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P24463

- CP3AC_CANFA

UniProt

P24463 - CP3AC_CANFA

Protein

Cytochrome P450 3A12

Gene

CYP3A12

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A12 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA12
    Cytochrome P450-PBD-1
    Gene namesi
    Name:CYP3A12
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A12PRO_0000051795Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000022014.

    Structurei

    3D structure databases

    ProteinModelPortaliP24463.
    SMRiP24463. Positions 30-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiP24463.
    KOiK07424.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24463-1 [UniParc]FASTAAdd to Basket

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    MDLIPSFSTE TWLLLAISLV LLYLYGTYTH GIFRKLGIPG PTPLPFVGTA    50
    LGYRNGFYVF DMKCFSKYGR MWGFYDGRQP VLAITDPDMI KTVLVKECYS 100
    VFTNRRTLGP VGFMKSAISL SEDEEWKRMR TLLSPTFTTG KLKEMFPIIG 150
    QYGDVLVNNL RKEAEKGKAI NLKDVFGAYS MDVITSTSFG VNIDSLNHPQ 200
    DPFVENTKKL LKFDFLDPFF FSILLFPFLT PVFEILNIWL FPKKVTDFFR 250
    KSVERMKESR LKDKQKHRVD FLQLMINSQN SKEMDTHKAL SDLELVAQSI 300
    IFIFAGYETT STSLSFLMYE LATHPDVQQK LQEEIDATFP NKALPTYDAL 350
    VQMEYLDMVL NETLRLYPIA GRLERVCKKD VEISGVFIPK GTVVMVPTFT 400
    LHRDQSLWPE PEEFRPERFS RKNKDSINPY TYLPFGTGPR NCIGMRFAIM 450
    NMKLALVRVL QNFSFKPCKE TQIPLKLNAQ GIIQPEKPIV LKVEPRDGSV 500
    NGA 503
    Length:503
    Mass (Da):57,721
    Last modified:March 1, 1992 - v1
    Checksum:i52171D03F9BD5D87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54915 mRNA. Translation: CAA38687.1.
    PIRiS04341.
    S14275.
    RefSeqiNP_001003340.1. NM_001003340.1.
    UniGeneiCfa.25714.

    Genome annotation databases

    GeneIDi415129.
    KEGGicfa:415129.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54915 mRNA. Translation: CAA38687.1 .
    PIRi S04341.
    S14275.
    RefSeqi NP_001003340.1. NM_001003340.1.
    UniGenei Cfa.25714.

    3D structure databases

    ProteinModelPortali P24463.
    SMRi P24463. Positions 30-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000022014.

    Chemistry

    ChEMBLi CHEMBL1907982.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 415129.
    KEGGi cfa:415129.

    Organism-specific databases

    CTDi 415129.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi P24463.
    KOi K07424.

    Miscellaneous databases

    NextBioi 20818808.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily."
      Ciaccio P.J., Graves P.E., Bourque D.P., Glinsmann-Gibson B., Halpert J.R.
      Biochim. Biophys. Acta 1088:319-322(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AC_CANFA
    AccessioniPrimary (citable) accession number: P24463
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3