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Protein

Cytochrome P450 2D10

Gene

Cyp2d10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211958 Miscellaneous substrates
R-MMU-211981 Xenobiotics
R-MMU-211999 CYP2E1 reactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D10 (EC:1.14.14.1)
Alternative name(s):
CYPIID10
Cytochrome P450-16-alpha
Cytochrome P450CB
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2d10
Synonyms:Cyp2d-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88602 Cyp2d10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517351 – 504Cytochrome P450 2D10Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24456
PaxDbiP24456
PeptideAtlasiP24456
PRIDEiP24456

PTM databases

iPTMnetiP24456
PhosphoSitePlusiP24456

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000094806
GenevisibleiP24456 MM

Interactioni

Protein-protein interaction databases

IntActiP24456, 7 interactors
MINTiP24456
STRINGi10090.ENSMUSP00000072555

Structurei

3D structure databases

ProteinModelPortaliP24456
SMRiP24456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOGENOMiHOG000036991
HOVERGENiHBG015789
InParanoidiP24456
KOiK07414
OMAiYDISHEV
OrthoDBiEOG091G0BT8
PhylomeDBiP24456
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P24456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ RWTSRYPPGP VPWPVLGNLL
60 70 80 90 100
QVDLDNMPYS LYKLQNRYGD VFSLQMGWKP MVVINGLKAM KEVLLTCGED
110 120 130 140 150
TADRPQVPIF EYLGVKPGSQ GVVLAPYGPE WREQRRFSVS TLRNFGLGKK
160 170 180 190 200
SLEDWVTKEA RHLCDAFTAQ AGQPINPNTM LNNAVCNVIA SLIFARRFEY
210 220 230 240 250
EDPYLIRMQK VLEDSLTEIS GLIPEVLNMF PILLRIPGLP GKVFQGQKSL
260 270 280 290 300
LAIVENLLTE NRNTWDPDQP PRNLTDAFLA EIEKVKGNAE SSFNDENLRM
310 320 330 340 350
VVLDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVRHPEM
360 370 380 390 400
ADQARMPYTN AVIHEVQRFG DIAPLNLPRI TSRDIEVQDF LIPKGSILIP
410 420 430 440 450
NMSSVLKDET VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGRRSCLGEP
460 470 480 490 500
LARMELFLFF TCLLQHFSFS VPNGQPRPRN LGVFPFPVAP YPYQLCAVMR

EQGH
Length:504
Mass (Da):57,233
Last modified:December 15, 1998 - v2
Checksum:i41375F9834489401
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46L → Q in AAA39878 (PubMed:2788458).Curated1
Sequence conflicti221 – 224GLIP → LAYS in AAA79023 (PubMed:2914938).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24263 Genomic DNA Translation: AAA79023.1
M27167 mRNA Translation: AAA39878.1
BC010989 mRNA Translation: AAH10989.1
BC057924 mRNA Translation: AAH57924.1
CCDSiCCDS27690.1
PIRiA30247
RefSeqiNP_034135.2, NM_010005.3
UniGeneiMm.174372

Genome annotation databases

EnsembliENSMUST00000072776; ENSMUSP00000072555; ENSMUSG00000094806
GeneIDi13101
KEGGimmu:13101
UCSCiuc007wzf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCP2DA_MOUSE
AccessioniPrimary (citable) accession number: P24456
Secondary accession number(s): Q64490
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 15, 1998
Last modified: March 28, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health