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Protein

Probable ATP-dependent Clp protease ATP-binding subunit

Gene

clpC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi216 – 223ATPSequence analysis8
Nucleotide bindingi553 – 560ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent Clp protease ATP-binding subunit
Gene namesi
Name:clpC
Ordered Locus Names:ML0235
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912351 – 848Probable ATP-dependent Clp protease ATP-binding subunitAdd BLAST848

Proteomic databases

PRIDEiP24428.

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0235.

Structurei

3D structure databases

ProteinModelPortaliP24428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 491Add BLAST32
Repeati93 – 1242Add BLAST32
Domaini425 – 460UVRPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 1242 X 32 AA approximate repeatsAdd BLAST107
Regioni171 – 418IAdd BLAST248
Regioni479 – 670IIAdd BLAST192

Sequence similaritiesi

Belongs to the ClpA/ClpB family. ClpC subfamily.Curated
Contains 1 UVR domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105C2Z. Bacteria.
COG0542. LUCA.
HOGENOMiHOG000218210.
KOiK03696.
OMAiENWDGEG.
OrthoDBiPOG091H019M.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
PF02151. UVR. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFERFTDRAR RVVVLAQEEA RMLNHNYIGT EHILLGLIHE GEGVAAKSLD
60 70 80 90 100
SLGISLEAVR SQVEDIIGQG QQAPSGHIPF TPRAKKVLEL SLREALQLGH
110 120 130 140 150
NYIGTEHILL GLIREGEGVA AQVLVKLGAE LTRVRQQVIQ LLSGYQGKEA
160 170 180 190 200
AEAGTGGRGG ESGSPSTSLV LDQFGRNLTA AAMESKLDPV IGREKEIERV
210 220 230 240 250
MQVLSRRTKN NPVLIGEPGV GKTAVVEGLA QAIVHGEVPE TLKDKQLYTL
260 270 280 290 300
DLGSLVAGSR YRGDFEERLK KVLKEINTRG DIILFIDELH TLVGAGAAEG
310 320 330 340 350
AIDAASILKP KLARGELQTI GATTLDEYRK YIEKDAALER RFQPVQVGEP
360 370 380 390 400
TVEHTIEILK GLRDRYEAHH RVSITDSAMV AAATLADRYI NDRFLPDKAI
410 420 430 440 450
DLIDEAGARM RIRRMTAPPD LREFDEKIAE ARREKESAID AQDFEKAASL
460 470 480 490 500
RDREKQLVAQ RAEREKQWRS GDLDVIAEVD DEQIAEVLGN WTGIPVFKLT
510 520 530 540 550
EAETTRLLRM EEELHKRIIG QEDAVKAVSK AIRRTRAGLK DPKRPSGSFI
560 570 580 590 600
FAGPSGVGKT ELSKALANFL FGDDDALIQI DMGEFHDRFT ASRLFGAPPG
610 620 630 640 650
YVGYEEGGQL TEKVRRKPFS VVLFDEIEKA HQEIYNSLLQ VLEDGRLTDG
660 670 680 690 700
QGRTVDFKNT VLIFTSNLGT SDISKPVGLG FTQGSGENDY ERMKQKVNDE
710 720 730 740 750
LKKHFRPEFL NRIDDIIVFH QLSRDEIIRM VDLMISRVAN QLKVKDMTLE
760 770 780 790 800
LTNKAKALLA KRGFDPVLGA RPLRRTIQRE IEDQLSEKIL FEEVGPGQVV
810 820 830 840
TVDVDNWDGE GPGEDVKFTF TGIRKPSTEP DLAKAGVHSA GGPEPVEQ
Length:848
Mass (Da):94,002
Last modified:April 27, 2001 - v2
Checksum:i49B191759397B697
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39H → P in AAA25352 (PubMed:1840579).Curated1
Sequence conflicti648 – 649TD → EF in CAA37573 (PubMed:2204033).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA. Translation: CAC29743.1.
X53488 Genomic DNA. Translation: CAA37573.1.
M67510 Genomic DNA. Translation: AAA25352.1.
PIRiC86938.
S11163.
RefSeqiNP_301295.1. NC_002677.1.
WP_010907619.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29743; CAC29743; CAC29743.
GeneIDi908260.
KEGGimle:ML0235.
PATRICi18050834. VBIMycLep78757_0368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA. Translation: CAC29743.1.
X53488 Genomic DNA. Translation: CAA37573.1.
M67510 Genomic DNA. Translation: AAA25352.1.
PIRiC86938.
S11163.
RefSeqiNP_301295.1. NC_002677.1.
WP_010907619.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP24428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0235.

Proteomic databases

PRIDEiP24428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29743; CAC29743; CAC29743.
GeneIDi908260.
KEGGimle:ML0235.
PATRICi18050834. VBIMycLep78757_0368.

Organism-specific databases

LepromaiML0235.

Phylogenomic databases

eggNOGiENOG4105C2Z. Bacteria.
COG0542. LUCA.
HOGENOMiHOG000218210.
KOiK03696.
OMAiENWDGEG.
OrthoDBiPOG091H019M.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
PF02151. UVR. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLPC_MYCLE
AccessioniPrimary (citable) accession number: P24428
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: April 27, 2001
Last modified: October 5, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.