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P24529

- TY3H_MOUSE

UniProt

P24529 - TY3H_MOUSE

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Protein

Tyrosine 3-monooxygenase

Gene

Th

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the physiology of adrenergic neurons.

Catalytic activityi

L-tyrosine + tetrahydrobiopterin + O2 = L-dopa + 4a-hydroxytetrahydrobiopterin.

Cofactori

Enzyme regulationi

Phosphorylation leads to an increase in the catalytic activity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi331 – 3311IronBy similarity
Metal bindingi336 – 3361IronBy similarity
Metal bindingi376 – 3761IronBy similarity

GO - Molecular functioni

  1. amino acid binding Source: Ensembl
  2. dopamine binding Source: Ensembl
  3. ferric iron binding Source: Ensembl
  4. ferrous iron binding Source: Ensembl
  5. oxygen binding Source: Ensembl
  6. tetrahydrobiopterin binding Source: Ensembl
  7. tyrosine 3-monooxygenase activity Source: MGI

GO - Biological processi

  1. cellular response to drug Source: Ensembl
  2. cellular response to glucose stimulus Source: Ensembl
  3. cellular response to growth factor stimulus Source: Ensembl
  4. cellular response to manganese ion Source: Ensembl
  5. cellular response to nicotine Source: Ensembl
  6. cerebral cortex development Source: Ensembl
  7. circadian sleep/wake cycle Source: Ensembl
  8. dopamine biosynthetic process from tyrosine Source: MGI
  9. eating behavior Source: MGI
  10. embryonic camera-type eye morphogenesis Source: BHF-UCL
  11. epinephrine biosynthetic process Source: Ensembl
  12. eye photoreceptor cell development Source: BHF-UCL
  13. fatty acid metabolic process Source: Ensembl
  14. glycoside metabolic process Source: Ensembl
  15. heart development Source: MGI
  16. isoquinoline alkaloid metabolic process Source: Ensembl
  17. learning Source: MGI
  18. locomotory behavior Source: MGI
  19. mating behavior Source: MGI
  20. memory Source: MGI
  21. multicellular organismal aging Source: Ensembl
  22. neurotransmitter biosynthetic process Source: UniProtKB-KW
  23. norepinephrine biosynthetic process Source: Ensembl
  24. organ morphogenesis Source: MGI
  25. phthalate metabolic process Source: Ensembl
  26. phytoalexin metabolic process Source: Ensembl
  27. regulation of heart contraction Source: MGI
  28. response to activity Source: Ensembl
  29. response to amphetamine Source: Ensembl
  30. response to corticosterone Source: Ensembl
  31. response to electrical stimulus Source: Ensembl
  32. response to estradiol Source: Ensembl
  33. response to ethanol Source: Ensembl
  34. response to ether Source: Ensembl
  35. response to herbicide Source: Ensembl
  36. response to hypoxia Source: Ensembl
  37. response to light stimulus Source: Ensembl
  38. response to lipopolysaccharide Source: Ensembl
  39. response to nutrient levels Source: Ensembl
  40. response to peptide hormone Source: Ensembl
  41. response to pyrethroid Source: Ensembl
  42. response to salt stress Source: Ensembl
  43. response to water deprivation Source: Ensembl
  44. response to zinc ion Source: Ensembl
  45. sensory perception of sound Source: Ensembl
  46. social behavior Source: Ensembl
  47. sphingolipid metabolic process Source: Ensembl
  48. synaptic transmission, dopaminergic Source: MGI
  49. synaptic vesicle amine transport Source: Ensembl
  50. terpene metabolic process Source: Ensembl
  51. visual perception Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Catecholamine biosynthesis, Neurotransmitter biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_217777. Catecholamine biosynthesis.
UniPathwayiUPA00747; UER00733.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine 3-monooxygenase (EC:1.14.16.2)
Alternative name(s):
Tyrosine 3-hydroxylase
Short name:
TH
Gene namesi
Name:Th
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:98735. Th.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. cytoplasm Source: MGI
  3. cytoplasmic side of plasma membrane Source: Ensembl
  4. cytosol Source: Ensembl
  5. dendrite Source: Ensembl
  6. melanosome membrane Source: Ensembl
  7. mitochondrion Source: Ensembl
  8. neuron projection Source: MGI
  9. nucleus Source: MGI
  10. perikaryon Source: MGI
  11. smooth endoplasmic reticulum Source: Ensembl
  12. synaptic vesicle Source: Ensembl
  13. terminal bouton Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 498497Tyrosine 3-monooxygenasePRO_0000205562Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Phosphoserine; by CaMK2By similarity
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei40 – 401Phosphoserine; by CaMK2 and PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24529.
PaxDbiP24529.
PRIDEiP24529.

PTM databases

PhosphoSiteiP24529.

Expressioni

Gene expression databases

BgeeiP24529.
CleanExiMM_TH.
ExpressionAtlasiP24529. baseline.
GenevestigatoriP24529.

Interactioni

Protein-protein interaction databases

IntActiP24529. 1 interaction.
MINTiMINT-4138908.
STRINGi10090.ENSMUSP00000000219.

Structurei

3D structure databases

ProteinModelPortaliP24529.
SMRiP24529. Positions 65-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi51 – 599Poly-Ala

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3186.
GeneTreeiENSGT00390000010268.
HOGENOMiHOG000233373.
HOVERGENiHBG006841.
InParanoidiP24529.
KOiK00501.
OMAiELDKCHH.
OrthoDBiEOG7KM5T1.
PhylomeDBiP24529.
TreeFamiTF313327.

