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P24464

- CP4AC_RAT

UniProt

P24464 - CP4AC_RAT

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Protein

Cytochrome P450 4A12

Gene
Cyp4a12, Cyp4a-8, Cyp4a8
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei319 – 3191Heme (covalent; via 1 link)
Metal bindingi455 – 4551Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. arachidonic acid metabolic process Source: RGD
  2. fatty acid metabolic process Source: UniProtKB
  3. kidney development Source: RGD
  4. lauric acid metabolic process Source: RGD
  5. response to testosterone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196408. PPARA activates gene expression.
REACT_198836. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4A12 (EC:1.14.14.1)
Alternative name(s):
CYPIVA12
CYPIVA8
Cytochrome P450-KP1
Cytochrome P450-PP1
Gene namesi
Name:Cyp4a12
Synonyms:Cyp4a-8, Cyp4a8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi628846. Cyp4a8.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. intracellular membrane-bounded organelle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Cytochrome P450 4A12PRO_0000051818Add
BLAST

Proteomic databases

PaxDbiP24464.
PRIDEiP24464.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP24464.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012448.

Structurei

3D structure databases

ProteinModelPortaliP24464.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00740000115505.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP24464.
KOiK07425.
OMAiANSACKL.
OrthoDBiEOG7CNZFK.
PhylomeDBiP24464.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24464-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSALSFTI FPGSILGFLQ IATVLTVLLL LFKTAQFYLH RRWLLRATQQ    50
FPSPPSHWFF GHKIPKDQEF QDILTRVKNF PSACPQWLWG SNVRIQVYDP 100
DYMKLILGRS DPKSHHSYRF LAPWIGYGLL LLNGQTWFQH RRMLTPAFHY 150
DTLKPYVGIM ADSVRIMLDK WEQIVGQDST LEIFQHITLM TLDTIMKCAF 200
SQEGSVQLDR KYKSYIKAVE DLNNLSFFRI RNIFHQNDII YSLSSNGRKA 250
RSAWQLAHEH TDQVIKSRKA QLQDEEELQK VKQKRRLDFL DILLFARIEN 300
GSSLSDKDLR AEVDTFMFEG HDTTASGISW IFYALATNPE HQQGCRKEIQ 350
SLLGDGASIT WDDLDKMPYT TMCIKEALRI YPPVTAVSRM LSTPVTFPDG 400
RSLPKGITVM LSFYGLHHNP TVWPNPEVFD PYRFAPESSR HSHSFLPFSG 450
GARNCIGKQF AMNELKVAVA LTLLRFELLP DPTRIPIPIP RLVLKSKNGI 500
YLRLKKLQ 508
Length:508
Mass (Da):58,559
Last modified:January 10, 2006 - v2
Checksum:i2C2218525FC65513
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321F → L in AAA63485. 1 Publication
Sequence conflicti69 – 691E → D in AAA63485. 1 Publication
Sequence conflicti101 – 1011D → E in AAA63485. 1 Publication
Sequence conflicti114 – 1163SHH → AHG in AAA63485. 1 Publication
Sequence conflicti226 – 2261S → F in AAA63485. 1 Publication
Sequence conflicti230 – 2334IRNI → VQNM in AAA63485. 1 Publication
Sequence conflicti239 – 2391I → F in AAA63485. 1 Publication
Sequence conflicti251 – 2522RS → HN in AAA63485. 1 Publication
Sequence conflicti259 – 2602EH → DY in AAA63485. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37828 mRNA. Translation: AAA63485.1.
BC081771 mRNA. Translation: AAH81771.1.
PIRiA36304.
PC4352.
RefSeqiNP_113793.2. NM_031605.2.
UniGeneiRn.10034.

Genome annotation databases

EnsembliENSRNOT00000012448; ENSRNOP00000012448; ENSRNOG00000008842.
GeneIDi266674.
KEGGirno:266674.
UCSCiRGD:628846. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37828 mRNA. Translation: AAA63485.1 .
BC081771 mRNA. Translation: AAH81771.1 .
PIRi A36304.
PC4352.
RefSeqi NP_113793.2. NM_031605.2.
UniGenei Rn.10034.

3D structure databases

ProteinModelPortali P24464.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000012448.

Proteomic databases

PaxDbi P24464.
PRIDEi P24464.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000012448 ; ENSRNOP00000012448 ; ENSRNOG00000008842 .
GeneIDi 266674.
KEGGi rno:266674.
UCSCi RGD:628846. rat.

Organism-specific databases

CTDi 266674.
RGDi 628846. Cyp4a8.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00740000115505.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
InParanoidi P24464.
KOi K07425.
OMAi ANSACKL.
OrthoDBi EOG7CNZFK.
PhylomeDBi P24464.
TreeFami TF105088.

Enzyme and pathway databases

Reactomei REACT_196408. PPARA activates gene expression.
REACT_198836. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Miscellaneous databases

NextBioi 624468.
PROi P24464.

Gene expression databases

Genevestigatori P24464.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel member of the cytochrome P450 subfamily IVA in rat prostate."
    Stroemstedt M., Hayashi S., Zaphiropoulos P.G., Gustafsson J.-A.
    DNA Cell Biol. 9:569-577(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Prostate.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Covalently linked heme in cytochrome P4504A fatty acid hydroxylases."
    Hoch U., Ortiz de Montellano P.R.
    J. Biol. Chem. 276:11339-11346(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: COVALENT HEME ATTACHMENT.

Entry informationi

Entry nameiCP4AC_RAT
AccessioniPrimary (citable) accession number: P24464
Secondary accession number(s): Q642E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 10, 2006
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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