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P24463

- CP3AC_CANFA

UniProt

P24463 - CP3AC_CANFA

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Protein

Cytochrome P450 3A12

Gene

CYP3A12

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A12 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA12
Cytochrome P450-PBD-1
Gene namesi
Name:CYP3A12
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A12PRO_0000051795Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022014.

Structurei

3D structure databases

ProteinModelPortaliP24463.
SMRiP24463. Positions 30-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP24463.
KOiK07424.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24463-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLIPSFSTE TWLLLAISLV LLYLYGTYTH GIFRKLGIPG PTPLPFVGTA
60 70 80 90 100
LGYRNGFYVF DMKCFSKYGR MWGFYDGRQP VLAITDPDMI KTVLVKECYS
110 120 130 140 150
VFTNRRTLGP VGFMKSAISL SEDEEWKRMR TLLSPTFTTG KLKEMFPIIG
160 170 180 190 200
QYGDVLVNNL RKEAEKGKAI NLKDVFGAYS MDVITSTSFG VNIDSLNHPQ
210 220 230 240 250
DPFVENTKKL LKFDFLDPFF FSILLFPFLT PVFEILNIWL FPKKVTDFFR
260 270 280 290 300
KSVERMKESR LKDKQKHRVD FLQLMINSQN SKEMDTHKAL SDLELVAQSI
310 320 330 340 350
IFIFAGYETT STSLSFLMYE LATHPDVQQK LQEEIDATFP NKALPTYDAL
360 370 380 390 400
VQMEYLDMVL NETLRLYPIA GRLERVCKKD VEISGVFIPK GTVVMVPTFT
410 420 430 440 450
LHRDQSLWPE PEEFRPERFS RKNKDSINPY TYLPFGTGPR NCIGMRFAIM
460 470 480 490 500
NMKLALVRVL QNFSFKPCKE TQIPLKLNAQ GIIQPEKPIV LKVEPRDGSV

NGA
Length:503
Mass (Da):57,721
Last modified:March 1, 1992 - v1
Checksum:i52171D03F9BD5D87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54915 mRNA. Translation: CAA38687.1.
PIRiS04341.
S14275.
RefSeqiNP_001003340.1. NM_001003340.1.
UniGeneiCfa.25714.

Genome annotation databases

GeneIDi415129.
KEGGicfa:415129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54915 mRNA. Translation: CAA38687.1 .
PIRi S04341.
S14275.
RefSeqi NP_001003340.1. NM_001003340.1.
UniGenei Cfa.25714.

3D structure databases

ProteinModelPortali P24463.
SMRi P24463. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000022014.

Chemistry

ChEMBLi CHEMBL1907982.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 415129.
KEGGi cfa:415129.

Organism-specific databases

CTDi 415129.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi P24463.
KOi K07424.

Miscellaneous databases

NextBioi 20818808.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily."
    Ciaccio P.J., Graves P.E., Bourque D.P., Glinsmann-Gibson B., Halpert J.R.
    Biochim. Biophys. Acta 1088:319-322(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Liver.

Entry informationi

Entry nameiCP3AC_CANFA
AccessioniPrimary (citable) accession number: P24463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3