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P24485 (CD53_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukocyte surface antigen CD53
Alternative name(s):
Cell surface glycoprotein CD53
Leukocyte antigen MRC OX-44
CD_antigen=CD53
Gene names
Name:Cd53
Synonyms:Ox-44
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells By similarity.

Subunit structure

Interacts with SCIMP By similarity.

Subcellular location

Cell membrane By similarity. Cell junction By similarity. Membrane; Multi-pass membrane protein. Note: Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes By similarity.

Tissue specificity

Spleen and thymus, B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes, peripheral T-cells.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 219218Leukocyte surface antigen CD53
PRO_0000219214

Regions

Topological domain2 – 1110Cytoplasmic Potential
Transmembrane12 – 3221Helical; Potential
Topological domain33 – 5422Extracellular Potential
Transmembrane55 – 6915Helical; Potential
Topological domain70 – 8011Cytoplasmic Potential
Transmembrane81 – 10626Helical; Potential
Topological domain107 – 18175Extracellular Potential
Transmembrane182 – 20625Helical; Potential
Topological domain207 – 21913Cytoplasmic Potential

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation1291N-linked (GlcNAc...) Potential
Glycosylation1481N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P24485 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: C73FC368311F172D

FASTA21924,168
        10         20         30         40         50         60 
MGMSSLKLLK YVLFFFNFLF WVCGCCILGF GIHLLVQNTY GILFRNLPFL TLGNVLVIVG 

        70         80         90        100        110        120 
SIIMVVAFLG CMGSIKENKC LLMSFFVLLL LILLAEVTLA ILLFVYEKKI NTLVAEGLND 

       130        140        150        160        170        180 
SIQHYHSDNS TRMAWDFIQS QLQCCGVNGS SDWISGPPSS CPSGADVQGC YKKGQAWFHS 

       190        200        210 
NFLYIGIVTI CVCVIQVLGM SFALTLNCQI DKTSQALGL 

« Hide

References

« Hide 'large scale' references
[1]"The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation."
Bellacosa A., Lazo P.A., Bear S.E., Tsichlis P.N.
Mol. Cell. Biol. 11:2864-2872(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen."
Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.
J. Exp. Med. 169:1497-1502(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-30.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57276 mRNA. Translation: AAA41775.1.
BC078900 mRNA. Translation: AAH78900.1.
PIRA39574.
RefSeqNP_036655.1. NM_012523.2.
XP_006233193.1. XM_006233131.1.
UniGeneRn.31988.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000024344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000024344; ENSRNOP00000024344; ENSRNOG00000017874.
GeneID24251.
KEGGrno:24251.
UCSCRGD:2310. rat.

Organism-specific databases

CTD963.
RGD2310. Cd53.

Phylogenomic databases

eggNOGNOG265641.
GeneTreeENSGT00740000115399.
HOGENOMHOG000230651.
HOVERGENHBG002324.
InParanoidP24485.
KOK06489.
OMAVCVIQVL.
OrthoDBEOG7PGDRZ.
PhylomeDBP24485.
TreeFamTF352892.

Gene expression databases

GenevestigatorP24485.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio602765.
PROP24485.

Entry information

Entry nameCD53_RAT
AccessionPrimary (citable) accession number: P24485
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families