Family and domain databases

Gene3Di1.10.800.10. 1 hit.
InterProiIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005962. Tyr_3_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
IPR021164. Tyrosine_hydroxylase_CS.
[Graphical view]
PANTHERiPTHR11473. PTHR11473. 1 hit.
PfamiPF00351. Biopterin_H. 1 hit.
PF12549. TOH_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000336. TH. 1 hit.
PRINTSiPR00372. FYWHYDRXLASE.
SUPFAMiSSF56534. SSF56534. 1 hit.
TIGRFAMsiTIGR01269. Tyr_3_monoox. 1 hit.
PROSITEiPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24529-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTPSASSPQ PKGFRRAVSE QDTKQAEAVT SPRFIGRRQS LIEDARKERE
60 70 80 90 100
AAAAAAAAAV ASAEPGNPLE AVVFEERDGN AVLNLLFSLR GTKPSSLSRA
110 120 130 140 150
LKVFETFEAK IHHLETRPAQ RPLAGSPHLE YFVRFEVPSG DLAALLSSVR
160 170 180 190 200
RVSDDVRSAR EDKVPWFPRK VSELDKCHHL VTKFDPDLDL DHPGFSDQAY
210 220 230 240 250
RQRRKLIAEI AFQYKQGEPI PHVEYTKEEI ATWKEVYATL KGLYATHACR
260 270 280 290 300
EHLEAFQLLE RYCGYREDSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF
310 320 330 340 350
LASLAFRVFQ CTQYIRHASS PMHSPEPDCC HELLGHVPML ADRTFAQFSQ
360 370 380 390 400
DIGLASLGAS DEEIEKLSTV YWFTVEFGLC KQNGELKAYG AGLLSSYGEL
410 420 430 440 450
LHSLSEEPEV RAFDPDTAAV QPYQDQTYQP VYFVSESFSD AKDKLRNYAS
460 470 480 490
RIQRPFSVKF DPYTLAIDVL DSPHTIRRSL EGVQDELHTL TQALSAIS
Length:498
Mass (Da):55,993
Last modified:January 23, 2007 - v3
Checksum:i62790179664F6DC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69200 mRNA. Translation: AAA40434.1.
X53503 Genomic DNA. Translation: CAA37580.1.
CCDSiCCDS22036.1.
PIRiJN0068.
RefSeqiNP_033403.1. NM_009377.1.
UniGeneiMm.1292.

Genome annotation databases

EnsembliENSMUST00000000219; ENSMUSP00000000219; ENSMUSG00000000214.
GeneIDi21823.
KEGGimmu:21823.
UCSCiuc009koi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69200 mRNA. Translation: AAA40434.1 .
X53503 Genomic DNA. Translation: CAA37580.1 .
CCDSi CCDS22036.1.
PIRi JN0068.
RefSeqi NP_033403.1. NM_009377.1.
UniGenei Mm.1292.

3D structure databases

ProteinModelPortali P24529.
SMRi P24529. Positions 65-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P24529. 1 interaction.
MINTi MINT-4138908.
STRINGi 10090.ENSMUSP00000000219.

PTM databases

PhosphoSitei P24529.

Proteomic databases

MaxQBi P24529.
PaxDbi P24529.
PRIDEi P24529.

Protocols and materials databases

DNASUi 21823.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000219 ; ENSMUSP00000000219 ; ENSMUSG00000000214 .
GeneIDi 21823.
KEGGi mmu:21823.
UCSCi uc009koi.1. mouse.

Organism-specific databases

CTDi 7054.
MGIi MGI:98735. Th.

Phylogenomic databases

eggNOGi COG3186.
GeneTreei ENSGT00390000010268.
HOGENOMi HOG000233373.
HOVERGENi HBG006841.
InParanoidi P24529.
KOi K00501.
OMAi ELDKCHH.
OrthoDBi EOG7KM5T1.
PhylomeDBi P24529.
TreeFami TF313327.

Enzyme and pathway databases

UniPathwayi UPA00747 ; UER00733 .
Reactomei REACT_217777. Catecholamine biosynthesis.

Miscellaneous databases

NextBioi 301244.
PROi P24529.
SOURCEi Search...

Gene expression databases

Bgeei P24529.
CleanExi MM_TH.
ExpressionAtlasi P24529. baseline.
Genevestigatori P24529.

Family and domain databases

Gene3Di 1.10.800.10. 1 hit.
InterProi IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005962. Tyr_3_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
IPR021164. Tyrosine_hydroxylase_CS.
[Graphical view ]
PANTHERi PTHR11473. PTHR11473. 1 hit.
Pfami PF00351. Biopterin_H. 1 hit.
PF12549. TOH_N. 2 hits.
[Graphical view ]
PIRSFi PIRSF000336. TH. 1 hit.
PRINTSi PR00372. FYWHYDRXLASE.
SUPFAMi SSF56534. SSF56534. 1 hit.
TIGRFAMsi TIGR01269. Tyr_3_monoox. 1 hit.
PROSITEi PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of mouse tyrosine hydroxylase deduced from its cDNA."
    Ichikawa S., Sasaoka T., Nagatsu T.
    Biochem. Biophys. Res. Commun. 176:1610-1616(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Morgan W.W., Bermudez J., Sharp Z.D.
    Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-30.
    Strain: BALB/c.
  3. Lubec G., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 78-90.
    Tissue: Brain.

Entry informationi

Entry nameiTY3H_MOUSE
AccessioniPrimary (citable) accession number: P24529
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3