Reviewed, UniProtKB/Swiss-Prot P24461 (CP2G1_RABIT)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 2G1
    EC=1.14.14.1
Alternative name(s):
    CYPIIG1
    P450-NMB
    Olfactive

Gene names

Name:

CYP2G1

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity	Olfactory epithelium.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 494	494	Cytochrome P450 2G1		PRO_0000051764
Sites
	Metal binding	439	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	46	1	L → E AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P24461-1 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: 4DA83F2E1CD230BC	FASTA	494	56,629
	10 20 30 40 50 60 MELGGAFTIF LALCFSCLLI LIAWKRVQKP GRLPPGPTPI PFLGNLLQVR TDATFQSFLK 70 80 90 100 110 120 LREKYGPVFT VYMGPRPVVI LCGHEAVKEA LVDRADEFSG RGELASVERN FQGHGVALAN 130 140 150 160 170 180 GERWRILRRF SLTILRDFGM GKRSIEERIQ EEAGYLLEEF RKTKGAPIDP TFFLSRTVSN 190 200 210 220 230 240 VISSVVFGSR FDYEDKQFLS LLRMINESFI EMSTPWAQLY DMYSGVMQYL PGRHNRIYYL 250 260 270 280 290 300 IEELKDFIAA RVKVNEASLD PQNPRDFIDC FLIKMHQDKN NPHTEFNLKN LVLTTLNLFF 310 320 330 340 350 360 AGTETVSSTL RYGFLLIMKH PEVQTKIYEE INQVIGPHRI PSVDDRVKMP FTDAVIHEIQ 370 380 390 400 410 420 RLTDIVPMGV PHNVIRDTHF RGYLLPKGTD VFPLLGSVLK DPKYFCHPDD FYPQHFLDEQ 430 440 450 460 470 480 GRFKKNEAFV PFSSGKRICL GEAMARMELF LYFTSILQNF SLHPLVPPVN IDITPKISGF 490 GNIPPTYELC LIAR

References

[1]	"cDNA and derived amino acid sequence of rabbit nasal cytochrome P450NMb (P450IIG1), a unique isozyme possibly involved in olfaction." Ding X., Porter T.D., Peng H.-M., Coon M.J. Arch. Biochem. Biophys. 285:120-125(1991) [PubMed: 1703755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes." Ding X.X., Coon M.J. Biochemistry 27:8330-8337(1988) [PubMed: 3242590] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-50.

Cross-references

Sequence databases
PIR	B31944. S13907.
3D structure databases
HSSP	HSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P24461.
Enzyme and pathway databases
BRENDA	1.14.14.1. 255.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008067. Cyt_P450_E_grp-I_CYP2A-like. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01684. EP450ICYP2A. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP2G1_RABIT

Accession

Primary (citable) accession number: P24461

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)