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Protein

Nucleoprotein

Gene

N

Organism
Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. Interaction with the M protein leads to the formation of virus particles. Binds to cellular membranes and phospholipids. Elicits cell-mediated immunity. May play roles in viral transcription and translation, and/or replication.

GO - Molecular functioni

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
NC
Short name:
Protein N
Gene namesi
Name:N
OrganismiPorcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)
Taxonomic identifieri11148 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001060161 – 382NucleoproteinAdd BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine; by hostBy similarity1
Modified residuei156Phosphoserine; by hostBy similarity1
Modified residuei254Phosphoserine; by hostBy similarity1
Modified residuei256Phosphoserine; by hostBy similarity1

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer and oligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with the M protein.

Structurei

3D structure databases

ProteinModelPortaliP24411.
SMRiP24411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 159RNA-bindingBy similarityAdd BLAST127
Regioni231 – 334DimerizationBy similarityAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 182Ser-richAdd BLAST27

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR001218. Corona_nucleocap.
IPR037179. Nucleocapsid_C.
IPR037195. Nucleocapsid_N.
PfamiView protein in Pfam
PF00937. Corona_nucleoca. 1 hit.
PIRSFiPIRSF003888. Corona_nucleocap. 1 hit.
SUPFAMiSSF103068. SSF103068. 1 hit.
SSF110304. SSF110304. 1 hit.

Sequencei

Sequence statusi: Complete.

P24411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQGQRVSW GDESTKIRGR SNSRGRKINN IPLSFFNPIT LQQGAKFWNS
60 70 80 90 100
CPRDFVPKGI GNRDQQIGYW NRQTRYRMVK GQRKELPERW FFYYLGTGPH
110 120 130 140 150
ADAKFKDKLD GVVWVAKDGA MNKPTTLGSR GANNESKALK FDGKVPGEFQ
160 170 180 190 200
LEVNQSRDNS RSRSQSRSRS RNRSQSRGRQ QSNNKKDDSV EQAVLAALKK
210 220 230 240 250
LGVYTEKQQQ RSRSKSKERS NSKTRDTTPK NENKHTWKRT AGKGDVTRFY
260 270 280 290 300
GARSSSANFG DSDLVANGSS AKHYPQLAEC VPSVSSILFG SYWTSKEDGD
310 320 330 340 350
QIEVTFTHKY HLPKDHPKTE QFLQQINAYA SPSELAKEQR KRKSRSKSAE
360 370 380
RSEQEVVPDS LIENYTDVFD DTQVEMIDEV TN
Length:382
Mass (Da):43,551
Last modified:March 1, 1992 - v1
Checksum:i76EE7091E5D93BC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24675 Genomic RNA. Translation: CAA80841.1.
PIRiE36607.

Similar proteinsi

Entry informationi

Entry nameiNCAP_CVPRM
AccessioniPrimary (citable) accession number: P24411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program