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P24468

- COT2_HUMAN

UniProt

P24468 - COT2_HUMAN

Protein

COUP transcription factor 2

Gene

NR2F2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi76 – 15176Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri79 – 9921NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri115 – 13925NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. protein homodimerization activity Source: UniProtKB
    4. retinoic acid binding Source: UniProtKB
    5. sequence-specific DNA binding Source: UniProtKB
    6. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    7. steroid hormone receptor activity Source: InterPro
    8. transcription corepressor activity Source: ProtInc
    9. zinc ion binding Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. blood vessel morphogenesis Source: Ensembl
    3. fertilization Source: Ensembl
    4. forebrain development Source: Ensembl
    5. intracellular receptor signaling pathway Source: GOC
    6. limb development Source: Ensembl
    7. lipid metabolic process Source: ProtInc
    8. maternal placenta development Source: Ensembl
    9. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
    10. negative regulation of endothelial cell migration Source: BHF-UCL
    11. negative regulation of endothelial cell proliferation Source: BHF-UCL
    12. negative regulation of transcription, DNA-templated Source: BHF-UCL
    13. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    14. neuron migration Source: Ensembl
    15. placenta blood vessel development Source: Ensembl
    16. positive regulation of transcription, DNA-templated Source: UniProtKB
    17. radial pattern formation Source: Ensembl
    18. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    19. regulation of transcription involved in lymphatic endothelial cell fate commitment Source: BHF-UCL
    20. response to estradiol Source: Ensembl
    21. signal transduction Source: ProtInc
    22. skeletal muscle tissue development Source: Ensembl
    23. trophoblast giant cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Activator, Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinkiP24468.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COUP transcription factor 2
    Short name:
    COUP-TF2
    Alternative name(s):
    Apolipoprotein A-I regulatory protein 1
    Short name:
    ARP-1
    COUP transcription factor II
    Short name:
    COUP-TF II
    Nuclear receptor subfamily 2 group F member 2
    Gene namesi
    Name:NR2F2
    Synonyms:ARP1, TFCOUP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:7976. NR2F2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi228 – 2281R → E: Reduces transcription activation by 40%; when associated with R-398. 1 Publication
    Mutagenesisi249 – 2491W → A: Reduces transcription activation by 50%; when associated with A-250. 1 Publication
    Mutagenesisi250 – 2501S → A: Reduces transcription activation by 50%; when associated with A-249. 1 Publication
    Mutagenesisi250 – 2501S → W: Reduces transcription activation by 50%. 1 Publication
    Mutagenesisi253 – 2542FV → AA: Reduces transcription activation by 50%.
    Mutagenesisi269 – 2702LL → AA: Reduces transcription activation by 50%.
    Mutagenesisi364 – 3652LL → AA: Reduces transcription activation by 80%.
    Mutagenesisi398 – 3981D → R: Reduces transcription activation by 40%; when associated with E-228. 1 Publication

    Organism-specific databases

    PharmGKBiPA31759.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414COUP transcription factor 2PRO_0000053606Add
    BLAST

    Proteomic databases

    MaxQBiP24468.
    PaxDbiP24468.
    PRIDEiP24468.

    PTM databases

    PhosphoSiteiP24468.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiP24468.
    BgeeiP24468.
    CleanExiHS_NR2F2.
    GenevestigatoriP24468.

    Interactioni

    Subunit structurei

    Interacts with SQSTM1 By similarity. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi112884. 16 interactions.
    DIPiDIP-29713N.
    IntActiP24468. 8 interactions.
    MINTiMINT-1183332.
    STRINGi9606.ENSP00000329908.

    Structurei

    Secondary structure

    1
    414
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi175 – 18713
    Helixi212 – 22918
    Beta strandi230 – 2323
    Helixi233 – 2353
    Helixi238 – 26023
    Helixi290 – 30415
    Helixi309 – 32012
    Helixi331 – 35222
    Helixi359 – 3646
    Helixi367 – 3726
    Helixi375 – 3828
    Helixi384 – 3874
    Helixi392 – 3943
    Helixi396 – 4005

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CJWX-ray1.48A175-414[»]
    ProteinModelPortaliP24468.
    SMRiP24468. Positions 75-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP24468.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 414298Interaction with ZFPM2By similarityAdd
    BLAST
    Regioni183 – 414232Ligand-bindingBy similarityAdd
    BLAST
    Regioni337 – 41478Important for dimerizationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi71 – 755Poly-Gln

