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P24461

- CP2G1_RABIT

UniProt

P24461 - CP2G1_RABIT

Protein

Cytochrome P450 2G1

Gene

CYP2G1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi439 – 4391Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. response to stimulus Source: UniProtKB-KW
    2. sensory perception of smell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2G1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIG1
    Cytochrome P450 olfactive
    Cytochrome P450-NMB
    Gene namesi
    Name:CYP2G1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Cytochrome P450 2G1PRO_0000051764Add
    BLAST

    Expressioni

    Tissue specificityi

    Olfactory epithelium.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000004975.

    Structurei

    3D structure databases

    ProteinModelPortaliP24461.
    SMRiP24461. Positions 31-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00670000097868.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    OMAiLRMINES.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24461-1 [UniParc]FASTAAdd to Basket

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    MELGGAFTIF LALCFSCLLI LIAWKRVQKP GRLPPGPTPI PFLGNLLQVR    50
    TDATFQSFLK LREKYGPVFT VYMGPRPVVI LCGHEAVKEA LVDRADEFSG 100
    RGELASVERN FQGHGVALAN GERWRILRRF SLTILRDFGM GKRSIEERIQ 150
    EEAGYLLEEF RKTKGAPIDP TFFLSRTVSN VISSVVFGSR FDYEDKQFLS 200
    LLRMINESFI EMSTPWAQLY DMYSGVMQYL PGRHNRIYYL IEELKDFIAA 250
    RVKVNEASLD PQNPRDFIDC FLIKMHQDKN NPHTEFNLKN LVLTTLNLFF 300
    AGTETVSSTL RYGFLLIMKH PEVQTKIYEE INQVIGPHRI PSVDDRVKMP 350
    FTDAVIHEIQ RLTDIVPMGV PHNVIRDTHF RGYLLPKGTD VFPLLGSVLK 400
    DPKYFCHPDD FYPQHFLDEQ GRFKKNEAFV PFSSGKRICL GEAMARMELF 450
    LYFTSILQNF SLHPLVPPVN IDITPKISGF GNIPPTYELC LIAR 494
    Length:494
    Mass (Da):56,629
    Last modified:March 1, 1992 - v1
    Checksum:i4DA83F2E1CD230BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461L → E AA sequence (PubMed:3242590)Curated

    Sequence databases

    PIRiS13907. B31944.
    RefSeqiNP_001182693.1. NM_001195764.1.
    UniGeneiOcu.7993.

    Genome annotation databases

    EnsembliENSOCUT00000005743; ENSOCUP00000004975; ENSOCUG00000005745.
    GeneIDi100359338.

    Cross-referencesi

    Sequence databases

    PIRi S13907. B31944.
    RefSeqi NP_001182693.1. NM_001195764.1.
    UniGenei Ocu.7993.

    3D structure databases

    ProteinModelPortali P24461.
    SMRi P24461. Positions 31-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000004975.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOCUT00000005743 ; ENSOCUP00000004975 ; ENSOCUG00000005745 .
    GeneIDi 100359338.

    Organism-specific databases

    CTDi 13108.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00670000097868.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    OMAi LRMINES.
    OrthoDBi EOG7RBZ85.
    TreeFami TF352043.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and derived amino acid sequence of rabbit nasal cytochrome P450NMb (P450IIG1), a unique isozyme possibly involved in olfaction."
      Ding X., Porter T.D., Peng H.-M., Coon M.J.
      Arch. Biochem. Biophys. 285:120-125(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes."
      Ding X.X., Coon M.J.
      Biochemistry 27:8330-8337(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-50.

    Entry informationi

    Entry nameiCP2G1_RABIT
    AccessioniPrimary (citable) accession number: P24461
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3