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Protein

Cytochrome P450 2G1

Gene

CYP2G1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi439Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processOlfaction, Sensory transduction
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2G1 (EC:1.14.14.1)
Alternative name(s):
CYPIIG1
Cytochrome P450 olfactive
Cytochrome P450-NMB
Gene namesi
Name:CYP2G1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517641 – 494Cytochrome P450 2G1Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131PhosphoserineBy similarity1
Modified residuei253N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Expressioni

Tissue specificityi

Olfactory epithelium.

Gene expression databases

BgeeiENSOCUG00000005745.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004975.

Structurei

3D structure databases

ProteinModelPortaliP24461.
SMRiP24461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00880000137861.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP24461.
KOiK07417.
OMAiIKMHQDK.
OrthoDBiEOG091G0BT8.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P24461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGGAFTIF LALCFSCLLI LIAWKRVQKP GRLPPGPTPI PFLGNLLQVR
60 70 80 90 100
TDATFQSFLK LREKYGPVFT VYMGPRPVVI LCGHEAVKEA LVDRADEFSG
110 120 130 140 150
RGELASVERN FQGHGVALAN GERWRILRRF SLTILRDFGM GKRSIEERIQ
160 170 180 190 200
EEAGYLLEEF RKTKGAPIDP TFFLSRTVSN VISSVVFGSR FDYEDKQFLS
210 220 230 240 250
LLRMINESFI EMSTPWAQLY DMYSGVMQYL PGRHNRIYYL IEELKDFIAA
260 270 280 290 300
RVKVNEASLD PQNPRDFIDC FLIKMHQDKN NPHTEFNLKN LVLTTLNLFF
310 320 330 340 350
AGTETVSSTL RYGFLLIMKH PEVQTKIYEE INQVIGPHRI PSVDDRVKMP
360 370 380 390 400
FTDAVIHEIQ RLTDIVPMGV PHNVIRDTHF RGYLLPKGTD VFPLLGSVLK
410 420 430 440 450
DPKYFCHPDD FYPQHFLDEQ GRFKKNEAFV PFSSGKRICL GEAMARMELF
460 470 480 490
LYFTSILQNF SLHPLVPPVN IDITPKISGF GNIPPTYELC LIAR
Length:494
Mass (Da):56,629
Last modified:March 1, 1992 - v1
Checksum:i4DA83F2E1CD230BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46L → E AA sequence (PubMed:3242590).Curated1

Sequence databases

PIRiS13907. B31944.
RefSeqiNP_001182693.1. NM_001195764.1.
UniGeneiOcu.7993.

Genome annotation databases

EnsembliENSOCUT00000005743; ENSOCUP00000004975; ENSOCUG00000005745.
GeneIDi100359338.
KEGGiocu:100359338.

Similar proteinsi

Entry informationi

Entry nameiCP2G1_RABIT
AccessioniPrimary (citable) accession number: P24461
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 25, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families