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri79 – 9921NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri115 – 13925NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG327099.
    HOGENOMiHOG000260820.
    HOVERGENiHBG005606.
    InParanoidiP24468.
    KOiK08548.
    OMAiGPPNNTQ.
    OrthoDBiEOG72RMZ5.
    PhylomeDBiP24468.
    TreeFamiTF352097.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P24468-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS    50
    TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK 100
    SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ 150
    RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP YPTSRFGSQC 200
    MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD QVALLRLTWS 250
    ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE 300
    KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR 350
    SQYPNQPTRF GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML 400
    LSGSSFNWPY MAIQ 414
    Length:414
    Mass (Da):45,571
    Last modified:March 1, 1992 - v1
    Checksum:iC24CB2E8C8A27E8C
    GO
    Isoform 2 (identifier: P24468-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-147: MAMVVSTWRD...KCLKVGMRRE → MQAVWDLEQGKYGF

    Show »
    Length:281
    Mass (Da):31,484
    Checksum:i038DD27B80868BB5
    GO
    Isoform 3 (identifier: P24468-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: Missing.

    Show »
    Length:261
    Mass (Da):29,163
    Checksum:i5526AD057E2A639E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 153153Missing in isoform 3. 2 PublicationsVSP_043897Add
    BLAST
    Alternative sequencei1 – 147147MAMVV…GMRRE → MQAVWDLEQGKYGF in isoform 2. 4 PublicationsVSP_042630Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64497 mRNA. Translation: AAA86429.1.
    U60477 Genomic DNA. Translation: AAB09475.1.
    AB307711 mRNA. Translation: BAH02302.1.
    FM208183 mRNA. Translation: CAR63888.1.
    AK298824 mRNA. Translation: BAG60954.1.
    AK301595 mRNA. Translation: BAG63083.1.
    AK316086 mRNA. Translation: BAH14457.1.
    HQ692849 mRNA. Translation: ADZ17360.1.
    HQ692850 mRNA. Translation: ADZ17361.1.
    AC016251 Genomic DNA. No translation available.
    CH471101 Genomic DNA. Translation: EAX02195.1.
    CH471101 Genomic DNA. Translation: EAX02196.1.
    CH471101 Genomic DNA. Translation: EAX02197.1.
    BC014664 mRNA. Translation: AAH14664.1.
    BC042897 mRNA. Translation: AAH42897.1.
    BC106083 mRNA. Translation: AAI06084.1.
    M62760 mRNA. Translation: AAA21479.1.
    CCDSiCCDS10375.1. [P24468-1]
    CCDS45358.1. [P24468-2]
    CCDS45359.1. [P24468-3]
    PIRiA37133.
    RefSeqiNP_001138627.1. NM_001145155.1. [P24468-2]
    NP_001138628.1. NM_001145156.1. [P24468-3]
    NP_001138629.1. NM_001145157.1. [P24468-3]
    NP_066285.1. NM_021005.3. [P24468-1]
    UniGeneiHs.347991.
    Hs.519445.

    Genome annotation databases

    EnsembliENST00000394166; ENSP00000377721; ENSG00000185551. [P24468-1]
    ENST00000394171; ENSP00000377726; ENSG00000185551. [P24468-3]
    ENST00000421109; ENSP00000401674; ENSG00000185551. [P24468-2]
    ENST00000453270; ENSP00000389853; ENSG00000185551. [P24468-3]
    GeneIDi7026.
    KEGGihsa:7026.
    UCSCiuc002btp.3. human. [P24468-2]
    uc010uri.2. human. [P24468-1]

    Polymorphism databases

    DMDMi114203.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64497 mRNA. Translation: AAA86429.1 .
    U60477 Genomic DNA. Translation: AAB09475.1 .
    AB307711 mRNA. Translation: BAH02302.1 .
    FM208183 mRNA. Translation: CAR63888.1 .
    AK298824 mRNA. Translation: BAG60954.1 .
    AK301595 mRNA. Translation: BAG63083.1 .
    AK316086 mRNA. Translation: BAH14457.1 .
    HQ692849 mRNA. Translation: ADZ17360.1 .
    HQ692850 mRNA. Translation: ADZ17361.1 .
    AC016251 Genomic DNA. No translation available.
    CH471101 Genomic DNA. Translation: EAX02195.1 .
    CH471101 Genomic DNA. Translation: EAX02196.1 .
    CH471101 Genomic DNA. Translation: EAX02197.1 .
    BC014664 mRNA. Translation: AAH14664.1 .
    BC042897 mRNA. Translation: AAH42897.1 .
    BC106083 mRNA. Translation: AAI06084.1 .
    M62760 mRNA. Translation: AAA21479.1 .
    CCDSi CCDS10375.1. [P24468-1 ]
    CCDS45358.1. [P24468-2 ]
    CCDS45359.1. [P24468-3 ]
    PIRi A37133.
    RefSeqi NP_001138627.1. NM_001145155.1. [P24468-2 ]
    NP_001138628.1. NM_001145156.1. [P24468-3 ]
    NP_001138629.1. NM_001145157.1. [P24468-3 ]
    NP_066285.1. NM_021005.3. [P24468-1 ]
    UniGenei Hs.347991.
    Hs.519445.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CJW X-ray 1.48 A 175-414 [» ]
    ProteinModelPortali P24468.
    SMRi P24468. Positions 75-407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112884. 16 interactions.
    DIPi DIP-29713N.
    IntActi P24468. 8 interactions.
    MINTi MINT-1183332.
    STRINGi 9606.ENSP00000329908.

