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P24457 (CP2DB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D11

EC=1.14.14.1
Alternative name(s):
CYPIID11
Cytochrome P450-16-alpha
Cytochrome P450CC
Testosterone 16-alpha hydroxylase
Gene names
Name:Cyp2d11
Synonyms:Cyp2d-11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 2D11
PRO_0000051737

Sites

Metal binding4461Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict551G → D in AAA37514. Ref.1
Sequence conflict771G → A in AAA37514. Ref.1
Sequence conflict931V → M in AAA37514. Ref.1
Sequence conflict1061Q → P in AAA37514. Ref.1
Sequence conflict1321Q → R in AAA37514. Ref.1
Sequence conflict1541D → E in AAA37514. Ref.1
Sequence conflict1741S → P in AAA37514. Ref.1
Sequence conflict1791T → P in AAA37514. Ref.1
Sequence conflict183 – 1853NAV → KST in AAA37514. Ref.1
Sequence conflict2041Y → F in AAA37514. Ref.1
Sequence conflict2891P → A in AAA37514. Ref.1
Sequence conflict3031G → L in AAA37514. Ref.1
Sequence conflict371 – 38616DIAPL…SRDIE → TLLHCLCHASQVVTFTQ in AAA37514. Ref.1
Sequence conflict4021M → L in AAA37514. Ref.1
Sequence conflict4081D → G in AAA37514. Ref.1
Sequence conflict5001R → H in AAA37514. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P24457 [UniParc].

Last modified September 18, 2013. Version 2.
Checksum: 2C432A8B5848E946

FASTA50456,988
        10         20         30         40         50         60 
MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ HWTSRCPPGP VPWPVLGNLL QVDLGNMPYS 

        70         80         90        100        110        120 
LYKLQNRYGD VFSLQMGWKP MVVINGLKAM KEVLLTCGED TADRPQVPIF EYLGVKPGSQ 

       130        140        150        160        170        180 
GVVLAPYGPE WQEQRRFSVS TLRNFGLGKK SLEDWVTKEA RHLCDAFTAQ AGQSINPNTM 

       190        200        210        220        230        240 
LNNAVCNVIA SLIFARRFEY EDPYLIRMLK MLKECFTEIS GFIPGVLNEF PIFLRIPGLA 

       250        260        270        280        290        300 
DMVFQGQKSF MAILDNLLTE NRTTWDPDQP PRNLTDAFLA EIEKAKGNPE SSFNDENLRM 

       310        320        330        340        350        360 
VVGDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVQHPEM ADQARMPYTN 

       370        380        390        400        410        420 
AVIHEVQRFG DIAPLPLPRI TSRDIEVQDF LVTKGSTLIP NMSSVLKDET VWEKPLRFHP 

       430        440        450        460        470        480 
EHFLDAQGHF VKPEAFMPFS AGHRSCLGEA LARMELFLFF TCLLQRFSIS VPDGQPQPSN 

       490        500 
YRVHAIPVAP FPYQLCAVMR EQGH 

« Hide

References

« Hide 'large scale' references
[1]"Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M24264 Genomic DNA. Translation: AAA37514.1.
AC113593 Genomic DNA. No translation available.
CCDSCCDS49680.1.
PIRS19169.
RefSeqNP_001098001.1. NM_001104531.1.
UniGeneMm.482764.

3D structure databases

ProteinModelPortalP24457.
SMRP24457. Positions 51-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1838193.
STRING10090.ENSMUSP00000086528.

Proteomic databases

PaxDbP24457.
PRIDEP24457.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000170255; ENSMUSP00000130338; ENSMUSG00000068085.
GeneID545123.
KEGGmmu:545123.

Organism-specific databases

CTD545123.
MGIMGI:88603. Cyp2d11.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117392.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidP24457.
KOK07414.
OMAFQVANIC.
OrthoDBEOG7RBZ85.
TreeFamTF352043.

Gene expression databases

GenevestigatorP24457.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio412286.
PROP24457.
SOURCESearch...

Entry information

Entry nameCP2DB_MOUSE
AccessionPrimary (citable) accession number: P24457
Secondary accession number(s): E9Q750
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: September 18, 2013
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot