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P24456

- CP2DA_MOUSE

UniProt

P24456 - CP2DA_MOUSE

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Protein
Cytochrome P450 2D10
Gene
Cyp2d10, Cyp2d-10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D10 (EC:1.14.14.1)
Alternative name(s):
CYPIID10
Cytochrome P450-16-alpha
Cytochrome P450CB
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2d10
Synonyms:Cyp2d-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:88602. Cyp2d10.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 2D10
PRO_0000051735Add
BLAST

Proteomic databases

PaxDbiP24456.
PRIDEiP24456.

PTM databases

PhosphoSiteiP24456.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiP24456.
GenevestigatoriP24456.

Interactioni

Protein-protein interaction databases

IntActiP24456. 7 interactions.
MINTiMINT-1862539.
STRINGi10090.ENSMUSP00000072555.

Structurei

3D structure databases

ProteinModelPortaliP24456.
SMRiP24456. Positions 51-500.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00750000117392.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP24456.
KOiK07414.
OMAiTHELAQW.
OrthoDBiEOG7RBZ85.
PhylomeDBiP24456.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24456-1 [UniParc]FASTAAdd to Basket

« Hide

MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ RWTSRYPPGP VPWPVLGNLL    50
QVDLDNMPYS LYKLQNRYGD VFSLQMGWKP MVVINGLKAM KEVLLTCGED 100
TADRPQVPIF EYLGVKPGSQ GVVLAPYGPE WREQRRFSVS TLRNFGLGKK 150
SLEDWVTKEA RHLCDAFTAQ AGQPINPNTM LNNAVCNVIA SLIFARRFEY 200
EDPYLIRMQK VLEDSLTEIS GLIPEVLNMF PILLRIPGLP GKVFQGQKSL 250
LAIVENLLTE NRNTWDPDQP PRNLTDAFLA EIEKVKGNAE SSFNDENLRM 300
VVLDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVRHPEM 350
ADQARMPYTN AVIHEVQRFG DIAPLNLPRI TSRDIEVQDF LIPKGSILIP 400
NMSSVLKDET VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGRRSCLGEP 450
LARMELFLFF TCLLQHFSFS VPNGQPRPRN LGVFPFPVAP YPYQLCAVMR 500
EQGH 504
Length:504
Mass (Da):57,233
Last modified:December 15, 1998 - v2
Checksum:i41375F9834489401
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461L → Q in AAA39878. 1 Publication
Sequence conflicti221 – 2244GLIP → LAYS in AAA79023. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24263 Genomic DNA. Translation: AAA79023.1.
M27167 mRNA. Translation: AAA39878.1.
BC010989 mRNA. Translation: AAH10989.1.
BC057924 mRNA. Translation: AAH57924.1.
CCDSiCCDS27690.1.
PIRiA30247.
RefSeqiNP_034135.2. NM_010005.3.
UniGeneiMm.174372.

Genome annotation databases

EnsembliENSMUST00000072776; ENSMUSP00000072555; ENSMUSG00000094806.
GeneIDi13101.
KEGGimmu:13101.
UCSCiuc007wzf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24263 Genomic DNA. Translation: AAA79023.1 .
M27167 mRNA. Translation: AAA39878.1 .
BC010989 mRNA. Translation: AAH10989.1 .
BC057924 mRNA. Translation: AAH57924.1 .
CCDSi CCDS27690.1.
PIRi A30247.
RefSeqi NP_034135.2. NM_010005.3.
UniGenei Mm.174372.

3D structure databases

ProteinModelPortali P24456.
SMRi P24456. Positions 51-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P24456. 7 interactions.
MINTi MINT-1862539.
STRINGi 10090.ENSMUSP00000072555.

PTM databases

PhosphoSitei P24456.

Proteomic databases

PaxDbi P24456.
PRIDEi P24456.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072776 ; ENSMUSP00000072555 ; ENSMUSG00000094806 .
GeneIDi 13101.
KEGGi mmu:13101.
UCSCi uc007wzf.2. mouse.

Organism-specific databases

CTDi 13101.
MGIi MGI:88602. Cyp2d10.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00750000117392.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi P24456.
KOi K07414.
OMAi THELAQW.
OrthoDBi EOG7RBZ85.
PhylomeDBi P24456.
TreeFami TF352043.

Miscellaneous databases

NextBioi 283094.
PROi P24456.
SOURCEi Search...

Gene expression databases

Bgeei P24456.
Genevestigatori P24456.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
    Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
    J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins."
    Ichikawa T., Itakura T., Negishi M.
    Biochemistry 28:4779-4784(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/J.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver and Salivary gland.

Entry informationi

Entry nameiCP2DA_MOUSE
AccessioniPrimary (citable) accession number: P24456
Secondary accession number(s): Q64490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 15, 1998
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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