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Protein

Gastrin-releasing peptide

Gene

Grp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity). Contributes to the regulation of food intake (PubMed:17208656).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide
Short name:
GRP
Cleaved into the following chain:
Alternative name(s):
GRP-10
Gene namesi
Name:Grp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi621740. Grp.

Subcellular locationi

  • Secreted By similarity
  • Cytoplasmic vesiclesecretory vesicle lumen By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
PeptideiPRO_000000303924 – 52Gastrin-releasing peptideAdd BLAST29
PeptideiPRO_000000304043 – 52Neuromedin-C10
PropeptideiPRO_000000304156 – 147By similarityAdd BLAST92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52Methionine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP24393.

PTM databases

PhosphoSitePlusiP24393.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016999.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022845.

Structurei

3D structure databases

SMRiP24393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ53. Eukaryota.
ENOG4111D8H. LUCA.
GeneTreeiENSGT00390000017865.
HOGENOMiHOG000112821.
HOVERGENiHBG005912.
InParanoidiP24393.
KOiK05224.
OMAiYIRWEEA.
OrthoDBiEOG091G0VOZ.
PhylomeDBiP24393.
TreeFamiTF336391.

Family and domain databases

InterProiView protein in InterPro
IPR000874. Bombesin.
IPR015674. Gastrin-RP.
PANTHERiPTHR16866:SF4. PTHR16866:SF4. 1 hit.
PfamiView protein in Pfam
PF02044. Bombesin. 1 hit.
PROSITEiView protein in PROSITE
PS00257. BOMBESIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGSELSLLL LALVLCQAPR GPAAPVSTGA GGGTVLAKMY PRGSHWAVGH
60 70 80 90 100
LMGKKSTDEL PPLYAADRDG LKEQLRGYIR WEEAARNLLG LLEAAGNRSH
110 120 130 140
QPPQDQPLGS LQPTWDPEDG SYFSDAQNAK LVDSLLQVLK GKEGTAS
Length:147
Mass (Da):15,702
Last modified:June 7, 2017 - v2
Checksum:i54AF30AEF24E56B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95 – 96AG → SR in AAA41197 (PubMed:2843761).2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31176 mRNA. Translation: AAA41197.1.
AABR07032332 Genomic DNA. No translation available.
CH473971 Genomic DNA. Translation: EDM14697.1.
CH473971 Genomic DNA. Translation: EDM14698.1.
PIRiA40922.
RefSeqiNP_598254.2. NM_133570.5.
UniGeneiRn.10930.

Genome annotation databases

EnsembliENSRNOT00000022845; ENSRNOP00000022845; ENSRNOG00000016999.
GeneIDi171101.
KEGGirno:171101.
UCSCiRGD:621740. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGRP_RAT
AccessioniPrimary (citable) accession number: P24393
Secondary accession number(s): G3V871
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 7, 2017
Last modified: July 5, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families