Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myelin P2 protein

Gene

Pmp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in lipid transport protein in Schwann cells. May bind cholesterol (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071Fatty acidBy similarity

GO - Molecular functioni

GO - Biological processi

  • membrane organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin P2 protein
Gene namesi
Name:Pmp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:102667. Pmp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 132131Myelin P2 proteinPRO_0000067389Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei44 – 441PhosphoserineBy similarity
Modified residuei91 – 911PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP24526.
MaxQBiP24526.
PaxDbiP24526.
PRIDEiP24526.

PTM databases

PhosphoSiteiP24526.

Expressioni

Gene expression databases

BgeeiP24526.
CleanExiMM_PMP2.
GenevisibleiP24526. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiP24526. 1 interaction.
STRINGi10090.ENSMUSP00000029034.

Structurei

3D structure databases

ProteinModelPortaliP24526.
SMRiP24526. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid bindingBy similarity

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP24526.
OMAiTMSNKFL.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP24526.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR031256. Myelin_P2.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF64. PTHR11955:SF64. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKFLGTWK LVSSEHFDDY MKALGVGLAN RKLGNLAKPT VIISKKGDYI
60 70 80 90 100
TIRTESAFKN TEISFKLGQE FDETTADNRK AKSIVTLERG SLKQVQKWDG
110 120 130
KETAIRRTLL DGRMVVECIM KGVVCTRIYE KV
Length:132
Mass (Da):14,935
Last modified:January 23, 2007 - v2
Checksum:iAB6A4E7F3834107C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S39508 Genomic DNA. Translation: AAB19249.2.
BC099520 mRNA. Translation: AAH99520.1.
CCDSiCCDS17236.1.
PIRiJH0407.
RefSeqiNP_001025476.1. NM_001030305.2.
UniGeneiMm.371777.

Genome annotation databases

EnsembliENSMUST00000029034; ENSMUSP00000029034; ENSMUSG00000052468.
GeneIDi18857.
KEGGimmu:18857.
UCSCiuc008oph.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S39508 Genomic DNA. Translation: AAB19249.2.
BC099520 mRNA. Translation: AAH99520.1.
CCDSiCCDS17236.1.
PIRiJH0407.
RefSeqiNP_001025476.1. NM_001030305.2.
UniGeneiMm.371777.

3D structure databases

ProteinModelPortaliP24526.
SMRiP24526. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP24526. 1 interaction.
STRINGi10090.ENSMUSP00000029034.

PTM databases

PhosphoSiteiP24526.

Proteomic databases

EPDiP24526.
MaxQBiP24526.
PaxDbiP24526.
PRIDEiP24526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029034; ENSMUSP00000029034; ENSMUSG00000052468.
GeneIDi18857.
KEGGimmu:18857.
UCSCiuc008oph.1. mouse.

Organism-specific databases

CTDi5375.
MGIiMGI:102667. Pmp2.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP24526.
OMAiTMSNKFL.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP24526.
TreeFamiTF316894.

Miscellaneous databases

NextBioi295236.
PROiP24526.
SOURCEiSearch...

Gene expression databases

BgeeiP24526.
CleanExiMM_PMP2.
GenevisibleiP24526. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR031256. Myelin_P2.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF64. PTHR11955:SF64. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the mouse myelin P2 protein gene."
    Narayanan V., Kaestner K.H., Tennekoon G.I.
    J. Neurochem. 57:75-80(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.

Entry informationi

Entry nameiMYP2_MOUSE
AccessioniPrimary (citable) accession number: P24526
Secondary accession number(s): Q4KL10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: April 13, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.