaliP24529.
    SMRiP24529. Positions 65-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi51 – 599Poly-Ala

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3186.
    GeneTreeiENSGT00390000010268.
    HOGENOMiHOG000233373.
    HOVERGENiHBG006841.
    InParanoidiP24529.
    KOiK00501.
    OMAiELDKCHH.
    OrthoDBiEOG7KM5T1.
    PhylomeDBiP24529.
    TreeFamiTF313327.

    Family and domain databases

    Gene3Di1.10.800.10. 1 hit.
    InterProiIPR001273. ArAA_hydroxylase.
    IPR018301. ArAA_hydroxylase_Fe/CU_BS.
    IPR019774. Aromatic-AA_hydroxylase_C.
    IPR005962. Tyr_3_mOase.
    IPR019773. Tyrosine_3-monooxygenase-like.
    IPR021164. Tyrosine_hydroxylase_CS.
    [Graphical view]
    PANTHERiPTHR11473. PTHR11473. 1 hit.
    PfamiPF00351. Biopterin_H. 1 hit.
    PF12549. TOH_N. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000336. TH. 1 hit.
    PRINTSiPR00372. FYWHYDRXLASE.
    SUPFAMiSSF56534. SSF56534. 1 hit.
    TIGRFAMsiTIGR01269. Tyr_3_monoox. 1 hit.
    PROSITEiPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
    PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24529-1 [UniParc]FASTAAdd to Basket

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    MPTPSASSPQ PKGFRRAVSE QDTKQAEAVT SPRFIGRRQS LIEDARKERE    50
    AAAAAAAAAV ASAEPGNPLE AVVFEERDGN AVLNLLFSLR GTKPSSLSRA 100
    LKVFETFEAK IHHLETRPAQ RPLAGSPHLE YFVRFEVPSG DLAALLSSVR 150
    RVSDDVRSAR EDKVPWFPRK VSELDKCHHL VTKFDPDLDL DHPGFSDQAY 200
    RQRRKLIAEI AFQYKQGEPI PHVEYTKEEI ATWKEVYATL KGLYATHACR 250
    EHLEAFQLLE RYCGYREDSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF 300
    LASLAFRVFQ CTQYIRHASS PMHSPEPDCC HELLGHVPML ADRTFAQFSQ 350
    DIGLASLGAS DEEIEKLSTV YWFTVEFGLC KQNGELKAYG AGLLSSYGEL 400
    LHSLSEEPEV RAFDPDTAAV QPYQDQTYQP VYFVSESFSD AKDKLRNYAS 450
    RIQRPFSVKF DPYTLAIDVL DSPHTIRRSL EGVQDELHTL TQALSAIS 498
    Length:498
    Mass (Da):55,993
    Last modified:January 23, 2007 - v3
    Checksum:i62790179664F6DC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69200 mRNA. Translation: AAA40434.1.
    X53503 Genomic DNA. Translation: CAA37580.1.
    CCDSiCCDS22036.1.
    PIRiJN0068.
    RefSeqiNP_033403.1. NM_009377.1.
    UniGeneiMm.1292.

    Genome annotation databases

    EnsembliENSMUST00000000219; ENSMUSP00000000219; ENSMUSG00000000214.
    GeneIDi21823.
    KEGGimmu:21823.
    UCSCiuc009koi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69200 mRNA. Translation: AAA40434.1 .
    X53503 Genomic DNA. Translation: CAA37580.1 .
    CCDSi CCDS22036.1.
    PIRi JN0068.
    RefSeqi NP_033403.1. NM_009377.1.
    UniGenei Mm.1292.

    3D structure databases

    ProteinModelPortali P24529.
    SMRi P24529. Positions 65-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P24529. 1 interaction.
    MINTi MINT-4138908.
    STRINGi 10090.ENSMUSP00000000219.

    PTM databases

    PhosphoSitei P24529.

    Proteomic databases

    MaxQBi P24529.
    PaxDbi P24529.
    PRIDEi P24529.

    Protocols and materials databases

    DNASUi 21823.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000219 ; ENSMUSP00000000219 ; ENSMUSG00000000214 .
    GeneIDi 21823.
    KEGGi mmu:21823.
    UCSCi uc009koi.1. mouse.

    Organism-specific databases

    CTDi 7054.
    MGIi MGI:98735. Th.

    Phylogenomic databases

    eggNOGi COG3186.
    GeneTreei ENSGT00390000010268.
    HOGENOMi HOG000233373.
    HOVERGENi HBG006841.
    InParanoidi P24529.
    KOi K00501.
    OMAi ELDKCHH.
    OrthoDBi EOG7KM5T1.
    PhylomeDBi P24529.
    TreeFami TF313327.

    Enzyme and pathway databases

    UniPathwayi UPA00747 ; UER00733 .
    Reactomei REACT_217777. Catecholamine biosynthesis.

    Miscellaneous databases

    NextBioi 301244.
    PROi P24529.
    SOURCEi Search...

    Gene expression databases

    Bgeei P24529.
    CleanExi MM_TH.
    Genevestigatori P24529.

    Family and domain databases

    Gene3Di 1.10.800.10. 1 hit.
    InterProi IPR001273. ArAA_hydroxylase.
    IPR018301. ArAA_hydroxylase_Fe/CU_BS.
    IPR019774. Aromatic-AA_hydroxylase_C.
    IPR005962. Tyr_3_mOase.
    IPR019773. Tyrosine_3-monooxygenase-like.
    IPR021164. Tyrosine_hydroxylase_CS.
    [Graphical view ]
    PANTHERi PTHR11473. PTHR11473. 1 hit.
    Pfami PF00351. Biopterin_H. 1 hit.
    PF12549. TOH_N. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000336. TH. 1 hit.
    PRINTSi PR00372. FYWHYDRXLASE.
    SUPFAMi SSF56534. SSF56534. 1 hit.
    TIGRFAMsi TIGR01269. Tyr_3_monoox. 1 hit.
    PROSITEi PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
    PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of mouse tyrosine hydroxylase deduced from its cDNA."
      Ichikawa S., Sasaoka T., Nagatsu T.
      Biochem. Biophys. Res. Commun. 176:1610-1616(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Morgan W.W., Bermudez J., Sharp Z.D.
      Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-30.
      Strain: BALB/c.
    3. Lubec G., Yang J.W., Zigmond M.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 78-90.
      Tissue: Brain.

    Entry informationi

    Entry nameiTY3H_MOUSE
    AccessioniPrimary (citable) accession number: P24529
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3