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P24399

- ZN239_MOUSE

UniProt

P24399 - ZN239_MOUSE

Protein

Zinc finger protein 239

Gene

Znf239

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri6 – 2823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri34 – 5623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri62 – 8423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri90 – 11223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri118 – 14023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri146 – 16823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri174 – 19623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 239
    Short name:
    Zfp-239
    Alternative name(s):
    Zinc finger protein MOK-2
    Gene namesi
    Name:Znf239
    Synonyms:Mok-2, Mok2, Zfp239
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1306812. Zfp239.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201Zinc finger protein 239PRO_0000047481Add
    BLAST

    Proteomic databases

    PRIDEiP24399.

    PTM databases

    PhosphoSiteiP24399.

    Expressioni

    Tissue specificityi

    Preferentially expressed in transformed mouse cells.

    Gene expression databases

    BgeeiP24399.
    CleanExiMM_ZFP239.
    GenevestigatoriP24399.

    Structurei

    3D structure databases

    ProteinModelPortaliP24399.
    SMRiP24399. Positions 2-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri6 – 2823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri34 – 5623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri62 – 8423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri90 – 11223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri118 – 14023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri146 – 16823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri174 – 19623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117413.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiP24399.
    OMAiMDEKPYK.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiP24399.
    TreeFamiTF337055.

    Family and domain databases

    Gene3Di3.30.160.60. 7 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24399-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKPYKCDK CGKGFTRSSS LLVHHSVHTG EKPFKCDRCG KGFSQSSKLH    50
    IHKRVHTGEK PYACEECGMS FSQRSNLHIH QRVHTGERPY KCGECGKGFS 100
    QSSNLHIHRC THTGEKPYQC YECGKGFSQS SDLRIHLRVH TGEKPYHCGK 150
    CGQGFSQSSK LLIHQRVHTG EKPYECSKCG KGFSQSSNLH IHQRVHRKEL 200
    H 201
    Length:201
    Mass (Da):22,818
    Last modified:June 12, 2007 - v2
    Checksum:iC7112D76DC7DC412
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271V → L in AAA39729. (PubMed:2104662)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32057 mRNA. Translation: AAA39729.1.
    AK133328 mRNA. Translation: BAE21606.1.
    BC003315 mRNA. Translation: AAH03315.1.
    CCDSiCCDS20466.1.
    PIRiI57505.
    RefSeqiNP_001001792.1. NM_001001792.1.
    NP_032642.2. NM_008616.2.
    XP_006505991.1. XM_006505928.1.
    XP_006505992.1. XM_006505929.1.
    XP_006505993.1. XM_006505930.1.
    XP_006505994.1. XM_006505931.1.
    XP_006505995.1. XM_006505932.1.
    XP_006505996.1. XM_006505933.1.
    XP_006505997.1. XM_006505934.1.
    XP_006505998.1. XM_006505935.1.
    UniGeneiMm.249661.

    Genome annotation databases

    EnsembliENSMUST00000079405; ENSMUSP00000078374; ENSMUSG00000042097.
    ENSMUST00000172088; ENSMUSP00000128270; ENSMUSG00000042097.
    GeneIDi22685.
    KEGGimmu:22685.
    UCSCiuc009dlc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32057 mRNA. Translation: AAA39729.1 .
    AK133328 mRNA. Translation: BAE21606.1 .
    BC003315 mRNA. Translation: AAH03315.1 .
    CCDSi CCDS20466.1.
    PIRi I57505.
    RefSeqi NP_001001792.1. NM_001001792.1.
    NP_032642.2. NM_008616.2.
    XP_006505991.1. XM_006505928.1.
    XP_006505992.1. XM_006505929.1.
    XP_006505993.1. XM_006505930.1.
    XP_006505994.1. XM_006505931.1.
    XP_006505995.1. XM_006505932.1.
    XP_006505996.1. XM_006505933.1.
    XP_006505997.1. XM_006505934.1.
    XP_006505998.1. XM_006505935.1.
    UniGenei Mm.249661.

    3D structure databases

    ProteinModelPortali P24399.
    SMRi P24399. Positions 2-199.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P24399.

    Proteomic databases

    PRIDEi P24399.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079405 ; ENSMUSP00000078374 ; ENSMUSG00000042097 .
    ENSMUST00000172088 ; ENSMUSP00000128270 ; ENSMUSG00000042097 .
    GeneIDi 22685.
    KEGGi mmu:22685.
    UCSCi uc009dlc.1. mouse.

    Organism-specific databases

    CTDi 22685.
    MGIi MGI:1306812. Zfp239.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117413.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi P24399.
    OMAi MDEKPYK.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi P24399.
    TreeFami TF337055.

    Miscellaneous databases

    NextBioi 303115.
    PROi P24399.
    SOURCEi Search...

    Gene expression databases

    Bgeei P24399.
    CleanExi MM_ZFP239.
    Genevestigatori P24399.

    Family and domain databases

    Gene3Di 3.30.160.60. 7 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells."
      Ernoult-Lange M., Kress M., Hamer D.
      Mol. Cell. Biol. 10:418-421(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiZN239_MOUSE
    AccessioniPrimary (citable) accession number: P24399
    Secondary accession number(s): Q99J71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3