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P24453

- CP1A2_MESAU

UniProt

P24453 - CP1A2_MESAU

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Protein

Cytochrome P450 1A2

Gene
CYP1A2
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei225 – 2251Substrate By similarity
Metal bindingi456 – 4561Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Cytochrome P450-MC4
Hepatic cytochrome P-450MC1
Gene namesi
Name:CYP1A2
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 513512Cytochrome P450 1A2PRO_0000051653Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681O-linked (GlcNAc) By similarity

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Found in lung and liver.

Inductioni

By 3-methylcholanthrene (3MC).

Structurei

3D structure databases

ProteinModelPortaliP24453.
SMRiP24453. Positions 33-512.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24453-1 [UniParc]FASTAAdd to Basket

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MALSQYTSLS TELVLATAIF CIVFWVARAL RTQVPKGLKT PPGPWGLPIL    50
GHVLTLGKNP HLSLTKLSKQ YGDVLQIRIG STPVVVLSGL DTIRQALVRQ 100
GDDFKGRPDL YSFTLITNGK SMTFNPDCGP VWAARRRLAQ DALKSFSIAS 150
DPTSASSCYL EDHVIKEANH LVSKLQKLTA EVGHFEPVNQ VVESVANVIG 200
AMCFGKNFPR KSEEMLRIVK GSSDFVENVS SGNAVDFFPI LRYLPNPDLK 250
RFKNFNDNFV LFLQKTVQEH YQDFNKNSIQ DITGALFKHS ENSKDSGGLI 300
PQEKIVNIVN DLFGAGFDTV TTAITLSILL LVTWPNVQRK IHKELDTVIG 350
RDRQPRLSDR LQLPYMEAFI LELYRYTSFV PFTIPHSTTR DTSLNGFYIP 400
KDRCIFINQW QVNHDEKQWK DPFVFRPERF LTDNDTVINK TLSEKVMLFG 450
LGKRRCIGEI PAKWEVFLFL AILLQQLEFS VPPGTKVDLT PTYGLTMKPQ 500
TCKYIQAWPR FSK 513
Length:513
Mass (Da):58,082
Last modified:January 23, 2007 - v4
Checksum:iD179B43386C19815
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491I → F in AAA37070. 1 Publication
Sequence conflicti52 – 532HV → MC in AAA37070. 1 Publication
Sequence conflicti253 – 2542KN → GG in AAA37070. 1 Publication
Sequence conflicti326 – 3261L → W in AAA37070. 1 Publication
Sequence conflicti356 – 3561R → L in AAA37070. 1 Publication
Sequence conflicti485 – 4851T → Q in AAA37070. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63787 mRNA. Translation: AAA37070.1.
D10252 mRNA. Translation: BAA01097.1.
D10914 Genomic DNA. Translation: BAA01718.1.
PIRiJX0190.
RefSeqiNP_001268302.1. NM_001281373.1.

Genome annotation databases

GeneIDi101825565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63787 mRNA. Translation: AAA37070.1 .
D10252 mRNA. Translation: BAA01097.1 .
D10914 Genomic DNA. Translation: BAA01718.1 .
PIRi JX0190.
RefSeqi NP_001268302.1. NM_001281373.1.

3D structure databases

ProteinModelPortali P24453.
SMRi P24453. Positions 33-512.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101825565.

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s."
    Lai T.S., Chiang J.Y.L.
    Arch. Biochem. Biophys. 283:429-439(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Hamster cytochrome P-450 IA gene family, P-450IA1 and P-450IA2 in lung and liver: cDNA cloning and sequence analysis."
    Sagami I., Ohmachi T., Fujii H., Kikuchi H., Watanabe M.
    J. Biochem. 110:641-647(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Purification and characterization of two forms of 2,3,4,7,8-pentachlorodibenzofuran-inducible cytochrome P-450 in hamster liver."
    Koga N., Ariyoshi N., Nakashima H., Yoshimura H.
    J. Biochem. 107:826-833(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-19.
    Tissue: Liver.

Entry informationi

Entry nameiCP1A2_MESAU
AccessioniPrimary (citable) accession number: P24453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 91 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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