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P24457

- CP2DB_MOUSE

UniProt

P24457 - CP2DB_MOUSE

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Protein

Cytochrome P450 2D11

Gene

Cyp2d11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D11 (EC:1.14.14.1)
Alternative name(s):
CYPIID11
Cytochrome P450-16-alpha
Cytochrome P450CC
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2d11
Synonyms:Cyp2d-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:88603. Cyp2d11.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 2D11PRO_0000051737Add
BLAST

Proteomic databases

PaxDbiP24457.
PRIDEiP24457.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP24457.

Interactioni

Protein-protein interaction databases

MINTiMINT-1838193.
STRINGi10090.ENSMUSP00000086528.

Structurei

3D structure databases

ProteinModelPortaliP24457.
SMRiP24457. Positions 51-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP24457.
KOiK07414.
OMAiFQVANIC.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24457-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ HWTSRCPPGP VPWPVLGNLL
60 70 80 90 100
QVDLGNMPYS LYKLQNRYGD VFSLQMGWKP MVVINGLKAM KEVLLTCGED
110 120 130 140 150
TADRPQVPIF EYLGVKPGSQ GVVLAPYGPE WQEQRRFSVS TLRNFGLGKK
160 170 180 190 200
SLEDWVTKEA RHLCDAFTAQ AGQSINPNTM LNNAVCNVIA SLIFARRFEY
210 220 230 240 250
EDPYLIRMLK MLKECFTEIS GFIPGVLNEF PIFLRIPGLA DMVFQGQKSF
260 270 280 290 300
MAILDNLLTE NRTTWDPDQP PRNLTDAFLA EIEKAKGNPE SSFNDENLRM
310 320 330 340 350
VVGDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVQHPEM
360 370 380 390 400
ADQARMPYTN AVIHEVQRFG DIAPLPLPRI TSRDIEVQDF LVTKGSTLIP
410 420 430 440 450
NMSSVLKDET VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGHRSCLGEA
460 470 480 490 500
LARMELFLFF TCLLQRFSIS VPDGQPQPSN YRVHAIPVAP FPYQLCAVMR

EQGH
Length:504
Mass (Da):56,988
Last modified:September 18, 2013 - v2
Checksum:i2C432A8B5848E946
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551G → D in AAA37514. (PubMed:2914938)Curated
Sequence conflicti77 – 771G → A in AAA37514. (PubMed:2914938)Curated
Sequence conflicti93 – 931V → M in AAA37514. (PubMed:2914938)Curated
Sequence conflicti106 – 1061Q → P in AAA37514. (PubMed:2914938)Curated
Sequence conflicti132 – 1321Q → R in AAA37514. (PubMed:2914938)Curated
Sequence conflicti154 – 1541D → E in AAA37514. (PubMed:2914938)Curated
Sequence conflicti174 – 1741S → P in AAA37514. (PubMed:2914938)Curated
Sequence conflicti179 – 1791T → P in AAA37514. (PubMed:2914938)Curated
Sequence conflicti183 – 1853NAV → KST in AAA37514. (PubMed:2914938)Curated
Sequence conflicti204 – 2041Y → F in AAA37514. (PubMed:2914938)Curated
Sequence conflicti289 – 2891P → A in AAA37514. (PubMed:2914938)Curated
Sequence conflicti303 – 3031G → L in AAA37514. (PubMed:2914938)Curated
Sequence conflicti371 – 38616DIAPL…SRDIE → TLLHCLCHASQVVTFTQ in AAA37514. (PubMed:2914938)CuratedAdd
BLAST
Sequence conflicti402 – 4021M → L in AAA37514. (PubMed:2914938)Curated
Sequence conflicti408 – 4081D → G in AAA37514. (PubMed:2914938)Curated
Sequence conflicti500 – 5001R → H in AAA37514. (PubMed:2914938)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24264 Genomic DNA. Translation: AAA37514.1.
AC113593 Genomic DNA. No translation available.
CCDSiCCDS49680.1.
PIRiS19169.
RefSeqiNP_001098001.1. NM_001104531.1.
UniGeneiMm.482764.

Genome annotation databases

EnsembliENSMUST00000170255; ENSMUSP00000130338; ENSMUSG00000068085.
GeneIDi545123.
KEGGimmu:545123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24264 Genomic DNA. Translation: AAA37514.1 .
AC113593 Genomic DNA. No translation available.
CCDSi CCDS49680.1.
PIRi S19169.
RefSeqi NP_001098001.1. NM_001104531.1.
UniGenei Mm.482764.

3D structure databases

ProteinModelPortali P24457.
SMRi P24457. Positions 51-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1838193.
STRINGi 10090.ENSMUSP00000086528.

Proteomic databases

PaxDbi P24457.
PRIDEi P24457.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000170255 ; ENSMUSP00000130338 ; ENSMUSG00000068085 .
GeneIDi 545123.
KEGGi mmu:545123.

Organism-specific databases

CTDi 545123.
MGIi MGI:88603. Cyp2d11.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi P24457.
KOi K07414.
OMAi FQVANIC.
OrthoDBi EOG7RBZ85.
TreeFami TF352043.

Miscellaneous databases

NextBioi 412286.
PROi P24457.
SOURCEi Search...

Gene expression databases

Genevestigatori P24457.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
    Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
    J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCP2DB_MOUSE
AccessioniPrimary (citable) accession number: P24457
Secondary accession number(s): E9Q750
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: September 18, 2013
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3