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P24424 (KITH_BHV1Q) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Thymidine kinase
PRO_0000175062

Regions

Nucleotide binding17 – 248ATP By similarity

Sites

Active site451Proton acceptor Potential
Binding site991Substrate By similarity
Binding site1431Substrate By similarity
Binding site1871ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P24424 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: C3DB4930FB300025

FASTA35936,903
        10         20         30         40         50         60 
MAEPARALRV VRIYLDGAHG LGKTTTGRAL AAASTAGEGV LFFPEPMAYW RTMFVTDALS 

        70         80         90        100        110        120 
GILAASARCA AASHGSARGA GGPAHRADAD AAGLVAYYQA RFAAPYLILH ARVSALLAPP 

       130        140        150        160        170        180 
GPAPGGTVTL VFDRHPVAAC LCYPFARYCL REINAEDLLM LAAAMPPEAP GANLVVCTLP 

       190        200        210        220        230        240 
PAEQQRRLAA RARPGDRADA GFLVAVRNAY ALLVNTCAFL RAGGAWRDGW DALEWADANA 

       250        260        270        280        290        300 
LAALADPSCD ECKMAPAPAL RDTLFAALKC RELYPGGGAG LPAVHAWALD ALAGRLAALE 

       310        320        330        340        350 
VFVLDVSAAP DACAAAVLDM RPAMQAACAD GAAGATLATL ARQFALEMAG EATAGPRGL 

« Hide

References

[1]"The location and nucleotide sequence of the thymidine kinase gene of bovine herpesvirus type 1.2."
Smith G.A., Young P.L., Mattick J.S.
J. Gen. Virol. 71:2417-2424(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

PIRKIBEBT. A36254.

3D structure databases

ProteinModelPortalP24424.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_BHV1Q
AccessionPrimary (citable) accession number: P24424
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families