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P24505 (SY61_DIPOM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Synaptotagmin-A
Alternative name(s):
Synaptic vesicle protein O-p65-A
Gene names
Name:P65-A
OrganismDiplobatis ommata (Ocellated electric ray) (Discopyge ommata)
Taxonomic identifier7785 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Batoidea › Torpediniformes › Narcinidae › Discopyge

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.

Cofactor

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Subunit structure

Homodimer or homotrimer (possible).

Subcellular location

Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass membrane protein. Cell junction › synapse. Note: Synaptic vesicles in neurons.

Tissue specificity

Forebrain, cerebellum and neuroendocrine cells.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Synaptotagmin-A
PRO_0000183983

Regions

Topological domain1 – 5757Vesicular Potential
Transmembrane58 – 8427Helical; Potential
Topological domain85 – 427343Cytoplasmic Potential
Domain162 – 25089C2 1
Domain292 – 38392C2 2
Region141 – 387247Phospholipid binding Probable

Sites

Metal binding1771Calcium 2; via carbonyl oxygen By similarity
Metal binding1781Calcium 1 By similarity
Metal binding1781Calcium 2 By similarity
Metal binding1841Calcium 1 By similarity
Metal binding2361Calcium 1 By similarity
Metal binding2361Calcium 2 By similarity
Metal binding2371Calcium 1; via carbonyl oxygen By similarity
Metal binding2381Calcium 1 By similarity
Metal binding2381Calcium 2 By similarity
Metal binding2381Calcium 3 By similarity
Metal binding2411Calcium 3 By similarity
Metal binding2421Calcium 3; via carbonyl oxygen By similarity
Metal binding2441Calcium 2 By similarity
Metal binding2441Calcium 3 By similarity

Amino acid modifications

Glycosylation261N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P24505 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: D23F9488A8A8600A

FASTA42747,768
        10         20         30         40         50         60 
MKLTEAYHDA LAALPATPPL PTAVANATEA AAGSEEGKQD GFSKVKVKEK FMNELNKIPL 

        70         80         90        100        110        120 
PPWALVAIAI VAIILGLTCC FCICKKCLLK KKNKKKGKEK GGKNAMTMKD VKEMGKSGKE 

       130        140        150        160        170        180 
QALKDEDEDA ETGLTTDGKE EEKEDEKLGK LQFSLDYDFQ NNQLIVGIIQ AAELPALDVG 

       190        200        210        220        230        240 
GTSDPYVKVF VLPDKKKKYE TKVHRKTLNP VFNESFIFKI PYSELGGKTL VMAVYDFDRF 

       250        260        270        280        290        300 
SKHDVIGEAK VPMNTVDFGH VTEEWRDLQG AEKEEQEKLG DICFSLRYVP TAGKLTVVIL 

       310        320        330        340        350        360 
EAKNLKKMDV GGLSDPYVKI HLMQNGKRLK KKKTTIKKNT LNPYYNESFS FEVPFEQIQK 

       370        380        390        400        410        420 
VQVVVTVLDY DKIGKNDAIG KVFVGYNSTA AELRHWSDML ANPRRPIAQW HTLQPEEEVD 


ATLGMKK

« Hide

References

[1]"Differential expression of the p65 gene family."
Wendland B., Miller K.G., Schilling J., Scheller R.H.
Neuron 6:993-1007(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M64275 mRNA. Translation: AAA49227.1.
PIRJH0413.

3D structure databases

ProteinModelPortalP24505.
SMRP24505. Positions 146-424.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005010.

Family and domain databases

InterProIPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR020477. C2_dom.
IPR018029. C2_membr_targeting.
IPR001565. Synaptotagmin.
IPR015428. Synaptotagmin1.
[Graphical view]
PANTHERPTHR10024:SF39. PTHR10024:SF39. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
PRINTSPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. C2_CaLB. 2 hits.
PROSITEPS50004. C2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSY61_DIPOM
AccessionPrimary (citable) accession number: P24505
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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