ID   MYP2_MOUSE              Reviewed;         132 AA.
AC   P24526; Q4KL10;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   24-JAN-2024, entry version 151.
DE   RecName: Full=Myelin P2 protein;
GN   Name=Pmp2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1711100; DOI=10.1111/j.1471-4159.1991.tb02101.x;
RA   Narayanan V., Kaestner K.H., Tennekoon G.I.;
RT   "Structure of the mouse myelin P2 protein gene.";
RL   J. Neurochem. 57:75-80(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in lipid transport protein in Schwann cells.
CC       May bind cholesterol (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC       ligands in its interior. {ECO:0000250}.
CC   -!- MISCELLANEOUS: P2 protein and myelin basic protein together constitute
CC       a major fraction of peripheral nervous system myelin protein.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC       protein (FABP) family. {ECO:0000305}.
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DR   EMBL; S39508; AAB19249.2; -; Genomic_DNA.
DR   EMBL; BC099520; AAH99520.1; -; mRNA.
DR   CCDS; CCDS17236.1; -.
DR   PIR; JH0407; JH0407.
DR   RefSeq; NP_001025476.1; NM_001030305.2.
DR   AlphaFoldDB; P24526; -.
DR   SMR; P24526; -.
DR   IntAct; P24526; 1.
DR   STRING; 10090.ENSMUSP00000029034; -.
DR   iPTMnet; P24526; -.
DR   PhosphoSitePlus; P24526; -.
DR   jPOST; P24526; -.
DR   MaxQB; P24526; -.
DR   PaxDb; 10090-ENSMUSP00000029034; -.
DR   PeptideAtlas; P24526; -.
DR   ProteomicsDB; 252632; -.
DR   Antibodypedia; 25321; 191 antibodies from 22 providers.
DR   Ensembl; ENSMUST00000029034.9; ENSMUSP00000029034.7; ENSMUSG00000052468.8.
DR   GeneID; 18857; -.
DR   KEGG; mmu:18857; -.
DR   UCSC; uc008oph.1; mouse.
DR   AGR; MGI:102667; -.
DR   CTD; 5375; -.
DR   MGI; MGI:102667; Pmp2.
DR   VEuPathDB; HostDB:ENSMUSG00000052468; -.
DR   eggNOG; KOG4015; Eukaryota.
DR   GeneTree; ENSGT00940000160445; -.
DR   HOGENOM; CLU_113772_0_0_1; -.
DR   InParanoid; P24526; -.
DR   OMA; YITIRTE; -.
DR   OrthoDB; 46617at2759; -.
DR   PhylomeDB; P24526; -.
DR   TreeFam; TF316894; -.
DR   BioGRID-ORCS; 18857; 5 hits in 80 CRISPR screens.
DR   PRO; PR:P24526; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; P24526; Protein.
DR   Bgee; ENSMUSG00000052468; Expressed in embryonic cell in blastocyst and 14 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043209; C:myelin sheath; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0015485; F:cholesterol binding; ISS:UniProtKB.
DR   GO; GO:0005504; F:fatty acid binding; ISS:UniProtKB.
DR   GO; GO:0015908; P:fatty acid transport; IBA:GO_Central.
DR   GO; GO:0061024; P:membrane organization; IDA:MGI.
DR   CDD; cd19469; FABP8; 1.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR000463; Fatty_acid-bd.
DR   InterPro; IPR031259; ILBP.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR031256; Myelin_P2.
DR   PANTHER; PTHR11955; FATTY ACID BINDING PROTEIN; 1.
DR   PANTHER; PTHR11955:SF64; MYELIN P2 PROTEIN; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR00178; FATTYACIDBP.
DR   SUPFAM; SSF50814; Lipocalins; 1.
DR   PROSITE; PS00214; FABP; 1.
DR   Genevisible; P24526; MM.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Lipid-binding; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P02690"
FT   CHAIN           2..132
FT                   /note="Myelin P2 protein"
FT                   /id="PRO_0000067389"
FT   BINDING         107
FT                   /ligand="(9Z)-octadecenoate"
FT                   /ligand_id="ChEBI:CHEBI:30823"
FT                   /evidence="ECO:0000250|UniProtKB:P02690"
FT   BINDING         107
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:P02689"
FT   BINDING         127..129
FT                   /ligand="(9Z)-octadecenoate"
FT                   /ligand_id="ChEBI:CHEBI:30823"
FT                   /evidence="ECO:0000250|UniProtKB:P02690"
FT   BINDING         127..129
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:P02689"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02690"
SQ   SEQUENCE   132 AA;  14935 MW;  AB6A4E7F3834107C CRC64;
     MSNKFLGTWK LVSSEHFDDY MKALGVGLAN RKLGNLAKPT VIISKKGDYI TIRTESAFKN
     TEISFKLGQE FDETTADNRK AKSIVTLERG SLKQVQKWDG KETAIRRTLL DGRMVVECIM
     KGVVCTRIYE KV
//