Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P24460 (CP2BB_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2B11

EC=1.14.14.1
Alternative name(s):
CYPIIB11
Cytochrome P450 PBD-2
Gene names
Name:CYP2B11
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By phenobarbital.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Cytochrome P450 2B11
PRO_0000051686

Sites

Metal binding4361Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue1281Phosphoserine; by PKA By similarity

Sequences

Sequence LengthMass (Da)Tools
P24460 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 8E9EA639B4B5E4D3

FASTA49456,267
        10         20         30         40         50         60 
MELSVLLLLA LLTGLLLLMA RGHPKAYGHL PPGPRPLPIL GNFLQMDRKG LLKSFLRLQE 

        70         80         90        100        110        120 
KYGDVFTVYL GPRRTVMLCG IDAIREALVD NAEAFSGRGK IAVVEPVFQG YGVVFANGER 

       130        140        150        160        170        180 
WKTLRRFSLA TMRDFGMGKR SVEERIQEEA QCLVEELRKT EGVLQDPTFF FHSMTANIIC 

       190        200        210        220        230        240 
SIVFGKRFGY KDPEFLRLMN LFYVSFALIS SFSSQMFELF HSFLKYFPGT HRQVYNNLQE 

       250        260        270        280        290        300 
IKAFIARMVE KHRETLDPSA PRDFIDAYLI RMDKEKAEPS SEFHHRNLID TALSLFFAGT 

       310        320        330        340        350        360 
ETTSTTLRYG FLLMLKYPHI AERIYKEIDQ VIGPHRLPSL DDRAKMPYTD AVIHEIQRFG 

       370        380        390        400        410        420 
DLLPIGVPHM VTKDICFRGY IIPKGTEVFP ILHSALNDPH YFEKPDVFNP DHFLDANGAL 

       430        440        450        460        470        480 
KKNEAFIPFS IGKRICLGEG IARMELFLFF TTILQNFSVA SPMAPEDIDL TPQEIGVGKL 

       490 
PPVYQISFLS RGGC 

« Hide

References

[1]"cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl."
Graves P.E., Elhag G.A., Ciaccio P.J., Bourque D.P., Halpert J.R.
Arch. Biochem. Biophys. 281:106-115(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Beagle.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M92447 mRNA. Translation: AAA30881.1.
PIRS11305.
RefSeqNP_001006653.1. NM_001006652.1.
UniGeneCfa.3883.

3D structure databases

ProteinModelPortalP24460.
SMRP24460. Positions 28-491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000007533.

Chemistry

ChEMBLCHEMBL1907981.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID474177.
KEGGcfa:474177.

Organism-specific databases

CTD1555.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.
KOK07412.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20850373.

Entry information

Entry nameCP2BB_CANFA
AccessionPrimary (citable) accession number: P24460
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: December 11, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families