Reviewed, UniProtKB/Swiss-Prot P24483 (ADX_RAT)

Names and origin

Protein names

Recommended name:
    Adrenodoxin, mitochondrial
Alternative name(s):
    Adrenal ferredoxin
    Ferredoxin-1

Gene names

Name:

Fdx1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Adrenodoxin transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome P450.
Cofactor	Binds 1 2Fe-2S cluster.
Subcellular location	Mitochondrion matrix.
Tissue specificity	Found in all tissues, most abundant in adrenals, ovaries and testes.
Sequence similarities	Belongs to the adrenodoxin/putidaredoxin family. Contains 1 2Fe-2S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 64	64	Mitochondrion
	Chain	65 – 188	124	Adrenodoxin, mitochondrial		PRO_0000000991
Regions
	Domain	69 – 175	107	2Fe-2S ferredoxin-type
Sites
	Metal binding	110	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	116	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	119	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	156	1	Iron-sulfur (2Fe-2S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P24483-1 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: B0686D5159A30240	FASTA	188	20,135
	10 20 30 40 50 60 MAAAPGARLL RAACASVAFR GLDCRRLLVC GTRAGPAVPQ WTPSPHTLAE AGPGRPLSVS 70 80 90 100 110 120 ARARSSSEDK VTVHFKNRDG ETLTTKGKVG DSLLDVVIEN NLDIDGFGAC EGTLACSTCH 130 140 150 160 170 180 LIFEDHIYEK LDAITDEEND MLDLAFGLTN RSRLGCQVCL TKAMDNMTVR VPEAVADVRQ SVDMSKNS

References

[1]	"Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues." Mellon S.H., Kushner J.A., Vaisse C. DNA Cell Biol. 10:339-347(1991) [PubMed: 1863358] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[2]	"Cloning and sequence analysis of a full-length cDNA of rat adrenodoxin." Sagara Y., Watanabe Y., Kawamura K., Yubisui T. Biol. Pharm. Bull. 19:39-41(1996) [PubMed: 8820908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Adrenal gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D50436 mRNA. Translation: BAA08927.1.
IPI	IPI00214587.
PIR	A39553.
RefSeq	NP_058822.1.
UniGene	Rn.6946
3D structure databases
SMR	P24483. Positions 69-172.
ModBase	Search...
Protein-protein interaction databases
STRING	P24483.
Proteomic databases
PRIDE	P24483.
Genome annotation databases
Ensembl	ENSRNOT00000016263; ENSRNOP00000016263; ENSRNOG00000012123; Rattus norvegicus. [Genome view]
GeneID	29189.
KEGG	rno:29189.
UCSC	NM_017126. rat.
Organism-specific databases
CTD	29189.
RGD	62036. Fdx1.
Phylogenomic databases
HOVERGEN	P24483.
Gene expression databases
ArrayExpress	P24483.
Genevestigator	P24483.
GermOnline	ENSRNOG00000012123. Rattus norvegicus.
Family and domain databases
InterPro	IPR001055. Adrenodoxin. IPR018298. Adrenodoxin_Fe-S_BS. IPR012675. b-grasp_ferredoxin-like. IPR001041. Ferredoxin. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
Pfam	PF00111. Fer2. 1 hit. [Graphical view]
PRINTS	PR00355. ADRENODOXIN.
PROSITE	PS51085. 2FE2S_FER_2. 1 hit. PS00814. ADX. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	608311.

Entry information

Entry name

ADX_RAT

Accession

Primary (citable) accession number: P24483

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	November 24, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)