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P24460

- CP2BB_CANFA

UniProt

P24460 - CP2BB_CANFA

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Protein

Cytochrome P450 2B11

Gene

CYP2B11

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B11 (EC:1.14.14.1)
Alternative name(s):
CYPIIB11
Cytochrome P450 PBD-2
Gene namesi
Name:CYP2B11
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Cytochrome P450 2B11PRO_0000051686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By phenobarbital.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007533.

Structurei

3D structure databases

ProteinModelPortaliP24460.
SMRiP24460. Positions 28-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP24460.
KOiK07412.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24460-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELSVLLLLA LLTGLLLLMA RGHPKAYGHL PPGPRPLPIL GNFLQMDRKG
60 70 80 90 100
LLKSFLRLQE KYGDVFTVYL GPRRTVMLCG IDAIREALVD NAEAFSGRGK
110 120 130 140 150
IAVVEPVFQG YGVVFANGER WKTLRRFSLA TMRDFGMGKR SVEERIQEEA
160 170 180 190 200
QCLVEELRKT EGVLQDPTFF FHSMTANIIC SIVFGKRFGY KDPEFLRLMN
210 220 230 240 250
LFYVSFALIS SFSSQMFELF HSFLKYFPGT HRQVYNNLQE IKAFIARMVE
260 270 280 290 300
KHRETLDPSA PRDFIDAYLI RMDKEKAEPS SEFHHRNLID TALSLFFAGT
310 320 330 340 350
ETTSTTLRYG FLLMLKYPHI AERIYKEIDQ VIGPHRLPSL DDRAKMPYTD
360 370 380 390 400
AVIHEIQRFG DLLPIGVPHM VTKDICFRGY IIPKGTEVFP ILHSALNDPH
410 420 430 440 450
YFEKPDVFNP DHFLDANGAL KKNEAFIPFS IGKRICLGEG IARMELFLFF
460 470 480 490
TTILQNFSVA SPMAPEDIDL TPQEIGVGKL PPVYQISFLS RGGC
Length:494
Mass (Da):56,267
Last modified:March 1, 1992 - v1
Checksum:i8E9EA639B4B5E4D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92447 mRNA. Translation: AAA30881.1.
PIRiS11305.
RefSeqiNP_001006653.1. NM_001006652.1.
UniGeneiCfa.3883.

Genome annotation databases

GeneIDi474177.
KEGGicfa:474177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92447 mRNA. Translation: AAA30881.1 .
PIRi S11305.
RefSeqi NP_001006653.1. NM_001006652.1.
UniGenei Cfa.3883.

3D structure databases

ProteinModelPortali P24460.
SMRi P24460. Positions 28-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000007533.

Chemistry

ChEMBLi CHEMBL1907981.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 474177.
KEGGi cfa:474177.

Organism-specific databases

CTDi 1555.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P24460.
KOi K07412.

Miscellaneous databases

NextBioi 20850373.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl."
    Graves P.E., Elhag G.A., Ciaccio P.J., Bourque D.P., Halpert J.R.
    Arch. Biochem. Biophys. 281:106-115(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Liver.

Entry informationi

Entry nameiCP2BB_CANFA
AccessioniPrimary (citable) accession number: P24460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3