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Protein

Zinc finger protein 239

Gene

Znf239

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri6 – 2823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri34 – 5623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri62 – 8423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri90 – 11223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri118 – 14023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 16823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 239
Short name:
Zfp-239
Alternative name(s):
Zinc finger protein MOK-2
Gene namesi
Name:Znf239
Synonyms:Mok-2, Mok2, Zfp239
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1306812. Zfp239.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Zinc finger protein 239PRO_0000047481Add
BLAST

Proteomic databases

MaxQBiP24399.
PRIDEiP24399.

PTM databases

PhosphoSiteiP24399.

Expressioni

Tissue specificityi

Preferentially expressed in transformed mouse cells.

Gene expression databases

BgeeiP24399.
CleanExiMM_ZFP239.
GenevestigatoriP24399.

Structurei

3D structure databases

ProteinModelPortaliP24399.
SMRiP24399. Positions 2-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri6 – 2823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri34 – 5623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri62 – 8423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri90 – 11223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri118 – 14023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 16823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121886.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP24399.
OMAiMDEKPYK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP24399.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKPYKCDK CGKGFTRSSS LLVHHSVHTG EKPFKCDRCG KGFSQSSKLH
60 70 80 90 100
IHKRVHTGEK PYACEECGMS FSQRSNLHIH QRVHTGERPY KCGECGKGFS
110 120 130 140 150
QSSNLHIHRC THTGEKPYQC YECGKGFSQS SDLRIHLRVH TGEKPYHCGK
160 170 180 190 200
CGQGFSQSSK LLIHQRVHTG EKPYECSKCG KGFSQSSNLH IHQRVHRKEL

H
Length:201
Mass (Da):22,818
Last modified:June 12, 2007 - v2
Checksum:iC7112D76DC7DC412
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271V → L in AAA39729 (PubMed:2104662).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32057 mRNA. Translation: AAA39729.1.
AK133328 mRNA. Translation: BAE21606.1.
BC003315 mRNA. Translation: AAH03315.1.
CCDSiCCDS20466.1.
PIRiI57505.
RefSeqiNP_001001792.1. NM_001001792.1.
NP_032642.2. NM_008616.2.
XP_006505991.1. XM_006505928.2.
XP_006505992.1. XM_006505929.2.
XP_006505993.1. XM_006505930.2.
XP_006505994.1. XM_006505931.2.
XP_006505995.1. XM_006505932.2.
XP_006505996.1. XM_006505933.1.
XP_006505997.1. XM_006505934.2.
XP_006505998.1. XM_006505935.1.
UniGeneiMm.249661.

Genome annotation databases

EnsembliENSMUST00000079405; ENSMUSP00000078374; ENSMUSG00000042097.
ENSMUST00000172088; ENSMUSP00000128270; ENSMUSG00000042097.
GeneIDi22685.
KEGGimmu:22685.
UCSCiuc009dlc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32057 mRNA. Translation: AAA39729.1.
AK133328 mRNA. Translation: BAE21606.1.
BC003315 mRNA. Translation: AAH03315.1.
CCDSiCCDS20466.1.
PIRiI57505.
RefSeqiNP_001001792.1. NM_001001792.1.
NP_032642.2. NM_008616.2.
XP_006505991.1. XM_006505928.2.
XP_006505992.1. XM_006505929.2.
XP_006505993.1. XM_006505930.2.
XP_006505994.1. XM_006505931.2.
XP_006505995.1. XM_006505932.2.
XP_006505996.1. XM_006505933.1.
XP_006505997.1. XM_006505934.2.
XP_006505998.1. XM_006505935.1.
UniGeneiMm.249661.

3D structure databases

ProteinModelPortaliP24399.
SMRiP24399. Positions 2-199.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP24399.

Proteomic databases

MaxQBiP24399.
PRIDEiP24399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079405; ENSMUSP00000078374; ENSMUSG00000042097.
ENSMUST00000172088; ENSMUSP00000128270; ENSMUSG00000042097.
GeneIDi22685.
KEGGimmu:22685.
UCSCiuc009dlc.1. mouse.

Organism-specific databases

CTDi22685.
MGIiMGI:1306812. Zfp239.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121886.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP24399.
OMAiMDEKPYK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP24399.
TreeFamiTF337055.

Miscellaneous databases

NextBioi303115.
PROiP24399.
SOURCEiSearch...

Gene expression databases

BgeeiP24399.
CleanExiMM_ZFP239.
GenevestigatoriP24399.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells."
    Ernoult-Lange M., Kress M., Hamer D.
    Mol. Cell. Biol. 10:418-421(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiZN239_MOUSE
AccessioniPrimary (citable) accession number: P24399
Secondary accession number(s): Q99J71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 12, 2007
Last modified: April 1, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.