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P24526 (MYP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myelin P2 protein
Gene names
Name:Pmp2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length132 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in lipid transport protein in Schwann cells. May bind cholesterol By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Domain

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.

Miscellaneous

P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein By similarity.

Sequence similarities

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCytoplasm
   LigandLipid-binding
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmembrane organization

Inferred from direct assay PubMed 20334434. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncholesterol binding

Inferred from sequence or structural similarity. Source: UniProtKB

fatty acid binding

Inferred from sequence or structural similarity. Source: UniProtKB

transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 132131Myelin P2 protein
PRO_0000067389

Regions

Region127 – 1293Fatty acid binding By similarity

Sites

Binding site1071Fatty acid By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P24526 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: AB6A4E7F3834107C

FASTA13214,935
        10         20         30         40         50         60 
MSNKFLGTWK LVSSEHFDDY MKALGVGLAN RKLGNLAKPT VIISKKGDYI TIRTESAFKN 

        70         80         90        100        110        120 
TEISFKLGQE FDETTADNRK AKSIVTLERG SLKQVQKWDG KETAIRRTLL DGRMVVECIM 

       130 
KGVVCTRIYE KV 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the mouse myelin P2 protein gene."
Narayanan V., Kaestner K.H., Tennekoon G.I.
J. Neurochem. 57:75-80(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thyroid.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S39508 Genomic DNA. Translation: AAB19249.2.
BC099520 mRNA. Translation: AAH99520.1.
CCDSCCDS17236.1.
PIRJH0407.
RefSeqNP_001025476.1. NM_001030305.2.
UniGeneMm.371777.

3D structure databases

ProteinModelPortalP24526.
SMRP24526. Positions 1-132.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000029034.

PTM databases

PhosphoSiteP24526.

Proteomic databases

PRIDEP24526.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029034; ENSMUSP00000029034; ENSMUSG00000052468.
GeneID18857.
KEGGmmu:18857.
UCSCuc008oph.1. mouse.

Organism-specific databases

CTD5375.
MGIMGI:102667. Pmp2.

Phylogenomic databases

eggNOGNOG322298.
GeneTreeENSGT00740000115236.
HOGENOMHOG000004829.
HOVERGENHBG005633.
InParanoidQ4KL10.
OMARTESAFK.
OrthoDBEOG7NW6BZ.
PhylomeDBP24526.
TreeFamTF316894.

Gene expression databases

BgeeP24526.
CleanExMM_PMP2.
GenevestigatorP24526.

Family and domain databases

Gene3D2.40.128.20. 1 hit.
InterProIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSPR00178. FATTYACIDBP.
SUPFAMSSF50814. SSF50814. 1 hit.
PROSITEPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295236.
PROP24526.
SOURCESearch...

Entry information

Entry nameMYP2_MOUSE
AccessionPrimary (citable) accession number: P24526
Secondary accession number(s): Q4KL10
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot