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Protein

Membrane protein

Gene

M

Organism
Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein
Short name:
M protein
Alternative name(s):
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Gene namesi
Name:M
OrganismiPorcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)
Taxonomic identifieri11148 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 47Virion surfaceSequence analysisAdd BLAST30
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 77IntravirionSequence analysis9
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 112Virion surfaceSequence analysisAdd BLAST14
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 262IntravirionSequence analysisAdd BLAST129

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17By similarityAdd BLAST17
ChainiPRO_000003715718 – 262Membrane proteinAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the coronaviruses M protein family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR002574. Corona_M.
PfamiView protein in Pfam
PF01635. Corona_M. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLILACA IACTCGERYC AMKDDTGLSC RNGTASDCES CFNRGDLIWL
60 70 80 90 100
LANWNFSWSI ILIIFITVLQ YGRPQFSWFV YGIKMLIMWL LWPIVLALTI
110 120 130 140 150
FNAYSEYQVS RYVMFGFSIA GAIVTFVLWI MYFVRSIQLY RRTKSWWSFN
160 170 180 190 200
PETNAILCVS ALGRSYVLPL EGVPTGVTLT LLSGNLYAEG FKIAGGMTID
210 220 230 240 250
NLPKYVMVAL PSRTIVYTLV GKKLKASSAT GWAYYVKSKA GDYSTEARTD
260
NLSEQEKLLH MV
Length:262
Mass (Da):29,587
Last modified:March 1, 1992 - v1
Checksum:i2B047572E98A5CE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24675 Genomic RNA. Translation: CAA80840.1.
PIRiD36607.

Similar proteinsi

Entry informationi

Entry nameiVME1_CVPRM
AccessioniPrimary (citable) accession number: P24412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 10, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program