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Protein

Peroxisome biogenesis factor 2

Gene

Pex2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Somewhat implicated in the biogenesis of peroxisomes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 284RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome biogenesis factor 2
Alternative name(s):
Peroxin-2
Peroxisomal membrane protein 3
Peroxisome assembly factor 1
Short name:
PAF-1
Gene namesi
Name:Pex2
Synonyms:Paf1, Pmp35, Pxmp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi61814. Pex2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei140 – 159HelicalSequence analysisAdd BLAST20
Transmembranei195 – 213HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • Cdc73/Paf1 complex Source: Ensembl
  • integral component of peroxisomal membrane Source: Ensembl
  • membrane Source: RGD
  • peroxisomal membrane Source: HGNC
  • peroxisome Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563711 – 305Peroxisome biogenesis factor 2Add BLAST305

Proteomic databases

PaxDbiP24392.
PRIDEiP24392.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008748.
GenevisibleiP24392. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011579.

Structurei

3D structure databases

ProteinModelPortaliP24392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 284RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG2879. Eukaryota.
ENOG41107WE. LUCA.
GeneTreeiENSGT00390000001846.
HOGENOMiHOG000294074.
HOVERGENiHBG000416.
InParanoidiP24392.
KOiK06664.
OMAiCTIGGRW.
OrthoDBiEOG091G0I1O.
PhylomeDBiP24392.
TreeFamiTF105312.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006845. Pex_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04757. Pex2_Pex12. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAREESTQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA
60 70 80 90 100
RFEPEVKAFL WLFLWRFTIY SKNATVGQSV LNIQYKNDSS PNPVYQPPSK
110 120 130 140 150
NQKLLYAVCT IGGRWLEERC YDLFRNRHLA SFGKAKQCMN FVVGLLKLGE
160 170 180 190 200
LMNFLIFLQK GKFATLTERL LGIHSVFCKP QSMREVGFEY MNRELLWHGF
210 220 230 240 250
AEFLVFLLPL INIQKLKAKL SSWCIPLTST AGSDSTLGSS GKECALCGEW
260 270 280 290 300
PTMPHTIGCE HVFCYYCVKS SFLFDMYFTC PKCGTEVHSV QPLKSGIEMS

EVNAL
Length:305
Mass (Da):34,768
Last modified:March 1, 1992 - v1
Checksum:i249058A5A5A8E854
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti125R → P.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57988 mRNA. Translation: CAA41054.1.
D30616 mRNA. Translation: BAA06306.1.
D30617 mRNA. Translation: BAA06307.1.
BC063169 mRNA. Translation: AAH63169.1.
PIRiB53782.
RefSeqiNP_058930.1. NM_017234.1.
XP_006232222.1. XM_006232160.3.
XP_006232223.1. XM_006232161.2.
UniGeneiRn.4065.

Genome annotation databases

EnsembliENSRNOT00000011579; ENSRNOP00000011579; ENSRNOG00000008748.
GeneIDi29534.
KEGGirno:29534.
UCSCiRGD:61814. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57988 mRNA. Translation: CAA41054.1.
D30616 mRNA. Translation: BAA06306.1.
D30617 mRNA. Translation: BAA06307.1.
BC063169 mRNA. Translation: AAH63169.1.
PIRiB53782.
RefSeqiNP_058930.1. NM_017234.1.
XP_006232222.1. XM_006232160.3.
XP_006232223.1. XM_006232161.2.
UniGeneiRn.4065.

3D structure databases

ProteinModelPortaliP24392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011579.

Proteomic databases

PaxDbiP24392.
PRIDEiP24392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011579; ENSRNOP00000011579; ENSRNOG00000008748.
GeneIDi29534.
KEGGirno:29534.
UCSCiRGD:61814. rat.

Organism-specific databases

CTDi5828.
RGDi61814. Pex2.

Phylogenomic databases

eggNOGiKOG2879. Eukaryota.
ENOG41107WE. LUCA.
GeneTreeiENSGT00390000001846.
HOGENOMiHOG000294074.
HOVERGENiHBG000416.
InParanoidiP24392.
KOiK06664.
OMAiCTIGGRW.
OrthoDBiEOG091G0I1O.
PhylomeDBiP24392.
TreeFamiTF105312.

Miscellaneous databases

PROiP24392.

Gene expression databases

BgeeiENSRNOG00000008748.
GenevisibleiP24392. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006845. Pex_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04757. Pex2_Pex12. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX2_RAT
AccessioniPrimary (citable) accession number: P24392
Secondary accession number(s): Q63733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.