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Protein

Cytochrome P450 2D11

Gene

Cyp2d11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211958 Miscellaneous substrates
R-MMU-211981 Xenobiotics
R-MMU-211999 CYP2E1 reactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D11 (EC:1.14.14.1)
Alternative name(s):
CYPIID11
Cytochrome P450-16-alpha
Cytochrome P450CC
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2d11
Synonyms:Cyp2d-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88603 Cyp2d11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517371 – 504Cytochrome P450 2D11Add BLAST504

Proteomic databases

MaxQBiP24457
PaxDbiP24457
PeptideAtlasiP24457
PRIDEiP24457

PTM databases

iPTMnetiP24457
PhosphoSitePlusiP24457
SwissPalmiP24457

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000068085

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130338

Structurei

3D structure databases

ProteinModelPortaliP24457
SMRiP24457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOGENOMiHOG000036991
HOVERGENiHBG015789
InParanoidiP24457
KOiK07414
OMAiFQHEMFP
OrthoDBiEOG091G0BT8
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P24457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ HWTSRCPPGP VPWPVLGNLL
60 70 80 90 100
QVDLGNMPYS LYKLQNRYGD VFSLQMGWKP MVVINGLKAM KEVLLTCGED
110 120 130 140 150
TADRPQVPIF EYLGVKPGSQ GVVLAPYGPE WQEQRRFSVS TLRNFGLGKK
160 170 180 190 200
SLEDWVTKEA RHLCDAFTAQ AGQSINPNTM LNNAVCNVIA SLIFARRFEY
210 220 230 240 250
EDPYLIRMLK MLKECFTEIS GFIPGVLNEF PIFLRIPGLA DMVFQGQKSF
260 270 280 290 300
MAILDNLLTE NRTTWDPDQP PRNLTDAFLA EIEKAKGNPE SSFNDENLRM
310 320 330 340 350
VVGDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVQHPEM
360 370 380 390 400
ADQARMPYTN AVIHEVQRFG DIAPLPLPRI TSRDIEVQDF LVTKGSTLIP
410 420 430 440 450
NMSSVLKDET VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGHRSCLGEA
460 470 480 490 500
LARMELFLFF TCLLQRFSIS VPDGQPQPSN YRVHAIPVAP FPYQLCAVMR

EQGH
Length:504
Mass (Da):56,988
Last modified:September 18, 2013 - v2
Checksum:i2C432A8B5848E946
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55G → D in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti77G → A in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti93V → M in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti106Q → P in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti132Q → R in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti154D → E in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti174S → P in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti179T → P in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti183 – 185NAV → KST in AAA37514 (PubMed:2914938).Curated3
Sequence conflicti204Y → F in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti289P → A in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti303G → L in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti371 – 386DIAPL…SRDIE → TLLHCLCHASQVVTFTQ in AAA37514 (PubMed:2914938).CuratedAdd BLAST16
Sequence conflicti402M → L in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti408D → G in AAA37514 (PubMed:2914938).Curated1
Sequence conflicti500R → H in AAA37514 (PubMed:2914938).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24264 Genomic DNA Translation: AAA37514.1
AC113593 Genomic DNA No translation available.
CCDSiCCDS49680.1
PIRiS19169
RefSeqiNP_001098001.1, NM_001104531.1
UniGeneiMm.482764

Genome annotation databases

EnsembliENSMUST00000170255; ENSMUSP00000130338; ENSMUSG00000068085
GeneIDi545123
KEGGimmu:545123
UCSCiuc009vas.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCP2DB_MOUSE
AccessioniPrimary (citable) accession number: P24457
Secondary accession number(s): E9Q750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: September 18, 2013
Last modified: March 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health