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Protein

Myelin P2 protein

Gene

Pmp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in lipid transport protein in Schwann cells. May bind cholesterol (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071Fatty acidBy similarity

GO - Molecular functioni

GO - Biological processi

  • membrane organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin P2 protein
Gene namesi
Name:Pmp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:102667. Pmp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 132131Myelin P2 proteinPRO_0000067389Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP24526.

PTM databases

PhosphoSiteiP24526.

Expressioni

Gene expression databases

BgeeiP24526.
CleanExiMM_PMP2.
GenevisibleiP24526. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029034.

Structurei

3D structure databases

ProteinModelPortaliP24526.
SMRiP24526. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid bindingBy similarity

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG322298.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP24526.
OMAiMCNRFVG.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP24526.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKFLGTWK LVSSEHFDDY MKALGVGLAN RKLGNLAKPT VIISKKGDYI
60 70 80 90 100
TIRTESAFKN TEISFKLGQE FDETTADNRK AKSIVTLERG SLKQVQKWDG
110 120 130
KETAIRRTLL DGRMVVECIM KGVVCTRIYE KV
Length:132
Mass (Da):14,935
Last modified:January 23, 2007 - v2
Checksum:iAB6A4E7F3834107C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S39508 Genomic DNA. Translation: AAB19249.2.
BC099520 mRNA. Translation: AAH99520.1.
CCDSiCCDS17236.1.
PIRiJH0407.
RefSeqiNP_001025476.1. NM_001030305.2.
UniGeneiMm.371777.

Genome annotation databases

EnsembliENSMUST00000029034; ENSMUSP00000029034; ENSMUSG00000052468.
GeneIDi18857.
KEGGimmu:18857.
UCSCiuc008oph.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S39508 Genomic DNA. Translation: AAB19249.2.
BC099520 mRNA. Translation: AAH99520.1.
CCDSiCCDS17236.1.
PIRiJH0407.
RefSeqiNP_001025476.1. NM_001030305.2.
UniGeneiMm.371777.

3D structure databases

ProteinModelPortaliP24526.
SMRiP24526. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029034.

PTM databases

PhosphoSiteiP24526.

Proteomic databases

PRIDEiP24526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029034; ENSMUSP00000029034; ENSMUSG00000052468.
GeneIDi18857.
KEGGimmu:18857.
UCSCiuc008oph.1. mouse.

Organism-specific databases

CTDi5375.
MGIiMGI:102667. Pmp2.

Phylogenomic databases

eggNOGiNOG322298.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP24526.
OMAiMCNRFVG.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP24526.
TreeFamiTF316894.

Miscellaneous databases

NextBioi295236.
PROiP24526.
SOURCEiSearch...

Gene expression databases

BgeeiP24526.
CleanExiMM_PMP2.
GenevisibleiP24526. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the mouse myelin P2 protein gene."
    Narayanan V., Kaestner K.H., Tennekoon G.I.
    J. Neurochem. 57:75-80(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.

Entry informationi

Entry nameiMYP2_MOUSE
AccessioniPrimary (citable) accession number: P24526
Secondary accession number(s): Q4KL10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.