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P24461

- CP2G1_RABIT

UniProt

P24461 - CP2G1_RABIT

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Protein
Cytochrome P450 2G1
Gene
CYP2G1
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi439 – 4391Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. response to stimulus Source: UniProtKB-KW
  2. sensory perception of smell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Olfaction, Sensory transduction

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2G1 (EC:1.14.14.1)
Alternative name(s):
CYPIIG1
Cytochrome P450 olfactive
Cytochrome P450-NMB
Gene namesi
Name:CYP2G1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Cytochrome P450 2G1
PRO_0000051764Add
BLAST

Expressioni

Tissue specificityi

Olfactory epithelium.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004975.

Structurei

3D structure databases

ProteinModelPortaliP24461.
SMRiP24461. Positions 31-494.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00670000097868.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
OMAiLRMINES.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24461-1 [UniParc]FASTAAdd to Basket

« Hide

MELGGAFTIF LALCFSCLLI LIAWKRVQKP GRLPPGPTPI PFLGNLLQVR    50
TDATFQSFLK LREKYGPVFT VYMGPRPVVI LCGHEAVKEA LVDRADEFSG 100
RGELASVERN FQGHGVALAN GERWRILRRF SLTILRDFGM GKRSIEERIQ 150
EEAGYLLEEF RKTKGAPIDP TFFLSRTVSN VISSVVFGSR FDYEDKQFLS 200
LLRMINESFI EMSTPWAQLY DMYSGVMQYL PGRHNRIYYL IEELKDFIAA 250
RVKVNEASLD PQNPRDFIDC FLIKMHQDKN NPHTEFNLKN LVLTTLNLFF 300
AGTETVSSTL RYGFLLIMKH PEVQTKIYEE INQVIGPHRI PSVDDRVKMP 350
FTDAVIHEIQ RLTDIVPMGV PHNVIRDTHF RGYLLPKGTD VFPLLGSVLK 400
DPKYFCHPDD FYPQHFLDEQ GRFKKNEAFV PFSSGKRICL GEAMARMELF 450
LYFTSILQNF SLHPLVPPVN IDITPKISGF GNIPPTYELC LIAR 494
Length:494
Mass (Da):56,629
Last modified:March 1, 1992 - v1
Checksum:i4DA83F2E1CD230BC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461L → E AA sequence 1 Publication

Sequence databases

PIRiS13907. B31944.
RefSeqiNP_001182693.1. NM_001195764.1.
UniGeneiOcu.7993.

Genome annotation databases

EnsembliENSOCUT00000005743; ENSOCUP00000004975; ENSOCUG00000005745.
GeneIDi100359338.

Cross-referencesi

Sequence databases

PIRi S13907. B31944.
RefSeqi NP_001182693.1. NM_001195764.1.
UniGenei Ocu.7993.

3D structure databases

ProteinModelPortali P24461.
SMRi P24461. Positions 31-494.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000004975.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000005743 ; ENSOCUP00000004975 ; ENSOCUG00000005745 .
GeneIDi 100359338.

Organism-specific databases

CTDi 13108.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00670000097868.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
OMAi LRMINES.
OrthoDBi EOG7RBZ85.
TreeFami TF352043.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA and derived amino acid sequence of rabbit nasal cytochrome P450NMb (P450IIG1), a unique isozyme possibly involved in olfaction."
    Ding X., Porter T.D., Peng H.-M., Coon M.J.
    Arch. Biochem. Biophys. 285:120-125(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes."
    Ding X.X., Coon M.J.
    Biochemistry 27:8330-8337(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-50.

Entry informationi

Entry nameiCP2G1_RABIT
AccessioniPrimary (citable) accession number: P24461
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: February 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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