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Protein

Antiviral protein DAP-30

Gene
N/A
Organism
Dianthus caryophyllus (Carnation) (Clove pink)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Single-chain ribosome-inactivating protein.

Catalytic activityi

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei200 – 2001By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antiviral protein, Hydrolase, Protein synthesis inhibitor, Toxin

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Antiviral protein DAP-30 (EC:3.2.2.22)
Alternative name(s):
Dianthin 30
Ribosome-inactivating protein
rRNA N-glycosidase
OrganismiDianthus caryophyllus (Carnation) (Clove pink)
Taxonomic identifieri3570 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesCaryophyllaceaeCaryophylleaeDianthus

Pathology & Biotechi

Protein family/group databases

Allergomei2796. Dia c RIP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 293270Antiviral protein DAP-30PRO_0000030789Add
BLAST

Structurei

Secondary structure

1
293
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 306Combined sources
Helixi36 – 5015Combined sources
Beta strandi63 – 653Combined sources
Beta strandi70 – 723Combined sources
Beta strandi74 – 818Combined sources
Beta strandi84 – 918Combined sources
Turni92 – 943Combined sources
Beta strandi97 – 1037Combined sources
Beta strandi109 – 1135Combined sources
Turni115 – 1173Combined sources
Helixi120 – 1267Combined sources
Helixi132 – 1343Combined sources
Beta strandi135 – 1373Combined sources
Helixi144 – 1507Combined sources
Helixi160 – 1634Combined sources
Helixi167 – 1748Combined sources
Turni175 – 1795Combined sources
Helixi184 – 19714Combined sources
Helixi199 – 2035Combined sources
Helixi205 – 2139Combined sources
Turni214 – 2163Combined sources
Helixi223 – 2308Combined sources
Helixi232 – 24110Combined sources
Beta strandi242 – 2443Combined sources
Beta strandi247 – 25610Combined sources
Beta strandi258 – 2614Combined sources
Helixi262 – 2654Combined sources
Beta strandi267 – 2704Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LP8X-ray1.65A24-277[»]
1LPCX-ray1.70A24-277[»]
1LPDX-ray1.70A24-277[»]
1RL0X-ray1.40A24-278[»]
ProteinModelPortaliP24476.
SMRiP24476. Positions 24-278.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24476.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.420.10. 1 hit.
4.10.470.10. 1 hit.
InterProiIPR001574. Ribosome_inactivat_prot.
IPR017988. Ribosome_inactivat_prot_CS.
IPR016138. Ribosome_inactivat_prot_sub1.
IPR016139. Ribosome_inactivat_prot_sub2.
IPR017989. Ribosome_inactivat_prot_subgr.
[Graphical view]
PfamiPF00161. RIP. 1 hit.
[Graphical view]
PRINTSiPR00396. SHIGARICIN.
SUPFAMiSSF56371. SSF56371. 1 hit.
PROSITEiPS00275. SHIGA_RICIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24476-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIYLVAAIA WILFQSSSWT TDAATAYTLN LANPSASQYS SFLDQIRNNV
60 70 80 90 100
RDTSLIYGGT DVAVIGAPST TDKFLRLNFQ GPRGTVSLGL RRENLYVVAY
110 120 130 140 150
LAMDNANVNR AYYFKNQITS AELTALFPEV VVANQKQLEY GEDYQAIEKN
160 170 180 190 200
AKITTGDQSR KELGLGINLL ITMIDGVNKK VRVVKDEARF LLIAIQMTAE
210 220 230 240 250
AARFRYIQNL VTKNFPNKFD SENKVIQFQV SWSKISTAIF GDCKNGVFNK
260 270 280 290
DYDFGFGKVR QAKDLQMGLL KYLGRPKSSS IEANSTDDTA DVL
Length:293
Mass (Da):32,717
Last modified:December 1, 1992 - v2
Checksum:iAC85AAAC8725D4F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59260 mRNA. Translation: CAA41953.1. Sequence problems.
PIRiS17519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59260 mRNA. Translation: CAA41953.1. Sequence problems.
PIRiS17519.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LP8X-ray1.65A24-277[»]
1LPCX-ray1.70A24-277[»]
1LPDX-ray1.70A24-277[»]
1RL0X-ray1.40A24-278[»]
ProteinModelPortaliP24476.
SMRiP24476. Positions 24-278.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei2796. Dia c RIP.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP24476.

Family and domain databases

Gene3Di3.40.420.10. 1 hit.
4.10.470.10. 1 hit.
InterProiIPR001574. Ribosome_inactivat_prot.
IPR017988. Ribosome_inactivat_prot_CS.
IPR016138. Ribosome_inactivat_prot_sub1.
IPR016139. Ribosome_inactivat_prot_sub2.
IPR017989. Ribosome_inactivat_prot_subgr.
[Graphical view]
PfamiPF00161. RIP. 1 hit.
[Graphical view]
PRINTSiPR00396. SHIGARICIN.
SUPFAMiSSF56371. SSF56371. 1 hit.
PROSITEiPS00275. SHIGA_RICIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIP0_DIACA
AccessioniPrimary (citable) accession number: P24476
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 1, 1992
Last modified: June 8, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibits HIV-1 infection and replication.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.