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Protein

Cytochrome P450 2D11

Gene

Cyp2d11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid epoxygenase activity Source: GO_Central
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: GO_Central
  4. iron ion binding Source: InterPro
  5. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
  6. oxygen binding Source: GO_Central
  7. steroid hydroxylase activity Source: GO_Central

GO - Biological processi

  1. arachidonic acid metabolic process Source: GO_Central
  2. exogenous drug catabolic process Source: GO_Central
  3. oxidation-reduction process Source: GO_Central
  4. xenobiotic metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D11 (EC:1.14.14.1)
Alternative name(s):
CYPIID11
Cytochrome P450-16-alpha
Cytochrome P450CC
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2d11
Synonyms:Cyp2d-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88603. Cyp2d11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 2D11PRO_0000051737Add
BLAST

Proteomic databases

PaxDbiP24457.
PRIDEiP24457.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP24457.

Interactioni

Protein-protein interaction databases

MINTiMINT-1838193.
STRINGi10090.ENSMUSP00000086528.

Structurei

3D structure databases

ProteinModelPortaliP24457.
SMRiP24457. Positions 51-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP24457.
KOiK07414.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ HWTSRCPPGP VPWPVLGNLL
60 70 80 90 100
QVDLGNMPYS LYKLQNRYGD VFSLQMGWKP MVVINGLKAM KEVLLTCGED
110 120 130 140 150
TADRPQVPIF EYLGVKPGSQ GVVLAPYGPE WQEQRRFSVS TLRNFGLGKK
160 170 180 190 200
SLEDWVTKEA RHLCDAFTAQ AGQSINPNTM LNNAVCNVIA SLIFARRFEY
210 220 230 240 250
EDPYLIRMLK MLKECFTEIS GFIPGVLNEF PIFLRIPGLA DMVFQGQKSF
260 270 280 290 300
MAILDNLLTE NRTTWDPDQP PRNLTDAFLA EIEKAKGNPE SSFNDENLRM
310 320 330 340 350
VVGDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVQHPEM
360 370 380 390 400
ADQARMPYTN AVIHEVQRFG DIAPLPLPRI TSRDIEVQDF LVTKGSTLIP
410 420 430 440 450
NMSSVLKDET VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGHRSCLGEA
460 470 480 490 500
LARMELFLFF TCLLQRFSIS VPDGQPQPSN YRVHAIPVAP FPYQLCAVMR

EQGH
Length:504
Mass (Da):56,988
Last modified:September 18, 2013 - v2
Checksum:i2C432A8B5848E946
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551G → D in AAA37514 (PubMed:2914938).Curated
Sequence conflicti77 – 771G → A in AAA37514 (PubMed:2914938).Curated
Sequence conflicti93 – 931V → M in AAA37514 (PubMed:2914938).Curated
Sequence conflicti106 – 1061Q → P in AAA37514 (PubMed:2914938).Curated
Sequence conflicti132 – 1321Q → R in AAA37514 (PubMed:2914938).Curated
Sequence conflicti154 – 1541D → E in AAA37514 (PubMed:2914938).Curated
Sequence conflicti174 – 1741S → P in AAA37514 (PubMed:2914938).Curated
Sequence conflicti179 – 1791T → P in AAA37514 (PubMed:2914938).Curated
Sequence conflicti183 – 1853NAV → KST in AAA37514 (PubMed:2914938).Curated
Sequence conflicti204 – 2041Y → F in AAA37514 (PubMed:2914938).Curated
Sequence conflicti289 – 2891P → A in AAA37514 (PubMed:2914938).Curated
Sequence conflicti303 – 3031G → L in AAA37514 (PubMed:2914938).Curated
Sequence conflicti371 – 38616DIAPL…SRDIE → TLLHCLCHASQVVTFTQ in AAA37514 (PubMed:2914938).CuratedAdd
BLAST
Sequence conflicti402 – 4021M → L in AAA37514 (PubMed:2914938).Curated
Sequence conflicti408 – 4081D → G in AAA37514 (PubMed:2914938).Curated
Sequence conflicti500 – 5001R → H in AAA37514 (PubMed:2914938).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24264 Genomic DNA. Translation: AAA37514.1.
AC113593 Genomic DNA. No translation available.
CCDSiCCDS49680.1.
PIRiS19169.
RefSeqiNP_001098001.1. NM_001104531.1.
UniGeneiMm.482764.

Genome annotation databases

EnsembliENSMUST00000170255; ENSMUSP00000130338; ENSMUSG00000068085.
GeneIDi545123.
KEGGimmu:545123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24264 Genomic DNA. Translation: AAA37514.1.
AC113593 Genomic DNA. No translation available.
CCDSiCCDS49680.1.
PIRiS19169.
RefSeqiNP_001098001.1. NM_001104531.1.
UniGeneiMm.482764.

3D structure databases

ProteinModelPortaliP24457.
SMRiP24457. Positions 51-500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1838193.
STRINGi10090.ENSMUSP00000086528.

Proteomic databases

PaxDbiP24457.
PRIDEiP24457.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170255; ENSMUSP00000130338; ENSMUSG00000068085.
GeneIDi545123.
KEGGimmu:545123.

Organism-specific databases

CTDi545123.
MGIiMGI:88603. Cyp2d11.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP24457.
KOiK07414.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.

Miscellaneous databases

NextBioi412286.
PROiP24457.
SOURCEiSearch...

Gene expression databases

GenevestigatoriP24457.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
    Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
    J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCP2DB_MOUSE
AccessioniPrimary (citable) accession number: P24457
Secondary accession number(s): E9Q750
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: September 18, 2013
Last modified: April 1, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.