Reviewed, UniProtKB/Swiss-Prot P24495 (PSA2_XENLA)

Names and origin

Protein names

Recommended name:
    Proteasome subunit alpha type-2
    EC=3.4.25.1
Alternative name(s):
    Proteasome component C3
    Macropain subunit C3
    Multicatalytic endopeptidase complex subunit C3
      Short name=xC3

Gene names

Name:

psma2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation By similarity.
Catalytic activity	Cleavage of peptide bonds with very broad specificity.
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the peptidase T1A family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus Proteasome
Molecular function	Hydrolase Protease Threonine protease
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex Inferred from electronic annotation. Source: InterPro
Molecular function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 234	233	Proteasome subunit alpha type-2		PRO_0000124080
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	121	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P24495-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: DAD6E27698410FA2	FASTA	234	25,834
	10 20 30 40 50 60 MAERGYSFSL TTFSPSGKLV QIEYALAAVA AGAPSVGIKA TNGVVLATEK KQKSILYDEQ 70 80 90 100 110 120 SAHKVEPITK HIGMVYSGMG PDYRVLVRRA RKLAQQYYLV YQEPIPTAQL VQRVASVMQE 130 140 150 160 170 180 YTQSGGVRPF GVSLLIAGWD EGRPYLFQSD PSGAYFAWKA TAMGKNYVNG KTFLEKRYNE 190 200 210 220 230 DLELEDAIHT AILTLKESFE GQMTEDNIEV GICNEAGFKR LTPAEVKDYL AAIA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deduced primary structure of a Xenopus proteasome subunit XC3 and expression of its mRNA during early development." Fujii G., Tashiro K., Emori Y., Saigo K., Tanaka K., Shiokawa K. Biochem. Biophys. Res. Commun. 178:1233-1239(1991) [PubMed: 1872843] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S51111 mRNA. Translation: AAB19485.1. BC072254 mRNA. Translation: AAH72254.1.
PIR	JH0421.
RefSeq	NP_001084053.1.
UniGene	Xl.2546
3D structure databases
HSSP	HSSP built from PDB template 1RYP based on UniProtKB P23639.
ModBase	Search...
Protein family/group databases
MEROPS	T01.972.
Proteomic databases
PRIDE	P24495.
Genome annotation databases
GeneID	399279.
KEGG	xla:399279.
Organism-specific databases
CTD	399279.
Xenbase	XB-FEAT-964710. psma2.
Phylogenomic databases
HOVERGEN	P24495.
Enzyme and pathway databases
BRENDA	3.4.25.1. 648.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_CS. IPR001353. Proteasome_sua/b. [Graphical view]
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PSA2_XENLA

Accession

Primary (citable) accession number: P24495
Secondary accession number(s): Q6INM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	January 23, 2007
Last modified:	October 13, 2009
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project