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P24526

- MYP2_MOUSE

UniProt

P24526 - MYP2_MOUSE

Protein

Myelin P2 protein

Gene

Pmp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May play a role in lipid transport protein in Schwann cells. May bind cholesterol By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei107 – 1071Fatty acidBy similarity

    GO - Molecular functioni

    1. cholesterol binding Source: UniProtKB
    2. fatty acid binding Source: UniProtKB
    3. transporter activity Source: InterPro

    GO - Biological processi

    1. membrane organization Source: MGI

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin P2 protein
    Gene namesi
    Name:Pmp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:102667. Pmp2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 132131Myelin P2 proteinPRO_0000067389Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP24526.

    PTM databases

    PhosphoSiteiP24526.

    Expressioni

    Gene expression databases

    BgeeiP24526.
    CleanExiMM_PMP2.
    GenevestigatoriP24526.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029034.

    Structurei

    3D structure databases

    ProteinModelPortaliP24526.
    SMRiP24526. Positions 1-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 1293Fatty acid bindingBy similarity

    Domaini

    Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG322298.
    GeneTreeiENSGT00740000115236.
    HOGENOMiHOG000004829.
    HOVERGENiHBG005633.
    InParanoidiQ4KL10.
    OMAiRTESAFK.
    OrthoDBiEOG7NW6BZ.
    PhylomeDBiP24526.
    TreeFamiTF316894.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PRINTSiPR00178. FATTYACIDBP.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00214. FABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24526-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNKFLGTWK LVSSEHFDDY MKALGVGLAN RKLGNLAKPT VIISKKGDYI    50
    TIRTESAFKN TEISFKLGQE FDETTADNRK AKSIVTLERG SLKQVQKWDG 100
    KETAIRRTLL DGRMVVECIM KGVVCTRIYE KV 132
    Length:132
    Mass (Da):14,935
    Last modified:January 23, 2007 - v2
    Checksum:iAB6A4E7F3834107C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S39508 Genomic DNA. Translation: AAB19249.2.
    BC099520 mRNA. Translation: AAH99520.1.
    CCDSiCCDS17236.1.
    PIRiJH0407.
    RefSeqiNP_001025476.1. NM_001030305.2.
    UniGeneiMm.371777.

    Genome annotation databases

    EnsembliENSMUST00000029034; ENSMUSP00000029034; ENSMUSG00000052468.
    GeneIDi18857.
    KEGGimmu:18857.
    UCSCiuc008oph.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S39508 Genomic DNA. Translation: AAB19249.2 .
    BC099520 mRNA. Translation: AAH99520.1 .
    CCDSi CCDS17236.1.
    PIRi JH0407.
    RefSeqi NP_001025476.1. NM_001030305.2.
    UniGenei Mm.371777.

    3D structure databases

    ProteinModelPortali P24526.
    SMRi P24526. Positions 1-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029034.

    PTM databases

    PhosphoSitei P24526.

    Proteomic databases

    PRIDEi P24526.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029034 ; ENSMUSP00000029034 ; ENSMUSG00000052468 .
    GeneIDi 18857.
    KEGGi mmu:18857.
    UCSCi uc008oph.1. mouse.

    Organism-specific databases

    CTDi 5375.
    MGIi MGI:102667. Pmp2.

    Phylogenomic databases

    eggNOGi NOG322298.
    GeneTreei ENSGT00740000115236.
    HOGENOMi HOG000004829.
    HOVERGENi HBG005633.
    InParanoidi Q4KL10.
    OMAi RTESAFK.
    OrthoDBi EOG7NW6BZ.
    PhylomeDBi P24526.
    TreeFami TF316894.

    Miscellaneous databases

    NextBioi 295236.
    PROi P24526.
    SOURCEi Search...

    Gene expression databases

    Bgeei P24526.
    CleanExi MM_PMP2.
    Genevestigatori P24526.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PRINTSi PR00178. FATTYACIDBP.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00214. FABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the mouse myelin P2 protein gene."
      Narayanan V., Kaestner K.H., Tennekoon G.I.
      J. Neurochem. 57:75-80(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thyroid.

    Entry informationi

    Entry nameiMYP2_MOUSE
    AccessioniPrimary (citable) accession number: P24526
    Secondary accession number(s): Q4KL10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3