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Protein

Adrenodoxin, mitochondrial

Gene

Fdx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons.By similarity

Cofactori

[2Fe-2S] clusterNote: Binds 1 [2Fe-2S] cluster.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi110Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi116Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi119Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi156Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1

GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: UniProtKB
  • electron transfer activity Source: RGD
  • iron ion binding Source: RGD

GO - Biological processi

  • adrenal gland development Source: RGD
  • cellular response to epinephrine stimulus Source: RGD
  • cellular response to leptin stimulus Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • cholesterol metabolic process Source: UniProtKB
  • hormone biosynthetic process Source: UniProtKB
  • NADPH oxidation Source: RGD
  • positive regulation of oxidoreductase activity Source: RGD
  • regulation of catalytic activity Source: RGD
  • response to gonadotropin Source: RGD
  • response to leptin Source: RGD
  • steroid biosynthetic process Source: UniProtKB-KW

Keywordsi

Biological processCholesterol metabolism, Electron transport, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism, Transport
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenodoxin, mitochondrial
Alternative name(s):
Adrenal ferredoxin
Ferredoxin-1
Gene namesi
Name:Fdx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62036 Fdx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 64MitochondrionAdd BLAST64
ChainiPRO_000000099165 – 188Adrenodoxin, mitochondrialAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineBy similarity1
Modified residuei70N6-acetyllysine; alternateBy similarity1
Modified residuei70N6-succinyllysine; alternateBy similarity1
Modified residuei162N6-succinyllysineBy similarity1
Modified residuei181PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP24483
PRIDEiP24483

PTM databases

iPTMnetiP24483
PhosphoSitePlusiP24483

Expressioni

Tissue specificityi

Found in all tissues, most abundant in adrenals, ovaries and testes.

Interactioni

Subunit structurei

Interacts with CYP11A1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016263

Structurei

3D structure databases

ProteinModelPortaliP24483
SMRiP24483
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 1752Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST107

Sequence similaritiesi

Belongs to the adrenodoxin/putidaredoxin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3309 Eukaryota
COG0633 LUCA
HOGENOMiHOG000244518
HOVERGENiHBG000092
InParanoidiP24483
KOiK22070
PhylomeDBiP24483

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR001055 Adrenodoxin
IPR018298 Adrenodoxin_Fe-S_BS
IPR012675 Beta-grasp_dom_sf
PfamiView protein in Pfam
PF00111 Fer2, 1 hit
PRINTSiPR00355 ADRENODOXIN
SUPFAMiSSF54292 SSF54292, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00814 ADX, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPGARLL RAACASVAFR GLDCRRLLVC GTRAGPAVPQ WTPSPHTLAE
60 70 80 90 100
AGPGRPLSVS ARARSSSEDK VTVHFKNRDG ETLTTKGKVG DSLLDVVIEN
110 120 130 140 150
NLDIDGFGAC EGTLACSTCH LIFEDHIYEK LDAITDEEND MLDLAFGLTN
160 170 180
RSRLGCQVCL TKAMDNMTVR VPEAVADVRQ SVDMSKNS
Length:188
Mass (Da):20,135
Last modified:March 1, 1992 - v1
Checksum:iB0686D5159A30240
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50436 mRNA Translation: BAA08927.1
PIRiA39553
RefSeqiNP_058822.1, NM_017126.1
UniGeneiRn.6946

Genome annotation databases

GeneIDi29189
KEGGirno:29189
UCSCiRGD:62036 rat

Similar proteinsi

Entry informationi

Entry nameiADX_RAT
AccessioniPrimary (citable) accession number: P24483
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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