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P24463

- CP3AC_CANFA

UniProt

P24463 - CP3AC_CANFA

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Protein
Cytochrome P450 3A12
Gene
CYP3A12
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A12 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA12
Cytochrome P450-PBD-1
Gene namesi
Name:CYP3A12
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A12
PRO_0000051795Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022014.

Structurei

3D structure databases

ProteinModelPortaliP24463.
SMRiP24463. Positions 30-496.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP24463.
KOiK07424.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24463-1 [UniParc]FASTAAdd to Basket

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MDLIPSFSTE TWLLLAISLV LLYLYGTYTH GIFRKLGIPG PTPLPFVGTA    50
LGYRNGFYVF DMKCFSKYGR MWGFYDGRQP VLAITDPDMI KTVLVKECYS 100
VFTNRRTLGP VGFMKSAISL SEDEEWKRMR TLLSPTFTTG KLKEMFPIIG 150
QYGDVLVNNL RKEAEKGKAI NLKDVFGAYS MDVITSTSFG VNIDSLNHPQ 200
DPFVENTKKL LKFDFLDPFF FSILLFPFLT PVFEILNIWL FPKKVTDFFR 250
KSVERMKESR LKDKQKHRVD FLQLMINSQN SKEMDTHKAL SDLELVAQSI 300
IFIFAGYETT STSLSFLMYE LATHPDVQQK LQEEIDATFP NKALPTYDAL 350
VQMEYLDMVL NETLRLYPIA GRLERVCKKD VEISGVFIPK GTVVMVPTFT 400
LHRDQSLWPE PEEFRPERFS RKNKDSINPY TYLPFGTGPR NCIGMRFAIM 450
NMKLALVRVL QNFSFKPCKE TQIPLKLNAQ GIIQPEKPIV LKVEPRDGSV 500
NGA 503
Length:503
Mass (Da):57,721
Last modified:March 1, 1992 - v1
Checksum:i52171D03F9BD5D87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54915 mRNA. Translation: CAA38687.1.
PIRiS04341.
S14275.
RefSeqiNP_001003340.1. NM_001003340.1.
UniGeneiCfa.25714.

Genome annotation databases

GeneIDi415129.
KEGGicfa:415129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54915 mRNA. Translation: CAA38687.1 .
PIRi S04341.
S14275.
RefSeqi NP_001003340.1. NM_001003340.1.
UniGenei Cfa.25714.

3D structure databases

ProteinModelPortali P24463.
SMRi P24463. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000022014.

Chemistry

ChEMBLi CHEMBL1907982.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 415129.
KEGGi cfa:415129.

Organism-specific databases

CTDi 415129.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi P24463.
KOi K07424.

Miscellaneous databases

NextBioi 20818808.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily."
    Ciaccio P.J., Graves P.E., Bourque D.P., Glinsmann-Gibson B., Halpert J.R.
    Biochim. Biophys. Acta 1088:319-322(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Liver.

Entry informationi

Entry nameiCP3AC_CANFA
AccessioniPrimary (citable) accession number: P24463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: December 11, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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