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P24529 (TY3H_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine 3-monooxygenase
EC=1.14.16.2
Alternative name(s):
Tyrosine 3-hydroxylase
Short name=TH
Gene names
Name:Th
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the physiology of adrenergic neurons.

Catalytic activity

L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.

Cofactor

Fe2+ ion.

Enzyme regulation

Phosphorylation leads to an increase in the catalytic activity.

Pathway

Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 498497Tyrosine 3-monooxygenase
PRO_0000205562

Regions

Compositional bias51 – 599Poly-Ala

Sites

Metal binding3311Iron By similarity
Metal binding3361Iron By similarity
Metal binding3761Iron By similarity

Amino acid modifications

Modified residue191Phosphoserine; by CaMK2 By similarity
Modified residue311Phosphoserine By similarity
Modified residue401Phosphoserine; by PKA By similarity

Sequences

Sequence LengthMass (Da)Tools
P24529 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 62790179664F6DC6

FASTA49855,993
        10         20         30         40         50         60 
MPTPSASSPQ PKGFRRAVSE QDTKQAEAVT SPRFIGRRQS LIEDARKERE AAAAAAAAAV 

        70         80         90        100        110        120 
ASAEPGNPLE AVVFEERDGN AVLNLLFSLR GTKPSSLSRA LKVFETFEAK IHHLETRPAQ 

       130        140        150        160        170        180 
RPLAGSPHLE YFVRFEVPSG DLAALLSSVR RVSDDVRSAR EDKVPWFPRK VSELDKCHHL 

       190        200        210        220        230        240 
VTKFDPDLDL DHPGFSDQAY RQRRKLIAEI AFQYKQGEPI PHVEYTKEEI ATWKEVYATL 

       250        260        270        280        290        300 
KGLYATHACR EHLEAFQLLE RYCGYREDSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF 

       310        320        330        340        350        360 
LASLAFRVFQ CTQYIRHASS PMHSPEPDCC HELLGHVPML ADRTFAQFSQ DIGLASLGAS 

       370        380        390        400        410        420 
DEEIEKLSTV YWFTVEFGLC KQNGELKAYG AGLLSSYGEL LHSLSEEPEV RAFDPDTAAV 

       430        440        450        460        470        480 
QPYQDQTYQP VYFVSESFSD AKDKLRNYAS RIQRPFSVKF DPYTLAIDVL DSPHTIRRSL 

       490 
EGVQDELHTL TQALSAIS

« Hide

References

[1]"Primary structure of mouse tyrosine hydroxylase deduced from its cDNA."
Ichikawa S., Sasaoka T., Nagatsu T.
Biochem. Biophys. Res. Commun. 176:1610-1616(1991) [PubMed: 1674869] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Morgan W.W., Bermudez J., Sharp Z.D.
Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-30.
Strain: BALB/c.
[3]Lubec G., Yang J.W., Zigmond M.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 78-90.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M69200 mRNA. Translation: AAA40434.1.
X53503 Genomic DNA. Translation: CAA37580.1.
IPIIPI00138131.
PIRJN0068.
RefSeqNP_033403.1. NM_009377.1.
UniGeneMm.1292.

3D structure databases

ProteinModelPortalP24529.
SMRP24529. Positions 75-498.
ModBaseSearch...

Protein-protein interaction databases

STRINGP24529.

PTM databases

PhosphoSiteP24529.

Proteomic databases

PRIDEP24529.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000219; ENSMUSP00000000219; ENSMUSG00000000214.
GeneID21823.
KEGGmmu:21823.
UCSCuc009koi.1. mouse.

Organism-specific databases

CTD7054.
MGIMGI:98735. Th.

Phylogenomic databases

eggNOGroNOG12445.
HOGENOMHBG484724.
HOVERGENHBG006841.
InParanoidP24529.
OMAHHLETRA.
PhylomeDBP24529.

Gene expression databases

ArrayExpressP24529.
BgeeP24529.
CleanExMM_TH.
GenevestigatorP24529.
GermOnlineENSMUSG00000000214. Mus musculus.

Family and domain databases

InterProIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005962. Tyr_3_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
IPR021164. Tyrosine_hydroxylase_CS.
[Graphical view]
Gene3DG3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
KOK00501.
PANTHERPTHR11473. Aaa_hydroxylase. 1 hit.
PfamPF00351. Biopterin_H. 1 hit.
PF12549. TOH_N. 2 hits.
[Graphical view]
PIRSFPIRSF000336. TH. 1 hit.
PRINTSPR00372. FYWHYDRXLASE.
SUPFAMSSF56534. Aaa_hydroxylase. 1 hit.
TIGRFAMsTIGR01269. Tyr_3_monoox. 1 hit.
PROSITEPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301244.
SOURCESearch...

Entry information

Entry nameTY3H_MOUSE
AccessionPrimary (citable) accession number: P24529
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: November 16, 2011
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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