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P24456 (CP2DA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D10

EC=1.14.14.1
Alternative name(s):
CYPIID10
Cytochrome P450-16-alpha
Cytochrome P450CB
Testosterone 16-alpha hydroxylase
Gene names
Name:Cyp2d10
Synonyms:Cyp2d-10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 2D10
PRO_0000051735

Sites

Metal binding4461Iron (heme axial ligand)

Experimental info

Sequence conflict461L → Q in AAA39878. Ref.2
Sequence conflict221 – 2244GLIP → LAYS in AAA79023. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P24456 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 41375F9834489401

FASTA50457,233
        10         20         30         40         50         60 
MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ RWTSRYPPGP VPWPVLGNLL QVDLDNMPYS 

        70         80         90        100        110        120 
LYKLQNRYGD VFSLQMGWKP MVVINGLKAM KEVLLTCGED TADRPQVPIF EYLGVKPGSQ 

       130        140        150        160        170        180 
GVVLAPYGPE WREQRRFSVS TLRNFGLGKK SLEDWVTKEA RHLCDAFTAQ AGQPINPNTM 

       190        200        210        220        230        240 
LNNAVCNVIA SLIFARRFEY EDPYLIRMQK VLEDSLTEIS GLIPEVLNMF PILLRIPGLP 

       250        260        270        280        290        300 
GKVFQGQKSL LAIVENLLTE NRNTWDPDQP PRNLTDAFLA EIEKVKGNAE SSFNDENLRM 

       310        320        330        340        350        360 
VVLDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVRHPEM ADQARMPYTN 

       370        380        390        400        410        420 
AVIHEVQRFG DIAPLNLPRI TSRDIEVQDF LIPKGSILIP NMSSVLKDET VWEKPLRFHP 

       430        440        450        460        470        480 
EHFLDAQGHF VKPEAFMPFS AGRRSCLGEP LARMELFLFF TCLLQHFSFS VPNGQPRPRN 

       490        500 
LGVFPFPVAP YPYQLCAVMR EQGH 

« Hide

References

« Hide 'large scale' references
[1]"Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins."
Ichikawa T., Itakura T., Negishi M.
Biochemistry 28:4779-4784(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/J.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver and Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M24263 Genomic DNA. Translation: AAA79023.1.
M27167 mRNA. Translation: AAA39878.1.
BC010989 mRNA. Translation: AAH10989.1.
BC057924 mRNA. Translation: AAH57924.1.
CCDSCCDS27690.1.
PIRA30247.
RefSeqNP_034135.2. NM_010005.3.
UniGeneMm.174372.

3D structure databases

ProteinModelPortalP24456.
SMRP24456. Positions 51-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP24456. 7 interactions.
MINTMINT-1862539.
STRING10090.ENSMUSP00000072555.

PTM databases

PhosphoSiteP24456.

Proteomic databases

PaxDbP24456.
PRIDEP24456.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000072776; ENSMUSP00000072555; ENSMUSG00000094806.
GeneID13101.
KEGGmmu:13101.
UCSCuc007wzf.2. mouse.

Organism-specific databases

CTD13101.
MGIMGI:88602. Cyp2d10.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117392.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidP24456.
KOK07414.
OMATHELAQW.
OrthoDBEOG7RBZ85.
PhylomeDBP24456.
TreeFamTF352043.

Gene expression databases

BgeeP24456.
GenevestigatorP24456.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283094.
PROP24456.
SOURCESearch...

Entry information

Entry nameCP2DA_MOUSE
AccessionPrimary (citable) accession number: P24456
Secondary accession number(s): Q64490
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 15, 1998
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot