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P24424

- KITH_BHV1Q

UniProt

P24424 - KITH_BHV1Q

Protein

Thymidine kinase

Gene

TK

Organism
Bovine herpesvirus 1.2 (strain Q3932) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451Proton acceptorSequence Analysis
    Binding sitei99 – 991SubstrateBy similarity
    Binding sitei143 – 1431SubstrateBy similarity
    Binding sitei187 – 1871ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 248ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    OrganismiBovine herpesvirus 1.2 (strain Q3932) (BoHV-1) (Infectious bovine rhinotracheitis virus)
    Taxonomic identifieri10321 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Thymidine kinasePRO_0000175062Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP24424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P24424-1 [UniParc]FASTAAdd to Basket

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    MAEPARALRV VRIYLDGAHG LGKTTTGRAL AAASTAGEGV LFFPEPMAYW    50
    RTMFVTDALS GILAASARCA AASHGSARGA GGPAHRADAD AAGLVAYYQA 100
    RFAAPYLILH ARVSALLAPP GPAPGGTVTL VFDRHPVAAC LCYPFARYCL 150
    REINAEDLLM LAAAMPPEAP GANLVVCTLP PAEQQRRLAA RARPGDRADA 200
    GFLVAVRNAY ALLVNTCAFL RAGGAWRDGW DALEWADANA LAALADPSCD 250
    ECKMAPAPAL RDTLFAALKC RELYPGGGAG LPAVHAWALD ALAGRLAALE 300
    VFVLDVSAAP DACAAAVLDM RPAMQAACAD GAAGATLATL ARQFALEMAG 350
    EATAGPRGL 359
    Length:359
    Mass (Da):36,903
    Last modified:March 1, 1992 - v1
    Checksum:iC3DB4930FB300025
    GO

    Sequence databases

    PIRiA36254. KIBEBT.

    Cross-referencesi

    Sequence databases

    PIRi A36254. KIBEBT.

    3D structure databases

    ProteinModelPortali P24424.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The location and nucleotide sequence of the thymidine kinase gene of bovine herpesvirus type 1.2."
      Smith G.A., Young P.L., Mattick J.S.
      J. Gen. Virol. 71:2417-2424(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiKITH_BHV1Q
    AccessioniPrimary (citable) accession number: P24424
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3