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P24485

- CD53_RAT

UniProt

P24485 - CD53_RAT

Protein

Leukocyte surface antigen CD53

Gene

Cd53

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells By similarity.By similarity

    GO - Biological processi

    1. positive regulation of myoblast fusion Source: UniProtKB
    2. regulation of growth Source: RGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukocyte surface antigen CD53
    Alternative name(s):
    Cell surface glycoprotein CD53
    Leukocyte antigen MRC OX-44
    CD_antigen: CD53
    Gene namesi
    Name:Cd53
    Synonyms:Ox-44
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi2310. Cd53.

    Subcellular locationi

    Cell membrane By similarity. Cell junction By similarity. Membrane; Multi-pass membrane protein
    Note: Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.By similarity

    GO - Cellular componenti

    1. cell-cell junction Source: UniProtKB
    2. cell surface Source: RGD
    3. immunological synapse Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 219218Leukocyte surface antigen CD53PRO_0000219214Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Spleen and thymus, B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes, peripheral T-cells.

    Gene expression databases

    GenevestigatoriP24485.

    Interactioni

    Subunit structurei

    Interacts with SCIMP.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024344.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1110CytoplasmicSequence Analysis
    Topological domaini33 – 5422ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini70 – 8011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 18175ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini207 – 21913CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 6915HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10626HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20625HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG265641.
    GeneTreeiENSGT00740000115399.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    InParanoidiP24485.
    KOiK06489.
    OMAiVCVIQVL.
    OrthoDBiEOG7PGDRZ.
    PhylomeDBiP24485.
    TreeFamiTF352892.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24485-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMSSLKLLK YVLFFFNFLF WVCGCCILGF GIHLLVQNTY GILFRNLPFL    50
    TLGNVLVIVG SIIMVVAFLG CMGSIKENKC LLMSFFVLLL LILLAEVTLA 100
    ILLFVYEKKI NTLVAEGLND SIQHYHSDNS TRMAWDFIQS QLQCCGVNGS 150
    SDWISGPPSS CPSGADVQGC YKKGQAWFHS NFLYIGIVTI CVCVIQVLGM 200
    SFALTLNCQI DKTSQALGL 219
    Length:219
    Mass (Da):24,168
    Last modified:January 23, 2007 - v3
    Checksum:iC73FC368311F172D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57276 mRNA. Translation: AAA41775.1.
    BC078900 mRNA. Translation: AAH78900.1.
    PIRiA39574.
    RefSeqiNP_036655.1. NM_012523.2.
    XP_006233193.1. XM_006233131.1.
    UniGeneiRn.31988.

    Genome annotation databases

    EnsembliENSRNOT00000024344; ENSRNOP00000024344; ENSRNOG00000017874.
    GeneIDi24251.
    KEGGirno:24251.
    UCSCiRGD:2310. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57276 mRNA. Translation: AAA41775.1 .
    BC078900 mRNA. Translation: AAH78900.1 .
    PIRi A39574.
    RefSeqi NP_036655.1. NM_012523.2.
    XP_006233193.1. XM_006233131.1.
    UniGenei Rn.31988.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024344 ; ENSRNOP00000024344 ; ENSRNOG00000017874 .
    GeneIDi 24251.
    KEGGi rno:24251.
    UCSCi RGD:2310. rat.

    Organism-specific databases

    CTDi 963.
    RGDi 2310. Cd53.

    Phylogenomic databases

    eggNOGi NOG265641.
    GeneTreei ENSGT00740000115399.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    InParanoidi P24485.
    KOi K06489.
    OMAi VCVIQVL.
    OrthoDBi EOG7PGDRZ.
    PhylomeDBi P24485.
    TreeFami TF352892.

    Miscellaneous databases

    NextBioi 602765.
    PROi P24485.

    Gene expression databases

    Genevestigatori P24485.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation."
      Bellacosa A., Lazo P.A., Bear S.E., Tsichlis P.N.
      Mol. Cell. Biol. 11:2864-2872(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen."
      Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.
      J. Exp. Med. 169:1497-1502(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-30.

    Entry informationi

    Entry nameiCD53_RAT
    AccessioniPrimary (citable) accession number: P24485
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3