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Protein

Leukocyte surface antigen CD53

Gene

Cd53

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte surface antigen CD53
Alternative name(s):
Cell surface glycoprotein CD53
Leukocyte antigen MRC OX-44
CD_antigen: CD53
Gene namesi
Name:Cd53
Synonyms:Ox-44
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2310. Cd53.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 11CytoplasmicSequence analysis10
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 54ExtracellularSequence analysisAdd BLAST22
Transmembranei55 – 69HelicalSequence analysisAdd BLAST15
Topological domaini70 – 80CytoplasmicSequence analysisAdd BLAST11
Transmembranei81 – 106HelicalSequence analysisAdd BLAST26
Topological domaini107 – 181ExtracellularSequence analysisAdd BLAST75
Transmembranei182 – 206HelicalSequence analysisAdd BLAST25
Topological domaini207 – 219CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002192142 – 219Leukocyte surface antigen CD53Add BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP24485.

Expressioni

Tissue specificityi

Spleen and thymus, B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes, peripheral T-cells.

Gene expression databases

BgeeiENSRNOG00000017874.
GenevisibleiP24485. RN.

Interactioni

Subunit structurei

Interacts with SCIMP.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024344.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP24485.
KOiK06489.
OMAiAKLWFHS.
OrthoDBiEOG091G0CQO.
PhylomeDBiP24485.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSSLKLLK YVLFFFNFLF WVCGCCILGF GIHLLVQNTY GILFRNLPFL
60 70 80 90 100
TLGNVLVIVG SIIMVVAFLG CMGSIKENKC LLMSFFVLLL LILLAEVTLA
110 120 130 140 150
ILLFVYEKKI NTLVAEGLND SIQHYHSDNS TRMAWDFIQS QLQCCGVNGS
160 170 180 190 200
SDWISGPPSS CPSGADVQGC YKKGQAWFHS NFLYIGIVTI CVCVIQVLGM
210
SFALTLNCQI DKTSQALGL
Length:219
Mass (Da):24,168
Last modified:January 23, 2007 - v3
Checksum:iC73FC368311F172D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57276 mRNA. Translation: AAA41775.1.
BC078900 mRNA. Translation: AAH78900.1.
PIRiA39574.
RefSeqiNP_036655.1. NM_012523.2.
UniGeneiRn.31988.

Genome annotation databases

EnsembliENSRNOT00000024344; ENSRNOP00000024344; ENSRNOG00000017874.
GeneIDi24251.
KEGGirno:24251.
UCSCiRGD:2310. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57276 mRNA. Translation: AAA41775.1.
BC078900 mRNA. Translation: AAH78900.1.
PIRiA39574.
RefSeqiNP_036655.1. NM_012523.2.
UniGeneiRn.31988.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024344.

Proteomic databases

PaxDbiP24485.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024344; ENSRNOP00000024344; ENSRNOG00000017874.
GeneIDi24251.
KEGGirno:24251.
UCSCiRGD:2310. rat.

Organism-specific databases

CTDi963.
RGDi2310. Cd53.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP24485.
KOiK06489.
OMAiAKLWFHS.
OrthoDBiEOG091G0CQO.
PhylomeDBiP24485.
TreeFamiTF352892.

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP24485.

Gene expression databases

BgeeiENSRNOG00000017874.
GenevisibleiP24485. RN.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD53_RAT
AccessioniPrimary (citable) accession number: P24485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.