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Protein

Thymidine kinase

Gene

TK

Organism
Bovine herpesvirus 1.2 (strain Q3932) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptorSequence Analysis
Binding sitei99 – 991SubstrateBy similarity
Binding sitei143 – 1431SubstrateBy similarity
Binding sitei187 – 1871ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 248ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiBovine herpesvirus 1.2 (strain Q3932) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Taxonomic identifieri10321 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Thymidine kinasePRO_0000175062Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP24424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P24424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPARALRV VRIYLDGAHG LGKTTTGRAL AAASTAGEGV LFFPEPMAYW
60 70 80 90 100
RTMFVTDALS GILAASARCA AASHGSARGA GGPAHRADAD AAGLVAYYQA
110 120 130 140 150
RFAAPYLILH ARVSALLAPP GPAPGGTVTL VFDRHPVAAC LCYPFARYCL
160 170 180 190 200
REINAEDLLM LAAAMPPEAP GANLVVCTLP PAEQQRRLAA RARPGDRADA
210 220 230 240 250
GFLVAVRNAY ALLVNTCAFL RAGGAWRDGW DALEWADANA LAALADPSCD
260 270 280 290 300
ECKMAPAPAL RDTLFAALKC RELYPGGGAG LPAVHAWALD ALAGRLAALE
310 320 330 340 350
VFVLDVSAAP DACAAAVLDM RPAMQAACAD GAAGATLATL ARQFALEMAG

EATAGPRGL
Length:359
Mass (Da):36,903
Last modified:February 29, 1992 - v1
Checksum:iC3DB4930FB300025
GO

Sequence databases

PIRiA36254. KIBEBT.

Cross-referencesi

Sequence databases

PIRiA36254. KIBEBT.

3D structure databases

ProteinModelPortaliP24424.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The location and nucleotide sequence of the thymidine kinase gene of bovine herpesvirus type 1.2."
    Smith G.A., Young P.L., Mattick J.S.
    J. Gen. Virol. 71:2417-2424(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiKITH_BHV1Q
AccessioniPrimary (citable) accession number: P24424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 29, 1992
Last sequence update: February 29, 1992
Last modified: January 6, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.