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P24455

- CP2A9_MESAU

UniProt

P24455 - CP2A9_MESAU

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Protein

Cytochrome P450 2A9

Gene

CYP2A9

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi438 – 4381Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2A9 (EC:1.14.14.1)
Alternative name(s):
CYPIIA9
Cytochrome P450-MC1-R
Testosterone 7-alpha-hydroxylase
Gene namesi
Name:CYP2A9
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Cytochrome P450 2A9PRO_0000051672Add
BLAST

Expressioni

Tissue specificityi

Liver.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996550.

Structurei

3D structure databases

ProteinModelPortaliP24455.
SMRiP24455. Positions 30-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24455-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGSGLILVA ILAYLSVMVL VFVWKQKFRG KLPPGPTPLP YIGNYLQLNT
60 70 80 90 100
KDIYSSITEL SERYGPVFTI YLGPRPVVVL YGYDAVKEAL VDQAEEFSGR
110 120 130 140 150
GEQATYNTLF KDYGVAFSSG ERAKQLRRFS IATLRDFGVG KRGVEERIQE
160 170 180 190 200
EAAYLIKMLR STRGAPIDPN DYLSQTVSNV ISSVVFGDAF DYEDKEFLEL
210 220 230 240 250
LHMMNEMNKF AASPVGQLYD MFHSVMKYLP GPQQQIIKNT KELEDFMIRK
260 270 280 290 300
VKQNQSTLDL NSARNFIDSF LIHMHEEKKN PTSEFNIKNL VMTSLNLFFA
310 320 330 340 350
GSETVSSTIR YGFLLLMKYP EVEAKVHEEI DRVIGRNRQP QFEDRMKMPY
360 370 380 390 400
TEAVINEIQR FANLAPLGIP RKTIKNTTFR GFFLPKDTDV YPILGSLLTD
410 420 430 440 450
PKFFTSPKHF NPQNFLDDRG QLKKIAAFVP FSVGKRFCLG DGLARMELFL
460 470 480 490
FLTTILQNFR LKFPKKLEDI DASPKPLGFS RIIPRYTMSF LPI
Length:493
Mass (Da):56,418
Last modified:December 15, 1998 - v2
Checksum:iE7376475D21AEC10
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti367 – 3671L → C in AAA37069. (PubMed:2275554)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86953 mRNA. Translation: BAA25259.1.
M63789 mRNA. Translation: AAA37069.1.
RefSeqiNP_001268294.1. NM_001281365.1.

Genome annotation databases

GeneIDi101826326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86953 mRNA. Translation: BAA25259.1 .
M63789 mRNA. Translation: AAA37069.1 .
RefSeqi NP_001268294.1. NM_001281365.1.

3D structure databases

ProteinModelPortali P24455.
SMRi P24455. Positions 30-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996550.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101826326.

Phylogenomic databases

HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of Syrian hamster testosterone 7 alpha-hydroxylase, CYP2A9."
    Kurose K., Tohkin M., Ushio F., Fukuhara M.
    Arch. Biochem. Biophys. 351:60-65(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s."
    Lai T.S., Chiang J.Y.L.
    Arch. Biochem. Biophys. 283:429-439(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-493.
    Tissue: Liver.

Entry informationi

Entry nameiCP2A9_MESAU
AccessioniPrimary (citable) accession number: P24455
Secondary accession number(s): O70538
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 15, 1998
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3