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Protein

Probable ganciclovir kinase

Gene

U69

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylates the antiviral nucleoside analog ganciclovir.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei218ATPBy similarity1
Active sitei313Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi201 – 209ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ganciclovir kinase (EC:2.7.1.-)
Gene namesi
Name:U69
Synonyms:15R
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009295 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881941 – 562Probable ganciclovir kinaseAdd BLAST562

Proteomic databases

PRIDEiP24446

Expressioni

Keywords - Developmental stagei

Early protein

Structurei

3D structure databases

ProteinModelPortaliP24446
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG09000040

Family and domain databases

InterProiView protein in InterPro
IPR010615 Herpes_UL97
IPR011009 Kinase-like_dom_sf
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF06734 UL97, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

P24446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNGVETPQG QKTQPINLPP VRKKLRKHEG LGKGVKRKLF AEDSSPLKKQ
60 70 80 90 100
ISACSDMETL SSPVKSECES RSASLDESFG KCKHEIACDC SAIEELLCHE
110 120 130 140 150
SLLDSPMKLS NAHTIFSSNK WKLELEKIIA SKQIFLDMSE NAELAAYGET
160 170 180 190 200
LCNLRIFEKI SSPFLFDVQS EERSYSVVYV PHNKELCGQF CQPEKTMARV
210 220 230 240 250
LGVGAYGKVF DLDKVAIKTA NEDESVISAF IAGVIRAKSG ADLLSHECVI
260 270 280 290 300
NNLLISNSVC MSHKVSLSRT YDIDLHKFED WDVRNVMNYY SVFCKLADAV
310 320 330 340 350
RFLNLKCRIN HFDISPMNIF LNHKKEIIFD AVLADYSLSE MHPNYNGTCA
360 370 380 390 400
IAKEYDKNLQ LVPISRNKFC DMFNPGFRPL VANAMILVNV CGAFDGENNP
410 420 430 440 450
LRHCNLDLCA FAQVVLSCVL RMTDKRGCRE AQLYYEKRLF ALANEACRLN
460 470 480 490 500
PLKYPFAYRD ACCKVLAEHV VLLGLLFYRD VVEIYEKLYD FLDERGEFGS
510 520 530 540 550
RDLFEATFLN NSKLTRRQPI REGLASLQSS EYGEKLLHDL RELFLINSTA
560
DLDKDTSSLF HM
Length:562
Mass (Da):63,717
Last modified:March 1, 1992 - v1
Checksum:i09111202754CC071
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68963 Genomic DNA Translation: AAA65577.1
X83413 Genomic DNA Translation: CAA58361.1
PIRiE36769 QQBEH5
RefSeqiNP_042962.1, NC_001664.2

Genome annotation databases

GeneIDi1487950
KEGGivg:1487950

Similar proteinsi

Entry informationi

Entry nameiGCVK_HHV6U
AccessioniPrimary (citable) accession number: P24446
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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