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Protein

Alkaline nuclease

Gene

U70

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei177Required for functionUniRule annotation1
Sitei213Required for functionUniRule annotation1
Sitei236Required for functionUniRule annotation1
Sitei238Required for functionUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Exonuclease, Hydrolase, Nuclease
Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline nucleaseUniRule annotation (EC:3.1.-.-UniRule annotation)
Gene namesi
Name:U70
Synonyms:16R
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009295 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001156941 – 488Alkaline nucleaseAdd BLAST488

Proteomic databases

PRIDEiP24447

Interactioni

Subunit structurei

Interacts with major DNA-binding protein; this interaction increases the nuclease processivity of the alkaline exonuclease.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP24447
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae alkaline nuclease family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900004U

Family and domain databases

Gene3Di3.90.320.10, 1 hit
HAMAPiMF_04009 HSV_AN, 1 hit
InterProiView protein in InterPro
IPR011604 Exonuc_phg/RecB_C
IPR001616 Herpes_alk_exo
IPR011335 Restrct_endonuc-II-like
IPR034720 Viral_alk_exo
PfamiView protein in Pfam
PF01771 Herpes_alk_exo, 1 hit
PRINTSiPR00924 ALKEXNUCLASE
SUPFAMiSSF52980 SSF52980, 1 hit

Sequencei

Sequence statusi: Complete.

P24447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLDQISETL SSVAEEEPLT MFLLDKLYAI REKIKQVPFS IVRLCHVYCM
60 70 80 90 100
LIKYNASNNN CILGRKLIEE MQQFLCGTRV DGSEDISMDL SELCKLYDYC
110 120 130 140 150
PLLCSALCRA PCVSVNKLFK IVERETRGQS ENPLWHALRK YTVTATKLYD
160 170 180 190 200
IYTTRCFLEY KGQQFFGEAV IYGAKHERVI RHLVATFYVK REVKETLGLL
210 220 230 240 250
LDPSSGVFGA SLDACFGISF NEDGFLMVKE KALIFEIKFK YKYLRDKEDH
260 270 280 290 300
FVSELLKNPT EKSFSDFILS HPVPVIEFRE RGKIPSSREY LMTYDFQYRP
310 320 330 340 350
QRKLRTCPTP AILAPHIKQL LCLNETQKST VIVFDCKSDL CEQKLSVFQK
360 370 380 390 400
AVFTVNVFVN PKHRYFFQSL LQQYVMTQFY INDHNNPEYI ESTEVPSVHI
410 420 430 440 450
VTAFFRRRTE EERSLHLVID ETEYIEEEIP LALIVTPVAP NPEFTCCVIT
460 470 480
DICNLWENNI CKQTSLQVWA QSAVNQYLAA CVRKPKTP
Length:488
Mass (Da):56,645
Last modified:March 1, 1992 - v1
Checksum:i0F38A10597366A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83413 Genomic DNA Translation: CAA58362.1
M68963 Genomic DNA Translation: AAA65578.1
PIRiF36769 QQBEHS
RefSeqiNP_042963.1, NC_001664.2

Genome annotation databases

GeneIDi1487951
KEGGivg:1487951

Similar proteinsi

Entry informationi

Entry nameiAN_HHV6U
AccessioniPrimary (citable) accession number: P24447
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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