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P24463 (CP3AC_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A12

EC=1.14.14.1
Alternative name(s):
CYPIIIA12
Cytochrome P450-PBD-1
Gene names
Name:CYP3A12
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A12
PRO_0000051795

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P24463 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 52171D03F9BD5D87

FASTA50357,721
        10         20         30         40         50         60 
MDLIPSFSTE TWLLLAISLV LLYLYGTYTH GIFRKLGIPG PTPLPFVGTA LGYRNGFYVF 

        70         80         90        100        110        120 
DMKCFSKYGR MWGFYDGRQP VLAITDPDMI KTVLVKECYS VFTNRRTLGP VGFMKSAISL 

       130        140        150        160        170        180 
SEDEEWKRMR TLLSPTFTTG KLKEMFPIIG QYGDVLVNNL RKEAEKGKAI NLKDVFGAYS 

       190        200        210        220        230        240 
MDVITSTSFG VNIDSLNHPQ DPFVENTKKL LKFDFLDPFF FSILLFPFLT PVFEILNIWL 

       250        260        270        280        290        300 
FPKKVTDFFR KSVERMKESR LKDKQKHRVD FLQLMINSQN SKEMDTHKAL SDLELVAQSI 

       310        320        330        340        350        360 
IFIFAGYETT STSLSFLMYE LATHPDVQQK LQEEIDATFP NKALPTYDAL VQMEYLDMVL 

       370        380        390        400        410        420 
NETLRLYPIA GRLERVCKKD VEISGVFIPK GTVVMVPTFT LHRDQSLWPE PEEFRPERFS 

       430        440        450        460        470        480 
RKNKDSINPY TYLPFGTGPR NCIGMRFAIM NMKLALVRVL QNFSFKPCKE TQIPLKLNAQ 

       490        500 
GIIQPEKPIV LKVEPRDGSV NGA 

« Hide

References

[1]"cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily."
Ciaccio P.J., Graves P.E., Bourque D.P., Glinsmann-Gibson B., Halpert J.R.
Biochim. Biophys. Acta 1088:319-322(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Beagle.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54915 mRNA. Translation: CAA38687.1.
PIRS04341.
S14275.
RefSeqNP_001003340.1. NM_001003340.1.
UniGeneCfa.25714.

3D structure databases

ProteinModelPortalP24463.
SMRP24463. Positions 30-496.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000022014.

Chemistry

ChEMBLCHEMBL1907982.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID415129.
KEGGcfa:415129.

Organism-specific databases

CTD415129.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidP24463.
KOK07424.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818808.

Entry information

Entry nameCP3AC_CANFA
AccessionPrimary (citable) accession number: P24463
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: December 11, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families