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P24485

- CD53_RAT

UniProt

P24485 - CD53_RAT

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Protein

Leukocyte surface antigen CD53

Gene

Cd53

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).By similarity

GO - Biological processi

  1. positive regulation of myoblast fusion Source: UniProtKB
  2. regulation of growth Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte surface antigen CD53
Alternative name(s):
Cell surface glycoprotein CD53
Leukocyte antigen MRC OX-44
CD_antigen: CD53
Gene namesi
Name:Cd53
Synonyms:Ox-44
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi2310. Cd53.

Subcellular locationi

Cell membrane By similarity. Cell junction By similarity. Membrane; Multi-pass membrane protein
Note: Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1110CytoplasmicSequence Analysis
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Topological domaini33 – 5422ExtracellularSequence AnalysisAdd
BLAST
Transmembranei55 – 6915HelicalSequence AnalysisAdd
BLAST
Topological domaini70 – 8011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei81 – 10626HelicalSequence AnalysisAdd
BLAST
Topological domaini107 – 18175ExtracellularSequence AnalysisAdd
BLAST
Transmembranei182 – 20625HelicalSequence AnalysisAdd
BLAST
Topological domaini207 – 21913CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: UniProtKB
  2. cell surface Source: RGD
  3. extracellular vesicular exosome Source: Ensembl
  4. immunological synapse Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 219218Leukocyte surface antigen CD53PRO_0000219214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Spleen and thymus, B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes, peripheral T-cells.

Gene expression databases

GenevestigatoriP24485.

Interactioni

Subunit structurei

Interacts with SCIMP.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024344.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265641.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP24485.
KOiK06489.
OMAiVCVIQVL.
OrthoDBiEOG7PGDRZ.
PhylomeDBiP24485.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24485-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGMSSLKLLK YVLFFFNFLF WVCGCCILGF GIHLLVQNTY GILFRNLPFL
60 70 80 90 100
TLGNVLVIVG SIIMVVAFLG CMGSIKENKC LLMSFFVLLL LILLAEVTLA
110 120 130 140 150
ILLFVYEKKI NTLVAEGLND SIQHYHSDNS TRMAWDFIQS QLQCCGVNGS
160 170 180 190 200
SDWISGPPSS CPSGADVQGC YKKGQAWFHS NFLYIGIVTI CVCVIQVLGM
210
SFALTLNCQI DKTSQALGL
Length:219
Mass (Da):24,168
Last modified:January 23, 2007 - v3
Checksum:iC73FC368311F172D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57276 mRNA. Translation: AAA41775.1.
BC078900 mRNA. Translation: AAH78900.1.
PIRiA39574.
RefSeqiNP_036655.1. NM_012523.2.
UniGeneiRn.31988.

Genome annotation databases

EnsembliENSRNOT00000024344; ENSRNOP00000024344; ENSRNOG00000017874.
GeneIDi24251.
KEGGirno:24251.
UCSCiRGD:2310. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57276 mRNA. Translation: AAA41775.1 .
BC078900 mRNA. Translation: AAH78900.1 .
PIRi A39574.
RefSeqi NP_036655.1. NM_012523.2.
UniGenei Rn.31988.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000024344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024344 ; ENSRNOP00000024344 ; ENSRNOG00000017874 .
GeneIDi 24251.
KEGGi rno:24251.
UCSCi RGD:2310. rat.

Organism-specific databases

CTDi 963.
RGDi 2310. Cd53.

Phylogenomic databases

eggNOGi NOG265641.
GeneTreei ENSGT00760000118983.
HOGENOMi HOG000230651.
HOVERGENi HBG002324.
InParanoidi P24485.
KOi K06489.
OMAi VCVIQVL.
OrthoDBi EOG7PGDRZ.
PhylomeDBi P24485.
TreeFami TF352892.

Miscellaneous databases

NextBioi 602765.
PROi P24485.

Gene expression databases

Genevestigatori P24485.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation."
    Bellacosa A., Lazo P.A., Bear S.E., Tsichlis P.N.
    Mol. Cell. Biol. 11:2864-2872(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen."
    Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.
    J. Exp. Med. 169:1497-1502(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-30.

Entry informationi

Entry nameiCD53_RAT
AccessioniPrimary (citable) accession number: P24485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3