Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P24456

- CP2DA_MOUSE

UniProt

P24456 - CP2DA_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome P450 2D10

Gene

Cyp2d10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_245291. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D10 (EC:1.14.14.1)
Alternative name(s):
CYPIID10
Cytochrome P450-16-alpha
Cytochrome P450CB
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2d10
Synonyms:Cyp2d-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:88602. Cyp2d10.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 2D10PRO_0000051735Add
BLAST

Proteomic databases

PaxDbiP24456.
PRIDEiP24456.

PTM databases

PhosphoSiteiP24456.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiP24456.
GenevestigatoriP24456.

Interactioni

Protein-protein interaction databases

IntActiP24456. 7 interactions.
MINTiMINT-1862539.
STRINGi10090.ENSMUSP00000072555.

Structurei

3D structure databases

ProteinModelPortaliP24456.
SMRiP24456. Positions 51-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP24456.
KOiK07414.
OMAiTHELAQW.
OrthoDBiEOG7RBZ85.
PhylomeDBiP24456.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24456-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ RWTSRYPPGP VPWPVLGNLL
60 70 80 90 100
QVDLDNMPYS LYKLQNRYGD VFSLQMGWKP MVVINGLKAM KEVLLTCGED
110 120 130 140 150
TADRPQVPIF EYLGVKPGSQ GVVLAPYGPE WREQRRFSVS TLRNFGLGKK
160 170 180 190 200
SLEDWVTKEA RHLCDAFTAQ AGQPINPNTM LNNAVCNVIA SLIFARRFEY
210 220 230 240 250
EDPYLIRMQK VLEDSLTEIS GLIPEVLNMF PILLRIPGLP GKVFQGQKSL
260 270 280 290 300
LAIVENLLTE NRNTWDPDQP PRNLTDAFLA EIEKVKGNAE SSFNDENLRM
310 320 330 340 350
VVLDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVRHPEM
360 370 380 390 400
ADQARMPYTN AVIHEVQRFG DIAPLNLPRI TSRDIEVQDF LIPKGSILIP
410 420 430 440 450
NMSSVLKDET VWEKPLRFHP EHFLDAQGHF VKPEAFMPFS AGRRSCLGEP
460 470 480 490 500
LARMELFLFF TCLLQHFSFS VPNGQPRPRN LGVFPFPVAP YPYQLCAVMR

EQGH
Length:504
Mass (Da):57,233
Last modified:December 15, 1998 - v2
Checksum:i41375F9834489401
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461L → Q in AAA39878. (PubMed:2788458)Curated
Sequence conflicti221 – 2244GLIP → LAYS in AAA79023. (PubMed:2914938)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24263 Genomic DNA. Translation: AAA79023.1.
M27167 mRNA. Translation: AAA39878.1.
BC010989 mRNA. Translation: AAH10989.1.
BC057924 mRNA. Translation: AAH57924.1.
CCDSiCCDS27690.1.
PIRiA30247.
RefSeqiNP_034135.2. NM_010005.3.
UniGeneiMm.174372.

Genome annotation databases

EnsembliENSMUST00000072776; ENSMUSP00000072555; ENSMUSG00000094806.
GeneIDi13101.
KEGGimmu:13101.
UCSCiuc007wzf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24263 Genomic DNA. Translation: AAA79023.1 .
M27167 mRNA. Translation: AAA39878.1 .
BC010989 mRNA. Translation: AAH10989.1 .
BC057924 mRNA. Translation: AAH57924.1 .
CCDSi CCDS27690.1.
PIRi A30247.
RefSeqi NP_034135.2. NM_010005.3.
UniGenei Mm.174372.

3D structure databases

ProteinModelPortali P24456.
SMRi P24456. Positions 51-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P24456. 7 interactions.
MINTi MINT-1862539.
STRINGi 10090.ENSMUSP00000072555.

PTM databases

PhosphoSitei P24456.

Proteomic databases

PaxDbi P24456.
PRIDEi P24456.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072776 ; ENSMUSP00000072555 ; ENSMUSG00000094806 .
GeneIDi 13101.
KEGGi mmu:13101.
UCSCi uc007wzf.2. mouse.

Organism-specific databases

CTDi 13101.
MGIi MGI:88602. Cyp2d10.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi P24456.
KOi K07414.
OMAi THELAQW.
OrthoDBi EOG7RBZ85.
PhylomeDBi P24456.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_245291. Xenobiotics.

Miscellaneous databases

NextBioi 283094.
PROi P24456.
SOURCEi Search...

Gene expression databases

Bgeei P24456.
Genevestigatori P24456.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
    Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
    J. Biol. Chem. 264:2920-2927(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins."
    Ichikawa T., Itakura T., Negishi M.
    Biochemistry 28:4779-4784(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/J.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver and Salivary gland.

Entry informationi

Entry nameiCP2DA_MOUSE
AccessioniPrimary (citable) accession number: P24456
Secondary accession number(s): Q64490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 15, 1998
Last modified: November 26, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3