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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation.By similarity

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei225SubstrateBy similarity1
Metal bindingi456Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processLipid metabolism, Steroid metabolism, Sterol metabolism
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1By similarity)
Alternative name(s):
CYPIA2
Cholesterol 25-hydroxylaseBy similarity
Cytochrome P450-MC4
Hepatic cytochrome P-450MC1
Gene namesi
Name:CYP1A2
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000516532 – 513Cytochrome P450 1A2Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68O-linked (GlcNAc) serineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP24453

Expressioni

Tissue specificityi

Found in lung and liver.

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliP24453
SMRiP24453
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944
OrthoDBiEOG091G0BT8

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008066 Cyt_P450_E_grp-I_CYP1
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01683 EP450ICYP1A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSQYTSLS TELVLATAIF CIVFWVARAL RTQVPKGLKT PPGPWGLPIL
60 70 80 90 100
GHVLTLGKNP HLSLTKLSKQ YGDVLQIRIG STPVVVLSGL DTIRQALVRQ
110 120 130 140 150
GDDFKGRPDL YSFTLITNGK SMTFNPDCGP VWAARRRLAQ DALKSFSIAS
160 170 180 190 200
DPTSASSCYL EDHVIKEANH LVSKLQKLTA EVGHFEPVNQ VVESVANVIG
210 220 230 240 250
AMCFGKNFPR KSEEMLRIVK GSSDFVENVS SGNAVDFFPI LRYLPNPDLK
260 270 280 290 300
RFKNFNDNFV LFLQKTVQEH YQDFNKNSIQ DITGALFKHS ENSKDSGGLI
310 320 330 340 350
PQEKIVNIVN DLFGAGFDTV TTAITLSILL LVTWPNVQRK IHKELDTVIG
360 370 380 390 400
RDRQPRLSDR LQLPYMEAFI LELYRYTSFV PFTIPHSTTR DTSLNGFYIP
410 420 430 440 450
KDRCIFINQW QVNHDEKQWK DPFVFRPERF LTDNDTVINK TLSEKVMLFG
460 470 480 490 500
LGKRRCIGEI PAKWEVFLFL AILLQQLEFS VPPGTKVDLT PTYGLTMKPQ
510
TCKYIQAWPR FSK
Length:513
Mass (Da):58,082
Last modified:January 23, 2007 - v4
Checksum:iD179B43386C19815
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49I → F in AAA37070 (PubMed:2275554).Curated1
Sequence conflicti52 – 53HV → MC in AAA37070 (PubMed:2275554).Curated2
Sequence conflicti253 – 254KN → GG in AAA37070 (PubMed:2275554).Curated2
Sequence conflicti326L → W in AAA37070 (PubMed:2275554).Curated1
Sequence conflicti356R → L in AAA37070 (PubMed:2275554).Curated1
Sequence conflicti485T → Q in AAA37070 (PubMed:2275554).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63787 mRNA Translation: AAA37070.1
D10252 mRNA Translation: BAA01097.1
D10914 Genomic DNA Translation: BAA01718.1
PIRiJX0190
RefSeqiNP_001268302.1, NM_001281373.1

Genome annotation databases

GeneIDi101825565

Similar proteinsi

Entry informationi

Entry nameiCP1A2_MESAU
AccessioniPrimary (citable) accession number: P24453
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 110 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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