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Protein

Cytochrome P450 2A9

Gene

CYP2A9

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi438Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2A9 (EC:1.14.14.1)
Alternative name(s):
CYPIIA9
Cytochrome P450-MC1-R
Testosterone 7-alpha-hydroxylase
Gene namesi
Name:CYP2A9
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516721 – 493Cytochrome P450 2A9Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphoserineBy similarity1
Modified residuei252N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Expressioni

Tissue specificityi

Liver.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996550.

Structurei

3D structure databases

ProteinModelPortaliP24455.
SMRiP24455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.
KOiK17685.
OrthoDBiEOG091G0BT8.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P24455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSGLILVA ILAYLSVMVL VFVWKQKFRG KLPPGPTPLP YIGNYLQLNT
60 70 80 90 100
KDIYSSITEL SERYGPVFTI YLGPRPVVVL YGYDAVKEAL VDQAEEFSGR
110 120 130 140 150
GEQATYNTLF KDYGVAFSSG ERAKQLRRFS IATLRDFGVG KRGVEERIQE
160 170 180 190 200
EAAYLIKMLR STRGAPIDPN DYLSQTVSNV ISSVVFGDAF DYEDKEFLEL
210 220 230 240 250
LHMMNEMNKF AASPVGQLYD MFHSVMKYLP GPQQQIIKNT KELEDFMIRK
260 270 280 290 300
VKQNQSTLDL NSARNFIDSF LIHMHEEKKN PTSEFNIKNL VMTSLNLFFA
310 320 330 340 350
GSETVSSTIR YGFLLLMKYP EVEAKVHEEI DRVIGRNRQP QFEDRMKMPY
360 370 380 390 400
TEAVINEIQR FANLAPLGIP RKTIKNTTFR GFFLPKDTDV YPILGSLLTD
410 420 430 440 450
PKFFTSPKHF NPQNFLDDRG QLKKIAAFVP FSVGKRFCLG DGLARMELFL
460 470 480 490
FLTTILQNFR LKFPKKLEDI DASPKPLGFS RIIPRYTMSF LPI
Length:493
Mass (Da):56,418
Last modified:December 15, 1998 - v2
Checksum:iE7376475D21AEC10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti367L → C in AAA37069 (PubMed:2275554).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86953 mRNA. Translation: BAA25259.1.
M63789 mRNA. Translation: AAA37069.1.
RefSeqiNP_001268294.1. NM_001281365.1.

Genome annotation databases

GeneIDi101826326.
KEGGiag:BAA25259.

Similar proteinsi

Entry informationi

Entry nameiCP2A9_MESAU
AccessioniPrimary (citable) accession number: P24455
Secondary accession number(s): O70538
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 15, 1998
Last modified: August 30, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families