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P24460

- CP2BB_CANFA

UniProt

P24460 - CP2BB_CANFA

Protein

Cytochrome P450 2B11

Gene

CYP2B11

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2B11 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIB11
    Cytochrome P450 PBD-2
    Gene namesi
    Name:CYP2B11
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Cytochrome P450 2B11PRO_0000051686Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei128 – 1281Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Inductioni

    By phenobarbital.

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000007533.

    Structurei

    3D structure databases

    ProteinModelPortaliP24460.
    SMRiP24460. Positions 28-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    KOiK07412.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24460-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELSVLLLLA LLTGLLLLMA RGHPKAYGHL PPGPRPLPIL GNFLQMDRKG    50
    LLKSFLRLQE KYGDVFTVYL GPRRTVMLCG IDAIREALVD NAEAFSGRGK 100
    IAVVEPVFQG YGVVFANGER WKTLRRFSLA TMRDFGMGKR SVEERIQEEA 150
    QCLVEELRKT EGVLQDPTFF FHSMTANIIC SIVFGKRFGY KDPEFLRLMN 200
    LFYVSFALIS SFSSQMFELF HSFLKYFPGT HRQVYNNLQE IKAFIARMVE 250
    KHRETLDPSA PRDFIDAYLI RMDKEKAEPS SEFHHRNLID TALSLFFAGT 300
    ETTSTTLRYG FLLMLKYPHI AERIYKEIDQ VIGPHRLPSL DDRAKMPYTD 350
    AVIHEIQRFG DLLPIGVPHM VTKDICFRGY IIPKGTEVFP ILHSALNDPH 400
    YFEKPDVFNP DHFLDANGAL KKNEAFIPFS IGKRICLGEG IARMELFLFF 450
    TTILQNFSVA SPMAPEDIDL TPQEIGVGKL PPVYQISFLS RGGC 494
    Length:494
    Mass (Da):56,267
    Last modified:March 1, 1992 - v1
    Checksum:i8E9EA639B4B5E4D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92447 mRNA. Translation: AAA30881.1.
    PIRiS11305.
    RefSeqiNP_001006653.1. NM_001006652.1.
    UniGeneiCfa.3883.

    Genome annotation databases

    GeneIDi474177.
    KEGGicfa:474177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92447 mRNA. Translation: AAA30881.1 .
    PIRi S11305.
    RefSeqi NP_001006653.1. NM_001006652.1.
    UniGenei Cfa.3883.

    3D structure databases

    ProteinModelPortali P24460.
    SMRi P24460. Positions 28-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000007533.

    Chemistry

    ChEMBLi CHEMBL1907981.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 474177.
    KEGGi cfa:474177.

    Organism-specific databases

    CTDi 1555.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    KOi K07412.

    Miscellaneous databases

    NextBioi 20850373.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl."
      Graves P.E., Elhag G.A., Ciaccio P.J., Bourque D.P., Halpert J.R.
      Arch. Biochem. Biophys. 281:106-115(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2BB_CANFA
    AccessioniPrimary (citable) accession number: P24460
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3