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P24457

- CP2DB_MOUSE

UniProt

P24457 - CP2DB_MOUSE

Protein

Cytochrome P450 2D11

Gene

Cyp2d11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (18 Sep 2013)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D11 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID11
    Cytochrome P450-16-alpha
    Cytochrome P450CC
    Testosterone 16-alpha hydroxylase
    Gene namesi
    Name:Cyp2d11
    Synonyms:Cyp2d-11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:88603. Cyp2d11.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 2D11PRO_0000051737Add
    BLAST

    Proteomic databases

    PaxDbiP24457.
    PRIDEiP24457.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    GenevestigatoriP24457.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1838193.
    STRINGi10090.ENSMUSP00000086528.

    Structurei

    3D structure databases

    ProteinModelPortaliP24457.
    SMRiP24457. Positions 51-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117392.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiP24457.
    KOiK07414.
    OMAiFQVANIC.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24457-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ HWTSRCPPGP VPWPVLGNLL    50
    QVDLGNMPYS LYKLQNRYGD VFSLQMGWKP MVVINGLKAM KEVLLTCGED 100
    TADRPQVPIF EYLGVKPGSQ GVVLAPYGPE WQEQRRFSVS TLRNFGLGKK 150
    SLEDWVTKEA RHLCDAFTAQ AGQSINPNTM LNNAVCNVIA SLIFARRFEY 200
    EDPYLIRMLK MLKECFTEIS GFIPGVLNEF PIFLRIPGLA DMVFQGQKSF 250
    MAILDNLLTE NRTTWDPDQP PRNLTDAFLA EIEKAKGNPE SSFNDENLRM 300
    VVGDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVQHPEM 350
    ADQARMPYTN AVIHEVQRFG DIAPLPLPRI TSRDIEVQDF LVTKGSTLIP 400
    NMSSVLKDET VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGHRSCLGEA 450
    LARMELFLFF TCLLQRFSIS VPDGQPQPSN YRVHAIPVAP FPYQLCAVMR 500
    EQGH 504
    Length:504
    Mass (Da):56,988
    Last modified:September 18, 2013 - v2
    Checksum:i2C432A8B5848E946
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551G → D in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti77 – 771G → A in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti93 – 931V → M in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti106 – 1061Q → P in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti132 – 1321Q → R in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti154 – 1541D → E in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti174 – 1741S → P in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti179 – 1791T → P in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti183 – 1853NAV → KST in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti204 – 2041Y → F in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti289 – 2891P → A in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti303 – 3031G → L in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti371 – 38616DIAPL…SRDIE → TLLHCLCHASQVVTFTQ in AAA37514. (PubMed:2914938)CuratedAdd
    BLAST
    Sequence conflicti402 – 4021M → L in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti408 – 4081D → G in AAA37514. (PubMed:2914938)Curated
    Sequence conflicti500 – 5001R → H in AAA37514. (PubMed:2914938)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24264 Genomic DNA. Translation: AAA37514.1.
    AC113593 Genomic DNA. No translation available.
    CCDSiCCDS49680.1.
    PIRiS19169.
    RefSeqiNP_001098001.1. NM_001104531.1.
    UniGeneiMm.482764.

    Genome annotation databases

    EnsembliENSMUST00000170255; ENSMUSP00000130338; ENSMUSG00000068085.
    GeneIDi545123.
    KEGGimmu:545123.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24264 Genomic DNA. Translation: AAA37514.1 .
    AC113593 Genomic DNA. No translation available.
    CCDSi CCDS49680.1.
    PIRi S19169.
    RefSeqi NP_001098001.1. NM_001104531.1.
    UniGenei Mm.482764.

    3D structure databases

    ProteinModelPortali P24457.
    SMRi P24457. Positions 51-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1838193.
    STRINGi 10090.ENSMUSP00000086528.

    Proteomic databases

    PaxDbi P24457.
    PRIDEi P24457.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000170255 ; ENSMUSP00000130338 ; ENSMUSG00000068085 .
    GeneIDi 545123.
    KEGGi mmu:545123.

    Organism-specific databases

    CTDi 545123.
    MGIi MGI:88603. Cyp2d11.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117392.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi P24457.
    KOi K07414.
    OMAi FQVANIC.
    OrthoDBi EOG7RBZ85.
    TreeFami TF352043.

    Miscellaneous databases

    NextBioi 412286.
    PROi P24457.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P24457.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
      Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
      J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiCP2DB_MOUSE
    AccessioniPrimary (citable) accession number: P24457
    Secondary accession number(s): E9Q750
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3