Growth arrest and DNA damage-inducible protein GADD45 alpha

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P24522 (GA45A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 alpha

Alternative name(s):
DNA damage-inducible transcript 1 protein
Short name=DDIT-1

Gene names

Name:	GADD45A
Synonyms:	DDIT1, GADD45

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In T cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity By similarity. Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
Subunit structure	Interacts with GADD45GIP1. Interacts with MAPK14 By similarity. Ref.5
Induction	By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediate by some kinase(s) other than PKC.
Sequence similarities	Belongs to the GADD45 family.

Ontologies

Keywords
Biological process	Cell cycle DNA damage Growth arrest
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA repair Traceable author statement. Source: ProtInc apoptotic process Traceable author statement. Source: ProtInc cell cycle arrest Traceable author statement. Source: ProtInc cellular response to ionizing radiation Inferred from mutant phenotype. Source: BHF-UCL cellular response to mechanical stimulus Inferred from expression pattern. Source: UniProtKB positive regulation of reactive oxygen species metabolic process Inferred from mutant phenotype. Source: BHF-UCL regulation of cyclin-dependent protein kinase activity Traceable author statement. Source: ProtInc signal transduction in response to DNA damage Inferred from mutant phenotype. Source: BHF-UCL
Cellular component	nucleus Inferred from direct assay. Source: LIFEdb
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
AICDA	Q9GZX7	5	EBI-448167,EBI-3834328
GADD45GIP1	Q8TAE8	3	EBI-448167,EBI-372506
NUCB2	P80303	2	EBI-448167,EBI-2296670
SH3GLB1	Q9Y371	2	EBI-448167,EBI-2623095
TDG	Q13569	3	EBI-448167,EBI-348333

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 165

165

Growth arrest and DNA damage-inducible protein GADD45 alpha

PRO_0000148331

Secondary structure

165

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P24522 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: F2ADC183F6C0F064
Show »

FASTA

165

18,336

        10         20         30         40         50         60 
MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVD PDNVVLCLLA 

        70         80         90        100        110        120 
ADEDDDRDVA LQIHFTLIQA FCCENDINIL RVSNPGRLAE LLLLETDAGP AASEGAEQPP 

       130        140        150        160 
DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C." Papathanasiou M.A., Kerr N.C.K., Robbins J.H., McBride O.W., Alamo I. Jr., Barrett S.F., Hickson I.D., Fornace A.J. Jr. Mol. Cell. Biol. 11:1009-1016(1991) [PubMed: 1990262] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Analysis of the mammalian gadd45 gene and its response to DNA damage." Hollander M.C., Alamo I. Jr., Jackman J., Wang M.G., McBride O.W., Fornace A.J. Jr. J. Biol. Chem. 268:24385-24393(1993) [PubMed: 8226988] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Lung.
[3]	NIEHS SNPs program Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[5]	"CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle." Chung H.K., Yi Y.-W., Jung N.-C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.-H., Bae Y.-S., Kim J.M., Bae I., Shong M. J. Biol. Chem. 278:28079-28088(2003) [PubMed: 12716909] [Abstract] Cited for: INTERACTION WITH GADD45GIP1. Tissue: Colon carcinoma.
[6]	"Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen." Smith M.L., Chen I.-T., Zhan Q., Bae I., Chen C.-Y., Gilmer T.M., Kastan M.B., O'Connor P.M., Fornace A.J. Jr. Science 266:1376-1380(1994) [PubMed: 7973727] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Wikipedia

GADD45A entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L24498 Genomic DNA. Translation: AAA72045.1.
M60974 mRNA. Translation: AAA35863.1.
AY135686 Genomic DNA. Translation: AAM88884.1.
BC011757 mRNA. Translation: AAH11757.1.

IPI

IPI00029104.

PIR

A39617.

RefSeq

NP_001915.1. NM_001924.3.

UniGene

Hs.80409.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2KG4	NMR	-	A	1-165	[»]

ProteinModelPortal

P24522.

SMR

P24522. Positions 1-165.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-24217N.

IntAct

P24522. 15 interactions.

MINT

MINT-133779.

STRING

P24522.

Polymorphism databases

DMDM

120751.

Proteomic databases

PRIDE

P24522.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000370986; ENSP00000360025; ENSG00000116717.

GeneID

1647.

KEGG

hsa:1647.

UCSC

uc001ddz.1. human.

Organism-specific databases

CTD

1647.

GeneCards

GC01P068111.

H-InvDB

HIX0000685.

HGNC

HGNC:4095. GADD45A.

MIM

126335. gene.

neXtProt

NX_P24522.

PharmGKB

PA28510.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG18503.

HOGENOM

HBG445270.

HOVERGEN

HBG051684.

InParanoid

P24522.

OMA

VTNPHAS.

OrthoDB

EOG41NTN5.

PhylomeDB

P24522.

Enzyme and pathway databases

Pathway_Interaction_DB

aurora_a_pathway. Aurora A signaling.
foxopathway. FoxO family signaling.
p38_mkk3_6pathway. p38 MAPK signaling pathway.

Gene expression databases

ArrayExpress

P24522.

Bgee

P24522.

CleanEx

HS_GADD45A.

Genevestigator

P24522.

GermOnline

ENSG00000116717. Homo sapiens.

Family and domain databases

InterPro

IPR024824. GADD45.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]

K04402.

PANTHER

PTHR10411. PTHR10411. 1 hit.

Pfam

PF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

6786.

SOURCE

Search...

Entry information

Entry name

GA45A_HUMAN

Accession

Primary (citable) accession number: P24522

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	January 25, 2012
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents