P24457 (CP2DB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 2D11
EC=1.14.14.1

Alternative name(s):
CYPIID11
Cytochrome P450-16-alpha
Cytochrome P450CC
Testosterone 16-alpha hydroxylase

Gene names

Name:	Cyp2d11
Synonyms:	Cyp2d-11

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Cytochrome P450 2D11		PRO_0000051737
Sites
	Metal binding	447	1	Iron (heme axial ligand)

Sequences

	Sequence		Length	Mass (Da)
	P24457 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: 402A681AE9ACC68E	FASTA	505	57,155
	10 20 30 40 50 60 MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ HWTSRCPPGP VPWPVLGNLL QVDLDNMPYS 70 80 90 100 110 120 LYKLQNRYGD VFSLQMAWKP MVVINGLKAM KEMLLTCGED TADRPPVPIF EYLGVKPGSQ 130 140 150 160 170 180 GVVLAPYGPE WREQRRFSVS TLRNFGLGKK SLEEWVTKEA RHLCDAFTAQ AGQPINPNPM 190 200 210 220 230 240 LNKSTCNVIA SLIFARRFEY EDPFLIRMLK MLKECFTEIS GFIPGVLNEF PIFLRIPGLA 250 260 270 280 290 300 DMVFQGQKSF MAILDNLLTE NRTTWDPDQP PRNLTDAFLA EIEKAKGNAE SSFNDENLRM 310 320 330 340 350 360 VVLDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVQHPEM ADQARMPYTN 370 380 390 400 410 420 AVIHEVQRFG TLLHCLCHAS QVVTFTQVQD FLVTKGSTLI PNLSSVLKGE TVWEKPLRFH 430 440 450 460 470 480 PEHFLDAQGH FVKPEAFMPF SAGHRSCLGE ALARMELFLF FTCLLQRFSI SVPDGQPQPS 490 500 NYRVHAIPVA PFPYQLCAVM HEQGH

References

[1]	"Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization." Wong G., Itakura T., Kawajiri K., Skow L., Negishi M. J. Biol. Chem. 264:2920-2927(1989) [PubMed: 2914938] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M24264 Genomic DNA. Translation: AAA37514.1.
IPI	IPI00136910.
PIR	S19169.
UniGene	Mm.482764.
3D structure databases
ProteinModelPortal	P24457.
SMR	P24457. Positions 37-499.
ModBase	Search...
Protein-protein interaction databases
STRING	P24457.
Proteomic databases
PRIDE	P24457.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc011zwu.1. mouse.
Organism-specific databases
MGI	MGI:88603. Cyp2d11.
Phylogenomic databases
eggNOG	roNOG04886.
GeneTree	ENSGT00560000076621.
HOGENOM	HBG749920.
HOVERGEN	HBG015789.
InParanoid	P24457.
OrthoDB	EOG40VVPH.
Gene expression databases
Bgee	P24457.
Genevestigator	P24457.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008069. Cyt_P450_E_grp-I_CYP2D-like. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01686. EP450ICYP2D. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

CP2DB_MOUSE

Accession

Primary (citable) accession number: P24457

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	September 21, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program