SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P24456

- CP2DA_MOUSE

UniProt

P24456 - CP2DA_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome P450 2D10
Gene
Cyp2d10, Cyp2d-10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D10 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID10
    Cytochrome P450-16-alpha
    Cytochrome P450CB
    Testosterone 16-alpha hydroxylase
    Gene namesi
    Name:Cyp2d10
    Synonyms:Cyp2d-10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:88602. Cyp2d10.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 2D10
    PRO_0000051735Add
    BLAST

    Proteomic databases

    PaxDbiP24456.
    PRIDEiP24456.

    PTM databases

    PhosphoSiteiP24456.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    BgeeiP24456.
    GenevestigatoriP24456.

    Interactioni

    Protein-protein interaction databases

    IntActiP24456. 7 interactions.
    MINTiMINT-1862539.
    STRINGi10090.ENSMUSP00000072555.

    Structurei

    3D structure databases

    ProteinModelPortaliP24456.
    SMRiP24456. Positions 51-500.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117392.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiP24456.
    KOiK07414.
    OMAiTHELAQW.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP24456.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24456-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ RWTSRYPPGP VPWPVLGNLL    50
    QVDLDNMPYS LYKLQNRYGD VFSLQMGWKP MVVINGLKAM KEVLLTCGED 100
    TADRPQVPIF EYLGVKPGSQ GVVLAPYGPE WREQRRFSVS TLRNFGLGKK 150
    SLEDWVTKEA RHLCDAFTAQ AGQPINPNTM LNNAVCNVIA SLIFARRFEY 200
    EDPYLIRMQK VLEDSLTEIS GLIPEVLNMF PILLRIPGLP GKVFQGQKSL 250
    LAIVENLLTE NRNTWDPDQP PRNLTDAFLA EIEKVKGNAE SSFNDENLRM 300
    VVLDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVRHPEM 350
    ADQARMPYTN AVIHEVQRFG DIAPLNLPRI TSRDIEVQDF LIPKGSILIP 400
    NMSSVLKDET VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGRRSCLGEP 450
    LARMELFLFF TCLLQHFSFS VPNGQPRPRN LGVFPFPVAP YPYQLCAVMR 500
    EQGH 504
    Length:504
    Mass (Da):57,233
    Last modified:December 15, 1998 - v2
    Checksum:i41375F9834489401
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461L → Q in AAA39878. 1 Publication
    Sequence conflicti221 – 2244GLIP → LAYS in AAA79023. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24263 Genomic DNA. Translation: AAA79023.1.
    M27167 mRNA. Translation: AAA39878.1.
    BC010989 mRNA. Translation: AAH10989.1.
    BC057924 mRNA. Translation: AAH57924.1.
    CCDSiCCDS27690.1.
    PIRiA30247.
    RefSeqiNP_034135.2. NM_010005.3.
    UniGeneiMm.174372.

    Genome annotation databases

    EnsembliENSMUST00000072776; ENSMUSP00000072555; ENSMUSG00000094806.
    GeneIDi13101.
    KEGGimmu:13101.
    UCSCiuc007wzf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24263 Genomic DNA. Translation: AAA79023.1 .
    M27167 mRNA. Translation: AAA39878.1 .
    BC010989 mRNA. Translation: AAH10989.1 .
    BC057924 mRNA. Translation: AAH57924.1 .
    CCDSi CCDS27690.1.
    PIRi A30247.
    RefSeqi NP_034135.2. NM_010005.3.
    UniGenei Mm.174372.

    3D structure databases

    ProteinModelPortali P24456.
    SMRi P24456. Positions 51-500.
    ModBasei Search...

    Protein-protein interaction databases

    IntActi P24456. 7 interactions.
    MINTi MINT-1862539.
    STRINGi 10090.ENSMUSP00000072555.

    PTM databases

    PhosphoSitei P24456.

    Proteomic databases

    PaxDbi P24456.
    PRIDEi P24456.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072776 ; ENSMUSP00000072555 ; ENSMUSG00000094806 .
    GeneIDi 13101.
    KEGGi mmu:13101.
    UCSCi uc007wzf.2. mouse.

    Organism-specific databases

    CTDi 13101.
    MGIi MGI:88602. Cyp2d10.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117392.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi P24456.
    KOi K07414.
    OMAi THELAQW.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P24456.
    TreeFami TF352043.

    Miscellaneous databases

    NextBioi 283094.
    PROi P24456.
    SOURCEi Search...

    Gene expression databases

    Bgeei P24456.
    Genevestigatori P24456.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
      Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
      J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins."
      Ichikawa T., Itakura T., Negishi M.
      Biochemistry 28:4779-4784(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/J.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver and Salivary gland.

    Entry informationi

    Entry nameiCP2DA_MOUSE
    AccessioniPrimary (citable) accession number: P24456
    Secondary accession number(s): Q64490
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: December 15, 1998
    Last modified: July 9, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi