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Protein

Protein S100-A11

Gene

S100A11

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates the differentiation and the cornification of keratinocytes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi22 – 351; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi65 – 762; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
Protein S100-C
S100 calcium-binding protein A11
Gene namesi
Name:S100A11
Synonyms:PCALG, S100C
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440121 – 102Protein S100-A11Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei7PhosphothreonineBy similarity1
Disulfide bondi10InterchainBy similarity
Modified residuei24N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylation at Thr-7 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP24480.

Expressioni

Tissue specificityi

Smooth muscle and non-muscle tissues.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004505.

Structurei

Secondary structure

1102
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 21Combined sources16
Helixi33 – 43Combined sources11
Helixi45 – 48Combined sources4
Helixi49 – 51Combined sources3
Turni54 – 56Combined sources3
Helixi57 – 63Combined sources7
Helixi75 – 86Combined sources12
Helixi90 – 92Combined sources3
Turni93 – 95Combined sources3
Helixi97 – 99Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NSHNMR-A/B2-102[»]
ProteinModelPortaliP24480.
SMRiP24480.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24480.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini52 – 87EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP24480.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF60. PTHR11639:SF60. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPTETERC IESLIAVFQK YAGKDGHSVT LSKTEFLSFM NTELAAFTKN
60 70 80 90 100
QKDPGVLDRM MKKLDLNSDG QLDFQEFLNL IGGLAVACHE SFVKAAPPQK

RF
Length:102
Mass (Da):11,429
Last modified:December 1, 1992 - v2
Checksum:i66D1FFBBA4F8DF45
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59R → Y AA sequence (PubMed:1917990).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10586 mRNA. Translation: BAA01443.1.
PIRiJQ1300.
RefSeqiNP_001075656.1. NM_001082187.1.
UniGeneiOcu.2358.

Genome annotation databases

GeneIDi100008975.
KEGGiocu:100008975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10586 mRNA. Translation: BAA01443.1.
PIRiJQ1300.
RefSeqiNP_001075656.1. NM_001082187.1.
UniGeneiOcu.2358.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NSHNMR-A/B2-102[»]
ProteinModelPortaliP24480.
SMRiP24480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004505.

Proteomic databases

PRIDEiP24480.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008975.
KEGGiocu:100008975.

Organism-specific databases

CTDi6282.

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP24480.

Miscellaneous databases

EvolutionaryTraceiP24480.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF60. PTHR11639:SF60. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10AB_RABIT
AccessioniPrimary (citable) accession number: P24480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.