P24442 (UL16_HHV6U) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Capsid-binding protein U65

Alternative name(s):
Protein U65

Gene names

Name:	U65
Synonyms:	11R

Organism

Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) [Reference proteome]

Taxonomic identifier

10370 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Roseolovirus › Human herpesvirus 6A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a role in virion morphogenesis and budding by interacting with the capsid By similarity.
Subunit structure	Interacts with capsid proteins By similarity.
Subcellular location	Virion tegument Potential. Host cytoplasm By similarity. Host nucleus By similarity. Note: Found in the nucleus up to 18 hours postinfection, but at later times is localized to punctate, cytoplasmic structures By similarity.
Sequence similarities	Belongs to the herpesviridae HHV-1 UL16 family.

Ontologies

Keywords
Cellular component	Host cytoplasm Host nucleus Virion Virion tegument
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell viral tegument Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Capsid-binding protein U65		PRO_0000115950

Sequences

	Sequence		Length	Mass (Da)
	P24442 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: 177BC8ED39DEE014	FASTA	335	37,877
	10 20 30 40 50 60 MAISTFSIGD LGYLRNFLQN ECNWFRICKK TFYREYRSVA TSSPTFSLNN KPKKFCMHCE 70 80 90 100 110 120 IVIFKRSEEF MFSLAVNGIH FGQFLTGKMK FNKKAVPEGL YYYILELGSI TPIDLGFIPR 130 140 150 160 170 180 YNSDCVTNMR CVTPEVIYEN CSIVCPEEAN RLTVKGSGDN KLTPLGGCGA WCLKNGGDLY 190 200 210 220 230 240 IYTFALAYDL FLTCYDKSTF PSLAKIIFDM IACESEDCVF CKDHNKHVSQ AGQIVGCVSN 250 260 270 280 290 300 QETCFCYTSC KKKMANINNP ELISLLCDQE INKIDIMYPK IKASLSLDIN SYAHGYFGDD 310 320 330 PYALKCVNWI PVRISAALSR LIVLSCPVCK RVVMD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human herpesvirus 6 is closely related to human cytomegalovirus." Lawrence G.L., Chee M., Craxton M.A., Gompels U.A., Honess R.W., Barrell B.G. J. Virol. 64:287-299(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution." Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J., Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A. Virology 209:29-51(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X83413 Genomic DNA. Translation: CAA58357.1. M68963 Genomic DNA. Translation: AAA65574.1.
PIR	B36769.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
ProtClustDB	PHA3352.
Family and domain databases
InterPro	IPR004286. Herpes_UL16/UL94. [Graphical view]
Pfam	PF03044. Herpes_UL16. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UL16_HHV6U

Accession

Primary (citable) accession number: P24442

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program