    Chemistry

    ChEMBLi CHEMBL1961790.

    PTM databases

    PhosphoSitei P24468.

    Polymorphism databases

    DMDMi 114203.

    Proteomic databases

    MaxQBi P24468.
    PaxDbi P24468.
    PRIDEi P24468.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394166 ; ENSP00000377721 ; ENSG00000185551 . [P24468-1 ]
    ENST00000394171 ; ENSP00000377726 ; ENSG00000185551 . [P24468-3 ]
    ENST00000421109 ; ENSP00000401674 ; ENSG00000185551 . [P24468-2 ]
    ENST00000453270 ; ENSP00000389853 ; ENSG00000185551 . [P24468-3 ]
    GeneIDi 7026.
    KEGGi hsa:7026.
    UCSCi uc002btp.3. human. [P24468-2 ]
    uc010uri.2. human. [P24468-1 ]

    Organism-specific databases

    CTDi 7026.
    GeneCardsi GC15P096869.
    HGNCi HGNC:7976. NR2F2.
    MIMi 107773. gene.
    neXtProti NX_P24468.
    PharmGKBi PA31759.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327099.
    HOGENOMi HOG000260820.
    HOVERGENi HBG005606.
    InParanoidi P24468.
    KOi K08548.
    OMAi GPPNNTQ.
    OrthoDBi EOG72RMZ5.
    PhylomeDBi P24468.
    TreeFami TF352097.

    Enzyme and pathway databases

    Reactomei REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinki P24468.

    Miscellaneous databases

    EvolutionaryTracei P24468.
    GeneWikii COUP-TFII.
    GenomeRNAii 7026.
    NextBioi 27451.
    PROi P24468.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P24468.
    Bgeei P24468.
    CleanExi HS_NR2F2.
    Genevestigatori P24468.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily."
      Ladias J.A.A., Karathanasis S.K.
      Science 251:561-565(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT.
    2. Speckmayer R.W.M., Paulweber B., Sandhofer F.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system."
      Kobayashi T., Kodani Y., Nozawa A., Endo Y., Sawasaki T.
      FEBS Lett. 582:2737-2744(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DNA-BINDING.
    4. "Characterisation of a new, DNA binding domain deficient chicken ovalbumin upstream promoter- transcription factor IIdelta isoform in the human brain."
      Schote A.B., Bechet T., Pirrotte P., Turner J.D., Muller C.P.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Liver.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Mammary gland.
    6. "Isolation of cDNA coding for multiple human nuclear receptor clones."
      Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Kidney.
    7. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Kidney and Spleen.
    10. "The COUP-TFs compose a family of functionally related transcription factors."
      Wang L.H., Ing N.H., Tsai S.Y., O'Malley B.W., Tsai M.J.
      Gene Expr. 1:207-216(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-351 (ISOFORM 1).
    11. "The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter."
      Chu K., Zingg H.H.
      J. Mol. Endocrinol. 19:163-172(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2."
      Avram D., Ishmael J.E., Nevrivy D.J., Peterson V.J., Lee S.H., Dowell P., Leid M.
      J. Biol. Chem. 274:14331-14336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, INTERACTION WITH NR2F6.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor."
      Kruse S.W., Suino-Powell K., Zhou X.E., Kretschman J.E., Reynolds R., Vonrhein C., Xu Y., Wang L., Tsai S.Y., Tsai M.J., Xu H.E.
      PLoS Biol. 6:E227-E227(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) OF 175-414, FUNCTION, SUBUNIT, INTERACTION WITH NCOA1; NCOA2; NCOA3 AND PPARGC1A, MUTAGENESIS OF ARG-228; TRP-249; SER-250; 253-PHE-VAL-254; 260-LEU-LEU-270; 364-LEU-LEU-365 AND ASP-398.

    Entry informationi

    Entry nameiCOT2_HUMAN
    AccessioniPrimary (citable) accession number: P24468
    Secondary accession number(s): B4DQJ2
    , B6ZGU1, Q03754, Q3KQR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 152 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3