##gff-version 3 P24394 UniProtKB Signal peptide 1 25 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P24394 UniProtKB Chain 26 825 . . . ID=PRO_0000010887;Note=Interleukin-4 receptor subunit alpha P24394 UniProtKB Topological domain 26 232 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24394 UniProtKB Transmembrane 233 256 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24394 UniProtKB Topological domain 257 825 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24394 UniProtKB Domain 125 224 . . . Note=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 P24394 UniProtKB Region 373 397 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P24394 UniProtKB Region 433 485 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P24394 UniProtKB Region 437 557 . . . Note=Required for IRS1 activation and IL4-induced cell growth P24394 UniProtKB Region 558 657 . . . Note=Required for IL4-induced gene expression P24394 UniProtKB Region 651 703 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P24394 UniProtKB Region 782 809 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P24394 UniProtKB Motif 212 216 . . . Note=WSXWS motif P24394 UniProtKB Motif 262 270 . . . Note=Box 1 motif P24394 UniProtKB Motif 711 716 . . . Note=ITIM motif P24394 UniProtKB Compositional bias 381 397 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P24394 UniProtKB Compositional bias 784 809 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P24394 UniProtKB Site 38 38 . . . Note=Major IL4 binding determinant P24394 UniProtKB Site 64 64 . . . Note=Minor IL4 binding determinant P24394 UniProtKB Site 66 66 . . . Note=Minor IL4 binding determinant P24394 UniProtKB Site 92 92 . . . Note=Minor IL4 binding determinant P24394 UniProtKB Site 94 94 . . . Note=Minor IL4 binding determinant P24394 UniProtKB Site 97 97 . . . Note=Major IL4 binding determinant P24394 UniProtKB Site 152 152 . . . Note=Minor IL4 binding determinant P24394 UniProtKB Site 208 208 . . . Note=Major IL4 binding determinant P24394 UniProtKB Modified residue 497 497 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8124718;Dbxref=PMID:8124718 P24394 UniProtKB Modified residue 575 575 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:8624803;Dbxref=PMID:8624803 P24394 UniProtKB Modified residue 603 603 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:8624803;Dbxref=PMID:8624803 P24394 UniProtKB Modified residue 631 631 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:8624803;Dbxref=PMID:8624803 P24394 UniProtKB Glycosylation 53 53 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24394 UniProtKB Glycosylation 98 98 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24394 UniProtKB Glycosylation 128 128 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24394 UniProtKB Glycosylation 134 134 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24394 UniProtKB Glycosylation 176 176 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24394 UniProtKB Glycosylation 209 209 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24394 UniProtKB Disulfide bond 34 44 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P24394 UniProtKB Disulfide bond 74 86 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P24394 UniProtKB Alternative sequence 1 23 . . . ID=VSP_053738;Note=In isoform 3. MGWLCSGLLFPVSCLVLLQVASS->MQKDARRE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P24394 UniProtKB Alternative sequence 225 227 . . . ID=VSP_011116;Note=In isoform 2. YRE->NIC;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24394 UniProtKB Alternative sequence 228 825 . . . ID=VSP_011117;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24394 UniProtKB Natural variant 75 75 . . . ID=VAR_059302;Note=I->F;Dbxref=dbSNP:rs1805010 P24394 UniProtKB Natural variant 75 75 . . . ID=VAR_059303;Note=I->L;Dbxref=dbSNP:rs1805010 P24394 UniProtKB Natural variant 75 75 . . . ID=VAR_008034;Note=Probable risk factor for atopic asthma and cedar pollen sensitization. I->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10390422,ECO:0000269|PubMed:14657871,ECO:0000269|PubMed:9070874,ECO:0000269|PubMed:9620765,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1805010,PMID:10390422,PMID:14657871,PMID:9070874,PMID:9620765 P24394 UniProtKB Natural variant 387 387 . . . ID=VAR_019999;Note=S->L;Dbxref=dbSNP:rs6413500 P24394 UniProtKB Natural variant 400 400 . . . ID=VAR_011657;Note=Probable risk factor for cedar pollen sensitization. E->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11285129,ECO:0000269|PubMed:14657871,ECO:0000269|PubMed:9070874,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1805011,PMID:11285129,PMID:14657871,PMID:9070874 P24394 UniProtKB Natural variant 431 431 . . . ID=VAR_011658;Note=C->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11285129,ECO:0000269|PubMed:9070874,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1805012,PMID:11285129,PMID:9070874 P24394 UniProtKB Natural variant 436 436 . . . ID=VAR_011659;Note=S->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11285129,ECO:0000269|PubMed:9070874,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1805013,PMID:11285129,PMID:9070874 P24394 UniProtKB Natural variant 492 492 . . . ID=VAR_049164;Note=A->T;Dbxref=dbSNP:rs35606110 P24394 UniProtKB Natural variant 492 492 . . . ID=VAR_049165;Note=A->V;Dbxref=dbSNP:rs34727572 P24394 UniProtKB Natural variant 503 503 . . . ID=VAR_011660;Note=Lowered total IgE concentration. S->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10233717,ECO:0000269|PubMed:11285129,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1805015,PMID:10233717,PMID:11285129 P24394 UniProtKB Natural variant 576 576 . . . ID=VAR_008035;Note=Probable risk factor for atopic dermatitis%3B lowered total IgE concentration%3B no effect on IL4-induced signal transduction. Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10201973,ECO:0000269|PubMed:10233717,ECO:0000269|PubMed:10809862,ECO:0000269|PubMed:11285129,ECO:0000269|PubMed:9392697,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1801275,PMID:10201973,PMID:10233717,PMID:10809862,PMID:11285129,PMID:9392697 P24394 UniProtKB Natural variant 579 579 . . . ID=VAR_011661;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11285129,ECO:0000269|Ref.5;Dbxref=dbSNP:rs3024677,PMID:11285129 P24394 UniProtKB Natural variant 675 675 . . . ID=VAR_020000;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs3024678 P24394 UniProtKB Natural variant 752 752 . . . ID=VAR_011662;Note=S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10677312,ECO:0000269|Ref.5;Dbxref=dbSNP:rs1805016,PMID:10677312 P24394 UniProtKB Natural variant 786 786 . . . ID=VAR_011663;Note=In 1.8%25 of the population. S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11513543,ECO:0000269|PubMed:9070874;Dbxref=dbSNP:rs1805014,PMID:11513543,PMID:9070874 P24394 UniProtKB Mutagenesis 38 38 . . . Note=700-fold reduction in IL4 binding. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 38 38 . . . Note=25-fold reduction in IL4 binding. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 39 39 . . . Note=No effect on IL4 binding. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 40 40 . . . Note=No effect on IL4 binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 64 64 . . . Note=100-fold reduction in IL4 binding. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 66 66 . . . Note=45-fold reduction in IL4 binding. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 67 67 . . . Note=No effect on IL4 binding. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 68 68 . . . Note=No effect on IL4 binding. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 91 91 . . . Note=Little effect on IL4 binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 92 92 . . . Note=50-fold reduction in IL4 binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 93 93 . . . Note=Little effect on IL4 binding. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 94 94 . . . Note=35-fold reduction in IL4 binding. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 95 95 . . . Note=No effect on IL4 binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 97 97 . . . Note=>150-fold reduction in IL4 binding. D->A%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 98 98 . . . Note=No effect on IL4 binding. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 99 99 . . . Note=10-fold reduction in IL4 binding. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 116 116 . . . Note=Little effect on IL4 binding. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 117 117 . . . Note=Little effect on IL4 binding. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 118 118 . . . Note=No effect on IL4 binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 119 119 . . . Note=No effect on IL4 binding. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 150 150 . . . Note=Little effect on IL4 binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 151 151 . . . Note=Little effect on IL4 binding. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 152 152 . . . Note=40-fold reduction in IL4 binding. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 152 152 . . . Note=No effect on IL4 binding. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 153 153 . . . Note=Little effect on IL4 binding. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 154 154 . . . Note=Little effect on IL4 binding. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 208 208 . . . Note=500-fold reduction in IL4 binding. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 208 208 . . . Note=200-fold reduction in IL4 binding. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11786020;Dbxref=PMID:11786020 P24394 UniProtKB Mutagenesis 497 497 . . . Note=Abolishes IRS1 tyrosine phosphorylation. No cell proliferation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8124718;Dbxref=PMID:8124718 P24394 UniProtKB Mutagenesis 575 575 . . . Note=Loss of CD23 gene induction%3B when associated with F-603 and F-631. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10201973,ECO:0000269|PubMed:8624803;Dbxref=PMID:10201973,PMID:8624803 P24394 UniProtKB Mutagenesis 603 603 . . . Note=Loss of CD23 gene induction%3B when associated with F-575 and F-631. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8624803;Dbxref=PMID:8624803 P24394 UniProtKB Mutagenesis 631 631 . . . Note=Loss of CD23 gene induction%3B when associated with F-575 and F-603. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8624803;Dbxref=PMID:8624803 P24394 UniProtKB Mutagenesis 713 713 . . . Note=Increased IL4-induced cell proliferation and STAT6 activation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11714803;Dbxref=PMID:11714803 P24394 UniProtKB Beta strand 28 36 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 38 50 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Helix 54 57 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 58 68 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 72 74 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 77 89 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 99 105 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 108 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Helix 117 119 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 127 132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Turn 135 137 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BPO P24394 UniProtKB Beta strand 139 144 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Helix 154 156 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 158 168 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 172 177 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 179 181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WGL P24394 UniProtKB Beta strand 183 186 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Helix 188 190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BPL P24394 UniProtKB Beta strand 193 195 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BPO P24394 UniProtKB Beta strand 197 204 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Helix 206 208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Beta strand 219 221 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IAR P24394 UniProtKB Helix 495 497 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IRS