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P24461 (CP2G1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2G1

EC=1.14.14.1
Alternative name(s):
CYPIIG1
Cytochrome P450 olfactive
Cytochrome P450-NMB
Gene names
Name:CYP2G1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Olfactory epithelium.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Cytochrome P450 2G1
PRO_0000051764

Sites

Metal binding4391Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict461L → E AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P24461 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 4DA83F2E1CD230BC

FASTA49456,629
        10         20         30         40         50         60 
MELGGAFTIF LALCFSCLLI LIAWKRVQKP GRLPPGPTPI PFLGNLLQVR TDATFQSFLK 

        70         80         90        100        110        120 
LREKYGPVFT VYMGPRPVVI LCGHEAVKEA LVDRADEFSG RGELASVERN FQGHGVALAN 

       130        140        150        160        170        180 
GERWRILRRF SLTILRDFGM GKRSIEERIQ EEAGYLLEEF RKTKGAPIDP TFFLSRTVSN 

       190        200        210        220        230        240 
VISSVVFGSR FDYEDKQFLS LLRMINESFI EMSTPWAQLY DMYSGVMQYL PGRHNRIYYL 

       250        260        270        280        290        300 
IEELKDFIAA RVKVNEASLD PQNPRDFIDC FLIKMHQDKN NPHTEFNLKN LVLTTLNLFF 

       310        320        330        340        350        360 
AGTETVSSTL RYGFLLIMKH PEVQTKIYEE INQVIGPHRI PSVDDRVKMP FTDAVIHEIQ 

       370        380        390        400        410        420 
RLTDIVPMGV PHNVIRDTHF RGYLLPKGTD VFPLLGSVLK DPKYFCHPDD FYPQHFLDEQ 

       430        440        450        460        470        480 
GRFKKNEAFV PFSSGKRICL GEAMARMELF LYFTSILQNF SLHPLVPPVN IDITPKISGF 

       490 
GNIPPTYELC LIAR 

« Hide

References

[1]"cDNA and derived amino acid sequence of rabbit nasal cytochrome P450NMb (P450IIG1), a unique isozyme possibly involved in olfaction."
Ding X., Porter T.D., Peng H.-M., Coon M.J.
Arch. Biochem. Biophys. 285:120-125(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes."
Ding X.X., Coon M.J.
Biochemistry 27:8330-8337(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-50.

Cross-references

Sequence databases

PIRB31944. S13907.
RefSeqNP_001182693.1. NM_001195764.1.
UniGeneOcu.7993.

3D structure databases

ProteinModelPortalP24461.
SMRP24461. Positions 31-494.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000004975.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSOCUT00000005743; ENSOCUP00000004975; ENSOCUG00000005745.
GeneID100359338.

Organism-specific databases

CTD13108.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00670000097868.
HOGENOMHOG000036992.
HOVERGENHBG015789.
OMALRMINES.
OrthoDBEOG7RBZ85.
TreeFamTF352043.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2G1_RABIT
AccessionPrimary (citable) accession number: P24461
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: February 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families