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P24399 (ZN239_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 239

Short name=Zfp-239
Alternative name(s):
Zinc finger protein MOK-2
Gene names
Name:Znf239
Synonyms:Mok-2, Mok2, Zfp239
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Tissue specificity

Preferentially expressed in transformed mouse cells.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 7 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Zinc finger protein 239
PRO_0000047481

Regions

Zinc finger6 – 2823C2H2-type 1
Zinc finger34 – 5623C2H2-type 2
Zinc finger62 – 8423C2H2-type 3
Zinc finger90 – 11223C2H2-type 4
Zinc finger118 – 14023C2H2-type 5
Zinc finger146 – 16823C2H2-type 6
Zinc finger174 – 19623C2H2-type 7

Experimental info

Sequence conflict271V → L in AAA39729. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P24399 [UniParc].

Last modified June 12, 2007. Version 2.
Checksum: C7112D76DC7DC412

FASTA20122,818
        10         20         30         40         50         60 
MAEKPYKCDK CGKGFTRSSS LLVHHSVHTG EKPFKCDRCG KGFSQSSKLH IHKRVHTGEK 

        70         80         90        100        110        120 
PYACEECGMS FSQRSNLHIH QRVHTGERPY KCGECGKGFS QSSNLHIHRC THTGEKPYQC 

       130        140        150        160        170        180 
YECGKGFSQS SDLRIHLRVH TGEKPYHCGK CGQGFSQSSK LLIHQRVHTG EKPYECSKCG 

       190        200 
KGFSQSSNLH IHQRVHRKEL H 

« Hide

References

« Hide 'large scale' references
[1]"A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells."
Ernoult-Lange M., Kress M., Hamer D.
Mol. Cell. Biol. 10:418-421(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32057 mRNA. Translation: AAA39729.1.
AK133328 mRNA. Translation: BAE21606.1.
BC003315 mRNA. Translation: AAH03315.1.
CCDSCCDS20466.1.
PIRI57505.
RefSeqNP_001001792.1. NM_001001792.1.
NP_032642.2. NM_008616.2.
XP_006505991.1. XM_006505928.1.
XP_006505992.1. XM_006505929.1.
XP_006505993.1. XM_006505930.1.
XP_006505994.1. XM_006505931.1.
XP_006505995.1. XM_006505932.1.
XP_006505996.1. XM_006505933.1.
XP_006505997.1. XM_006505934.1.
XP_006505998.1. XM_006505935.1.
UniGeneMm.249661.

3D structure databases

ProteinModelPortalP24399.
SMRP24399. Positions 2-199.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP24399.

Proteomic databases

PRIDEP24399.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079405; ENSMUSP00000078374; ENSMUSG00000042097.
ENSMUST00000172088; ENSMUSP00000128270; ENSMUSG00000042097.
GeneID22685.
KEGGmmu:22685.
UCSCuc009dlc.1. mouse.

Organism-specific databases

CTD22685.
MGIMGI:1306812. Zfp239.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117413.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidP24399.
OMAMDEKPYK.
OrthoDBEOG7KSX7Q.
PhylomeDBP24399.
TreeFamTF337055.

Gene expression databases

BgeeP24399.
CleanExMM_ZFP239.
GenevestigatorP24399.

Family and domain databases

Gene3D3.30.160.60. 7 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio303115.
PROP24399.
SOURCESearch...

Entry information

Entry nameZN239_MOUSE
AccessionPrimary (citable) accession number: P24399
Secondary accession number(s): Q99J71
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 12, 2007
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot