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P24526

- MYP2_MOUSE

UniProt

P24526 - MYP2_MOUSE

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Protein

Myelin P2 protein

Gene

Pmp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in lipid transport protein in Schwann cells. May bind cholesterol (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071Fatty acidBy similarity

GO - Molecular functioni

  1. cholesterol binding Source: UniProtKB
  2. fatty acid binding Source: UniProtKB
  3. transporter activity Source: InterPro

GO - Biological processi

  1. membrane organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin P2 protein
Gene namesi
Name:Pmp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:102667. Pmp2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 132131Myelin P2 proteinPRO_0000067389Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP24526.

PTM databases

PhosphoSiteiP24526.

Expressioni

Gene expression databases

BgeeiP24526.
CleanExiMM_PMP2.
GenevestigatoriP24526.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029034.

Structurei

3D structure databases

ProteinModelPortaliP24526.
SMRiP24526. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid bindingBy similarity

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG322298.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP24526.
OMAiRTESAFK.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP24526.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24526-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNKFLGTWK LVSSEHFDDY MKALGVGLAN RKLGNLAKPT VIISKKGDYI
60 70 80 90 100
TIRTESAFKN TEISFKLGQE FDETTADNRK AKSIVTLERG SLKQVQKWDG
110 120 130
KETAIRRTLL DGRMVVECIM KGVVCTRIYE KV
Length:132
Mass (Da):14,935
Last modified:January 23, 2007 - v2
Checksum:iAB6A4E7F3834107C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S39508 Genomic DNA. Translation: AAB19249.2.
BC099520 mRNA. Translation: AAH99520.1.
CCDSiCCDS17236.1.
PIRiJH0407.
RefSeqiNP_001025476.1. NM_001030305.2.
UniGeneiMm.371777.

Genome annotation databases

EnsembliENSMUST00000029034; ENSMUSP00000029034; ENSMUSG00000052468.
GeneIDi18857.
KEGGimmu:18857.
UCSCiuc008oph.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S39508 Genomic DNA. Translation: AAB19249.2 .
BC099520 mRNA. Translation: AAH99520.1 .
CCDSi CCDS17236.1.
PIRi JH0407.
RefSeqi NP_001025476.1. NM_001030305.2.
UniGenei Mm.371777.

3D structure databases

ProteinModelPortali P24526.
SMRi P24526. Positions 1-132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000029034.

PTM databases

PhosphoSitei P24526.

Proteomic databases

PRIDEi P24526.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029034 ; ENSMUSP00000029034 ; ENSMUSG00000052468 .
GeneIDi 18857.
KEGGi mmu:18857.
UCSCi uc008oph.1. mouse.

Organism-specific databases

CTDi 5375.
MGIi MGI:102667. Pmp2.

Phylogenomic databases

eggNOGi NOG322298.
GeneTreei ENSGT00760000118898.
HOGENOMi HOG000004829.
HOVERGENi HBG005633.
InParanoidi P24526.
OMAi RTESAFK.
OrthoDBi EOG7NW6BZ.
PhylomeDBi P24526.
TreeFami TF316894.

Miscellaneous databases

NextBioi 295236.
PROi P24526.
SOURCEi Search...

Gene expression databases

Bgeei P24526.
CleanExi MM_PMP2.
Genevestigatori P24526.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR00178. FATTYACIDBP.
SUPFAMi SSF50814. SSF50814. 1 hit.
PROSITEi PS00214. FABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the mouse myelin P2 protein gene."
    Narayanan V., Kaestner K.H., Tennekoon G.I.
    J. Neurochem. 57:75-80(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.

Entry informationi

Entry nameiMYP2_MOUSE
AccessioniPrimary (citable) accession number: P24526
Secondary accession number(s): Q4KL10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3